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compositionComposition:DOMPERIDONE-30MG+ESOMEPRAZOLE-40MG
prescriptionPrescription Medicine
Nexpro RD 40 Capsule 10's
Nexpro RD 40 Capsule 10's
Nexpro RD 40 Capsule 10's
Nexpro RD 40 Capsule 10's
Nexpro RD 40 Capsule 10's

Nexpro RD 40 Capsule is used to treat gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and stomach ulcers. It contains Esomeprazole and Domperidone, which blocks acid production and increases the movements and contractions of stomach muscles. Thus, helps in treating acidity-related problems. It may cause common side effects, such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DOMPERIDONE-30MG+ESOMEPRAZOLE-40MG

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Nexpro RD 40 Capsule

Nexpro RD 40 Capsule belongs to the class of drugs known as Proton pump inhibitors, which reduce the amount of acid your stomach produces. It treats gastroesophageal reflux disease (GERD), stomach ulcers, Zollinger-Ellison syndrome (overproduction of acid due to a pancreatic tumour), duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.

Nexpro RD 40 Capsule is a combination of Esomeprazole and Domperidone that helps reduce stomach acid by blocking the action of an enzyme (H+/K+ ATPase, also known as the gastric proton pump), thus preventing the release of stomach acid and relieving symptoms of food pipe lining inflammation (esophagitis), gastroesophageal reflux disease (GERD), or heartburn.

Not everyone who is taking Nexpro RD 40 Capsule will get these side effects. In some cases, you may experience certain common side effects, such as dry mouth, stomach pain, diarrhoea, headache, and flatulence. Most of these side effects do not require medical attention and will resolve over time. However, if you experience these side effects persistently, talk to your doctor.

Take Nexpro RD 40 Capsule as advised. Your physician will decide the dosage based on your medical condition. You should take Nexpro RD 40 Capsule 30 minutes before food. It is recommended not to exceed the recommended dose of Nexpro RD 40 Capsule . Do not chew, crush, or break the medicine.

Inform your physician if you are allergic to Nexpro RD 40 Capsule . Consult your doctor before taking Nexpro RD 40 Capsule if you are pregnant or breastfeeding. Nexpro RD 40 Capsule may cause dizziness, so drive only if you are alert. Nexpro RD 40 Capsule should not be given to children as safety has not been established. Avoid consuming alcohol and Nexpro RD 40 Capsule as it could lead to increased drowsiness and elevate stomach acid production.

Uses of Nexpro RD 40 Capsule

Nexpro RD 40 Capsule is used to treat Gastroesophageal reflux disease (GERD), Zollinger-Ellison syndrome, and Stomach ulcers. The detailed uses of Nexpro RD 40 Capsule are as follows:

  • Gastric reflux disease (GERD): By lowering stomach acid, Nexpro RD 40 Capsule helps control GERD symptoms such as acid reflux, regurgitation, and heartburn.
  • Ulcer Treatment: Nexpro RD 40 Capsule promotes healing and inhibits recurrence by treating duodenal and stomach ulcers.
  • Zollinger-Ellison Syndrome: By lowering the production of excessive stomach acid, Nexpro RD 40 Capsule helps to control symptoms and avoid problems.
  • Management of Erosive Esophagitis: Nexpro RD 40 Capsule heals oesophagal damage brought on by acid reflux by treating erosive esophagitis.
  • Relief from nausea and vomiting: Nexpro RD 40 Capsule offers immediate relief by blocking certain substances in the body that cause nausea and vomiting.

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Directions for Use

  • Take Nexpro RD 40 Capsule an hour before your meal, ideally in the morning or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Key Benefits

  • Nexpro RD 40 Capsule is effective in healing erosive esophagitis (inflammation of the food pipe), heartburn, Zollinger-Ellison syndrome, duodenal ulcers, gastric ulcers, and Crohn’s disease-associated ulcers.
  • Nexpro RD 40 Capsule works by irreversibly blocking the proton pump gate, which secretes stomach acid. It can be prescribed to all age groups, including special populations like the elderly, pregnant, lactating mothers, and patients with kidney and liver disease.
  • Nexpro RD 40 Capsule helps manage acidity-related conditions, promotes digestion, and provides relief from associated discomfort.

