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Clop-GM Neo Cream is used to treat fungal and bacterial skin infections. Also, it helps to reduce swelling, itching, and redness caused due to certain skin problems. It works by acting inside skin cells and inhibits the release of certain chemical messengers in the body that cause redness, itching, and swelling. It works by damaging fungal cell membranes and kills fungi. Also, it works by inhibiting the production of essential proteins required for bacteria to grow, multiply and increase in numbers, thereby destroying the bacteria. Some people may experience side effects such as dry skin, acne, thinning of the skin, itching, pain, swelling, redness, irritation, or burning sensation at the site of application.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CLOBETASOL-0.05%W/W+CLOTRIMAZOLE-1%W/W+NEOMYCIN-0.5%W/W

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Topical

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Clop-GM Neo Cream

Clop-GM Neo Cream is a topical medication prescribed to treat various skin infections that are accompanied by severe inflammation, redness, and itching. It is typically used for skin conditions where a fungal or bacterial infection is present alongside swelling and irritation. By targeting the infection and the inflammation simultaneously, it helps restore the skin to its healthy state.

For the best results, you must apply Clop-GM Neo Cream consistently and exactly as directed by your doctor. It is typically applied in a thin layer to the affected area once or twice daily. Because this is a topical medicine, food intake does not affect how it works. Making simple lifestyle adjustments, such as keeping the affected skin clean and dry, can greatly support your recovery process.

While Clop-GM Neo Cream is highly effective, some people may experience mild, localised side effects like dry skin, burning, or redness at the application site. If you notice severe skin thinning, stretch marks, or signs of an allergic reaction, stop using the medication and consult your doctor immediately.

Do not use this if you have viral skin infections, tuberculosis of the skin, or if you are allergic to any of the ingredients. Before starting this treatment, talk to your doctor or pharmacist if you have poor blood circulation, a weakened immune system, or if you need to treat a large area of broken skin.

Please consult your doctor if you are pregnant, planning to become pregnant, or breastfeeding before using this product. Tell your healthcare provider about all other topical creams or ointments you use to avoid potential interactions.

Uses of Clop-GM Neo Cream

Clop-GM Neo Cream is used to treat inflammatory skin conditions that are complicated by fungal or bacterial infections, helping to control infection while reducing redness, swelling, and itching:

  • Inflamed skin infections: Clop-GM Neo Cream helps clear skin infections that are complicated by redness, swelling, and intense itching by killing the underlying fungi and bacteria while calming skin irritation.
  • Eczema with secondary infections: Helps relieve inflammation, itching, and infection in eczema with bacterial or fungal complications. However, this combination contains clobetasol, a very potent corticosteroid, so it should only be used for short durations and strictly under medical supervision to avoid skin thinning, rebound flare-ups, and other steroid-related side effects.
  • Severe ringworm or athlete's foot: It targets stubborn fungal infections while rapidly reducing the painful burning, scaling, and inflammation associated with them.
     

Key Benefits

Some of the key benefits of Clop-GM Neo Cream in managing infected inflammatory skin conditions include:

  • Rapid Itch Relief: Quickly reduces intense itching and irritation, helping prevent scratching and further skin damage.
  • Anti-Inflammatory Action: Calms redness, swelling, and inflammation, improving overall skin comfort and appearance.
  • Antifungal Effect: Helps eliminate fungal infections responsible for conditions like ringworm and athlete’s foot.
  • Antibacterial Protection: Controls bacterial growth in infected or broken skin, supporting faster recovery.
  • Faster Skin Healing: Promotes recovery of damaged skin and helps restore the skin barrier more effectively.
     
Side effects of Clop-GM Neo Cream 15 gm
  • Burning sensation is an abnormal side effect that needs medical attention. To relieve the burning feeling, your doctor may prescribe painkillers or antidepressants.
  • Focused exercises can improve strength and reduce burning by soothing muscles.
  • Change in lifestyle and improving nutrition can reduce the causes of burning sensation and provide relief.
  • Your doctor may suggest nerve block injections as it is related to sensation in the skin.
  • Burning feeling in a specific area would need mild electrical currents to reduce pain that targets the nerve affected. This practice must be done only if your doctor mentions it.
Here are the steps to manage medication-triggered Stinging:
  • If you experience burning or stinging sensations and suspect that they may be related to medication, consult a doctor or healthcare expert to determine the cause and best course of treatment.
  • Avoid harsh products, extreme temperatures, and other potential irritants that may exacerbate burning or stinging.
  • Your healthcare professional may recommend applying a soothing or protective agent, such as a cream, gel, or ointment, to help alleviate burning or stinging.
  • Follow your healthcare professional's advice on how to care for the affected area, as gentle cleaning and care instructions may vary depending on the location and severity of the burning or stinging.
  • Schedule follow-up appointments with your doctor to monitor your symptoms and adjust your treatment plan as needed. If the burning or irritation persists or worsens, seek medical attention.

