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Clearz Max Cream is used to treat melasma (dark brown patches on the skin). It blocks the production of certain chemical messengers that make the skin red, swollen, and itchy, decreasing the amount of melanin (a skin pigment) and increasing the renewal of skin cells. In some cases, this medicine may cause side effects such as application site reactions (burning, irritation, itching, and redness).

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

FLUOCINOLONE ACETONIDE-0.1MG+HYDROQUINONE-20MG+TRETINOIN-0.25MG

Manufacturer/Marketer :

Dr Reddy's Laboratories Ltd

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Clearz Max Cream

Clearz Max Cream is a topical skin cream prescribed to treat moderate-to-severe melasma, which causes dark, patchy discoloration on the face. It is formulated to help fade these stubborn dark spots and restore an even skin tone. This medication is typically prescribed for short-term use to target specific areas of discoloration.

For the best results, you must apply this medication consistently once daily at night, at least 30 minutes before bedtime. Because the active ingredients make your skin highly sensitive, you should apply it only to a clean, dry face. Incorporating daily sun protection and wearing wide-brimmed hats are essential lifestyle changes that will help maintain your progress.

While using Clearz Max Cream, you may experience mild skin peeling, redness, or dryness as your skin adjusts to the treatment. These effects are usually temporary and manageable with a gentle moisturizer. However, you should consult your doctor immediately if you experience severe skin burning, swelling, or dark blue-black discoloration.

Do not use this cream if you have a known allergy to any of its ingredients or if you have an active skin infection. It is also important to talk to your doctor before starting this treatment if you have rosacea, broken skin, or a history of skin thinning. Pregnant and breastfeeding individuals must not use this medication, as it can be absorbed through the skin and may cause harm.

You should avoid using other drying or abrasive skin products, such as alcohol-based toners or strong exfoliating scrubs, while using Clearz Max Cream because they can cause severe skin irritation. It is also wise to limit smoking and alcohol consumption, as they can impair your skin's natural healing process. If you are caring for elderly individuals, consult a doctor first, as older skin may be more sensitive to thinning.

Uses of Clearz Max Cream

Clearz Max Cream is a topical combination medicine used to treat melasma and other forms of skin hyperpigmentation by reducing inflammation, lightening dark patches, and promoting healthy skin cell renewal. 

  • Melasma: Clearz Max Cream helps lighten dark, patchy skin discoloration typically found on the cheeks, forehead, upper lip, and chin.
  • Post-inflammatory hyperpigmentation: Clearz Max Cream reduces stubborn dark spots left behind by acne, skin injuries, or localized inflammation.
  • Senile lentigines (age spots): Clearz Max Cream helps fade flat, dark brown spots caused by chronic sun exposure and aging on the face.

Key Benefits

Clearz Max Cream combines three complementary ingredients to reduce discoloration, calm inflammation, and improve overall skin appearance.

  • Reduces dark patches: Hydroquinone decreases melanin production, helping to fade melasma and other forms of hyperpigmentation.
  • Promotes skin renewal: Tretinoin speeds up skin cell turnover, improving skin texture and enhancing the fading of dark spots.
  • Relieves redness and irritation: Fluocinolone acetonide reduces inflammation, redness, and irritation that may occur with skin pigmentation disorders or tretinoin use.
  • Improves overall skin tone: With regular use as directed, this combination helps produce a clearer, smoother, and more even-looking complexion.
Side effects of Clearz Max Cream 15 gm
Managing Medication-Triggered Erythema (Redness of the Skin or Skin redness): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.
  • Moisturize frequently with thick, broad-spectrum moisturizers containing sunscreen.
  • Use warm water for short baths, and gentle cleansers.
  • Pat dry and apply moisturizer immediately.
  • Use a humidifier to add moisture to the air, and choose breathable fabrics like cotton and silk.
  • Wash clothes with fragrance-free detergents to minimize irritation.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.
  • Burning sensation is an abnormal side effect that needs medical attention. To relieve the burning feeling, your doctor may prescribe painkillers or antidepressants.
  • Focused exercises can improve strength and reduce burning by soothing muscles.
  • Change in lifestyle and improving nutrition can reduce the causes of burning sensation and provide relief.
  • Your doctor may suggest nerve block injections as it is related to sensation in the skin.
  • Burning feeling in a specific area would need mild electrical currents to reduce pain that targets the nerve affected. This practice must be done only if your doctor mentions it.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Apply Clearz Max Cream on the clean and dry affected area as your doctor advises.
  • Wash your hands after using Clearz Max Cream unless the treatment is for your hands.

