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Durapain Tablet is used to get relief from pain and inflammation (redness and swelling). It contains Diclofenac and Tramadol, which works by blocking the release of chemical messengers responsible for causing pain and inflammation. Also, it blocks the transmission of pain signals to the brain. It may cause common side effects such as nausea, loss of appetite, vomiting, dizziness, indigestion, sleepiness, constipation, heartburn, stomach pain, and dryness in the mouth. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interactions: Durapain Tablet is known to interact with painkillers (nimesulide, oxyphenbutazone), blood clotting agents (warfarin), blood pressure-lowering agents (hydrochlorothiazide), medicines for depression (lithium), antifungals (itraconazole, voriconazole),  benzodiazepines (alprazolam, diazepam, estazolam, flurazepam, lorazepam, triazolam),  antibiotics (erythromycin), HIV medications (indinavir, nelfinavir, ritonavir) and medicines used to treat abnormal heart rhythms (quinidine).

Drug-Food Interactions: Durapain Tablet should not be taken along with St. John's Wort plant (a natural remedy to treat depression).

Drug-Disease Interactions: People with peptic ulcers, gastric bleeding, severe heart failure, diarrhoea and high blood pressure should avoid intake of Durapain Tablet as it may lead to life-threatening conditions.

Critical

Drug-Drug Interactions

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How does the drug interact with Durapain Tablet:
Co-administration of Linezolid with tramadol and diclofenac can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Linezolid with tramadol and diclofenac is not recommended, consult a doctor before taking it. Consult a doctor if you experience confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, stomach cramps, nausea, vomiting, and diarrhoea. Do not stop using any medications without talking to a doctor.
Critical
How does the drug interact with Durapain Tablet:
Combining Phenelzine with Tramadol and Diclofenac can increase the risk of serotonin syndrome and seizures.

How to manage the interaction:
Taking Durapain Tablet with Phenelzine results in an interaction, but it can be taken if prescribed by a doctor. However, if you experience confusion, hallucination, fever, shivering, impaired vision, muscle spasms or stiffness, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not stop using any medications without consulting a doctor.
How does the drug interact with Durapain Tablet:
Taking Safinamide with Tramadol and diclofenac can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Safinamide with Tramadol and diclofenac is not recommended as it can result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fever, excessive sweating, shivering, blurred vision, muscle pain or stiffness, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Durapain Tablet:
Taking rasagiline with tramadol and diclofenac can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Tramadol and diclofenac with Rasagiline is not recommended, as it can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and fainting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Durapain Tablet:
Combining Tranylcypromine with Tramadol and diclofenac can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Tranylcypromine with Tramadol and diclofenac is not recommended but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering, blurred vision, pain in the muscles or stiffness, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Durapain Tablet:
Co-administration of Ziprasidone with Tramadol and Diclofenac can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Tramadol and Diclofenac with Ziprasidone together can result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Durapain Tablet:
Co-administration of tramadol and diclofenac with Meloxicam can increase the risk or severity of gastrointestinal side effects.

How to manage the interaction:
Taking Meloxicam with tramadol and diclofenac is not recommended as it can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as dizziness, lightheadedness, black tarry stools, coughing up or vomiting fresh or dried blood that looks like coffee grounds, severe headache, and weakness. Do not stop any medication without a doctor's advice.
Critical
How does the drug interact with Durapain Tablet:
Co-administration of Tramadol with Alvimopan can make the side effects worse or more dangerous.

How to manage the interaction:
Taking Alvimopan with Tramadol and diclofenac is not recommended, but it can be taken if prescribed by your doctor. However, contact your doctor if you experience abdominal pain, nausea, vomiting, and diarrhea. Do not stop using any medications without consulting a doctor.
How does the drug interact with Durapain Tablet:
Co-administration of Baclofen with Tramadol and Diclofenac may significantly lead to adverse effects such as respiratory distress (a condition in which fluid builds up in the lungs).

How to manage the interaction:
Taking baclofen with Tramadol and Diclofenac can result in an interaction, but it can be taken on a doctor's advice. If you experience any symptoms such as dizziness, drowsiness, difficulty concentrating, numbness and tingling of extremities, or hypersensitivity to light and noise, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Durapain Tablet:
Co-administration of tramadol and diclofenac with levomilnacipran can increase the effect of tramadol.

How to manage the interaction:
Taking levomilnacipran with tramadol and diclofenac together can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any symptoms such as confusion, hallucination, seizure, increased heart rate, blurred vision, tremors, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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