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Naprosyn 500+ Tablet 15's
Naprosyn 500+ Tablet 15's

Naprosyn 500+ Tablet is used to reduce pain and swelling in muscles and joints in conditions such as osteoarthritis, rheumatoid arthritis, ankylosing spondylitis (pain and stiffness in the backbone), cervical spondylitis (wear and tear of spinal discs in the neck) and acute gout (severe pain due to excess of uric acid). It contains Naproxen, which works by reducing the production of chemicals, known as prostaglandins, that cause pain and swelling. In some cases, you may experience indigestion, heartburn, stomach pain, nausea, headache, dizziness, drowsiness, bruising, itching, rash, and ringing in your ears. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Health Queries

I had a fracture in my nasal bone, and there is some discharge coming from it. Is this normal, or do I need to get it checked?

Vikas Singh

Vikas Singh

M Pharmacy

Discharge after a nasal bone fracture is not always normal and may suggest infection or delayed healing. Mild, clear discharge can occur, but if it is persistent, foul-smelling, or associated with pain or fever, it needs attention. Keep the area clean and avoid touching or putting pressure on the nose. It is important to consult a doctor to rule out infection and ensure proper healing.

I have been diagnosed with frozen shoulder. What are the effective treatment options to relieve pain and improve shoulder movement?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Frozen shoulder usually improves gradually but may take several months. Treatment focuses on pain relief and restoring movement. Gentle physiotherapy and regular shoulder stretching exercises are the most important steps. You may use warm compresses and take pain relievers as prescribed for discomfort. Early and consistent physiotherapy gives the best results, so avoid keeping the shoulder completely immobile.

I have been experiencing pain in my left jaw for the past 3 days. I also have acidity issues. There is no tooth pain, but it hurts whenever I try to open my mouth. How should I manage it?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

Pain in the left jaw while opening the mouth, without tooth pain, is often due to jaw joint (TMJ) strain, muscle spasm, or teeth clenching rather than acidity. Try giving your jaw rest (avoid wide opening, hard foods, chewing gum), apply warm compresses 2-3 times daily, and do gentle jaw relaxation exercises. If pain persists beyond a few days, consult a dentist or doctor for proper evaluation.

My left knee has been painful for two months, and my back also hurts.

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

Two months of left knee pain could be caused by ligament tension, arthritis, or cartilage deterioration. Knee and back discomfort might be caused by nerve compression, spinal disorders, or poor posture. The cause can be found and treated with the use of an orthopedic evaluation, an X-ray or MRI if necessary, and physiotherapy.

What can I do for joint pain in my legs and hands?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

You can use gentle exercises, warm compresses, and medication to reduce joint pain. Maintaining a healthy weight, staying active, and consulting your doctor for proper evaluation or prescribed treatments can also help.

Have a query?

Side effects of Naprosyn 500+ Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
  • Drink warm fluids such as warm water with honey, broth, soup or herbal tea to soothe sore throat.
  • Gargle with warm salt water.
  • Suck on lozenges to increase the production of saliva and soothe your throat.
  • Use a humidifier to soothe sore throat as it adds moisture to the air and makes breathing easier.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.

Drug-Drug Interactions

verifiedApollotooltip
NaproxenKetorolac
Critical
NaproxenMeloxicam
Critical

Drug-Drug Interactions

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NaproxenKetorolac
Critical
How does the drug interact with Naprosyn 500+ Tablet:
Coadministration of Ketorolac with Naprosyn 500+ Tablet can increase the risk or severity of gastric bleeding and ulceration.

How to manage the interaction:
Taking Ketorolac with Naprosyn 500+ Tablet together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
NaproxenMeloxicam
Critical
How does the drug interact with Naprosyn 500+ Tablet:
Co-administration of Naprosyn 500+ Tablet with Meloxicam can increase the risk or severity of gastric bleeding, ulceration, and rarely, perforation leading to serious blood loss.

How to manage the interaction:
Taking Meloxicam with Naprosyn 500+ Tablet is not advised as it can possibly result in an interaction, it can be taken if your doctor has advised it. You should seek immediate medical attention if you experience any unusual bleeding or bruising or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness.
NaproxenCidofovir
Critical
How does the drug interact with Naprosyn 500+ Tablet:
Taking cidofovir with Naprosyn 500+ Tablet may increase the risk or severity of kidney problems

How to manage the interaction:
Taking Naprosyn 500+ Tablet with Cidofovir is generally avoided as it can possibly result in an interaction. You should seek immediate medical attention if you develop signs and symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm.
NaproxenApixaban
Severe
How does the drug interact with Naprosyn 500+ Tablet:
Coadministration of Naprosyn 500+ Tablet and Apixaban co-administration may raise the risk of bleeding.

