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Avonza Tablet is used to treat HIV infection. It works by inhibiting enzymes which are necessary for the reproduction of the virus. In some cases, this medicine may cause side effects such as headache, dizziness, nausea, insomnia and fatigue. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

EFAVIRENZ-400MG+LAMIVUDINE-300MG+TENOFOVIR DISOPROXIL FUMARATE-300MG

Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Avonza Tablet

Avonza Tablet is a prescription medicine used to treat Human Immunodeficiency Virus type 1 (HIV-1) in adults and eligible pediatric patients. This medication works by keeping the viral load in your body as low as possible, which helps protect and support your immune system. It is not a cure for HIV, but it helps manage the condition and reduces the risk of developing serious complications.

To achieve the best results, you must take Avonza Tablet once every day, consistently at the exact same time. It is best taken on an empty stomach, ideally right before bedtime, as this helps minimise potential nervous system side effects. Adopting a balanced diet, staying hydrated, and engaging in moderate exercise can further support your overall immune health while on this therapy.

Some people may experience common side effects like dizziness, unusual dreams, headache, or trouble sleeping when starting this medication, which usually improve over time. However, you must consult your doctor immediately if you experience serious side effects such as severe skin rashes, persistent mood changes, or signs of liver problems.

Talk to your doctor before starting this medicine if you have pre-existing health conditions such as liver disease, kidney problems, or a history of mental health disorders. Do not take this if you have severe liver damage or certain heart rhythm abnormalities. Your healthcare provider will evaluate whether this treatment is safe for your specific health profile.

This medicine can interact with several other drugs, alcohol, and certain herbal supplements, which can either reduce its effectiveness or increase the risk of side effects. Avoid alcohol while taking this medication as it can strain your liver and worsen dizziness. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor or pharmacist to discuss the risks and benefits of using this medicine.

Uses of Avonza Tablet

Your doctor may prescribe this medicine to treat:

  • HIV-1 Infection: Helps control HIV-1 infection by reducing the amount of virus in the body, allowing the immune system to function more effectively. It is used as part of combination antiretroviral therapy and does not cure HIV infection.

Key Benefits

Avonza Tablet helps control HIV infection, improve immune function, and reduce the risk of HIV-related complications. Key benefits include:

  • Reduces Viral Load: Helps lower the amount of HIV in the blood, allowing the immune system to recover and function more effectively.
  • Supports Immune Health: By controlling viral replication, Avonza Tablet helps increase or maintain CD4 cell counts, reducing the risk of opportunistic infections and HIV-related illnesses.
  • Provides Convenient Once-Daily Combination Therapy: Combines three antiretroviral medicines into a single tablet, simplifying treatment and helping improve adherence to long-term HIV therapy.
Side effects of Avonza Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
  • Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
  • Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
  • Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
  • Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
  • Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
  • Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
  • Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
Here are the step-by-step strategies to manage the side effects of " Muscle Pain" caused by medication usage:
  • Report to Your Doctor: Inform your doctor about the muscle pain, as they may need to adjust your medication.
  • Stretch Regularly: Gentle stretching can help relieve muscle pain and stiffness.
  • Stay Hydrated: Adequate water intake supports muscle health by removing harmful substances and maintaining proper muscle function.
  • Warm or Cold Compresses: Apply cold or warm compresses to the affected area to reduce pain and inflammation.
  • Rest and Relaxation: Adequate rest helps alleviate muscle strain, while relaxation techniques like deep breathing and meditation can soothe muscle tightness, calm the mind, and promote relief from discomfort.
  • Gentle Exercise: Participate in low-impact activities, such as yoga or short walks, to improve flexibility, reduce muscle tension, and alleviate discomfort.
  • Consult a physician: If your symptoms don't improve or get worse, go to the doctor for help and guidance.
  • Eat a balanced diet rich in fruits, vegetables, whole grains, lean protein, and healthy fats.
  • Opt for lean protein sources like chicken, fish, and turkey.
  • Nourish your body with healthy fats from sources like avocados, olive oil, and fatty fish to support overall well-being.
  • Restrict your consumption of processed foods, sugary beverages, and refined carbs to minimize negative impacts on your health.
  • Adopt a mindful approach to alcohol consumption, opting for moderation to maintain a healthy balance.
  • Engage in moderate exercise like walking, swimming, or yoga.
  • Maintain a healthy weight to alleviate spleen pressure.
  • Refrain from participating in high-risk activities that involve physical collision or intense impact.
  • Ensure your safety while driving by consistently wearing a seatbelt to minimize injury risk.
  • Stay hydrated by drinking plenty of water.
  • Consult your doctor before making diet and lifestyle changes.

