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Naprosyn 250 Tablet 15's
Naprosyn 250 Tablet 15's
Naprosyn 250 Tablet 15's

Naprosyn 250 Tablet is used to reduce pain and swelling in muscles and joints in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (pain and stiffness in the backbone), cervical spondylitis (wear and tear of spinal discs in the neck) and acute gout (severe pain due to excess of uric acid). It contains Naproxen, which works by reducing the production of chemicals, known as prostaglandins, that cause pain and swelling. In some cases, you may experience indigestion, heartburn, stomach pain, nausea, headache, dizziness, drowsiness, bruising, itching, rash, and ringing in your ears. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Health Queries

I am a 35-year-old woman suffering from migraines for the past year. I take Naprosyn 250 Tablet when they start, but I am concerned about long-term side effects. Could you please advise?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

You can continue using Naprosyn 250 mg (Naproxen) as prescribed for occasional migraine relief. However, long-term or frequent use may increase the risk of side effects affecting the stomach, kidneys, or heart. Please talk to your doctor about preventive treatments and lifestyle measures that may help you rely less on painkillers.

I have been experiencing migraines every 2-3 days for the past two years. I take Naprosyn 250 Tablet for relief, but I am looking for a permanent solution. Please advise.

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Frequent migraines lasting over two years need evaluation by a doctor or neurologist. Naprosyn 250 mg Tablet (Naproxen) helps relieve pain temporarily but does not prevent future attacks. A doctor can identify triggers, prescribe preventive medications such as beta-blockers or anticonvulsants, and advise lifestyle measures to reduce migraine frequency and achieve long-term relief.

I experience migraines every 2-3 days. My doctor prescribed Naprosyn 250 Tablet, but my pain persists. What can I do to manage my headaches?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

You should follow up with your doctor, as frequent migraines may require preventive treatment. Keeping a headache diary, avoiding triggers, managing stress, and using prescribed medications as advised can help. If the pain is severe or the pattern changes, seek medical attention promptly.

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Side effects of Naprosyn 250 Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Drug-Drug Interactions

verifiedApollotooltip
NaproxenMeloxicam
Critical
NaproxenKetorolac
Critical

Drug-Drug Interactions

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NaproxenMeloxicam
Critical
How does the drug interact with Naprosyn 250 Tablet:
Co-administration of Naprosyn 250 Tablet with Meloxicam can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Meloxicam with Naprosyn 250 Tablet is not advised as it can possibly result in an interaction, it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness.
NaproxenKetorolac
Critical
How does the drug interact with Naprosyn 250 Tablet:
Coadministration of Ketorolac with Naprosyn 250 Tablet can increase the risk or severity of gastric bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac with Naprosyn 250 Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
NaproxenCidofovir
Critical
How does the drug interact with Naprosyn 250 Tablet:
Taking cidofovir with Naprosyn 250 Tablet may increase the risk or severity of kidney problems

How to manage the interaction:
Taking Naprosyn 250 Tablet with Cidofovir is generally avoided as it can possibly result in an interaction. You should seek immediate medical attention if you develop signs and symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
NaproxenTinzaparin
Severe
How does the drug interact with Naprosyn 250 Tablet:
Coadministration of Naprosyn 250 Tablet and Tinzaparin may increase the risk or severity of unusual bleeding problems.

How to manage the interaction:
Taking Naprosyn 250 Tablet and Tinzaparin together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult the doctor. Do not discontinue any medication without a doctor's advice.
NaproxenApixaban
Severe
How does the drug interact with Naprosyn 250 Tablet:
Coadministration of Naprosyn 250 Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Naprosyn 250 Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
NaproxenMorphine
Severe
How does the drug interact with Naprosyn 250 Tablet:
Coadministration of Naprosyn 250 Tablet and Morphine may increase the blood levels and side effects of Morphine.

How to manage the interaction:
Co-administration of Morphine with Naprosyn 250 Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.
NaproxenTenofovir alafenamide
Severe
How does the drug interact with Naprosyn 250 Tablet:
Coadministration of Naprosyn 250 Tablet and Tenofovir alafenamide may increase the effectiveness of Tenofovir alafenamide.

How to manage the interaction:
There may be a possible interaction between Naprosyn 250 Tablet and Tenofovir alafenamide, but they can be taken together if they are prescribed by doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, consult the doctor. Do not discontinue any medication without a doctor's advice.
NaproxenIopamidol
Severe
How does the drug interact with Naprosyn 250 Tablet:
Combine use of Naprosyn 250 Tablet and iopamidol may increase the effectiveness of iopamidol.

How to manage the interaction:
There may be a possible interaction between Naprosyn 250 Tablet and Iopamidol , but they can be taken together if they are prescribed by doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm and weakness consult the doctor. Do not discontinue any medication without a doctor's advice.
NaproxenPiroxicam
Severe
How does the drug interact with Naprosyn 250 Tablet:
Coadministration of Naprosyn 250 Tablet and Piroxicam can increase the risk or severity of stomach bleeding, inflammation(swelling with redness and pain), ulcers.

How to manage the interaction:
There may be a possible interaction between Naprosyn 250 Tablet and Piroxicam, but they can be taken together if they are prescribed by doctor. However, if you experience unusual bleeding or bruising, dizziness, lightheadedness, red or black, tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness, consult the doctor. Do not discontinue any medication without a doctor's advice.
NaproxenTemsirolimus
Severe
How does the drug interact with Naprosyn 250 Tablet:
Coadministration of Naprosyn 250 Tablet and Temsirolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
Taking Naprosyn 250 Tablet and Temsirolimus together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, consult the doctor. Do not discontinue any medication without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Nov 18, 2025 | 7:35 AM IST

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