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compositionComposition:DOXORUBICIN-2MG/ML
prescription
Prescription Medicine
info
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Adripeg 20 Injection 10 ml is an anti-cancer medicine used to treat cancer. It contains Doxorubicin, which belongs to the class of anthracycline topoisomerase inhibitors. It inhibits the topoisomerase II enzyme by intercalating the DNA base pairs; this causes double-helix DNA to be uncoiled, destroying DNA and RNA synthesis. Thus, it treats cancer.

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Written By Dr. Lakshmithulasi Yarragunta , PharmD (PB)
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DOXORUBICIN-2MG/ML

Manufacturer/Marketer :

Halsted Pharma Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Adripeg 20 Injection 10 ml

Adripeg 20 Injection 10 ml is a prescription medicine given as an injection to treat several types of cancer, including breast, ovarian, bladder, and thyroid cancers, as well as certain blood cancers. Its medical purpose is to target and slow down or stop the growth of abnormal cancer cells in the body. By destroying these fast-growing cells, it helps control the spread of the disease.

Because this medicine is a highly specialised cancer treatment, it is given at specific intervals determined by your healthcare team to allow your body time to recover between cycles. It is injected directly into a vein by a trained medical professional in a hospital or clinic setting, meaning there are no home food instructions. However, maintaining a balanced diet, resting well, and staying highly hydrated can help support your body during treatment.

While receiving Adripeg 20 Injection 10 ml, you may experience common side effects such as nausea, temporary hair loss, fatigue, and mouth sores. It is vital to consult your doctor immediately if you experience serious side effects, such as chest pain, breathing difficulties, signs of infection, or pain and swelling at the injection site.

Before starting treatment, tell your doctor if you have a history of heart disease, liver damage, or low blood cell counts. Do not take this if you have severe heart problems, extremely low blood cell counts, or have had a severe allergic reaction to similar cancer medications.

This medicine can interact with other drugs, such as certain vaccines or other chemotherapy treatments, which can increase the risk of side effects or reduce how well the medicine works. Always consult your doctor if you are pregnant, planning to become pregnant, breastfeeding, or if you are caring for an elderly patient, as special precautions are needed.

Uses of Adripeg 20 Injection 10 ml

Adripeg 20 Injection 10 ml is used to treat several types of cancer. The detailed uses of Adripeg 20 Injection 10 ml are as follows:

  • Breast cancer: It helps by targeting and destroying cancer cells within the breast tissue to prevent the disease from spreading.
  • Ovarian cancer: It works to slow down and stop the multiplication of abnormal cells in the ovaries.
  • Bladder cancer: It assists in shrinking or eliminating cancerous tumours located in the bladder.
  • Leukaemia: It helps control the overproduction of abnormal white blood cells in the bone marrow.
  • Lymphoma: It aids in reducing cancerous cells in the lymphatic system to manage the disease.

Key Benefits

Adripeg 20 Injection 10 ml helps treat certain types of cancer by slowing or stopping the growth of rapidly dividing cancer cells. When used as prescribed, it helps control the disease, reduce tumour burden, and support better treatment outcomes.

  • Helps Control Cancer Growth: By targeting rapidly growing cancer cells, this medicine helps slow or stop their growth, reducing tumour size and limiting the progression of the disease.
  • Relieves Cancer-Related Symptoms: As tumours shrink or stop growing, this medicine may help reduce pain, pressure, and other symptoms caused by cancer, improving daily comfort and quality of life.
  • Supports Long-Term Treatment Goals: By helping prevent cancer cells from multiplying and spreading, this medicine supports remission when achievable, reduces the risk of disease progression, and contributes to improved long-term treatment outcomes.
Side effects of Adripeg 20 Injection 10 ml
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
  • Using a cold compress may help relieve itching and inflammation associated with conjunctivitis.
  • A warm compress and washing the eyes with water can help with crusting on the eyelids.
  • Avoid wearing contact lens until you feel better; use spectacles instead.
  • Do not rub the eyes.
  • Practise good hand hygiene and avoid touching the eyes to prevent the spread of infection.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Adripeg 20 Injection 10 ml will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Adripeg 20 Injection 10 ml Works

Adripeg 20 Injection 10 ml contains doxorubicin, which works by targeting the genetic material inside cancer cells. Cancer cells multiply rapidly, which requires them to constantly copy their DNA. This medicine binds to the DNA of these rapidly dividing cells and blocks a key enzyme they need to repair and replicate themselves. By damaging the DNA and stopping this enzyme from working, Adripeg 20 Injection 10 ml prevents the cancer cells from dividing and growing. This ultimately leads to the self-destruction of the abnormal cells, helping to control and reduce the spread of cancer throughout the body.
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Alcohol

Unsafe

Alcohol intake might increase the risk of stomach or intestine bleeding. Alcohol consumption is not recommended.

