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  3. Angiotec 500 mg Tablet 10's

Angiotec 500 mg Tablet 10's, Pack of 10 TabletS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Angiotec 500 mg Tablet is used alone or with other medicines to treat angina pectoris. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines. In some cases, it may cause side effects such as constipation, dizziness, headache, or feeling sick. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

RANOLAZINE-500MG

Manufacturer/Marketer :

Oaknet Healthcare Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Angiotec 500 mg Tablet

Angiotec 500 mg Tablet is used alone or with other medicines to treat angina pectoris. Angina pectoris is discomfort in the chest or chest pain, which generally occurs due to coronary artery disease (CAD) when an adequate amount of oxygen and blood is not reaching the heart and its muscles. It can also be due to the blockage of the heart's arteries. It helps prevent any further attack of angina by making the heart work more efficiently, and it is used as an add-on to existing treatment in patients whose disease is not adequately controlled by other medicines for angina pectoris, such as beta-blockers or calcium antagonists, or in patients who cannot take these medicines.

The active substance in Angiotec 500 mg Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels, through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Angiotec 500 mg Tablet is thought to help the heart relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Your doctor will tell you how to take the Angiotec 500 mg Tablet based on your medical condition. You may sometimes experience constipation, dizziness, headache, or feeling sick. Most of these side effects of Angiotec 500 mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not consume Angiotec 500 mg Tablet if you are allergic to any component in this medicine. Angiotec 500 mg Tablet should not be stopped even if you feel better for the best results, as it prevents any future harm. If you stop taking the Angiotec 500 mg Tablet on your own, your chest pain can come back in more severe form. If you plan to get pregnant or are pregnant or breastfeeding, please consult your doctor to avoid any unwanted harm to the baby. Some lifestyle modifications are important for best results when taking Angiotec 500 mg Tablet , like smoking cessation, decreasing alcohol intake, eating well, regular exercise, and managing stress. Angiotec 500 mg Tablet should be taken with caution if you have any liver or kidney problems. Also, inform your doctor if you are taking other medications to avoid unwanted side effects or contraindications.

Uses of Angiotec 500 mg Tablet

Angiotec 500 mg Tablet used in the treatment of Angina Pectoris. The detailed use of Angiotec 500 mg Tablet is as follows:<br/>• Treatment of Angina Pectoris: Angiotec 500 mg Tablet is used in the treatment of angina pectoris by improving oxygen supply to the heart muscle and enhancing cardiac efficiency, particularly in areas with fixed epicardial lesions, thereby decreasing chest pain episodes and improving patient quality of life.<br/>

Directions for Use

• Angiotec 500 mg Tablet can be taken with or without food. Avoid consuming grapefruit or grapefruit juice while taking ths medication.• It is usually taken twice daily at the same time each day or as prescribed by your doctor.• Swallow Angiotec 500 mg Tablet as a whole with a glass of water.• Do not chew, crush, or break it.

Medicinal Benefits

Angiotec 500 mg Tablet is prescribed for treating angina. Angiotec 500 mg Tablet is an anti-anginal medication used to treat angina pectoris. It reduces sodium ions' flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called ‘sodium-dependent calcium channels’ through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Angiotec 500 mg Tablet is thought to help the heart relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

How Angiotec 500 mg Tablet Works

The active substance in Angiotec 500 mg Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called 'sodium-dependent calcium channels, through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Angiotec 500 mg Tablet is thought to help the heart relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

Storage

Keep Angiotec 500 mg Tablet out of the sight and reach of children.
Side effects of Angiotec 500 mg Tablet
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

What if I have taken an overdose of Angiotec 500 mg Tablet

Do not take more than the prescribed dose of Angiotec 500 mg Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Angiotec 500 mg Tablet should be taken with caution in liver/kidney disease, are pregnant, plan to become pregnant, or are breastfeeding, history of heart disease. Also, grapefruit juice should be avoided while taking Angiotec 500 mg Tablet . As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery. Do regular exercise to avoid the feeling of heaviness in the abdomen.

