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D-Venizep 100 Tablet is used to treat depression. It contains clonazepam and desvenlafaxine which work by increasing the levels of chemical messengers in the brain that help maintain mental balance. In some cases, this medicine may cause side effects such as nausea, tiredness, constipation, confusion, and insomnia. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions

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How does the drug interact with D-Venizep 100 Tablet:
Taking tranylcypromine with D-Venizep 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and D-Venizep 100 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with D-Venizep 100 Tablet:
Taking rasagiline with D-Venizep 100 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking D-Venizep 100 Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with D-Venizep 100 Tablet:
Taking Safinamide with D-Venizep 100 Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking D-Venizep 100 Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with D-Venizep 100 Tablet:
Combining Isocarboxazid and D-Venizep 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and D-Venizep 100 Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with D-Venizep 100 Tablet:
Combining Procarbazine and D-Venizep 100 Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and D-Venizep 100 Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with D-Venizep 100 Tablet and do not discontinue any medications without first consulting your doctor.
ClonazepamSodium oxybate
Critical
How does the drug interact with D-Venizep 100 Tablet:
Taking D-Venizep 100 Tablet with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking D-Venizep 100 Tablet and Tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
DesvenlafaxineDesipramine
Severe
How does the drug interact with D-Venizep 100 Tablet:
Co-administration of Desipramine and D-Venizep 100 Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Desipramine and D-Venizep 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with D-Venizep 100 Tablet:
Although it is a rare adverse effect, Coadministration of Imipramine and D-Venizep 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Co-administration of Imipramine and D-Venizep 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxinePhenelzine
Severe
How does the drug interact with D-Venizep 100 Tablet:
Co-administration of Phenelzine and D-Venizep 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Phenelzine and D-Venizep 100 Tablet can lead to interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DesvenlafaxineSufentanil
Severe
How does the drug interact with D-Venizep 100 Tablet:
The combined use of Sufentanil and D-Venizep 100 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Co-administration of Sufentanil and D-Venizep 100 Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, consult the doctor immediately. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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CLONAZEPAM-0.5MG+DESVENLAFAXINE-100MGCaffeine containing foods/drinks

Drug-Food Interactions

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CLONAZEPAM-0.5MG+DESVENLAFAXINE-100MGCaffeine containing foods/drinks
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Limit or avoid caffeine intake while taking desvenlafaxine and clonazepam as it increases the risk of side effects. Limit or avoid caffeine intake while being treated with desvenlafaxine and clonazepam.

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