Directions for Use

To get the most benefit from Clop-GM Neo Cream and to use it safely, follow these step-by-step instructions:

  • Wash your hands thoroughly with soap and water before applying the medicine.
  • Gently clean and completely dry the affected skin area.
  • Apply a thin film of the cream to the affected area and rub it in gently.
  • Wash your hands after applying the medication, unless you are treating your hands.
  • Do not cover the treated area with bandages, wraps, or tight dressings unless your doctor specifically tells you to do so, as this can increase the risk of side effects.

Always follow your doctor's exact instructions regarding how much cream to apply and how long to continue the treatment.
 

How Clop-GM Neo Cream Works

Clop-GM Neo Cream contains clobetasol, clotrimazole, and neomycin, which work together to treat mixed skin infections by reducing inflammation, fighting fungal growth, and controlling bacterial infection. Clobetasol is a potent anti-inflammatory corticosteroid that helps suppress the overactive immune response in the skin. It reduces the release of inflammatory mediators and narrows dilated blood vessels, leading to a rapid decrease in redness, swelling, and intense itching. Clotrimazole is an antifungal agent that works by disrupting the structure of fungal cell membranes. This damages the integrity of the fungal cells, preventing them from growing and multiplying, and ultimately helps eliminate the fungal infection. Neomycin is an antibacterial agent that inhibits bacterial protein synthesis. By preventing bacteria from producing essential proteins required for growth and survival, it helps stop bacterial multiplication and allows the immune system to clear the infection more effectively. Together, these three actions help reduce inflammation, eliminate fungal infection, control bacterial growth, and relieve associated symptoms such as itching, redness, and irritation.
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Alcohol

Caution

Interaction of Clop-GM Neo Cream with alcohol is unknown. Please consult a doctor before consuming alcohol while using Clop-GM Neo Cream.

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Pregnancy

Caution

The safety of Clop-GM Neo Cream in pregnant women is unknown. However, neomycin present in Clop-GM Neo Cream crosses the placenta and may harm an unborn baby. So it is not recommended for use in pregnant women.

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Breast Feeding

Caution

It is unknown whether Clop-GM Neo Cream is excreted in human milk. It is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

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Driving

Safe if prescribed

Clop-GM Neo Cream usually does not affect your ability to drive or operate machinery.

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Liver

Caution

If you have any concerns regarding the use of Clop-GM Neo Cream in patients with Liver problems, please consult a doctor.

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Kidney

Safe if prescribed

If you have any concerns regarding the use of Clop-GM Neo Cream in patients with Kidney problems, please consult a doctor.

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Children

Caution

Clop-GM Neo Cream is not recommended for children below 2 years. However, in children above 2 years, it should be used with caution and in doses only as prescribed by a doctor.

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Heart

Consult your doctor

Clop-GM Neo Cream is not recommended for use in heart patients unless prescribed by the physician

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Geriatrics

Consult your doctor

Please consult a doctor before giving Clop-GM Neo Cream to geriatric patients. Your doctor will prescribe Clop-GM Neo Cream if the benefits outweigh the risks.

What if I have taken an overdose of Clop-GM Neo Cream

Do not apply Clop-GM Neo Cream in large amounts or use it for a long time than recommended, as it does not give quick or better results but increases the risk of side effects.

Diet & Lifestyle Advise

  • Keep the infected skin dry and clean: Keep the infected skin dry and clean, as damp environments encourage fungi and bacteria to grow.
  • Wear loose-fitting, breathable cotton clothing: Wear loose-fitting, breathable cotton clothing to prevent friction and sweat buildup over the treated skin.
  • Avoid scratching, picking, or rubbing the healing skin: Avoid scratching, picking, or rubbing the healing skin, which can introduce new bacteria and worsen inflammation.
  • Use mild, fragrance-free body washes and soaps: Use mild, fragrance-free body washes and soaps to prevent further irritation to sensitive skin.
  • Do not share personal items: Do not share towels, clothing, or bedding with others to prevent spreading the infection.
     

