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  3. Benadryl Cough Formula Syrup, 150 ml

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Benadryl Cough Formula Syrup, 150 ml, Pack of 1 Syrup
Benadryl Cough Formula Syrup, 150 ml, Pack of 1 Syrup
Benadryl Cough Formula Syrup, 150 ml, Pack of 1 Syrup
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Benadryl Cough Formula Syrup is a mucolytic medicine used in the treatment of cough and respiratory disorders with viscous mucus. This medicine contains an ingredient that works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Common side effects include nausea, taste change, and numbness in the mouth, tongue and throat.

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Composition :

AMMONIUM CHLORIDE-138MG + DIPHENHYDRAMINE HYDROCHLORIDE-14.08MG + ETHANOL-0.2625ML + SODIUM CITRATE-57.03MG

Manufacturer/Marketer :

Johnson & Johnson Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Benadryl Cough Formula Syrup

Benadryl Cough Formula Syrup is used to treat cough. Coughing (dry or productive) is the body’s way of clearing irritants (like allergens, mucus, or smoke) from airways and preventing infection. A dry cough is tickly and doesn't produce any viscous or thick mucus, while a chesty cough (wet cough) means mucous or sputum is produced to help clear your airways.

Benadryl Cough Formula Syrup is a combination of Ammonium chloride, Diphenhydramine hydrochloride, Sodium citrate, and ethanol. Ammonium chloride works by increasing the volume of fluid in the airways, reducing the stickiness of mucus. Diphenhydramine works by blocking the action of histamine. Sodium citrate works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose.

In some cases, you may experience drowsiness, dizziness, dry mouth, nervousness, stomach pain, diarrhoea, or constipation. Most of these side effects of Benadryl Cough Formula Syrup do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are allergic to Benadryl Cough Formula Syrup or any other medicines, please tell your doctor. Benadryl Cough Formula Syrup is not recommended for children below 2 years of age unless advised by a doctor. If you are pregnant or breastfeeding, it is advised to inform your doctor before using Benadryl Cough Formula Syrup. Benadryl Cough Formula Syrup should be used with caution in elderly patients due to the increased risk of side effects.

Description

Benadryl Syrup is used in the treatment of cough, and also, relieves allergy symptoms such as runny nose, stuffy nose, sneezing, watery eyes and congestion or stuffiness

Uses of Benadryl Cough Formula Syrup

Benadryl Cough Formula Syrup is used to treat cough. The detailed uses of Benadryl Cough Formula Syrup are as follows:

  • Relief from Cough: Benadryl Cough Formula Syrup is primarily used to alleviate cough symptoms caused by a common cold or allergies. It reduces the cough reflex, which relieves long-term coughing.
  • Allergy Relief: The syrup contains antihistamines, which can help relieve allergy symptoms such as a runny nose, sneezing, and an itchy throat.
  • Cold Symptom Treatment: Benadryl Cough Formula Syrup is helpful in managing common cold symptoms by suppressing coughs and reducing allergies.
  • Sedation: Due to its sedative properties, Benadryl Cough Formula Syrup induces sleep, which treats individuals who have difficulty sleeping because of coughing or allergy symptoms.
  • Moisturising the Airway: Benadryl Cough Formula Syrup keeps the airway wet, which relieves irritation and reduces the urge to cough.

Have a query?

Directions for Use

  • Benadryl Cough Formula Syrup can be taken with or without food, or as a doctor advises.
  • Follow your doctor's instructions regarding dosage and timing for optimal results.
  • Take the prescribed dose of Benadryl Cough Formula Syrup by mouth using the measuring cup/dosing syringe/dropper provided in the pack.
  • Shake the bottle well before use.

Medicinal Benefits

  • Benadryl Cough Formula Syrup contains Ammonium chloride, Diphenhydramine hydrochloride, Sodium citrate and ethanol used to treat cough.
  • Ammonium chloride is an expectorant that increases the volume of fluid in the airways, reduces the stickiness of mucus, and helps remove it from the airways.
  • Diphenhydramine hydrochloride is an antihistamine (anti-allergic drug) that blocks the action of histamine, a substance responsible for causing allergic reactions.
  • It helps relieve allergy symptoms, such as sneezing, running nose, watery eyes, itching, swelling, and congestion or stiffness.
  • Sodium citrate is a mucolytic agent (cough/sputum thinner) that works by thinning and loosening phlegm (mucus) in the lungs, windpipe and nose.
  • Ethanol acts as a preservative.

