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  3. Bosenat-125mg Tablet 10's

Bosenat-125mg Tablet 10's, Pack of 10 TabletS
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Written By Veda Maddala , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy

Bosenat-125mg Tablet is used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). It can even increase our exercising ability, delay disease progression, and improve quality of life. It contains Bosentan, which narrows the blood vessels and increases the pressure in the blood vessels of the lungs. It helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs. In some cases, you may experience swelling of legs and ankles, headaches, and diarrhoea. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Composition :

BOSENTAN-125MG

Manufacturer/Marketer :

Natco Pharma Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Bosenat-125mg Tablet

Bosenat-125mg Tablet is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). Bosenat-125mg Tablet can even increase our exercising ability, delay disease progression, and improve quality of life. Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Hypertension is a chronic condition in which blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart.

Bosenat-125mg Tablet contains Bosentan, an endothelin receptor antagonist used to treat pulmonary arterial hypertension. It works by blocking the action of endothelin. Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bosenat-125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs.

Take Bosenat-125mg Tablet as prescribed by your doctor. You are advised to take Bosenat-125mg Tablet for as long as your doctor has prescribed it for you, depending on your medical condition. You may experience swelling of legs and ankles, headaches, and diarrhoea in some cases. Most of these side effects of Bosenat-125mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Please inform your doctor if you have liver dysfunction before starting Bosenat-125mg Tablet . If you are pregnant or breastfeeding, do not take Bosenat-125mg Tablet a pregnancy category X drug. If you are taking Bosenat-125mg Tablet , women should use a reliable form of the contraceptive pill to avoid pregnancy and continue to use it one month after stopping Bosenat-125mg Tablet . Also, the blood test for liver functions should be monitored regularly and for the haemoglobin level.

Uses of Bosenat-125mg Tablet

Bosenat-125mg Tablet is used in the treatment of high blood pressure in the lungs and related conditions. The detailed uses of Bosenat-125mg Tablet are as follows: <br/> • Treatment of pulmonary arterial hypertension (PAH): Bosenat-125mg Tablet helps lower high blood pressure in the arteries of the lungs, improving exercise ability and slowing disease progression.<br/> • Management of idiopathic PAH: Used in patients with an unknown cause of PAH to relieve symptoms such as shortness of breath and fatigue.<br/> • PAH associated with connective tissue disease: Bosenat-125mg Tablet lowers symptoms and improves quality of life in patients with PAH associated with connective tissue medical conditions, such as scleroderma.<br/> • Prevention of digital ulcers: Reduces the occurrence of painful finger or toe ulcers in patients with systemic sclerosis.<br/>

Directions for Use

  • Bosenat-125mg Tablet can be taken with or without food as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Swallow Bosenat-125mg Tablet as a whole with a glass of water.
  • Do not crush, break or chew it.

Medicinal Benefits

Bosenat-125mg Tablet is an anti-hypertension medication primarily used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). Bosenat-125mg Tablet can even increase our exercising ability, delay disease progression, and improve quality of life. It works by blocking the action of endothelin. Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bosenat-125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs. It also improves the quality of life, exercise ability, and delays the progression of pulmonary arterial hypertension.

How Bosenat-125mg Tablet Works

Bosenat-125mg Tablet contains Bosentan, an endothelin receptor antagonist used to treat pulmonary arterial hypertension. It works by blocking the action of endothelin. Endothelin narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bosenat-125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Bosenat-125mg Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Get plenty of rest and avoid activities that tire you out to allow your body fight the infection.
  • Drink lots of fluids to help loosen mucus in the lungs.
  • Use over-the-counter medications like paracetamol or ibuprofen to manage fever.
  • Use a humidifier as it helps soothe irritated airways.
  • Do not make changes to your medication schedule or take over-the-counter medicines without consulting your doctor.
  • Stay hydrated by taking fluids like water, juices and soups etc.
  • Eat fruits and vegetables which contain vitamins.
  • Take iron rich food like dry fruits, green leafy vegetables and sea food etc.
  • Reduce intake of milk, cheese, yogurt, soy, chocolate, ice cream, Grapes, Popcorn, canned salmon, pomegranate.
  • Regular exercise like walking, jogging is helpful.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Managing Medication-Triggered Flushing (Reddening of the skin): A Step-by-Step Guide:
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication or providing guidance on managing your erythema symptoms.
  • Your doctor may recommend or prescribe certain medications to help alleviate symptoms.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce redness and itching.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin hydrated.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