Health Queries

There are eruptions and rashes on the skin. What could be the cause, and what treatment should be taken?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Skin eruptions and rashes can occur due to many common causes, such as allergies, heat, infections, or irritation from soaps and chemicals, and conditions like Contact Dermatitis or Urticaria are frequent reasons. They may appear as red patches, itching, or small bumps, and are often not serious. Basic care includes keeping the skin clean, avoiding known triggers, using a gentle moisturiser, and wearing loose cotton clothes; an anti-allergic medicine may help reduce itching if needed. Avoid using strong or mixed creams without medical advice, as they can sometimes worsen the condition. If the rash persists, spreads, becomes painful, or is associated with fever, it is important to consult a doctor for proper diagnosis and treatment.

I have itching around the anal area for the past week. I tried using Clop-GM cream, but there is no improvement. What could be the cause, and what treatment would you recommend?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Itching around the anal area for a week can be caused by a fungal infection, irritation from sweat or poor hygiene, allergies, or conditions like Pruritus Ani, and using creams like Clop-GM may not help because they contain steroids that can worsen infections over time. The best approach is to keep the area clean and dry, avoid tight or synthetic clothing, and stop using mixed or steroid creams without advice. A simple antifungal cream (such as clotrimazole) applied regularly may help if a fungal infection is present, and maintaining good hygiene and drying the area after washing is very important. If itching persists, worsens, or is associated with pain, discharge, or bleeding, consult a doctor for proper diagnosis and treatment.

I have a recurring skin infection on my hand that looks like a ring-shaped ulcer. I used Zole-F and Clop-GM cream, which helped temporarily, but it keeps coming back. How can I treat it permanently?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

A recurring ring-shaped lesion on your hand is most likely Ringworm, and the reason it keeps coming back is often the use of combination creams like Clop-GM, which contain steroids that give temporary relief but allow the fungus to persist and spread. For permanent treatment, stop using such mixed creams and switch to a proper antifungal cream (such as terbinafine or luliconazole) applied regularly for at least 2-4 weeks and continued even after the rash clears. Keep the area clean and dry, avoid scratching, do not share towels, and wash clothes separately to prevent reinfection. If the infection is recurrent or not improving, a doctor may prescribe oral antifungal medicines for a longer duration. Consulting a dermatologist will help confirm the diagnosis and ensure complete and lasting treatment.

I have been suffering from Ringworm for the past two months. I have used creams like Tocoderm, Clop-GM, Fourderm, Dermikem and tablets like Candiforce and Flusole, but there is no improvement. What should I do next?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

If your Ringworm has not improved after two months of using multiple creams and tablets, it is likely that the infection is persistent or not being treated correctly, which is common when using mixed creams like Clop-GM or Fourderm. The best next step is to stop using such combination creams and use a proper antifungal treatment as prescribed by a doctor, usually a single antifungal cream (like luliconazole or terbinafine) applied regularly for a few weeks, and sometimes a longer course of oral antifungal medicine if needed. Keep the area clean and dry, avoid tight clothing, do not share towels, and continue treatment for at least 2-4 weeks even after the rash improves to prevent recurrence. Since your case is not improving, it is important to consult a dermatologist for a proper diagnosis and the right treatment plan.

What can help with hair loss and itching on the back of my head and cheeks? Does CLOP GM help with this?

Veda Maddala

Veda Maddala

M Pharmacy

Hair loss with itching is usually due to dandruff, seborrheic dermatitis, or fungal infection, not something Clop GM is meant for. Clop GM is a steroid, antibiotic and antifungal cream and is not recommended for the scalp or face. A proper anti-dandruff shampoo or antifungal treatment works better. See a dermatologist if it persists.
health query

Have a query?

How Soon It Starts Working

The time required for Clop-GM Neo Cream to start to work: The time required for Clop-GM Neo Cream to show its action is unknown. The time for which the effects of Clop-GM Neo Cream last: The duration of action for Clop-GM Neo Cream is unknown.