How Benadryl Cough Formula Syrup Works

Benadryl Cough Formula Syrup is a combination of four drugs, namely: Ammonium chloride (expectorants), Diphenhydramine hydrochloride (antihistamine), Sodium citrate (mucolytic), and ethanol. Ammonium chloride works by increasing the volume of fluid in the airways, reducing the stickiness of mucus. Diphenhydramine hydrochloride works by blocking the action of histamine, a substance responsible for causing allergic reactions. Sodium citrate works by thinning and loosening phlegm (mucus) in the lungs, windpipe, and nose. Thereby, it helps to cough out easily. Ethanol acts as a preservative.

Storage

• Store in a cool and dry place away from sunlight. • Keep Benadryl Cough Formula Syrup out of the sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

What if I have taken an overdose of Benadryl Cough Formula Syrup

Never take more than the prescribed dose. Overdose of Benadryl Cough Formula Syrup may cause dilated pupils, convulsions, and extreme sleepiness. Before becoming sleepy, children may experience mental/emotional disturbances (such as restlessness, anger, or hallucinations). If you suspect that you might have taken an overdose of Benadryl Cough Formula Syrup, seek emergency medical help.

Drug Warnings

  • If you are allergic to Benadryl Cough Formula Syrup or any other medicines, please tell your doctor.
  • Benadryl Cough Formula Syrup is not recommended for children below 2 years of age unless advised by a doctor.
  • If you are pregnant or breastfeeding, it is advised to inform your doctor before using Benadryl Cough Formula Syrup.
  • Benadryl Cough Formula Syrup should be used with caution in elderly patients due to increased risk of side effects.
  • Avoid using Benadryl Cough Formula Syrup if you have taken medicines such as linezolid, phenelzine, selegiline, rasagiline, isocarboxazid, tranylcypromine and methylene blue injection in the past 14 days.
  • If you have asthma, inform your doctor before taking Benadryl Cough Formula Syrup. Drive only if you are alert, as Benadryl Cough Formula Syrup may cause dizziness.
  • You are recommended to avoid alcohol consumption with Benadryl Cough Formula Syrup as it may increase drowsiness or dizziness.

Drug-Drug Interactions

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DiphenhydramineEliglustat
Critical
DiphenhydraminePotassium chloride
Critical

Drug-Drug Interactions

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DiphenhydramineEliglustat
Critical
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
When Benadryl Cough Formula Syrup, 150 ml is taken with Eliglustat, it can cause a decrease in metabolism.

How to manage the interaction:
Taking Benadryl Cough Formula Syrup, 150 ml with Eliglustat is not recommended, please consult your doctor before taking it. It can be taken if prescribed by your doctor. Do not stop taking any medication without consulting your doctor.
DiphenhydraminePotassium chloride
Critical
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
Taking Benadryl Cough Formula Syrup, 150 ml with Potassium chloride can increase the risk of stomach ulcers.

How to manage the interaction:
Taking Benadryl Cough Formula Syrup, 150 ml with Potassium chloride is not recommended, as it can lead to an interaction, but it can be taken if a doctor has prescribed it. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, contact your doctor. Do not stop taking any medication without consulting your doctor.
DiphenhydramineThioridazine
Critical
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
When Thioridazine is taken with Benadryl Cough Formula Syrup, 150 ml, it can slow down the way Benadryl Cough Formula Syrup, 150 ml is broken down in the body.

How to manage the interaction:
Taking Benadryl Cough Formula Syrup, 150 ml with Thioridazine is not recommended, please consult your doctor before taking it. It can be taken if your doctor advises it. Do not stop taking any medication without consulting your doctor.
DiphenhydramineSodium oxybate
Critical
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
Taking Benadryl Cough Formula Syrup, 150 ml with Sodium oxybate can enhance the sedative effects on the central nervous system.