Drug-Drug Interactions

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RanolazineDelavirdine
Critical
RanolazineVoriconazole
Critical

Drug-Drug Interactions

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RanolazineDelavirdine
Critical
How does the drug interact with Angiotec 500 mg Tablet:
Co-administration of Delavirdine and Angiotec 500 mg Tablet may significantly increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Delavirdine with Angiotec 500 mg Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineVoriconazole
Critical
How does the drug interact with Angiotec 500 mg Tablet:
Co-administration of Angiotec 500 mg Tablet together with Voriconazole may significantly increase the blood levels and effects of Angiotec 500 mg Tablet.

How to manage the interaction:
Taking Angiotec 500 mg Tablet with Voriconazole together can result in an interaction, but it can be taken if a doctor has advised it. Consult a doctor if you experience dizziness, or fast or pounding heartbeats. Do not discontinue any medications without consulting a doctor.
RanolazinePosaconazole
Critical
How does the drug interact with Angiotec 500 mg Tablet:
When Posaconazole is taken with Angiotec 500 mg Tablet, may significantly increase the blood levels and effects of Angiotec 500 mg Tablet.

How to manage the interaction:
Although there is an interaction between posaconazole and Angiotec 500 mg Tablet, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
RanolazineDexamethasone
Critical
How does the drug interact with Angiotec 500 mg Tablet:
When Dexamethasone is taken with Angiotec 500 mg Tablet, may significantly reduce the blood levels of Angiotec 500 mg Tablet.

How to manage the interaction:
Co-administration of Angiotec 500 mg Tablet and Dexamethasone can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RanolazineRibociclib
Critical
How does the drug interact with Angiotec 500 mg Tablet:
When Ribociclib is taken with Angiotec 500 mg Tablet, may increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Angiotec 500 mg Tablet with Rifampicin is not recommended, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as excessive drowsiness, dizziness, lightheadedness, fainting, confusion, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
RanolazineMesoridazine
Critical
How does the drug interact with Angiotec 500 mg Tablet:
Co-administration of Mesoridazine and Angiotec 500 mg Tablet may significantly increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Phenylbutazone with Angiotec 500 mg Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
RanolazineFosamprenavir
Critical
How does the drug interact with Angiotec 500 mg Tablet:
Co-administration of Fosamprenavir and Angiotec 500 mg Tablet may significantly can occasionally cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Fosamprenavir with Angiotec 500 mg Tablet can lead to an interaction, please consult a doctor before taking it. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineMifepristone
Critical
How does the drug interact with Angiotec 500 mg Tablet:
When Mifepristone is taken with Angiotec 500 mg Tablet, may cause an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Phenylbutazone with Angiotec 500 mg Tablet can lead to an interaction. They can be taken together if advised by a doctor. However, contact a doctor if you experience any symptoms such as dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop taking any medications without consulting a doctor.
RanolazineClarithromycin
Critical
How does the drug interact with Angiotec 500 mg Tablet:
When Angiotec 500 mg Tablet and Clarithromycin are taken together, significantly increases the blood levels and effects of Angiotec 500 mg Tablet.

How to manage the interaction:
Co-administration of Clarithromycin and Ranozaline can lead to an interaction, it can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
RanolazineSaquinavir
Critical
How does the drug interact with Angiotec 500 mg Tablet:
When Angiotec 500 mg Tablet is taken with Saquinavir, may significantly increase the blood levels and effects of Angiotec 500 mg Tablet.

How to manage the interaction:
Taking Angiotec 500 mg Tablet with Saquinavir together can possibly result in an interaction, but it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe

Drug-Food Interactions

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RANOLAZINE-500MGGrapefruit and Grapefruit Juice
Severe
Common Foods to Avoid:
Grapefruit Juice, Grapefruit

How to manage the interaction:
Grapefruit juice can increase the levels of Angiotec 500 mg Tablet, and high blood levels of food can occasionally cause an irregular heart rhythm that may be serious. Grapefruit and grapefruit juice should be avoided while taking Angiotec 500 mg Tablet if possible.

Diet & Lifestyle Advise

  • Maintain a healthy lifestyle by exercising regularly, maintaining weight, and eating a healthy diet.

  • If you suffer from kidney or liver disease, please inform your doctor before taking the Angiotec 500 mg Tablet .
  • Alcohol consumption along with Angiotec 500 mg Tablet should be avoided as it may cause excessive drowsiness and increase muscle pain.
  • As a precautionary measure, junk food items from outside and stick to freshly prepared home-cooked meals for a speedy recovery.