How Nexpro RD 40 Capsule Works

Nexpro RD 40 Capsule is a combination of two drugs: Esomeprazole (proton pump inhibitor) and Domperidone (a dopamine antagonist). Esomeprazole works by blocking an enzyme called gastric proton pump, which is responsible for the production of acid. Domperidone works by increasing the movements and contractions of stomach muscles. Together, Nexpro RD 40 Capsule helps in treating acidity-related problems.

Storage

Store in a cool and dry place away from sunlight
Side effects of Nexpro RD 40 Capsule
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage Gastrointestinal Air and Swelling (GAS) caused by medication:
  • Tell your doctor about your GAS symptoms. They may change your medication regimen or prescribe additional drugs to help you manage them.
  • To manage GAS symptoms, eat a balanced diet of fibre, vegetables, and fruits.
  • Drink enough water throughout the day to avoid constipation and treat GAS symptoms.
  • Regular exercise like yoga and walking may help stimulate digestion and alleviate GAS symptoms.
  • Take probiotics only if your doctor advises, as they may help alleviate GAS symptoms by promoting gut health.
  • Take medication for GAS symptoms only if your doctor advises, as certain medications can interact with your existing prescriptions or worsen symptoms.
  • If symptoms persist, worsen, or are accompanied by severe abdominal pain, vomiting, or bleeding, seek immediate medical attention.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

What if I have taken an overdose of Nexpro RD 40 Capsule

Do not take more than the prescribed dose of Nexpro RD 40 Capsule as it may cause overdose. If you suspect you have taken overdose, please consult a doctor immediately.

Drug Warnings

  • Avoid taking Nexpro RD 40 Capsule if you are allergic to Nexpro RD 40 Capsule or have any history of gastric cancer, liver disease, low magnesium levels, or low vitamin B1.
  • Inform your doctor before taking Nexpro RD 40 Capsule if you have severe kidney, heart or liver disease, or if you are due to have Chromogranin A blood test; if you have fungal infections, heart problems or HIV infection.
  • Talk to your doctor if you experience weight loss, problems with swallowing, stomach pain, indigestion, vomit food or blood, or if you pass black stools while taking Nexpro RD 40 Capsule .
  • On long-term treatment, Nexpro RD 40 Capsule may cause low magnesium levels, vitamin B12 levels, and might increase the risk of bone fractures; the doctor may advise regular tests for monitoring your condition.
  • Consult your doctor if you are pregnant or breastfeeding.
  • Nexpro RD 40 Capsule may cause dizziness, so drive only if you are alert.
  • Avoid caffeine-containing beverages (coffee, tea), spicy/deep-fried/processed foods, carbonated drinks, and acidic foods like citrus fruits/vegetables (tomatoes).
  • Nexpro RD 40 Capsule should not be given to children as safety has not been established.
  • Avoid consuming alcohol along with Nexpro RD 40 Capsule as it could lead to increased drowsiness and can elevate the production of stomach acid.
  • A prolonged intake of Nexpro RD 40 Capsule is linked with a greater risk of Clostridium difficile-associated diarrhoea, so if you develop diarrhoea that does not improve, immediately consult a doctor. 

Drug-Drug Interactions

verifiedApollotooltip
EsomeprazoleRilpivirine
Critical
DomperidoneHalofantrine
Severe

Drug-Drug Interactions

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EsomeprazoleRilpivirine
Critical
How does the drug interact with Nexpro RD 40 Capsule:
Nexpro RD 40 Capsule may reduce rilpivirine absorption and blood levels, making the medicine less effective against HIV.