How to manage the interaction:
Even though combining Naprosyn 500+ Tablet and Apixaban may cause an interaction, it is still possible to take it if your doctor advises you to. Consult a doctor if you experience symptoms like blood in your urine or stool (or a black stool), severe bruising, prolonged nosebleeds, feeling dizzy or lightheaded, weakness or severe headache, vomiting blood or coughing up blood, heavy menstrual bleeding (in women), difficulty breathing, or chest pain. Without consulting a doctor, never stop taking any medications.
NaproxenDeferasirox
Severe
How does the drug interact with Naprosyn 500+ Tablet:
Using deferasirox together with Naprosyn 500+ Tablet may increase the risk of gastrointestinal ulcers.

How to manage the interaction:
Co-administration of Naprosyn 500+ Tablet with Deferasirox can possibly result in an interaction, but it can be taken if your doctor has advised it. This risk is higher in older people with certain blood disorders or low platelet counts. If you have symptoms like stomach pain, bloating, dizziness, or black stools, it's important to consult a doctor. Do not stop using any medications without a doctor's advice.
NaproxenCelecoxib
Severe
How does the drug interact with Naprosyn 500+ Tablet:
Coadministration of Naprosyn 500+ Tablet and Celecoxib can increase the risk or severity of bleeding and ulcers of the stomach.

How to manage the interaction:
Taking Naprosyn 500+ Tablet and Celecoxib together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you notice any unusual bleeding or bruising, other signs of bleeding, dizziness, lightheadedness, red or black tarry stools, coughing up or vomiting blood, severe headache, and weakness, you should contact your doctor immediately. Do not stop using any medications without talking to a doctor.
NaproxenOmacetaxine mepesuccinate
Severe
How does the drug interact with Naprosyn 500+ Tablet:
Coadministration of Naprosyn 500+ Tablet and Omacetaxine mepesuccinate may increase the effectiveness of Naprosyn 500+ Tablet.

How to manage the interaction:
There may be a possible interaction between Naprosyn 500+ Tablet and Omacetaxine mepesuccinate, but they can be taken together if they are prescribed by doctor. However, if you experience unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness, consult the doctor. Do not discontinue any medication without a doctor's advice.
NaproxenTacrolimus
Severe
How does the drug interact with Naprosyn 500+ Tablet:
Coadministration of Naprosyn 500+ Tablet and Tacrolimus may increase the risk or severity of kidney problems.

How to manage the interaction:
There may be a possible interaction between Naprosyn 500+ Tablet and Tacrolimus, but they can be taken together if they are prescribed by doctor. However, if you experience unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness lightheadedness red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds severe headache and weakness consult your doctor immediately. Do not discontinue any medication without a doctor's advice.
NaproxenMethotrexate
Severe
How does the drug interact with Naprosyn 500+ Tablet:
Coadministration of Methotrexate with Naprosyn 500+ Tablet can increase the levels and side effects of Methotrexate.

How to manage the interaction:
Taking Methotrexate with Naprosyn 500+ Tablet together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as mouth ulcers or sores, vomiting, fever, chills, body aches, sore throat, muscle weakness, diarrhea, rash, loss of appetite, joint pain or swelling, yellow discoloration of skin and eyes, dark urine, breathing difficulty, dry cough, paleness, dizziness or fainting, unusual bruising or bleeding, seizures(fits), Consult a doctor. Do not stop using any medications without consulting a doctor.
NaproxenRofecoxib
Severe
How does the drug interact with Naprosyn 500+ Tablet:
Coadministration of Naprosyn 500+ Tablet and Rofecoxib can increase the risk or severity of stomach bleeding and rarely lead to serious blood loss.

How to manage the interaction:
There may be a possible interaction between Naprosyn 500+ Tablet and Rofecoxib, but they can be taken together if they are prescribed by doctor. However, if you experience unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness, consult the doctor. Do not discontinue any medication without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Apr 6, 2026 | 11:34 AM IST

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