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Xafinact 50 Tablet 10's
Xafinact 50 Tablet 10's
Xafinact 50 Tablet 10's
Xafinact 50 Tablet 10's
Xafinact 50 Tablet 10's
Xafinact 50 Tablet is used to treat Parkinson's disease. It contains Safinamide which works by increasing the amount of dopamine (a chemical messenger that is needed to control movement) in the brain. In some cases, this medicine may cause side effects such as dizziness, headache, nausea, insomnia, and sleepiness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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Health Queries

My father has been diagnosed with Parkinson's disease and is undergoing treatment with a neurologist.

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Your father should continue following his neurologist's treatment plan, as Parkinson's disease management requires regular monitoring and medication adjustments. Supportive care, such as physical therapy, exercise, and a balanced diet, can also help improve mobility and quality of life.

I sometimes notice my fingers shaking when holding cups or paper, but I am unaware of it. Could this indicate Parkinson's disease, and how is it diagnosed?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Unnoticed finger shaking while holding objects may be an early sign of tremor, but it does not always indicate Parkinson's disease. A neurologist diagnoses based on medical history, physical and neurological exams, and, when indicated, imaging or lab tests to rule out other causes.

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Side effects of Xafinact 50 Tablet
  • Uncontrolled and involuntary movements need immediate medical attention.
  • Observe your movements and try to understand and control the particular movement.
  • Regularly do strengthening exercises to improve blood flow throughout the body and avoid involuntary movements.
  • Implement massage techniques to enhance blood flow to organs.
  • Take a balanced diet and quit smoking.
  • Practice yoga and meditation to improve thought processes and reduce uncontrolled and involuntary movements.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the steps to manage medication-triggered Nervousness:
  • Tell your doctor immediately if you experience symptoms of Nervousness, such as anxiety, jitteriness, or an increased heart rate, after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen to alleviate symptoms of Nervousness. This can include switching to a different medication, reducing the dosage, or temporarily stopping the medication. Your doctor may also recommend alternative techniques like relaxation, mindfulness meditation, or journaling. These techniques can help reduce anxiety and Nervousness.
  • Practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling, to help manage Nervousness.
  • Engage in regular physical activity, such as walking or jogging, to help reduce anxiety and improve mood.
  • Your doctor may advise considering cognitive-behavioural therapy (CBT) or other forms of talk therapy to address underlying anxiety or Nervousness.
  • You should maintain regular follow-up appointments with your doctor to monitor nervousness symptoms, adjust treatment plans as needed, and discuss any concerns or questions.
  • Pounding in the ears needs immediate medical attention when you hear abnormal sounds through your ears.
  • Get a physical examination, and an ENT will help identify factors that led to ear pounding.
  • Avoid anxiety and stress, as it can worsen your condition.
  • Follow your doctor's instructions, and use a white noise machine to reduce the pounding sound in your ear. Soft music and low-volume radio can also help if there is no white noise machine.
  • Take a balanced diet and limit your intake of caffeine, alcohol and nicotine.

Drug-Drug Interactions

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SafinamideImipramine
Critical
SafinamideClomipramine
Critical

Drug-Drug Interactions

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SafinamideImipramine
Critical
How does the drug interact with Xafinact 50 Tablet:
Coadministration of Xafinact 50 Tablet with Imipramine can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet and imipramine together is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideClomipramine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Clomipramine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Clomipramine with Xafinact 50 Tablet can possibly result in an interaction but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting a doctor.
SafinamideTapentadol
Critical
How does the drug interact with Xafinact 50 Tablet:
Using Tapentadol together with Xafinact 50 Tablet can increase the risk of high blood pressure and serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Xafinact 50 Tablet and Tapentadol together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
SafinamideTranylcypromine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Tranylcypromine with Xafinact 50 Tablet can increase the risk of high blood pressure and serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Tranylcypromine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideCyclobenzaprine
Critical
How does the drug interact with Xafinact 50 Tablet:
Coadministration of Xafinact 50 Tablet with Cyclobenzaprine might raise serotonin hormone levels which can increase the risk of developing side effects.

How to manage the interaction:
Taking Xafinact 50 Tablet with Cyclobenzaprine is not recommended, but can be taken together if prescribed by a doctor. However, if you experience fever, palpitations, excessive sweating, muscle spasm, or diarrhea, contact a doctor immediately. Do not discontinue the medications without consulting a doctor.
SafinamideTrimipramine
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Trimipramine can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Trimipramine is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideMilnacipran
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Milnacipran can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Milnacipran is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideTramadol
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Tramadol can increase the risk of serotonin syndrome (A condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Tramadol is not recommended as it can possibly result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideFentanyl
Critical
How does the drug interact with Xafinact 50 Tablet:
Taking Xafinact 50 Tablet with Fentanyl can increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Xafinact 50 Tablet with Fentanyl is not recommended as it can result in an interaction, but it can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain, stomach cramps, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
SafinamideNortriptyline
Critical
How does the drug interact with Xafinact 50 Tablet:
Coadministration of Nortriptyline with Xafinact 50 Tablet may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Nortriptyline with Xafinact 50 Tablet together can result in an interaction, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe

Drug-Food Interactions

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SAFINAMIDE-50MGTyramine-containing food
Severe
Common Foods to Avoid:
Pepperoni, Miso Soup, Natto, Ricotta, Salami, Shoyu, Shrimp, Stilton Cheese, Swiss Cheese, Tamari, Tempeh, Fish, Farm Cheese, Fava Beans, Fermented Seafood, Fermented Tofu, Gorgonzola Cheese, Chicken Liver, Chocolates, Cottage Cheese, Cream Cheese, Dried Sausage, Dry-Type Summer Sausages, Cheddar Cheese, Cashews, Camembert, Beef Liver, American Cheese, Almonds, Avocado

How to manage the interaction:
Eating tyramine containing foods while you are taking Xafinact 50 Tablet can raise your blood pressure levels. Avoid Tyramine containing food while on the treatment with Xafinact 50 Tablet. Consult your doctor immediately If you experience symptoms such as headache, sleep disturbances, tremor(shaking of hands & legs), restlessness, nervousness, anxiety, palpitation, and rapid heartbeat. Do not stop taking the medication without consulting a doctor.

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