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LITHOSYN SR 400MG TABLET is used to prevent and treat mood disorders like mania and bipolar disorder. It contains Lithium, which helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person's mood. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Drug-Drug Interactions

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Drug-Drug Interaction: LITHOSYN SR 400MG TABLET may have interaction with high blood pressure-lowering medicines (ramipril, lisinopril, methyldopa, amlodipine, diltiazem), pain killers (ibuprofen, diclofenac, celecoxib, indomethacin), asthma drugs (theophylline), antipsychotics (olanzapine, haloperidol, clozapine, sertindole), fits related drugs (phenytoin, clonazepam, carbamazepine), heart-related medicines (quinidine, amiodarone, propafenone, ranolazine, procainamide, disopyramide, ajmaline, cibenzoline, hydroquinidine, azimilide, ibutilide, sotalol, dofetilide), antidepressants (paroxetine, amitriptyline, fluoxetine), antibiotics (trimethoprim, spectinomycin, co-trimoxazole, metronidazole, tetracyclines).

Drug-Food Interaction: LITHOSYN SR 400MG TABLET may interact with caffeine. Therefore, reduce the intake of caffeine including coffee, tea or herbal medicines as it may decrease the effect of LITHOSYN SR 400MG TABLET. Also, avoid alcohol intake as it may increase side effects such as drowsiness, dizziness or difficulty in concentrating. Intake of sodium may also alter lithium levels. Hence, maintain a constant dietary intake of salt.

Drug-Disease Interaction: If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, Brugada syndrome (a hereditary syndrome affecting the heart), hypothyroidism (low thyroid levels) and low sodium levels, inform your doctor before taking LITHOSYN SR 400MG TABLET.

Drug-Drug Interactions

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How does the drug interact with Lithosyn Sr 400mg Tablet:
Taking Cisapride with Lithosyn Sr 400mg Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lithosyn Sr 400mg Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Cidofovir can cause higher levels of Lithosyn Sr 400mg Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Lithosyn Sr 400mg Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Taking Lithosyn Sr 400mg Tablet with Enalapril may significantly increase the blood levels of Lithosyn Sr 400mg Tablet.

How to manage the interaction:
Co-administration of Enalapril with Lithosyn Sr 400mg Tablet can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience drowsiness, dizziness, loose stools, vomiting, muscle weakness, shaking of hands and legs, excessive thirst, and increased urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Taking deferasirox with Lithosyn Sr 400mg Tablet may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possible interaction between Lithosyn Sr 400mg Tablet and Deferasirox, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience nausea, vomiting, loss of hunger, increased or decreased urination, fluid retention, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, palpitations and confusion. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Coadministration of Lithosyn Sr 400mg Tablet and Ibuprofen can increases the blood levels of Lithosyn Sr 400mg Tablet.

How to manage the interaction:
Co-administration of Lithosyn Sr 400mg Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like drowsiness, dizziness, confusion, diarrhea, vomiting, muscle weakness, muscle inco-ordination, tremor, blurred vision, ringing in the ear, excessive thirst, and increased urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Coadministration of Haloperidol with Lithosyn Sr 400mg Tablet can increase the levels and risk of developing Lithosyn Sr 400mg Tablet side effects.

How to manage the interaction:
Although taking Haloperidol and Lithosyn Sr 400mg Tablet together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience tiredness, dizziness, confusion, difficulty breathing, an irregular heartbeat, weakness, or fever, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Taking Bupropion with Lithosyn Sr 400mg Tablet can increase the risk of seizures(fits).

How to manage the interaction:
Co-administration of bupropion along with Lithosyn Sr 400mg Tablet can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience any unusual symptoms like staring, stiffening of the legs and hands, stiffening of body, loss of consciousness, breathing difficulties or cessation, lack of urinary or bowel control, and Falling suddenly for no apparent reason, contact a doctor immediately. Do not stop using any medications without talking to a doctor.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Taking Enalapril with Lithosyn Sr 400mg Tablet increases the levels of Lithosyn Sr 400mg Tablet in your blood, which may cause Lithosyn Sr 400mg Tablet toxicity. The risk is increased if you are elderly, dehydrated, or have a history of kidney or heart disease.

How to manage the interaction:
Although using Enalapril and Lithosyn Sr 400mg Tablet together may cause an interaction, they can be taken together if your doctor prescribes it. However, if you experience diarrhoea, vomiting, sleepiness, dizziness, muscular weakness, blurred vision, increased thirst and urination, or ringing in the ears, you should seek medical attention. Do not stop taking any medication without consulting your doctor.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Taking Lithosyn Sr 400mg Tablet with Sertraline can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is an interaction between Sertraline and Lithosyn Sr 400mg Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Lithosyn Sr 400mg Tablet:
Taking ondansetron with Lithosyn Sr 400mg Tablet can increase the risk of serotonin syndrome a condition in which a chemical called serotonin builds up in body).

How to manage the interaction:
Although taking ondansetron along with Lithosyn Sr 400mg Tablet can result in an interaction but can be taken together if prescribed by a doctor. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools, or fast or rapid heartbeats during therapy, consult a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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