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Pregnancy

Unsafe

Adripeg 20 Injection 10 ml is not recommended for use in pregnancy as it may harm your foetus. Hence, if you are pregnant or planning pregnancy, inform your doctor before receiving Adripeg 20 Injection 10 ml. Use reliable methods of birth control while on treatment with Adripeg 20 Injection 10 ml.

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Breast Feeding

Unsafe

It is not recommended for use in breastfeeding as it may pass into breast milk and harm your infant. Hence, if you are breastfeeding, inform your doctor before receiving Adripeg 20 Injection 10 ml. Your doctor may suggest you stop feeding while on treatment with this medicine.

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Driving

Caution

Adripeg 20 Injection 10 ml may cause dizziness and tiredness; therefore, avoid driving vehicles or operating machinery until you return to normal.

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Liver

Caution

Adripeg 20 Injection 10 ml should be used with caution in patients with liver impairment. However, this medicine is contraindicated in patients with severe liver disease. If you have a pre-existing or a history of liver disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

If you have a pre-existing or a history of kidney disease, inform your doctor. Your doctor may adjust the dose or prescribe a suitable alternative, if necessary, based on your condition.

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Children

Consult your doctor

Adripeg 20 Injection 10 ml is used to treat neuroblastoma (cancer that starts in nerve cells and primarily affects children) and Wilms' tumor (a form of kidney cancer that affects children). Your doctor may recommend a suitable dosage based on your child's condition.

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Heart

Caution

Adripeg 20 Injection 10 ml should be avoided or used with extreme caution in people with heart problems due to its high risk of cardiotoxicity. If necessary, close cardiac monitoring and consideration of safer alternatives are essential.

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Geriatrics

Caution

Geriatric patients can receive Adripeg 20 Injection 10 ml, but with extra caution due to increased risks of heart damage and bone marrow suppression. Close monitoring of cardiac function and organ health is essential throughout treatment.

What if I have taken an overdose of Adripeg 20 Injection 10 ml

Since this medicine is given by trained medical professionals in a controlled clinical environment, an overdose is highly unlikely. However, if you suspect an error has occurred or experience sudden, severe symptoms after an injection, seek immediate medical attention.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of water and clear fluids to help flush the medicine through your kidneys and prevent dehydration from nausea.
  • Eat small, frequent meals: If you experience nausea, eating smaller portions throughout the day rather than three large meals can help keep your stomach settled.
  • Choose soft, bland foods: To manage or prevent painful mouth sores, avoid spicy, acidic, or crunchy foods, and opt for soft, easy-to-chew options instead.
  • Practice strict food safety: Because your immune system may be weakened, avoid raw or undercooked meats, eggs, and seafood, and wash all fruits and vegetables thoroughly.
  • Protect your skin from the sun: This treatment can make your skin more sensitive to sunlight, so wear protective clothing and apply broad-spectrum sunscreen when outdoors.
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Have a query?

How Soon It Starts Working

The time required for Adripeg 20 Injection 10 ml to start to work: The peak effect of Adripeg 20 Injection 10 ml starts immediately after the IV administration. The time for which the effects of Adripeg 20 Injection 10 ml last: The peak effect of Adripeg 20 Injection 10 ml lasts for 1 to 2 days.

What if you forget to take Adripeg 20 Injection 10 ml

If you miss an appointment for your injection, contact your doctor or clinic immediately to reschedule. Keeping a consistent treatment schedule is very important for the success of your therapy.

Storage

• In a clinical setting, vials of Adripeg 20 Injection 10 ml are stored in a refrigerator at 2°C to 8°C (36°F to 46°F) and kept in their original packaging to protect them from light.

Drug Warnings

  • Monitor the injection site: Tell your nurse or doctor immediately if you feel any burning, stinging, or pain while the injection is being given, as this can indicate the medicine is leaking outside the vein.
  • Keep all blood test appointments: Regular blood tests are required to monitor your blood cells and ensure it is safe for you to receive your next dose.
  • Watch your heart health: Report any heart palpitations, rapid heartbeats, or sudden ankle swelling to your doctor right away, as this medicine can affect your heart muscles.
  • Avoid live vaccines: Do not receive any live vaccines while undergoing treatment, as your weakened immune system may not be able to handle them safely.
  • Avoid crowds and sick people: Because your white blood cell count may drop, take precautions to avoid catching infections from others.
  • Expect urine colour changes: Do not be alarmed if your urine turns a reddish or pinkish colour for a day or two after your injection; this is a harmless effect of the medicine's natural colour.

Drug-Drug Interactions

verifiedApollotooltip

Certain heart medications or other cancer drugs: May increase the risk of heart damage when combined with Adripeg 20 Injection 10 ml.