Habit Forming

No

Therapeutic Class

ANTIANGINALS

Angiotec 500 mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Safe if prescribed

Angiotec 500 mg Tablet does not have any reported interaction; hence, if you experience any difficulty, discuss with your doctor.

bannner image

Pregnancy

Unsafe

Angiotec 500 mg Tablet should not be used when pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Angiotec 500 mg Tablet .

bannner image

Breast Feeding

Unsafe

Angiotec 500 mg Tablet should not be used in nursing mothers. Please consult the doctor if you have any concerns regarding this.

bannner image

Driving

Safe if prescribed

Angiotec 500 mg Tablet does not have any reported interaction; hence, in case you experience any difficulty, discuss with your doctor.

bannner image

Liver

Caution

Angiotec 500 mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Kidney

Caution

Angiotec 500 mg Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. The dose may have to be adjusted by your doctor.

bannner image

Children

Caution

Angiotec 500 mg Tablet is not recommended for children below the age of 18. The safety and effectiveness of Angiotec 500 mg Tablet have not been established in children due to limited testing of this drug on children by competent authorities worldwide.

Have a query?

FAQs

Angiotec 500 mg Tablet is used alone or with other medicines to treat angina pectoris.

The active substance in Angiotec 500 mg Tablet is Ranolazine, which reduces sodium ions flow into the heart muscle cells. This interferes with the activity of special channels on the cell surface called &amp;#039;sodium-dependent calcium channels through which calcium ions normally enter the cells. This reduces the number of calcium ions that enter the cells. Calcium ions normally cause the heart muscle to contract. By reducing the flow of calcium into the cells, Angiotec 500 mg Tablet is thought to help the heart to relax, improving blood flow to the heart muscle and relieving the symptoms of angina pectoris.

No, Angiotec 500 mg Tablet does not stop acute attacks (sudden attacks) of angina, but Angiotec 500 mg Tablet helps prevent a new attack.

No, alcohol should not be taken with Angiotec 500 mg Tablet as it may lead to unwanted side effects and increase angina attacks.

Yes, smoking (tobacco) decreases the efficacy of Angiotec 500 mg Tablet , especially when taken for angina (chest pain), so it should be avoided while taking Angiotec 500 mg Tablet .

Yes, Angiotec 500 mg Tablet can cause an upset stomach when taken empty stomach. So, to avoid it, Angiotec 500 mg Tablet should be taken with a meal for best results.

Yes, Angiotec 500 mg Tablet can cause drowsiness. If you feel excessively sleepy, please consult your doctor for better advice.

Some major side effects include a rapid, pounding, or irregular heartbeat, difficulty breathing, and fainting. If you encounter any of these symptoms, contact your doctor immediately.

Do not take more than the prescribed dose of Angiotec 500 mg Tablet as it may cause overdose. The symptoms of overdose include nausea, vomiting, confusion, dizziness, double vision, fainting, difficulty speaking, uncontrollable shaking of a part of the body, hallucinations and burning, pain, numbness, or tingling in any part of the body. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Angiotec 500 mg Tablet may increase the blood levels and effects of metoprolol. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects.

Angiotec 500 mg Tablet might raise metformin levels, increasing the risk of lactic acidosis. If you are prescribed ranolazine while taking metformin, discuss it with a healthcare physician. They may offer a lesser dose of metformin as a safer alternative.

You can take it if prescribed by the doctor. However, limit simvastatin to 20 mg once daily in individuals taking any dose of Angiotec 500 mg Tablet .

Country of origin

India

Manufacturer/Marketer address

Stiefel India Ltd., 401& 402, A Wing, IV Floor, Floral Deck Plaza, Opp. Rolta Bhavan, Central MIDC Road, Andheri (East), Mumbai – 400093
Other Info - ANG0110

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:34 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.6442.pdf
  2. https://medlineplus.gov/druginfo/meds/a606015.html
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021526s029lbl.pdf
  4. https://www.ema.europa.eu/en/documents/product-information/ranexa-epar-product-information_en.pdf

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