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Lefra 20 Tablet 10's
Lefra 20 Tablet 10's
Lefra 20 Tablet 10's

Lefra 20 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. It contains Leflunomide, which suppresses the activated immune system to reduce pain, inflammation and swelling. This medicine may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Side effects of Lefra 20 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Eat protein-rich foods like fish, poultry, eggs, and legumes.
  • Include foods with minerals and vitamins essential for hair health.
  • Join a support group to connect with others experiencing hair loss.
  • Openly discuss your feelings about hair loss.
  • Consider covering up with wigs, hats, or scarves.
  • Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Drug-Drug Interactions

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LeflunomideItraconazole
Severe
LeflunomideCerivastatin
Severe

Drug-Drug Interactions

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LeflunomideItraconazole
Severe
How does the drug interact with Lefra 20 Tablet:
Co-administration of Lefra 20 Tablet and itraconazole can raise the risk of liver problems.

How to manage the interaction:
Lefra 20 Tablet and itraconazole may interact, but if a doctor prescribes them, you can still use them. If you have any of the following symptoms: fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, weakness, lack of hunger, nausea, vomiting, abdominal pain, dark urine, light stools, or yellowing of the skin or eyes, then you must visit a doctor. Never discontinue taking a drug without consulting a doctor.
LeflunomideCerivastatin
Severe
How does the drug interact with Lefra 20 Tablet:
Lefra 20 Tablet can cause liver problems, and combining it with other drugs, such as Cerivastatin, can raise the risk.

How to manage the interaction:
Although there is a possible interaction between Lefra 20 Tablet and Cerivastatin, you can take these medicines together if prescribed by your doctor. If you notice any of these symptoms - fever, joint pain, rash, or stomach pain, contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideSimvastatin
Severe
How does the drug interact with Lefra 20 Tablet:
The combined use of Lefra 20 Tablet and simvastatin can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Lefra 20 Tablet and simvastatin can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes, consult the doctor immediately. Avoid alcohol and Do not stop using any medications without a doctor's advice.
LeflunomideTizanidine
Severe
How does the drug interact with Lefra 20 Tablet:
Coadministration of tizanidine and Lefra 20 Tablet can increase the risk of liver problems.

How to manage the interaction:
Taking Tizanidine and Lefra 20 Tablet together can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideMacitentan
Severe
How does the drug interact with Lefra 20 Tablet:
Taking Lefra 20 Tablet with Macitentan affects the liver and may increase the risk of liver problems.

How to manage the interaction:
Although taking Lefra 20 Tablet and Macitentan together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark colored urine, light colored stools, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
LeflunomideIdarubicin
Severe
How does the drug interact with Lefra 20 Tablet:
Taking Idarubicin and Lefra 20 Tablet can increase the risk of developing serious infections.

How to manage the interaction:
Although there is an interaction, Idarubicin can be taken with Lefra 20 Tablet, if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medications without a doctor's advice.
LeflunomideNicotinamide
Severe
How does the drug interact with Lefra 20 Tablet:
Coadministration of nicotinamide with Lefra 20 Tablet can increase the risk or severity of liver problems.

How to manage the interaction:
Although there is an interaction between nicotinamide and Lefra 20 Tablet, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideDuloxetine
Severe
How does the drug interact with Lefra 20 Tablet:
Coadministration of duloxetine and Lefra 20 Tablet can increase the risk of liver problems.

How to manage the interaction:
Although taking Duloxetine with Cyclobenzaprine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience fever, chills, joint pain or swelling, itching, abdominal pain, dark-coloured urine, light-coloured stools, and/or yellowing of the skin or eyes, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
LeflunomideBexarotene
Severe
How does the drug interact with Lefra 20 Tablet:
Combining Bexarotene with Lefra 20 Tablet can increase the risk of negative side effects.

How to manage the interaction:
Although taking Lefra 20 Tablet and Bexarotene together can evidently cause an interaction, it can be taken if your doctor has suggested it. If you notice any of these symptoms - liver problems, complications, infection, fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, pain, joint pain, swelling, bruising, skin rash, itching, loss of appetite, tiredness, nausea, vomiting, dark urine or bleeding - contact your doctor right away. Do not stop using any medications without a doctor's advice.
LeflunomideEnalapril
Severe
How does the drug interact with Lefra 20 Tablet:
Enalapril has the potential to cause liver damage; this effect can be increased by the coadministration of medications that affect the liver, such as Lefra 20 Tablet. This effect can be seen even long after discontinuing Lefra 20 Tablet as it stays in your blood longer.

How to manage the interaction:
Although taking Enalapril together with Lefra 20 Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of liver damage like fever, chills, unusual bleeding, dark-coloured urine, light colour stools, yellowish discolouration of skin and eyes, and abdominal pain. It is advised not to consume alcohol while using these medications as it may increase the damage o the liver. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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