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Amifru 40 Tablet is used to treat hypertension (high blood pressure) and oedema (fluid retention). It contains Furosemide and Amiloride, which helps in clearing the excess fluids in the body in the form of urine. It can cause side effects, such as dizziness, light-headedness, headache, blurred vision, nausea, vomiting, loss of appetite, stomach/abdominal pain, gas and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Manufacturer/Marketer :

Torrent Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Amifru 40 Tablet

Amifru 40 Tablet is an oral prescription medication used to reduce excess fluid buildup in the body, a condition known as oedema. It is commonly prescribed to treat swelling associated with heart failure, liver disease, or kidney disorders. By helping your body rid itself of extra water, this medicine eases the strain on your heart and blood vessels.

To get the best results, you should take this medicine consistently every day at the same time, usually in the morning to prevent nighttime bathroom trips. It can be taken with or without food, though taking it with a meal may help prevent an upset stomach. Combining this treatment with a low-salt diet can significantly improve how well the medicine works.

While taking this medicine, you may experience mild side effects like a dry mouth, mild headache, or dizziness. However, you must contact your doctor immediately if you experience serious symptoms such as severe muscle cramps, an irregular heartbeat, or extreme weakness. These symptoms can indicate a significant shift in your body's fluid and mineral balance.

Before starting this treatment, talk to your doctor if you have diabetes, gout, or a history of liver or kidney problems. Do not take this if you have high potassium levels in your blood, severe kidney failure, or if your body is unable to produce urine. It is crucial to have your blood monitored regularly to ensure this medicine is safe for you.

This medicine can interact with alcohol, which may cause your blood pressure to drop too low and make you feel dizzy. You should also tell your doctor about all other medications you take, especially pain relievers, as they can reduce this drug's effectiveness. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist before taking this medication to ensure it is the safest option.

Uses of Amifru 40 Tablet

Amifru 40 Tablet is used to treat oedema. The detailed uses of Amifru 40 Tablet are as follows:

  • Fluid retention (oedema): This medicine helps your body remove excess water that has pooled in your tissues due to heart, liver, or kidney conditions, reducing uncomfortable swelling in your legs, ankles, or abdomen.
  • High blood pressure (hypertension): By removing extra fluid and salt from your bloodstream, this medication relaxes your blood vessels and lowers your blood pressure, which helps prevent future heart attacks or strokes.
     

Key Benefits

This medicine offers real-world relief by targeting the root causes of fluid buildup, helping you feel lighter and move more easily. Here is how it helps:

  • Eases breathing and physical movement: By clearing excess fluid from the lungs and limbs, it reduces shortness of breath and heaviness in the legs.
  • Protects mineral balance: Unlike standard fluid tablets that can cause you to lose too much potassium, this combination helps retain this vital mineral, preventing severe muscle weakness and painful cramping.
  • Reduces strain on the heart: Lowering overall fluid volume makes it easier for your heart to pump blood, helping you feel less tired during daily activities.
     

Directions for Use

  • Amifru 40 Tablet can be taken with or without food as advised by your doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Amifru 40 Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Amifru 40 Tablet Works

Amifru 40 Tablet contains two active components that work together in your kidneys to remove excess fluid while keeping your minerals balanced. The first active component, furosemide, is a powerful water-removing agent. It acts directly on your kidneys to prompt the filtration and removal of extra salt and water, which leaves your body through your urine. This action quickly reduces swelling and decreases the volume of blood your heart must pump. The second active component, amiloride, is a potassium-retaining agent. Because standard water-removing medicines often cause the body to lose too much potassium, an essential mineral for healthy heart and muscle function, this second component helps your kidneys hold onto potassium. Together, these two ingredients safely remove excess fluid without dangerously depleting your body's vital mineral stores.
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Alcohol

Caution

Alcohol may lower your blood pressure. It would help if you avoided or limit consuming alcohol whilst taking Amifru 40 Tablet

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Pregnancy

Caution

It is advised to seek medical advice before using Amifru 40 Tablet if you plan to conceive or pregnant before starting Amifru 40 Tablet .