Directions for Use

  • Avonza Tablet should be taken on an empty stomach, or as prescribed by your doctor.
  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Swallow Avonza Tablet as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Avonza Tablet Works

Avonza Tablet contains efavirenz, lamivudine, and tenofovir disoproxil fumarate, which work together to prevent HIV from multiplying. Efavirenz is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks the HIV reverse transcriptase enzyme, preventing the virus from making copies of its genetic material. Lamivudine and tenofovir disoproxil fumarate are nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs). They act as defective building blocks during viral DNA synthesis, causing premature termination of the viral DNA chain and preventing HIV from replicating. Together, these medicines reduce the amount of HIV in the body, helping protect the immune system and slow disease progression.
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Alcohol

Caution

Consumption of alcohol may increase the risk of side-effects.

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Pregnancy

Caution

Avonza Tablet is not recommended for use in pregnant women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this Avonza Tablet .

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Breast Feeding

Caution

Avonza Tablet is not recommended for use in breastfeeding women unless absolutely necessary. All the risks and benefits should be discussed with the doctor before taking this medicine. Your doctor may advise you to discontinue the drug or to discontinue breastfeeding based on your clinical condition.

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Driving

Caution

Avonza Tablet may cause dizziness, so do not drive or operate heavy machinery if you feel dizzy.

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Liver

Caution

Avonza Tablet should be used with caution in patients with liver diseases. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Avonza Tablet should be used with caution in patients with kidney diseases. The dose may have to be adjusted by your doctor.

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Children

Caution

Avonza Tablet is not recommended for use in children below 2 years. In children above 2 years of age, dose adjustments may be necessary.

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Heart

Caution

Please inform your doctor if you have a history of heart disease before taking Avonza Tablet . Your doctor will prescribe it only if the potential benefits outweigh the possible risks.

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Geriatrics

Caution

Avonza Tablet should be used in elderly patients only when prescribed by a doctor. If you have any concerns about using Avonza Tablet for geriatrics, please consult a doctor.

What if I have taken an overdose of Avonza Tablet

If you take more than your prescribed dose, seek emergency medical attention or contact a poison control centre immediately. An overdose can significantly increase your risk of severe nervous system side effects and liver damage.

Diet & Lifestyle Advise

  • Avoid high-fat meals around your dose: High-fat meals can increase the absorption of the efavirenz component, which may worsen dizziness, drowsiness, and other nervous system side effects.
  • Avoid alcohol: Alcohol can increase dizziness, drowsiness, and liver strain while taking Avonza Tablet .
  • Eat a balanced diet: Include plenty of fruits, vegetables, whole grains, and lean proteins to help support your immune system and overall health.
  • Stay well hydrated: Drink plenty of water throughout the day to support kidney function and maintain good hydration.
  • Take your medicine consistently: Take Avonza Tablet at the same time every day and do not miss doses, as consistent treatment helps keep the virus under control and reduces the risk of drug resistance.
health query

Have a query?

How Soon It Starts Working

The time required for Avonza Tablet to start to work: Avonza Tablet ideally shows its action within few hours after administration. The time for which the effects of Avonza Tablet last: The effect of Avonza Tablet lasts for 24 hours.

What if you forget to take Avonza Tablet

If you miss a dose, take it as soon as you remember, unless your next scheduled dose is less than 12 hours away. If your next dose is due in less than 12 hours, skip the missed dose and resume your regular bedtime schedule. Do not take two doses at the same time to make up for a missed one.

Storage

•Store Avonza Tablet tablets at room temperature, ideally between 20°C and 25°C (68°F to 77°F). •Keep the medicine in its original container with the bottle tightly closed to protect it from light and moisture.

Drug Warnings

  • Take it at bedtime: Taking Avonza Tablet at bedtime may help reduce dizziness, drowsiness, and other nervous system side effects, particularly during the first few weeks of treatment.
  • Do not stop treatment without medical advice: Stopping Avonza Tablet suddenly or missing doses can increase the risk of HIV treatment failure and the development of drug resistance.
  • Attend regular check-ups: Your doctor may monitor your kidney function, liver function, viral load, and overall response to treatment through regular blood tests.
  • Use caution when driving: Avonza Tablet may cause dizziness, drowsiness, abnormal dreams, or difficulty concentrating. Avoid driving or operating machinery until you know how it affects you.
  • Tell your doctor if you have hepatitis B: If you have hepatitis B infection, do not stop taking Avonza Tablet without medical supervision, as this may cause a severe flare-up of hepatitis.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are using any of the following medicines, as they may interact with Avonza Tablet .