What if you forget to take Clop-GM Neo Cream

Apply the missed dose as soon as you remember. If it is almost time for the next dose, skip the missed dose and follow your regular schedule. Do not apply Clop-GM Neo Cream more frequently to make up for the missed dose.

Storage

• Store Clop-GM Neo Cream at room temperature, away from heat, direct sunlight, and moisture. • Do not freeze the product.

Drug Warnings

  • Sensitive Areas: Do not use Clop-GM Neo Cream on your face, underarms, or groin area unless your doctor specifically instructs you to, as the skin in these areas is thin and more prone to side effects.
  • Eye Contact: Avoid getting this cream in or near your eyes, nose, or mouth. If contact occurs, rinse immediately and thoroughly with cool water.
  • Duration of Use: Do not use this medication for longer than your doctor prescribed; prolonged use of strong topical steroids can cause permanent skin damage.
  • Open Wounds: Do not apply this cream to large open wounds, deep cuts, or severely blistered skin.
     

Drug-Drug Interactions

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Drug-Drug Interactions
The following medicines may interact with Clop-GM Neo Cream and increase the risk of side effects or reduce safety:

  • Other topical steroid creams: Combining Clop-GM Neo Cream with other topical steroids can increase the risk of skin thinning and systemic absorption.
  • Oral steroids or immunosuppressants: Taking these alongside Clop-GM Neo Cream may increase the risk of steroid-related side effects throughout the body.

Drug-Disease Interactions

Certain medical conditions may worsen with the use of Clop-GM Neo Cream or require careful medical supervision:

  • Viral skin infections: Do not use this cream if you have chickenpox, shingles, or herpes, as it can make viral infections worse.
  • Rosacea or Acne: Applying this medication to areas affected by acne or rosacea can worsen these conditions.
  • Skin Tuberculosis: Do not use this medication if you have tuberculosis infections of the skin.
     
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CORTICOSTEROIDS AND ANTIFUNGALS]