How to manage the interaction:
Taking Benadryl Cough Formula Syrup, 150 ml with Sodium oxybate is not recommended, but it can be taken if prescribed by a doctor. However contact your doctor if you experience shortness of breath, increased sweating, palpitations, or confusion. Do not stop using any medications without consulting a doctor.
DiphenhydraminePotassium citrate
Critical
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
Taking Benadryl Cough Formula Syrup, 150 ml and Potassium citrate together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Benadryl Cough Formula Syrup, 150 ml with Potassium citrate is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
EthanolMetronidazole
Critical
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
Drinking alcohol while taking Metronidazole can increase the risk or severity of side effects.

How to manage the interaction:
Taking Metronidazole with Benadryl Cough Formula Syrup, 150 ml is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience flushing, throbbing in head and neck, throbbing headache, difficulty breathing, nausea, vomiting, sweating, thirst, chest pain, rapid heartbeat, palpitation, low blood pressure, dizziness, lightheadedness, blurred vision, and confusion, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EthanolAcitretin
Critical
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
Coadministration of Acitretin with Benadryl Cough Formula Syrup, 150 ml can increase the risk and severity of birth defects.

How to manage the interaction:
Taking Acitretin with Benadryl Cough Formula Syrup, 150 ml together is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience headaches, nausea, vomiting, and visual disturbances, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DiphenhydramineEsketamine
Severe
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
Taking Benadryl Cough Formula Syrup, 150 ml with Esketamine can increase the risk of adverse effects.

How to manage the interaction:
Co-administration of Benadryl Cough Formula Syrup, 150 ml with Esketamine can result in an interaction, but it can be taken if your doctor has advised it. However, contact your doctor if you experience drowsiness, confusion, or difficulty concentrating. Do not discontinue any medications without consulting a doctor.
DiphenhydramineKetamine
Severe
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
Taking ketamine with Benadryl Cough Formula Syrup, 150 ml can increase the risk of side effects.

How to manage the interaction:
Although taking Benadryl Cough Formula Syrup, 150 ml with Ketamine can result in an interaction, they can be taken together if prescribed by your doctor. However, if you experience severe dizziness, confusion, drowsiness, confusion, difficulty concentrating, or excessive sleepiness consult your doctor immediately. Do not discontinue using any medications without consulting a doctor.
DiphenhydramineTamoxifen
Severe
How does the drug interact with Benadryl Cough Formula Syrup, 150 ml:
Benadryl Cough Formula Syrup, 150 ml reduces the blood levels and effectiveness of tamoxifen.

How to manage the interaction:
Although taking Benadryl Cough Formula Syrup, 150 ml with Tamoxifen can possibly reduce the effectiveness of Tamoxifen, they can be taken together if prescribed by your doctor. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid dairy products such as milk, as they may increase mucus production.
  • Also, avoid processed or refined foods. Instead, replace baked foods, fried foods, white bread, white pasta, french fries, sugary desserts and chips with green leafy vegetables.
  • Drink plenty of fluids to avoid a dry throat while you have a cough. It also helps loosen mucus.
  • Avoid citrus fruits as they may worsen the cough. Eat fruits rich in water content such as pears, watermelon, peaches and pineapples.

Habit Forming

No

Therapeutic Class

EXPECTORANT AND COUGH PRODUCTS

Benadryl Cough Formula Syrup Substitute

Substitutes safety advice
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Alcohol

Unsafe

Avoid consumption of alcohol with Benadryl Cough Formula Syrup as it may increase drowsiness or dizziness.

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Pregnancy

Consult your doctor

Benadryl Cough Formula Syrup is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Please consult a doctor if you are pregnant.

bannner image

Breast Feeding

Consult your doctor

Benadryl Cough Formula Syrup may be excreted in human milk. Therefore, Benadryl Cough Formula Syrup is given to breastfeeding mothers only if the doctor thinks benefits are greater than risks.

bannner image

Driving

Unsafe

Benadryl Cough Formula Syrup may cause dizziness in some people. Therefore, drive only if you are alert after taking Benadryl Cough Formula Syrup.

bannner image

Liver

Caution

Take Benadryl Cough Formula Syrup with caution, especially if you have a history of liver diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Kidney

Caution

Take Benadryl Cough Formula Syrup with caution, especially if you have a history of kidney diseases/conditions. The dose may be adjusted by your doctor as required.

bannner image

Children

Caution

Benadryl Cough Formula Syrup is not recommended for children below 2 years of age unless advised by a doctor.