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Breast Feeding

Caution

Amifru 40 Tablet may pass into the breast milk during breastfeeding. Please consult your doctor before using Amifru 40 Tablet if you are a lactating mother.

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Driving

Caution

Amifru 40 Tablet may cause side effects due to lowering of the blood pressure such as dizziness or tiredness. If you feel dizzy or tired when taking this medicine, do not drive or use any tools or machines.

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Liver

Caution

Let your doctor know if you have any history of liver diseases before using Amifru 40 Tablet . Amifru 40 Tablet is to be administered with caution in patients with severe hepatic impairment.

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Kidney

Caution

Amifru 40 Tablet to be taken with caution, especially if you have a history of Kidney diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions.

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Children

Unsafe

Amifru 40 Tablet is not recommended for use in people below 18 years as the efficacy and safety have not been established.

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Heart

Safe if prescribed

Amifru 40 Tablet is safe for use in heart patients if recommended by the physician.

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Geriatrics

Caution

Amifru 40 Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Amifru 40 Tablet

If you suspect an overdose, seek emergency medical care immediately. Taking too much of this medicine can lead to severe dehydration, confusion, rapid blood pressure drops, and serious electrolyte imbalances.

Diet & Lifestyle Advise

  • Limit your daily salt intake: High sodium levels cause your body to hold onto extra water, which directly counters the benefits of this medicine.
  • Avoid potassium-rich salt substitutes: Do not use salt substitutes that contain potassium, and avoid taking potassium supplements unless specifically directed by your doctor.
  • Change positions slowly: Get up slowly from sitting or lying down to give your body time to adjust, preventing dizziness and accidental falls.
  • Track your weight daily: Weigh yourself at the same time each morning after using the bathroom. Report any sudden weight gain of more than two pounds in a single day to your doctor, as this can indicate fluid retention.
     
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How Soon It Starts Working

The time required for Amifru 40 Tablet to start to work: The time required for Amifru 40 Tablet to start to work is 1 hour after administration. The time for which the effects of Amifru 40 Tablet last: The effect of Amifru 40 Tablet lasts for 6 to 8 hours.

What if you forget to take Amifru 40 Tablet

If you miss a dose, take it as soon as you remember. However, if it is late in the afternoon or close to your next scheduled dose, skip the missed dose and resume your normal schedule. Do not take a double dose to make up for a missed one, and avoid taking it close to bedtime to prevent sleep disruption.

Storage

•Store this medication at room temperature, ideally between 15°C and 30°C. •Keep the tablets in their original packaging to protect them from direct light and moisture.

Drug Warnings

  • Always take this medicine early in the day, ideally before 4 PM, to prevent frequent nighttime trips to the bathroom.

  • Check your blood pressure regularly at home and keep a log for your doctor.

  • Avoid drinking alcohol while taking this medicine, as it can dangerously drop your blood pressure and cause severe dizziness.

  • Protect your skin from direct sunlight by wearing sunscreen and protective clothing, as this medicine can make you burn more easily.

  • Ensure you get routine blood tests as scheduled by your healthcare provider to monitor your kidney function and mineral levels.

 

 

Drug-Drug Interactions

verifiedApollotooltip
  • Lithium: Combining this medicine with lithium can cause toxic levels of lithium to build up in your blood.
  • ACE Inhibitors: Taking this medicine alongside ACE inhibitors or potassium supplements can raise your potassium levels to a dangerous point.
  • NSAID Pain Relievers: Using pain relievers like ibuprofen can strain your kidneys and make this fluid medicine less effective.
     

Drug-Drug Interactions

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How does the drug interact with Amifru 40 Tablet:
Coadministration of Amiloride and Furosemide with Spironolactone may increase potassium levels in the blood.

How to manage the interaction:
Taking Amiloride and Furosemide with Spironolactone is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, consult the doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs. Do not stop taking any medication without doctor's advice.
How does the drug interact with Amifru 40 Tablet:
Taking Eplerenone together with Amifru 40 Tablet can result in hyperkalemia (increased levels of potassium in the blood).