What if I have taken an overdose of Bosenat-125mg Tablet

Do not take more than the prescribed dose of Bosenat-125mg Tablet as it may cause an overdose. The symptoms of overdose include nausea, vomiting, headache, sweating, fast heartbeat, dizziness, or blurred vision. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Bosenat-125mg Tablet if you are allergic to Bosenat-125mg Tablet or any of its ingredients. Please inform your doctor if you have liver dysfunction before starting Bosenat-125mg Tablet . If you are pregnant or breastfeeding, do not take Bosenat-125mg Tablet as it is a pregnancy category X drug. It can lead to defects in the baby if taken during pregnancy. Also, after stopping Bosenat-125mg Tablet at least after a gap of one month, you should try to conceive so that Bosenat-125mg Tablet flushes out of the body completely. If you are taking Bosenat-125mg Tablet , women should use a reliable form of the contraceptive pill to avoid pregnancy and continue to use it one month after stopping Bosenat-125mg Tablet . Blood tests for liver function should be monitored regularly, and for haemoglobin level as well. Low haemoglobin could be a sign of anaemia.

Drug-Drug Interactions

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BosentanRegorafenib
Critical
BosentanCiclosporin
Critical

Drug-Drug Interactions

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BosentanRegorafenib
Critical
How does the drug interact with Bosenat-125mg Tablet:
Taking regorafenib with Bosenat-125mg Tablet it can increases the risk of side effects.

How to manage the interaction:
Taking Regorafenib with Bosenat-125mg Tablet is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
BosentanCiclosporin
Critical
How does the drug interact with Bosenat-125mg Tablet:
When Bosenat-125mg Tablet is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Ciclosporin with Bosenat-125mg Tablet is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
BosentanUlipristal
Severe
How does the drug interact with Bosenat-125mg Tablet:
Bosenat-125mg Tablet can lower the levels of Ulipristal in your blood, which could decrease its effectiveness in treating your condition.

How to manage the interaction:
Although using Bosenat-125mg Tablet and Ulipristal together can possibly result in an interaction, they can be taken together if prescribed by your doctor. Do not stop taking any medications without consulting a doctor.
BosentanRitonavir
Severe
How does the drug interact with Bosenat-125mg Tablet:
Taking Bosenat-125mg Tablet with ritonavir may significantly increase the blood levels of Bosenat-125mg Tablet.

How to manage the interaction:
Although using Bosenat-125mg Tablet and Ritonavir together can possibly result in an interaction, they can be taken together if prescribed by a doctor. Do not stop taking any medications without consulting a doctor.
BosentanBosutinib
Severe
How does the drug interact with Bosenat-125mg Tablet:
Taking bosutinib with Bosenat-125mg Tablet ay reduce the blood levels of bedaquiline, which may decrease its effectiveness in treating your condition.

How to manage the interaction:
There may be a possibility of interaction between Bosutinib and Bosenat-125mg Tablet, but it can be taken if prescribed by a doctor. Do not stop using any medications without first talking to your doctor.
BosentanBedaquiline
Severe
How does the drug interact with Bosenat-125mg Tablet:
Taking bedaquiline with Bosenat-125mg Tablet ay reduce the blood levels of bedaquiline, which may decrease its effectiveness in treating your condition.

How to manage the interaction:
Although using Bosenat-125mg Tablet and Bedaquiline+ together can possibly result in an interaction, they can be taken together if advised by your doctor. Do not stop using any medications without first talking to your doctor.
BosentanDaclatasvir
Severe
How does the drug interact with Bosenat-125mg Tablet:
Bosenat-125mg Tablet can lower the levels of Daclatasvir in your blood, which could decrease its effectiveness in treating your condition.

How to manage the interaction:
Although using Bosenat-125mg Tablet and Daclatasvir together can possibly result in an interaction, they can be taken together if advised by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.
BosentanCobicistat
Severe
How does the drug interact with Bosenat-125mg Tablet:
Coadministration of Bosenat-125mg Tablet with cobicistat may significantly increase the blood levels of Bosenat-125mg Tablet, potentially increasing the risk of side effects.

How to manage the interaction:
Although taking Cobicistat and Bosenat-125mg Tablet together can evidently cause an interaction, it can be taken if your doctor has suggested it. Do not stop using any medications without first talking to your doctor.
BosentanDesogestrel
Severe
How does the drug interact with Bosenat-125mg Tablet:
Bosenat-125mg Tablet can reduce the levels of Desogestrel in the blood.