  • Live vaccines: May cause severe infections because the body's immune defence is lowered.
  • Seizure medicines: Adripeg 20 Injection 10 ml may lower the absorption of these drugs, making them less effective.
DoxorubicinZiprasidone
Critical
DoxorubicinChloroquine
Severe

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
How does the drug interact with Adripeg 20 Injection 10 ml:
Coadministration of Adripeg 20 Injection 10 ml with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Adripeg 20 Injection 10 ml is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxorubicinChloroquine
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
Using chloroquine together with doxurubicin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Adripeg 20 Injection 10 ml together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinHydroxychloroquine
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
The combined use of Adripeg 20 Injection 10 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Adripeg 20 Injection 10 ml and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DoxorubicinHaloperidol
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
Co-administration of Adripeg 20 Injection 10 ml and Haloperidol can increase the risk or severity of irregular heart rhythms which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Adripeg 20 Injection 10 ml with Haloperidol can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinBaricitinib
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
Using baricitinib together with Adripeg 20 Injection 10 ml may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Adripeg 20 Injection 10 ml if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
DoxorubicinTofacitinib
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
Taking Tofacitinib with Adripeg 20 Injection 10 ml may increase the risk of serious infection.

How to manage the interaction:
Although taking Tofacitinib and Adripeg 20 Injection 10 ml together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. It is important to keep a close eye on your condition. Do not stop using any medications without a doctor's advice.
DoxorubicinMifepristone
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
Co-administration of Adripeg 20 Injection 10 ml with mifepristone can increase the risk of irregular heart rhythms. Prolonged treatment with Mifepristone may result in low potassium levels.

How to manage the interaction:
Taking Adripeg 20 Injection 10 ml with mifepristone together is avoided as it can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, breathing difficulty, rapid heartbeat, weakness, tiredness, drowsiness, confusion, painful muscle cramping, nausea, or vomiting, constipation, abdominal cramping, chest pain, and/or swelling in the legs or feet, get medical attention. Do not discontinue any medications without consulting a doctor.
DoxorubicinEtanercept
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
When Etanercept is used with Adripeg 20 Injection 10 ml, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Adripeg 20 Injection 10 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
DoxorubicinClozapine
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
Taking Adripeg 20 Injection 10 ml and clozapine may increase the risk of neutropenia.

How to manage the interaction:
Co-administration of Adripeg 20 Injection 10 ml with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - like a severe infection, fever, diarrhea, sore throat, muscle pain, or difficulty breathing - it's important to call your doctor right away." Do not discontinue any medications without first consulting your doctor.
DoxorubicinInfliximab
Severe
How does the drug interact with Adripeg 20 Injection 10 ml:
Combining Infliximab with Adripeg 20 Injection 10 ml can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Adripeg 20 Injection 10 ml can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip
  • There are no major, clinically established food interactions with this injectable medicine. However, it is always best to discuss your overall diet and use of herbal supplements with your healthcare team.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

No. You should avoid becoming pregnant while receiving Adripeg 20 Injection 10 ml because it can harm an unborn baby. This medicine may also affect fertility by disrupting menstrual cycles in women or reducing sperm production in men, although pregnancy is still possible. Both men and women should use effective contraception during treatment and for the period recommended by their doctor after the final dose. Talk to your doctor about fertility preservation or family planning before starting treatment.
If you notice burning, stinging, pain, swelling, or redness around the injection site during your treatment, tell your nurse or doctor immediately. Adripeg 20 Injection 10 ml is a vesicant, meaning it can cause serious skin and tissue damage if it leaks outside the vein. Prompt treatment can help reduce the risk of injury.
Yes, temporary hair loss is a very common side effect of Adripeg 20 Injection 10 ml. This usually affects the scalp, but can also affect eyebrows, eyelashes, and body hair. Hair typically begins to grow back after the treatment cycles are fully completed. Talk to your doctor if you have concerns about hair loss.
The medicine itself has a deep red colour, which your body naturally filters out through your kidneys. This can cause your urine to look reddish or pinkish for 1 to 2 days after your injection. This is expected and harmless, but if it lasts longer, talk to your doctor.
Adripeg 20 Injection 10 ml is given as an injection or a slow drip (infusion) directly into a vein. This process is performed by trained healthcare professionals in a hospital or specialised clinic to ensure it is done safely. Talk to your doctor about your specific treatment schedule.
Yes, this medicine can sometimes affect the heart muscles, especially at higher cumulative doses. Your doctor will likely test your heart function before and during your treatment to ensure it remains safe for you to continue. Talk to your doctor if you experience shortness of breath or swollen ankles.
You should avoid receiving live vaccines while using this medicine, as your immune system is weakened and you could become sick. It is safe to discuss any scheduled or needed vaccines with your healthcare team before starting therapy. Talk to your doctor before getting any immunisations.
The medicine is processed by your liver and slowly cleared from your body over several days, though its effects on cells can last longer. Your doctor schedules your treatment cycles carefully to allow your healthy cells time to recover between doses. Talk to your doctor for more details about your specific cycle.

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Country of origin

India

Manufacturer/Marketer address

Ground floor, Plot No.25-HIG, Survey No.912P. 913P, 941P, 944P 945 to 962 and 964P Phase XV, KPHB Colony, Kukatpally. Medchal- Malkajgiri District, Telangana State, India
Other Info - ADR0102
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