How to manage the interaction:
Although taking Eplerenone with Amifru 40 Tablet is not recommended it can be taken if prescribed by a doctor. However contact a doctor if you experience nausea, vomiting, tingling in your hands and legs, confusion, headache, or heart palpitations. Do not stop using any medications without consulting a doctor.
How does the drug interact with Amifru 40 Tablet:
Taking Ziprasidone with Furosemide and amiloride can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Furosemide and Amiloride is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, weakness, tiredness, drowsiness, confusion, and muscle pain. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Amifru 40 Tablet:
The use of desmopressin combined with Amiloride and Furosemide may raise the risk of hyponatremia, a condition characterized by low blood sodium levels.

How to manage the interaction:
Although taking Desmopressin with Amifru 40 Tablet together can possibly result in an interaction, it can be taken if a doctor has advised it. However, contact your doctor if you experience Loss of appetite, nausea, vomiting, headache, lethargy, muscle spasms, weakness, decreased urine, and/or unexpected weight gain. Do not stop using any medications without consulting a doctor.
Amiloride + FurosemidePotassium gluconate
Severe
How does the drug interact with Amifru 40 Tablet:
When Amiloride and Furosemide is taken with Potassium gluconate may increase potassium levels in the blood.

How to manage the interaction:
Although taking Amiloride and Furosemide with Potassium gluconate together may lead to an interaction but can be taken if prescribed by the doctor. However, consult the doctor if you experience nausea, vomiting, weakness, tingling in your hands and feet, and feelings of heaviness in your legs. Do not stop using any medications without talking to a doctor.
Severe
How does the drug interact with Amifru 40 Tablet:
Coadministration of Captopril with amiloride may cause a rise in potassium levels in your blood.

How to manage the interaction:
Although taking amiloride and captopril together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience symptoms including fatigue, disorientation, numbness or tingling, and irregular heartbeats. Do not discontinue any medications without a doctor's advice.
Severe
How does the drug interact with Amifru 40 Tablet:
Coadministration of Amiloride and Furosemide with Etacrynic acid can increase the risk of adverse effects.

How to manage the interaction:
Coadministration of Amiloride and Furosemide with Etacrynic acid can result in an interaction, but it can be taken if prescribed by a doctor. However, contact your doctor if you experience ringing in your ears or hearing loss. Do not stop using any medications without consulting a doctor.
How does the drug interact with Amifru 40 Tablet:
Coadministration of Amiloride and Furosemide with Neomycin can increase the risk of side effects.

How to manage the interaction:
Coadministration of Amiloride and Furosemide with Neomycin can result in an interaction, but it can be taken if prescribed by a doctor. However, contact your doctor if you experience hearing loss or ringing in your ears. Do not stop using any medications without consulting a doctor.
How does the drug interact with Amifru 40 Tablet:
using Amiloride and furosemide with Pimozide increases the risk of irregular heart rhythms.

How to manage the interaction:
Coadministration of Amiloride and furosemide with Pimozide can result in an interaction, but it can be taken if prescribed by a doctor. However, contact your doctor if you experience nausea, vomiting, dizziness, lightheadedness, or confusion. Do not stop using any medications without consulting a doctor.
How does the drug interact with Amifru 40 Tablet:
Combining Tizanidine and Furosemide can lower your blood pressure.

How to manage the interaction:
Taking Tizanidine and Furosemide together can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like headache, dizziness, lightheadedness, and fainting, contact your doctor immediately. Avoid driving or operating hazardous machinery until you know how the medications affect you, use caution when getting up from a sitting or lying position, and do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Potassium-Rich Salt Substitutes: Avoid consuming salt substitutes containing potassium, as they can raise blood potassium to unsafe levels.
     