How Clearz Max Cream Works

Clearz Max Cream contains fluocinolone acetonide, hydroquinone, and tretinoin, which work together through complementary mechanisms to treat melasma and other forms of hyperpigmentation while helping to minimise treatment-related skin irritation. Hydroquinone is a skin-lightening agent that inhibits the enzyme tyrosinase, which is essential for the production of melanin (the pigment responsible for skin color). By reducing melanin synthesis, hydroquinone gradually lightens existing dark patches and helps prevent the formation of new pigmentation. Tretinoin, a vitamin A derivative (retinoid), increases the turnover of skin cells by promoting the shedding of pigmented keratinocytes and stimulating the growth of new skin cells. This accelerates the removal of excess melanin from the skin, improves the penetration and effectiveness of hydroquinone, and enhances overall skin texture. Fluocinolone acetonide is a low-potency topical corticosteroid that suppresses the release of inflammatory mediators, reducing redness, swelling, itching, and irritation. It also helps minimize the skin irritation that can occur with hydroquinone and tretinoin therapy, improving tolerability and treatment adherence. Together, these three ingredients provide a comprehensive approach to treating hyperpigmentation by reducing melanin production, accelerating the removal of pigmented skin cells, and controlling inflammation, resulting in a more even skin tone and improved skin appearance.
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Alcohol

Consult your doctor

The interaction of alcohol with Clearz Max Cream is unknown. Please consult a doctor before consuming alcohol while using Clearz Max Cream.

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Pregnancy

Caution

The safety of Clearz Max Cream in pregnant women is unknown and is given to a pregnant woman only if the doctor thinks the benefits outweigh the risks.

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Breast Feeding

Caution

It is unknown whether Clearz Max Cream is excreted in human milk. Please consult a doctor before using Clearz Max Cream while breastfeeding.

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Driving

Safe if prescribed

Clearz Max Cream usually does not affect your ability to drive or operate machinery.

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Liver

Consult your doctor

If you have any concerns regarding the use of Clearz Max Cream in patients with liver problems, please consult a doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Clearz Max Cream in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Clearz Max Cream is not recommended for children below 12 years of age, as the safety and effectiveness were not established.

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Heart

Caution

Limited information was available regarding the use of Clearz Max Cream in patients with heart problems. Please consult your doctor before using Clearz Max Cream.

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Geriatrics

Caution

Clearz Max Cream should be used with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Clearz Max Cream.

What if I have taken an overdose of Clearz Max Cream

If you accidentally apply too much cream, gently wipe off the excess. If the medication is swallowed, or if severe skin irritation or burning occurs due to excessive use, seek immediate medical attention.

Diet & Lifestyle Advise

  • Use Sunscreen Daily: Apply a broad-spectrum sunscreen with an SPF of 30 or higher every morning, even on cloudy days, as treated skin is highly sensitive to UV rays.
  • Protect Your Skin from the Sun: Wear protective clothing, such as a wide-brimmed hat and sunglasses, and limit direct sun exposure, especially during peak sunlight hours.
  • Avoid Harsh Skincare Products: Avoid using chemical peels, physical scrubs, alcohol-based toners, or other irritating skincare products unless recommended by your healthcare provider.
  • Maintain a Skin-Healthy Diet: Stay well-hydrated and eat a balanced diet rich in antioxidants, including berries, leafy greens, and citrus fruits, to support healthy skin repair and overall skin health.