FAQs

Benadryl Cough Formula Syrup belongs to a class of medications called expectorants used to treat cough.

Benadryl Cough Formula Syrup contains Ammonium chloride, Diphenhydramine hydrochloride, Sodium citrate and ethanol. Ammonium chloride increases the volume of fluid in the airways, reduces the stickiness of mucus and helps to remove it from the airways. Diphenhydramine hydrochloride blocks the action of histamine, a substance responsible for causing allergic reactions. Sodium citrate works by thinning and loosening phlegm (mucus) in the lungs, windpipe and nose. Thereby, helps to cough out easily. Ethanol is a preservative.

Benadryl Cough Formula Syrup may cause dry mouth as a temporary side effect in some people. It is not necessary for everyone taking Benadryl Cough Formula Syrup to experience this side effect. However, to avoid such side effects, drink plenty of water, regularly rinse your mouth, practice good oral hygiene and suck on sugarless candy. However, if the condition persists or worsens, please consult a doctor.

Benadryl Cough Formula Syrup may cause drowsiness or dizziness. It is not necessary for everyone taking Benadryl Cough Formula Syrup to experience this side effect. However, avoid driving if you feel drowsy or dizzy after taking Benadryl Cough Formula Syrup.

You are recommended to take Benadryl Cough Formula Syrup for as long as your doctor has prescribed it. However, if the symptoms persist or worsen with rash, fever or persistent headache after 1 week of using Benadryl Cough Formula Syrup, please consult your doctor.

You are not recommended to stop taking Benadryl Cough Formula Syrup without consulting your doctor as it may worsen cough or cause recurring symptoms. Therefore, take Benadryl Cough Formula Syrup for as long as your doctor has prescribed it and if you experience any difficulty while taking Benadryl Cough Formula Syrup, please consult your doctor.

If you use Benadryl Cough Formula Syrup with other anti-allergic medicine, it will increase the side effects of Benadryl Cough Formula Syrup which can be serious and require emergency treatment as Benadryl Cough Formula Syrup already contains an anti-allergic medicine in it. Thus, always avoid using Benadryl Cough Formula Syrup with other medicines or inform your doctor about it.

Benadryl Cough Formula Syrup may interact with the action of some anti-diabetic medications. Thus, before taking Benadryl Cough Formula Syrup, inform your doctor if you are using antidiabetic medications. Benadryl Cough Formula Syrup should be used by diabetic patients only if prescribed by a doctor.

Your doctor determines the dose and frequency of Benadryl Cough Formula Syrup. Do not take more than recommended daily dose. You should maintain a gap of at least 6 hours between the consecutive dose of Benadryl Cough Formula Syrup.

No, Benadryl Cough Formula Syrup should not be used for anxiety. Benadryl Cough Formula Syrup is used to treat cough, cold and relieve symptoms like runny and stuffy nose, sneezing, watery eyes, etc.

You should take Benadryl Cough Formula Syrup in doses and duration as prescribed by your doctor. Do not take more than 4 doses in a day.

No, you should not, since the doctor can determine this after careful clinical examinations as different underlying conditions may cause similar symptoms. Benadryl Cough Formula Syrup also has many side effects and contraindications which can lead to severe conditions when ignored. Therefore, do not recommend self-administration. Ask your friend to use it only after taking a doctor’s advice.

Elderly patients should always consult a doctor before using Benadryl Cough Formula Syrup as they are more prone to the side effects of this medicine. Also, conditions like prostate problem, glaucoma, and kidney and liver diseases are more likely seen in the elderly population which worsens the side effects of Benadryl Cough Formula Syrup.

Benadryl Cough Formula Syrup usually starts working within 15 to 30 minutes after taking it but it may vary from person to person.