FAQs

Clop-GM Neo Cream is used to treat fungal and bacterial skin infections. It also helps to reduce swelling, itching, and redness caused by certain skin problems.
Clop-GM Neo Cream contains Clobetasol, Clotrimazole and Neomycin. Clobetasol is a corticosteroid that works by acting inside skin cells and inhibits the release of certain chemical messengers in the body that cause redness, itching and swelling. When the skin reacts to any allergens, such chemicals are released normally. The fungal cell membranes are essential for their survival as they prevent the entry of unwanted substances into the cells and stops the leakage of cell contents. Clotrimazole is an antifungal that works by causing holes in the fungal cell membranes and kills fungi. Neomycin is an antibiotic that works by inhibiting the production of essential proteins that are necessary for bacteria to grow, multiply and increase in numbers. Thereby, destroys bacteria.
Yes, Clop-GM Neo Cream may cause skin itching at the site of application as a temporary side effect. However, if the itching persists or worsens, please consult a doctor.
You are recommended to cover the treated area of skin with bandages or dressings only if advised by your doctor else it may increase the risk of side effects.
No, Clop-GM Neo Cream is not recommended to treat acne as it may worsen the condition. Clop-GM Neo Cream is only used to reduce itching, swelling and redness caused due to certain skin infections. However, please consult a doctor before using Clop-GM Neo Cream.
Use Clop-GM Neo Cream for the full duration prescribed by your doctor, even if your symptoms improve earlier. Stopping treatment too soon may allow the fungal or bacterial infection to return or worsen. If your condition does not improve after 2–4 weeks or if you wish to stop treatment, consult your doctor before discontinuing the medicine
Yes, Clop-GM Neo Cream may cause dryness of the skin. You can use a moisturizer while using Clop-GM Neo Cream to prevent dry skin. However, do not apply Clop-GM Neo Cream and moisturizer at the same time as it may reduce the effectiveness of Clop-GM Neo Cream. Please consult a doctor before using other products with Clop-GM Neo Cream.
Yes, fungal infection is a contagious skin condition which spreads from one person to another through direct skin to skin contact or by contact with contaminated soil or surfaces and infected animals. Therefore, it is recommended to avoid close direct contact until the infection is clear and avoid sharing things with the infected person as it can also spread the infection.
Clop-GM Neo Cream is not recommended for use in children unless advised by a doctor. Children's skin is more delicate and can absorb larger amounts of Clop-GM Neo Cream, increasing the risk of side effects. Additionally, the steroids in this medicine may affect a child's growth. Therefore, always consult a doctor before using Clop-GM Neo Cream or other medicines for children.
No, Clop-GM Neo Cream should not be used on burns or any damaged skin. Do not self-medicate.
Avoid applying Clop-GM Neo Cream on broken skin, open wounds, or face. Avoid airtight dressings as it may increase the risk of side effects. Clop-GM Neo Cream is flammable, so avoid smoking or going near naked flames. Do not exceed the recommended dose.
Consult your doctor for the correct dosage, as the frequency depends on your condition. Using more than the recommended dose or for longer than prescribed may reduce its effectiveness or cause increased side effects.
Clop-GM Neo Cream contains clobetasol (corticosteroid), clotrimazole (antifungal), and neomycin (antibacterial) as its active substances.
Clop-GM Neo Cream is for external use only. Apply a small amount to the affected area as directed by your doctor. Using your fingertip, spread it as a thin layer on clean and dry skin. Avoid getting it in your eyes, nose, or mouth. If accidental contact occurs, rinse the area thoroughly with water. Wash your hands before and after applying Clop-GM Neo Cream, unless your hands are the treated area, to prevent spread of infection.
Use Clop-GM Neo Cream as prescribed by your doctor only, both in dosage and duration as prolonged or excessive use of Clop-GM Neo Cream can get the medicine absorbed into the bloodstream, leading to adrenal suppression or Cushing's syndrome, which may cause weight gain, high blood pressure, and a round face. It can also cause skin discoloration, visible veins, and thinning skin, and increased hair growth. If your symptoms worsen, consult your doctor.
Store Clop-GM Neo Cream below 25°C. Replace cap tightly after use. Keep this medicine out of the sight and reach of children.
You may notice relief from itching, redness, and irritation within a few days, while complete improvement may take a few weeks depending on the condition being treated. Continue using Clop-GM Neo Cream for the full prescribed duration even if your skin appears better. Consult your doctor if your symptoms do not improve after 2 weeks.
No. Do not apply Clop-GM Neo Cream to broken, damaged, open, deep, or large wounds unless specifically directed by your doctor. Applying the medicine to damaged skin can increase absorption into the bloodstream and raise the risk of side effects.
If Clop-GM Neo Cream accidentally gets into your eyes, rinse them thoroughly with plenty of water immediately. If irritation, redness, burning, or vision changes persist, seek medical attention and consult your doctor.
The safety of Clop-GM Neo Cream during pregnancy and breastfeeding is not fully established. Since neomycin may cross the placenta and it is unknown whether the medicine passes into breast milk, use it only if your doctor determines the benefits outweigh the risks. If breastfeeding, avoid applying the medicine to the breast or chest area to prevent accidental ingestion by the infant. Consult your doctor before use.
Clop-GM Neo Cream causes side effects such as dry skin, acne, thinning of skin, itching, pain, swelling, redness, and irritation or burning sensation at the site of application. These side effects will gradually reduce over time. However, please consult a doctor, if these side effects persist for longer durations.
No, Clop-GM Neo Cream should not be used for diaper rash. The strong steroid component can be easily absorbed through an infant's skin, leading to serious side effects. Talk to your doctor for safe alternatives.
It is best to avoid applying makeup over the treated area, as cosmetics can irritate inflamed skin and interfere with how the medication is absorbed. Talk to your doctor or pharmacist if you must use face products.
Yes, prolonged use of Clop-GM Neo Cream, especially on sensitive areas like the face or skin folds, can lead to skin thinning and stretch marks. Use it strictly as directed and do not exceed the prescribed duration. Talk to your doctor if you notice skin changes.

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Reference

  1. Drugs.com Clinical Review Team. Clobetasol Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Clotrimazole Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Neomycin Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Electronic Medicines Compendium (EMC). Pil.939 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Electronic Medicines Compendium (EMC). Pil.8270 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  6. Clobetasol propionate. 1993. [Accessed on 04 Apr. 2019]Check here
  7. PubChem PubChem. [Accessed on 31 Mar. 2019]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Danneskiold Samsøes Allé 41, DK-1434 Copenhagen K, Denmark, 1 St Katharine’s Way, London E1W 1UN, United Kingdom
Other Info - CLO0372

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