Health Queries

I'm a 27-year-old woman. For many years, I have struggled with freckles on my cheeks and nose. Is there a medication or face cleanser that can get rid of them?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

You can lighten and manage freckles with proper skincare; use a mild cleanser with chemicals like kojic acid or niacinamide and apply a pigmentation cream at night. Freckles are typically inherited and caused by sun exposure, so they may not entirely go away.

Please advise or recommend a lotion for the black mark on my face.

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Dark spots (black marks) on the face usually happen due to sun exposure, acne marks, or pigmentation, and creams with ingredients like kojic acid, vitamin C, niacinamide, or glycolic acid help lighten them over time. If the spot is increasing, very dark, or not improving, consult a skin doctor for stronger treatment.

My color was fair when I was a child, but now it's black. Could you please offer a simple solution?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Skin color usually becomes darker over time due to sun exposure, tanning, pollution, and natural changes, and it is not possible to permanently change your natural skin tone, but you can improve brightness and reduce tanning by simple care; wash your face twice daily, use a gentle moisturizer, and most importantly apply sunscreen with at least SPF 30 every morning to prevent further darkening. You can also use creams with mild ingredients like Vitamin C or Niacinamide to improve glow gradually.
health query

Have a query?

How Soon It Starts Working

  • The time required for Clearz Max Cream to start to work: Clearz Max Cream ideally shows its action within 2 to 4 weeks of consistent use.
  • The time for which the effects of Clearz Max Cream last: The duration of action for Clearz Max Cream is clinically unknown.

What if you forget to take Clearz Max Cream

If you miss an evening application, skip the missed dose and apply the cream the following evening at your regular time. Do not apply a double amount of cream to make up for a missed application.

Storage

•Store Clearz Max Cream in a cool place, ideally in the refrigerator between 2°C and 8°C (36°F to 46°F), or as directed on the product packaging.

Drug Warnings

  • Check the Product Before Use: Inspect the cream before each application. If it has turned dark brown or changed significantly in color, do not use it and consult your pharmacist.
  • Apply a Thin Layer: Use only a small, pea-sized amount to cover the affected areas. Applying more than recommended will not improve results and may increase skin irritation.
  • Avoid Hair Removal Procedures: Do not use waxing, chemical depilatories, or laser hair removal on treated areas, as the skin may become more sensitive and prone to injury.
  • Do Not Cover the Treated Area: Avoid covering the treated skin with bandages, tight wraps, or dressings unless specifically instructed by your healthcare provider.
  • Avoid Other Irritating Topical Products: Do not use products containing salicylic acid, sulfur, or resorcinol on the treated area unless advised by your healthcare provider, as they may increase skin irritation.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Topical exfoliants and acne treatments: Medications containing sulfur, salicylic acid, or benzoyl peroxide can severely increase skin dryness, peeling, and irritation when used with Clearz Max Cream.
  • Other topical corticosteroids: Using other steroid creams on the face at the same time can increase the risk of skin thinning and absorption into the bloodstream.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Clearz Max Cream when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[RETINOIDS]