  • Medicines containing the same active ingredients: Do not take other medicines containing efavirenz, lamivudine, or tenofovir unless prescribed by your doctor.
  • Nephrotoxic medicines (such as certain NSAIDs or intravenous antivirals): May increase the risk of kidney damage, particularly due to the tenofovir component.
  • Medicines for tuberculosis, seizures, or hepatitis C: Some medicines (such as rifampicin, certain anticonvulsants, or some direct-acting antivirals) may reduce the effectiveness of Avonza Tablet or increase side effects.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

verifiedApollotooltip
  • High-fat meals: Avoid high-fat meals around the time of dosing, as they can increase efavirenz absorption and worsen nervous system side effects.
  • St. John's wort: Avoid herbal products containing St. John's wort, as they can reduce the effectiveness of Avonza Tablet and increase the risk of HIV drug resistance.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIVIRALS]

FAQs

Avonza Tablet is used to treat HIV infection.
Avonza Tablet is a combination of three medicines: Efavirenz, Lamivudine, and Tenofovir disoproxil fumarate. These drugs belong to a group of medicines called nucleoside analogue reverse transcriptase inhibitors. They work by inhibiting the reverse transcriptase enzyme from working, which is required by the HIV-infected cells to make new viruses. This effect helps to inhibit viral replication. Avonza Tablet also increases the CD4 cell (white blood cells that protect against infection) count in your blood.
Avonza Tablet may cause side-effects such as headache, dizziness, nausea, insomnia (difficulty in sleeping), weakness, depression, cough, diarrhoea, rash, impaired concentration, abnormal dreams, fatigue, nasal congestion (stuffy nose), pain. Inform your doctor if any of these side-effects persist or get worse.
Avonza Tablet should not be stopped suddenly. Inform your doctor before stopping Avonza Tablet .
Yes. One of the components of Avonza Tablet (tenofovir disoproxil fumarate) may reduce bone mineral density in some people, especially with long-term use. Your doctor may recommend regular monitoring, weight-bearing exercise, and calcium and vitamin D supplements if appropriate.
Avonza Tablet may not be suitable for everyone. Inform your doctor if you have liver disease, kidney disease, high cholesterol, central nervous system disorders, or a history of lactic acidosis before starting treatment. Your doctor will determine whether this medicine is appropriate for you.
No, it is best to take Avonza Tablet on an empty stomach, preferably at bedtime. Food, especially high-fat meals, can cause your body to absorb too much of the medicine too quickly, which increases the likelihood of side effects like dizziness and vivid dreams. Talk to your doctor or pharmacist if you struggle with this schedule.
Unusual or vivid dreams are a common side effect of the efavirenz component in Avonza Tablet . These side effects typically start during the first few weeks of treatment and usually improve over time. Taking your dose at bedtime on an empty stomach can help reduce these effects. Talk to your doctor if the dreams become severely disturbing.
No, Avonza Tablet does not cure HIV infection. It is a daily treatment that suppresses the virus to very low levels, helping your immune system stay healthy and reducing the risk of complications. You must continue taking it exactly as prescribed to keep the virus under control. Talk to your doctor for more information.
It is highly recommended to avoid or limit alcohol while taking Avonza Tablet . Both alcohol and this medicine are processed by the liver, and combining them increases the risk of liver damage and can make central nervous system side effects like dizziness and sleepiness much worse. Talk to your doctor or pharmacist about safe habits.
If you remember within 12 hours of your usual bedtime dose, take it immediately on an empty stomach. If your next dose is less than 12 hours away, skip the missed dose and take your next regular dose at your usual bedtime. Never take a double dose to make up for a missed one. Talk to your doctor if you frequently miss doses.
If you are pregnant, planning to become pregnant, or think you might be pregnant, you must discuss this with your doctor immediately. Some components of Avonza Tablet require careful consideration during pregnancy to ensure both your health and your baby's safety. Talk to your doctor to determine the best treatment options for you.
Signs of liver damage include yellowing of your skin or the whites of your eyes, dark or tea-colored urine, light-colored stools, persistent nausea, loss of appetite, or pain in the upper right side of your stomach. If you notice any of these symptoms, call your doctor right away. Talk to your doctor or pharmacist if you have concerns.
Some over-the-counter pain relievers, specifically NSAIDs like ibuprofen, can increase the strain on your kidneys when taken regularly with Avonza Tablet . It is always safest to ask a healthcare professional before taking any new medication. Talk to your doctor or pharmacist for a safe pain relief recommendation.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A618028 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Efavirenz Lamivudine And Tenofovir Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. U.S. Food and Drug Administration (FDA). Efavirenz Lamivudine Tenoforvir Dsisoproxile Funarate Tablets Nda208255 Psg Page Rc May 2019 [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  5. Lamivudine Lamivudine. 2012. [Accessed on 09 Apr. 2019]Check here
  6. Tenofovir disoproxil. 2018. [Accessed on 09 Apr. 2019]Check here
  7. Efavirenz Efavirenz. 2014. [Accessed on 09 Apr. 2019. 2019]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Mylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7th to 12th floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103
Other Info - AVO0042
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