Yes, one of the active components of Benadryl Cough Formula Syrup is Diphenhydramine, which is used to relieve cough caused by minor throat or airway irritation. Allergic symptoms like stuffy nose, runny nose, coughing, sneezing and red and watery eyes are controlled with an antihistaminic medicine, Diphenhydramine. It blocks the action of histamine, a substance responsible for causing allergic reactions and thus provides relief from above symptoms.

Benadryl Cough Formula Syrup may cause side effects such as dry mouth, drowsiness, dizziness, diarrhoea, constipation or stomach pain. However, these are usually mild and resolve on their own. If these side effects persist or worsen, please consult your doctor.

Alzheimer's disease is not known to be caused by Benadryl Cough Formula Syrup. However, you should always take Benadryl Cough Formula Syrup exactly as prescribed by your doctor. Do not take more than the recommended dose.

Benadryl Cough Formula Syrup is a cough and cold preparation used to provide relief from the symptoms of cold, cough and sore throat. It is not known to be used in the treatment of allergies.

Benadryl Cough Formula Syrup may cause stomach upset in some people. However, Benadryl Cough Formula Syrup is not known to cause constipation. It is recommended to take Benadryl Cough Formula Syrup exactly as prescribed by your doctor.

Benadryl Cough Formula Syrup and Ascoril Plus Expectorant are both used to treat colds and coughs. Benadryl Cough Formula Syrup provides relief from allergy symptoms and dry coughs, while Ascoril Plus is specifically designed for wet coughs associated with respiratory infections. Benadryl Cough Formula Syrup contains diphenhydramine, ammonium chloride, sodium citrate and ethanol, while Ascoril Plus contains bromhexine, guaifenesin, menthol, and terbutaline. Benadryl Cough Formula Syrup works by blocking the action of histamine, a substance responsible for causing allergic reactions and also it thins mucus, while Ascoril Plus loosens and thins mucus, making it easier to clear the airways.

No, Benadryl Cough Formula Syrup and Grilinctus syrup are both medicines used to treat coughs and colds. However, they have different active components and mechanisms of action. Benadryl Cough Formula Syrup contains diphenhydramine, ammonium chloride, sodium citrate and ethanol. It works by blocking the action of histamine, a substance responsible for causing allergic reactions and provides relief from symptoms such as watery eyes, runny nose, and sore throat. It also thins the mucus, making it easier to cough out. On the other hand, Grilinctus syrup contains ammonium chloride, chlorpheniramine, dextromethorphan, and guaifenesin. It is used to relieve symptoms of irritating, dry, and allergic cough, common cold, and bronchitis.

No, it is not recommended to breastfeed while taking Benadryl Cough Formula Syrup as it contains diphenhydramine, which may pass into the breast milk and may harm the baby. Therefore, inform your doctor if you are breastfeeding before taking Benadryl Cough Formula Syrup.

Store Benadryl Cough Formula Syrup at room temperature away from excessive heat and direct sunlight. Do not freeze. Keep it out of reach of children.

No, do not use Benadryl Cough Formula Syrup with other cough medicines unless advised by your doctor.

If you have asthma or other respiratory conditions, consult your doctor before using Benadryl Cough Formula Syrup as it can thicken mucus secretions.

If cough lasts for more than a week, returns, or coexists with a rash, fever, or persistent headache, consult a doctor.

No, do not use Benadryl Cough Formula Syrup after its expiration date as the ingredients may become less effective and lose their potency.

Country of origin

India

Manufacturer/Marketer address

Johnson & Johnson Private Limited. 501 Arena Space Behind Majas Bus Depot Off Jogeshwari Vikhroli Link Road Jogeshwari (E) Mumbai 400 060 Contact no: 022 66646464
Other Info - BEN0053

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 15, 2025 | 3:43 PM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://media.healthdirect.org.au/medicines/GuildLink_Information/199371/CMI/pccbornf10915.pdf
  2. https://www.nps.org.au/medicine-finder/chemists-own-difenacol-cough-mixture
  3. https://www.news-medical.net/drugs/Benadryl-Original-Oral-Liquid-(New-Formula).aspx

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