How to manage the interaction:
Although taking Nexpro RD 40 Capsule with Rilpivirine can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if your symptoms do not improve. Do not discontinue using any medications without consulting a doctor.
DomperidoneHalofantrine
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Coadministration of Nexpro RD 40 Capsule with Halofantrine can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Nexpro RD 40 Capsule and Halofantrine together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneKetoconazole
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Coadministration of Nexpro RD 40 Capsule with Ketoconazole can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Nexpro RD 40 Capsule and Ketoconazole together can cause an interaction, it can be taken if a doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneMethadone
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Coadministration of Nexpro RD 40 Capsule with Methadone can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Nexpro RD 40 Capsule and Methadone together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneMizolastine
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Combining Mizolastine with Nexpro RD 40 Capsule can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Although taking Nexpro RD 40 Capsule and Mizolastine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DomperidoneBepridil
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Co-administration of Domeperidone and Bepridil can increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Nexpro RD 40 Capsule and Bepridil together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneClarithromycin
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Coadministration of Nexpro RD 40 Capsule with Clarithromycin can increase the risk of side effects.

How to manage the interaction:
There may be a possibility of interaction between Nexpro RD 40 Capsule and Clarithromycin, but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.
DomperidoneRitonavir
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Coadministration of Nexpro RD 40 Capsule with Ritonavir can increase the blood levels of Nexpro RD 40 Capsule.

How to manage the interaction:
There may be a possibility of interaction between Nexpro RD 40 Capsule and Ritonavir, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.
DomperidoneToremifene
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Coadministration of Nexpro RD 40 Capsule with Toremifene can Increase the risk of irregular heart rhythm.

How to manage the interaction:
Although taking Nexpro RD 40 Capsule and Toremifene together can cause an interaction, it can be taken if your doctor has suggested it. If you experience lightheadedness, tiredness, increased heart rate, consult a doctor. Do not discontinue any medications without consulting a doctor.
DomperidoneCisapride
Severe
How does the drug interact with Nexpro RD 40 Capsule:
Coadministration of Nexpro RD 40 Capsule with Cisapride can increase the blood levels of Nexpro RD 40 Capsule.

How to manage the interaction:
There may be a possibility of interaction between Nexpro RD 40 Capsule and Cisapride, but it can be taken if prescribed by a doctor. In case you experience any side effects like swelling of the ankles or feet, unusual tiredness, redness, changes in menstrual ability, contact a doctor. It is recommended to do this to ensure your heart stays healthy. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Avoid smoking and alcohol consumption. Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.
  • Maintain a healthy weight by regular exercising.
  • Avoid lying down after eating as it causes acid reflux.
  • Avoid tight-fitting clothes as it might increase the pressure on the abdomen leading to acid reflux.
  • Practise relaxation techniques and avoid stress by doing yoga or meditation.
  • Avoid foods such as high-fat food, spicy food, chocolates, citrus fruits, pineapple, tomato, onion, garlic, tea and soda. 
  • Avoid sitting continuously as it may trigger acidity. Take a break of 5minutes every hour by doing brisk walking or stretching.

Habit Forming

No

Therapeutic Class

[GASTROINTESTINAL AGENTS]

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Nexpro RD 40 Capsule . Alcohol intake leads to increased production of stomach acid, thereby increasing acidity and heartburn.

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Pregnancy

Consult your doctor

Consult your doctor before taking Nexpro RD 40 Capsule if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Nexpro RD 40 Capsule ; your doctor will decide whether Nexpro RD 40 Capsule can be taken by breastfeeding mothers or not.

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Driving

Unsafe

Nexpro RD 40 Capsule may cause dizziness. Do not drive or operate machinery unless you are alert.

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Liver

Consult your doctor

Dose adjustment may be needed. Consult your doctor before taking Nexpro RD 40 Capsule if you have a liver impairment or any concerns regarding this.

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Kidney

Consult your doctor

Dose adjustment may be needed. Consult your doctor before taking Nexpro RD 40 Capsule if you have kidney impairment or any concerns regarding this.

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Children

Unsafe

Nexpro RD 40 Capsule should not be given to children as safety and effectiveness were not established.

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Heart

Unsafe

This medicine is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Nexpro RD 40 Capsule can be given in elderly patients with caution due to the serious adverse effects.

Country of origin

India

Manufacturer/Marketer address

Off. Ashram Road, Ahmedabad - 380 009., Gujarat, India
Other Info - NEX0009

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