How to manage the interaction:
Co-administration of Desogestrel with Bosenat-125mg Tablet can result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
BosentanCobimetinib
Severe
How does the drug interact with Bosenat-125mg Tablet:
Taking cobimetinib with Bosenat-125mg Tablet may significantly reduce the blood levels of cobimetinib, which may make the medication less effective in treating your condition.

How to manage the interaction:
Although there is a possible interaction between Cobimetinib and Bosenat-125mg Tablet, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor immediately. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Keep your weight under control with a BMI of 19.5-24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mmHg.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, then only one serving for women and two servings for men is advisable.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Monitor your blood pressure daily, and if there is too much fluctuation, then immediately contact your doctor.
  • Try to include heart-healthy omega-3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Bosenat-125mg Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Bosenat-125mg Tablet should not be taken along with alcohol to avoid unpleasant side effects.

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Pregnancy

Unsafe

Bosenat-125mg Tablet is a category X pregnancy drug and it can cause harm to the baby, so it should not be taken if you are pregnant or planning to get pregnant.

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Breast Feeding

Unsafe

Bosenat-125mg Tablet is known to pass through breast milk and may cause harm to the baby, so it should not be taken if you are breastfeeding.

bannner image

Driving

Caution

Bosenat-125mg Tablet may cause hypotension (low blood pressure), which may make you feel dizzy. If you feel dizzy, please do not drive a car.

bannner image

Liver

Caution

Bosenat-125mg Tablet to be taken with caution, especially if you have or have had a history of liver disease. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

bannner image

Kidney

Caution

Bosenat-125mg Tablet to be taken with caution, especially if you have or have had a kidney disease history. Your doctor will have to change the dosage depending on your medical condition and your reaction to treatment.

bannner image

Children

Caution

Bosenat-125mg Tablet is not recommended for use in children.

Have a query?

FAQs

Bosenat-125mg Tablet is used to treat pulmonary arterial hypertension (high pressure in the blood vessels that carry blood from the heart to the lungs). Bosenat-125mg Tablet can even increase our exercising ability, delay disease progression, and improve quality of life.

Bosenat-125mg Tablet is an anti-hypertension medication primarily used to treat‚ pulmonary arterial hypertension. It works by blocking the action of endothelin. Endothelin‚ narrows the blood vessels and increases the pressure in the blood vessels of the lungs. Bosenat-125mg Tablet helps to relax blood vessels by blocking endothelin and increasing the blood supply to the lungs.

Pulmonary arterial hypertension is high pressure in the blood vessels that carry blood from the heart to the lungs. It can be due to constriction of blood vessels or some blockage in blood vessels pathway.

Yes, in rare cases, $Name can cause anaemia. It can decrease your haemoglobin level, which may lead to anaemia. So, please regularly check your haemoglobin level if you are taking Bosenat-125mg Tablet .

It is usually taken with or without food. It should be swallowed as a whole with a glass of water; do not chew or crush it. Take it exactly as directed. Do not take more or less of it or more often than your doctor prescribes.

If you have liver problems, use Bosenat-125mg Tablet with caution and only under the guidance of your doctor. Patients with a history of liver disease should be closely monitored while taking Bosenat-125mg Tablet , as it may affect liver function. Your doctor may adjust the dosage or frequency of Bosenat-125mg Tablet based on your individual needs and medical condition.

Bosenat-125mg Tablet is a category X pregnancy drug, and it can cause harm to the baby, so it should not be taken if you are pregnant or planning to get pregnant.

Common side effects of Bosenat-125mg Tablet may include swelling of legs and ankles, headaches, and diarrhoea in some cases. Most of these side effects of Bosenat-125mg Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Store in a cool and dry place away from sunlight. Keep Bosenat-125mg Tablet out of the sight and reach of children.

Country of origin

India

Manufacturer/Marketer address

Natco House, Road No.2, Banjara Hills, Hyderabad-500 034, India
Other Info - BOS0070

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Santoshini Reddy GDoctor badge

Reviewed By

Santoshini Reddy G

M Pharmacy

Last Updated

Jul 22, 2025 | 8:56 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.nps.org.au/assets/medicines/fd69280f-1c31-472b-8cf5-a7c4009a20c9.pdf
  2. https://pubmed.ncbi.nlm.nih.gov/16780392/
  3. https://www.webmd.com/drugs/2/drug-22252-1889/bosentan-oral/bosentan-tablet-for-oral-suspension/details
  4. https://www.medicines.org.uk/emc/files/pil.10161.pdf
  5. https://www.medicines.org.uk/emc/files/pil.820.pdf
  6. https://wellonapharma.com/product/finished/bosentan-tablets
  7. https://medlineplus.gov/druginfo/meds/a605001.html

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