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NEXVENLA OD PLUS 50MG TABLET is used to treat depression. It contains clonazepam and desvenlafaxine which work by increasing the levels of chemical messengers in the brain that help maintain mental balance. In some cases, this medicine may cause side effects such as nausea, tiredness, constipation, confusion, and insomnia. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: NEXVENLA OD PLUS 50MG TABLET may have interaction with pain killers (tramadol, aspirin, acetaminophen, pethidine), narcotic pain relievers (morphine, codeine), blood thinners (warfarin), cholesterol medications (pravastatin), fits medicine (phenobarbital, phenytoin, sodium valproate, carbamazepine), anti-depression medication (aripiprazole, escitalopram), blood pressure medications (metoprolol), medications to treat stomach problems (cimetidine).

Drug-Food Interactions: Avoid consuming alcohol along with NEXVENLA OD PLUS 50MG TABLET as it may increase the sedative effects, and one can also experience impairment in thinking and judgment.

Drug-Disease Interactions: NEXVENLA OD PLUS 50MG TABLET may interact with disease conditions such as heart problems, acute alcohol intoxication, epilepsy, glaucoma, renal/liver disease, respiratory depression, and drug dependency.

Critical

Drug-Drug Interactions

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Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking desvenlafaxine and clonazepam with sodium oxybate can result in breathing issues, low blood pressure, and an increased chance of side effects.

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam, and sodium oxybate, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience dizziness, sleepiness, difficulty concentrating, lightheadedness, or confusion. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking safinamide with desvenlafaxine and clonazepam can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and safinamide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Co-administration of phenelzine with desvenlafaxine and clonazepam can cause high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam, and phenelzine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience headache, weakness, confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking isocarboxazid with desvenlafaxine and clonazepam can cause high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and isocarboxazid, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, weakness, headache, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking procarbazine with desvenlafaxine and clonazepam can cause high blood pressure and also increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and procarbazine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience headache, confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking tranylcypromine with desvenlafaxine and clonazepam may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and tranylcypromine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Co-administration of selegiline with desvenlafaxine and clonazepam can cause high blood pressure and also increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and selegiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking rasagiline with desvenlafaxine and clonazepam can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam and rasagiline, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Co-administration of dihydroergotamine with desvenlafaxine and clonazepam may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam, and dihydroergotamine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Nexvenla Od Plus 50mg Tablet:
Taking fluoxetine with desvenlafaxine and clonazepam may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in the body).

How to manage the interaction:
Although there is an interaction between desvenlafaxine, clonazepam, and fluoxetine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, fever, excessive sweating, shivering or shaking, blurred vision, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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CLONAZEPAM-0.5MG+DESVENLAFAXINE-50MGCaffeine containing foods/drinks

Drug-Food Interactions

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CLONAZEPAM-0.5MG+DESVENLAFAXINE-50MGCaffeine containing foods/drinks
Common Foods to Avoid:
Cocoa, Coffee, Dark Chocolate, Energy Drinks With Caffeine, Green Tea, Kola Nut, Tea, Tiramisu

How to manage the interaction:
Limit or avoid caffeine intake while taking desvenlafaxine and clonazepam as it increases the risk of side effects. Limit or avoid caffeine intake while being treated with desvenlafaxine and clonazepam.

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