Cleft 10 Tablet 10's
MRP ₹116.5
(Inclusive of all Taxes)
₹17.5 Cashback (15%)
Extra 15% Off with Bank Offers
Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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India's Most Trusted Pharmacy
Genuine Products
Composition :
LEFLUNOMIDE-10MG
Manufacturer/Marketer :
Sun Pharmaceutical Industries Ltd
Consume Type :
ORAL
Return Policy :
Not Returnable
Expires on or after :
About Cleft 10 Tablet
Cleft 10 Tablet is used to relieve symptoms of rheumatoid arthritis and psoriatic arthritis. Rheumatoid arthritis and Psoriatic arthritis are autoimmune diseases characterised by joint inflammation, stiffness, and pain.
Cleft 10 Tablet contains 'Leflunomide', an isoxazole immunomodulatory agent which works by suppressing the activated immune system. Thereby, it helps reduce pain, inflammation and swelling.
In some cases, Cleft 10 Tablet may cause side effects such as diarrhoea, nausea, stomach pain, indigestion, rash, and hair loss. Most of these side effects do not require medical attention and will resolve gradually over time. However, talk to your doctor if you experience these side effects persistently.
Do not take Cleft 10 Tablet if you are pregnant or planning for pregnancy, as Cleft 10 Tablet may cause serious congenital disabilities. Cleft 10 Tablet should not be taken by breastfeeding mothers as it passes into breast milk. Cleft 10 Tablet may cause dizziness, so drive with caution.
Uses of Cleft 10 Tablet
Cleft 10 Tablet is used in the treatment of Rheumatoid arthritis and Psoriatic arthritis. The detailed uses of Cleft 10 Tablet are as follows:
- Rheumatoid Arthritis (RA): Cleft 10 Tablet reduces joint pain, swelling, and stiffness; slows progression of joint damage.
- Psoriatic Arthritis: Cleft 10 Tablet eases symptoms like joint inflammation and skin lesions associated with psoriasis.
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Directions for Use
- Take Cleft 10 Tablet with or without food as advised by your doctor.
- It is usually taken once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
- Swallow Cleft 10 Tablet as a whole with a glass of water.
- Do not crush, chew, or break it.
Medicinal Benefits
- Cleft 10 Tablet relieves symptoms of rheumatoid arthritis and psoriatic arthritis.
- It inhibits dihydroorotate dehydrogenase, reducing excessive immune cell activity.
- It has antiproliferative properties, helping suppress abnormal cell growth.
- Cleft 10 Tablet reduces inflammation, redness, pain, and swelling in affected joints.
- It improves joint function and mobility, enhancing the quality of life in arthritis patients.
How Cleft 10 Tablet Works
Cleft 10 Tablet contains 'Leflunomide' an isoxazole immunomodulatory agent which works by blocking the formation of genetic material, i.e. DNA required for survival of replicating (dividing) cells of the immune system. As a result, it suppresses the activated immune system to reduce pain, inflammation and swelling.
Storage
• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Cleft 10 Tablet
Here are the precise steps to cope with diarrhoea caused by medication usage:
- Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
- Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
- Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
- Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
- Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
- Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
- Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the step-by-step strategies to manage the side effects of "indigestion" caused by medication usage:
- Take medications with food (if recommended): It can help prevent stomach distress and indigestion.
- Eat smaller, more frequent meals: Divide daily food intake into smaller, more frequent meals to ease digestion.
- Avoid trigger foods: Identify and avoid foods that trigger indigestion, such as spicy, fatty, or acidic foods.
- Stay upright after eating: Sit or stand upright for at least 1-2 hours after eating to prevent stomach acid from flowing into the oesophagus.
- Avoid carbonated drinks: Avoid drinking carbonated beverages, such as soda or beer, which can worsen indigestion.
- Manage stress: To alleviate indigestion, engage in stress-reducing activities like deep breathing exercises or meditation.
- Consult a doctor if needed: If indigestion worsens or persists, consult a healthcare professional to adjust the medication regimen or explore alternative treatments.
- Eat protein-rich foods like fish, poultry, eggs, and legumes.
- Include foods with minerals and vitamins essential for hair health.
- Join a support group to connect with others experiencing hair loss.
- Openly discuss your feelings about hair loss.
- Consider covering up with wigs, hats, or scarves.
- Be patient and avoid seeking miracle cures.
Dealing with Medication-Induced Headache:
- Hydrate your body: Drink enough water to prevent dehydration and headaches.
- Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
- Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
- Take rest: lie down in a quiet, dark environment.
- Cold or warm compresses can help reduce tension.
- Stay Upright: Maintain good posture to keep symptoms from getting worse.
- To treat headaches naturally, try acupuncture or massage therapy.
- Over-the-counter pain relievers include acetaminophen and ibuprofen.
- Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
- Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
- Frequent Headaches: If you get reoccurring headaches, consult your doctor.
- Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
- Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
- Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
- Protect your skin from extreme heat and try to apply wet compresses.
