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D-Venizep LS Tablet 10's is used to treat depression. It contains clonazepam and desvenlafaxine which work by increasing the levels of chemical messengers in the brain that help maintain mental balance. In some cases, this medicine may cause side effects such as nausea, tiredness, constipation, confusion, and insomnia. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical

Drug-Drug Interactions

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ClonazepamSodium oxybate
Critical
How does the drug interact with D-Venizep LS Tablet:
Taking D-Venizep LS Tablet with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking D-Venizep LS Tablet and Tramadol together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with D-Venizep LS Tablet:
Taking tranylcypromine with D-Venizep LS Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Tranylcypromine and D-Venizep LS Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with D-Venizep LS Tablet:
Taking rasagiline with D-Venizep LS Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking D-Venizep LS Tablet with Rasagiline together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with D-Venizep LS Tablet:
Taking Safinamide with D-Venizep LS Tablet can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking D-Venizep LS Tablet with Safinamide is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
DesvenlafaxineIsocarboxazid
Critical
How does the drug interact with D-Venizep LS Tablet:
Combining Isocarboxazid and D-Venizep LS Tablet might raise serotonin hormone levels in the body and may affect the brain or nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Taking Isocarboxazid and D-Venizep LS Tablet together is generally avoided as it can lead to an interaction, it can be taken only if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with D-Venizep LS Tablet:
Combining Procarbazine and D-Venizep LS Tablet can increase the risk of a rare but serious condition called the serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Taking Procarbazine and D-Venizep LS Tablet together is not recommended as it can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like confusion, hallucination, seizure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea, contact your doctor immediately. you should wait at least 14 days after stopping isocarboxazid before you start treatment with D-Venizep LS Tablet and do not discontinue any medications without first consulting your doctor.
How does the drug interact with D-Venizep LS Tablet:
When Buprenorphine is used with D-Venizep LS Tablet, it may lead to significant adverse effects such as respiratory difficulties.

How to manage the interaction:
Co-administration of Buprenorphine alongside D-Venizep LS Tablet can result in an interaction, it can be taken if a doctor has advised it. Do not exceed the doses, frequency, or duration of usage advised by a doctor. You should avoid driving or operating hazardous machinery until you know how these drugs affect you. Do not discontinue any medications without consulting a doctor.
ClonazepamCodeine
Severe
How does the drug interact with D-Venizep LS Tablet:
Co-administration of D-Venizep LS Tablet with Codeine may cause serious side effects like respiratory depression.

How to manage the interaction:
Consult a doctor if you are taking D-Venizep LS Tablet with Codeine. Until you know how the medicines affect you, avoid driving or operating hazardous machinery as these medications may cause drowsiness, dizziness, difficulty concentrating, and impairment in judgment, reaction speed, and motor coordination. Do not exceed the dose and duration prescribed by your doctor. Do not stop using any medications without talking to a doctor.
ClonazepamDroperidol
Severe
How does the drug interact with D-Venizep LS Tablet:
Co-administration of Droperidol with D-Venizep LS Tablet may increase the severity of slow heart rate and low blood pressure, and using it with D-Venizep LS Tablet may increase the risks.

How to manage the interaction:
Although taking D-Venizep LS Tablet and Droperidol together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you notice any of these signs - heart beating too slowly, low blood pressure, an irregular heartbeat, sudden dizziness, feeling lightheaded, fainting, or your heartbeat feels strange - make sure to call a doctor right away." Do not stop using any medications without a doctor's advice.
ClonazepamPethidine
Severe
How does the drug interact with D-Venizep LS Tablet:
Combining Meperidine with D-Venizep LS Tablet can increase the risk of side effects.

How to manage the interaction:
Taking Pethidine with D-Venizep LS Tablet together can possibly result in an interaction, but it can be taken if your doctor has advised it. Your doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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CLONAZEPAM-0.25MG+DESVENLAFAXINE-50MGCaffeine containing foods/drinks

Drug-Food Interactions

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CLONAZEPAM-0.25MG+DESVENLAFAXINE-50MGCaffeine containing foods/drinks
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Limit or avoid caffeine intake while taking desvenlafaxine and clonazepam as it increases the risk of side effects. Limit or avoid caffeine intake while being treated with desvenlafaxine and clonazepam.

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