FAQs

Clearz Max Cream is used to treat melasma (dark brown patches on the skin).
Clearz Max Cream contains three medicines, namely: Fluocinolone acetonide (steroid), Hydroquinone (skin lightening or bleaching agent), and Tretinoin (a form of Vitamin A or retinoids). Fluocinolone acetonide is a steroid that blocks the production of certain chemical messengers (prostaglandins) that make the skin red, swollen, and itchy. Hydroquinone belongs to the class of skin lightening agents that work by decreasing the amount of melanin (a skin pigment) that is responsible for the darkening of the skin. Tretinoin belongs to the class of retinoids (man-made vitamin A) that works by increasing the renewal of skin cells, which helps in the natural exfoliation of skin's outer layers.
Clearz Max Cream causes common side effects at the application site (burning, irritation, itching, and redness). Most of these side effects of Clearz Max Cream do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.
Yes, Clearz Max Cream may increase the skin sensitivity to sunlight in the treated areas. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use sunscreen and wear protective clothing while going out to prevent sunburn.
Yes, Clearz Max Cream may cause skin irritation, burning sensation, or itching at the site of application in rare cases. However, if the irritation persists or worsens, stop using Clearz Max Cream and consult a doctor.
To use Clearz Max Cream, clean the affected area and pat it dry. Then, apply Clearz Max Cream to the affected area as advised by your doctor and gently rub it in.
Clearz Max Cream is not recommended for children under 12 years old, as its safety and effectiveness in this age group have not been established. If your child requires treatment, consult your paediatrician for an appropriate suggestion.
If Clearz Max Cream gets in your eyes, act fast! Rinse your eyes with water for a few minutes. Remove contact lenses if you have them. Gently pat the area, don't rub. If your eyes still hurt or feel uncomfortable, see a doctor. By acting quickly, you can help make your eyes feel better.
Clearz Max Cream is generally considered safe when used as prescribed by a doctor. However, like all medications, it can have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.
Store Clearz Max Cream in its original container, keeping it cool, dry, and out of sunlight. Keep it out of the reach of children. Regularly check the expiration date. When you need to dispose of the medicine, remove the label, place it in a plastic bag, and throw it away in the household trash. Remember, never flush the medicine down the toilet or sink to prevent harm to others and the environment.
Before using this medication, you should inform your doctor about your medical history, including any ongoing medicines, to avoid potential interactions and minimise side effects.
Taking more than the recommended dosage does not provide additional relief and can increase the risk of adverse effects such as skin irritation, redness, and peeling.
No, you should apply this cream only at night. The active ingredients make your skin extremely sensitive to sunlight, and applying it during the day significantly increases your risk of severe sunburn and skin irritation. Talk to your doctor if you have questions about your application schedule.
Mild peeling and dryness are very common when you first start using this cream. You can apply a mild, fragrance-free moisturizer during the day to help soothe your skin. If the peeling becomes painful, severe, or red, temporarily stop application and talk to your doctor or pharmacist.
Yes, you can use makeup. However, you must apply a broad-spectrum sunscreen to your face first, let it absorb fully, and then apply your cosmetics. Choose gentle, non-comedogenic makeup products that will not clog your pores or dry out your skin. Talk to your doctor if your makeup causes irritation.
No, you must not use this cream if you are pregnant, planning to become pregnant, or breastfeeding. Some of the active ingredients can be absorbed through your skin and may pose serious risks to an unborn baby. Talk to your doctor immediately about safer alternatives.
This cream contains ingredients that can react when exposed to air, heat, and light, causing the cream to turn light yellow or light brown. Always seal the tube tightly after each use. If the cream has turned dark brown, talk to your pharmacist before using it.
This medication is specifically formulated for use on facial skin to treat melasma and dark spots. Do not apply it to large areas of your body, sensitive skin folds, or thin skin areas without direct instructions from your physician. Talk to your doctor first.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Drugs.com Clinical Review Team. Hydroquinone Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Mayo Clinic Staff. Drg 20060789 Inhalation and Dosage Monograph. Rochester, MN: Mayo Foundation for Medical Education; 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Tretinoin Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  5. Fluocinolone acetonide, hydroquinone, and tretinoin [Prescribing Information]. 2014. [Accessed on 29 Apr. 2019]Check here
  6. Fluocinolone acetonide + hydroquinone + tretinoin [Prescribing Information]. 2013. [Accessed on 29 Apr. 2019]Check here
  7. CiplaMed CiplaMed. [Accessed on 14 Aug. 2024]Check here

Country of origin

India

Manufacturer/Marketer address

Dr. Reddy's Laboratories Ltd., 8-2-337, Road No. 3, Banjara Hills, Hyderabad, Telangana 500034, INDIA
Other Info - CLE0160

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