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[DIURETIC]

FAQs

Amifru 40 Tablet is used to treat Hypertension (high blood pressure) and Oedema (fluid retention).
Amifru 40 Tablet treats hypertension (high blood pressure) and oedema (fluid retention). Amifru 40 Tablet consists of diuretic medications: Furosemide and Amiloride. It works by acting on different parts of the kidney to remove extra fluid and certain electrolytes while maintaining the body's potassium balance.
Amifru 40 Tablet can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.
Furosemide in Amifru 40 Tablet may affect your blood sugar levels. Hence, therapy with loop diuretics should be administered cautiously in patients with diabetes mellitus, glucose intolerance, or a history of hyperglycemia (high glucose levels). Please consult your doctor before taking Amifru 40 Tablet if you have diabetes.
It is advised to follow a high protein and less fatty diet. Also reduce the intake of table salt in your foods, which plays a significant role in blood pressure and fluid build-up in the body. Furosemide in Amifru 40 Tablet may reduce the potassium levels in your blood. It is recommended to add potassium-rich foods, such as bananas, orange juice to your diet.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and go back to your regular dosing schedule.
No, it is not safe to get an MRI while using Amifru 40 Tablet , especially if contrast dye is utilized, as it can affect your kidney. Before arranging an MRI, inform your doctor about all of your drugs.
Store Amifru 40 Tablet by keeping it in a cool and dry place away from sunlight. Keep it out of reach of children. Never flush the medicine down the toilet or sink. To dispose of Amifru 40 Tablet , place it in a plastic bag, and discard it in the household trash.
Amifru 40 Tablet contains the combination of two active ingredients they are Amiloride (a potassium-sparing diuretic) and Furosemide (a loop diuretic).
Amifru 40 Tablet helps to clear excess fluids in the body by increasing urine production. Usually, to avoid nighttime urination, it is best to take this medication during the daytime. However, based on the severity of the condition the doctor prescribes you the best schedule to take Amifru 40 Tablet . Always follow your doctor's instructions.
Amifru 40 Tablet is generally considered safe when used as a doctor prescribes. However, like all medications, it can also have side effects and potential interactions with other drugs. It's important to follow your doctor's instructions and inform them of any pre-existing and existing medical conditions or medication history to avoid negative complications.
Generally, Amifru 40 Tablet can cause potential damage to the heart, particularly if taken in high doses or for extended periods. Furosemide can cause electrolyte imbalances, leading to arrhythmias (irregular heartbeat), while Amiloride helps conserve potassium. To minimize risks, follow your doctor's guidance, attend regular check-ups, and monitor your heart health closely, especially if you have any pre-existing health-related issues.
Take Amifru 40 Tablet as directed by your doctor. The frequency of taking Amifru 40 Tablet may vary depending on the severity of your condition. Always follow your doctor's prescribed duration and frequency of dosing to have safe and optimal results.
The common side effects of Amifru 40 Tablet caused in some individuals may include dizziness, light-headedness, headache, blurred vision, nausea, vomiting, loss of appetite, stomach/abdominal pain, gas, and diarrhoea. Most of these side effects of Amifru 40 Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, please reach out to your doctor.
You should avoid or limit alcohol while on this medication. Alcohol can worsen side effects like dizziness, lightheadedness, and low blood pressure when combined with this medicine. Talk to your doctor or pharmacist for guidance on alcohol consumption.
Severe muscle cramps can indicate that your body's fluid or mineral levels are unbalanced. If you experience persistent cramps, spasms, or muscle weakness, contact your doctor right away.
It is best to avoid taking pain relievers like ibuprofen or naproxen while using this medicine. These drugs can reduce the effectiveness of Amifru 40 Tablet and put extra strain on your kidneys. Talk to your doctor or pharmacist to find safe alternatives for pain relief.
This medicine is generally not recommended during pregnancy as it can affect fluid levels. If you are pregnant, planning to become pregnant, or breastfeeding, talk to your doctor or pharmacist to discuss safer treatment options.

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Country of origin

India

Manufacturer/Marketer address

Elder House Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.
Other Info - AMI0007
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