- Soak in the cool bath, which gives a soothing impact to the affected area.
What if I have taken an overdose of Cleft 10 Tablet
Do not take more than the prescribed dose of Cleft 10 Tablet as it may cause an overdose. The symptoms of overdose include weakness, stomach pain, diarrhoea, pale skin, extreme tiredness, shortness of breath and fast heartbeat. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.
Drug Warnings
- Do not take Cleft 10 Tablet if you are allergic to leflunomide, have severe liver or kidney problems, low levels of protein in the blood, immune system problems, bone marrow problems, or serious infections.
- Cleft 10 Tablet is not recommended to be used in pregnant women, lactating mothers and people below 18 years of age.
- Talk to your doctor before taking Cleft 10 Tablet if you have/had serious infections like interstitial lung disease (inflammation of the lungs), tuberculosis (TB), or pneumonia.
- Cleft 10 Tablet may cause dizziness, so drive with caution.
- Cleft 10 Tablet may make you more susceptible to infections; notify the doctor if you develop infections, sore throat, breathlessness, jaundice, unexplained bleeding or bruising.
- Inform your doctor if you are taking any other medicines, including supplements and herbal products.
Drug-Drug Interactions
Severe
Severe
Drug-Drug Interactions
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Severe
How does the drug interact with Cleft 10 Tablet:
Coadministration of Cleft 10 Tablet and bortezomib may increase the risk of infections.
How to manage the interaction:
Although using Bortezomib and Cleft 10 Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
Coadministration of Cleft 10 Tablet and bortezomib may increase the risk of infections.
How to manage the interaction:
Although using Bortezomib and Cleft 10 Tablet together can possibly result in an interaction, they can be taken together if advised by your doctor. However, contact a doctor if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, red or irritated skin, or burning during urination. Do not stop taking any medications without consulting a doctor.
Severe
How does the drug interact with Cleft 10 Tablet:
When atorvastatin and Cleft 10 Tablet are taken together it can increase the risk of liver problems.
How to manage the interaction:
Although taking Atorvastatin and Cleft 10 Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
When atorvastatin and Cleft 10 Tablet are taken together it can increase the risk of liver problems.
How to manage the interaction:
Although taking Atorvastatin and Cleft 10 Tablet together can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Cleft 10 Tablet:
Using Flurbiprofen with Cleft 10 Tablet can increase the risk of liver problems.
How to manage the interaction:
There may be a possibility of interaction between Flurbiprofen and Cleft 10 Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact your doctor right away: liver problems, liver disease, unusual liver enzyme levels, fever, chills, joint discomfort, swelling, bruises, skin irritation, itching, loss of appetite, tiredness, feeling sick, throwing up, dark urine, or bleeding. Do not discontinue any medications without first consulting your doctor.
Using Flurbiprofen with Cleft 10 Tablet can increase the risk of liver problems.
How to manage the interaction:
There may be a possibility of interaction between Flurbiprofen and Cleft 10 Tablet, but it can be taken if prescribed by a doctor. If you notice any of these signs, it's important to contact your doctor right away: liver problems, liver disease, unusual liver enzyme levels, fever, chills, joint discomfort, swelling, bruises, skin irritation, itching, loss of appetite, tiredness, feeling sick, throwing up, dark urine, or bleeding. Do not discontinue any medications without first consulting your doctor.
Severe
How does the drug interact with Cleft 10 Tablet:
Combining Infliximab with Cleft 10 Tablet can increase the risk or severity of developing serious infections.
How to manage the interaction:
Taking Cleft 10 Tablet with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, burning, paleness, fatigue, dizziness, lightheadedness, and bruising or bleeding when you pee, contact a doctor right away. Do not discontinue any medications without first consulting a doctor.
Combining Infliximab with Cleft 10 Tablet can increase the risk or severity of developing serious infections.
How to manage the interaction:
Taking Cleft 10 Tablet with Infliximab together can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, pain, burning, paleness, fatigue, dizziness, lightheadedness, and bruising or bleeding when you pee, contact a doctor right away. Do not discontinue any medications without first consulting a doctor.
Severe
How does the drug interact with Cleft 10 Tablet:
Taking Temozolomide with Cleft 10 Tablet can increase the risk of infections.
How to manage the interaction:
Although taking temozolomide and Cleft 10 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
Taking Temozolomide with Cleft 10 Tablet can increase the risk of infections.
How to manage the interaction:
Although taking temozolomide and Cleft 10 Tablet together can result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, pain or burning during urination, vomiting, dark-colored urine, light-colored stools, and/or yellowing of the skin or eyes. Do not stop using any medications without consulting a doctor.
Severe
How does the drug interact with Cleft 10 Tablet:
Enalapril has the potential to cause liver damage; this effect can be increased by the coadministration of medications that affect the liver, such as Cleft 10 Tablet. This effect can be seen even long after discontinuing Cleft 10 Tablet as it stays in your blood longer.
How to manage the interaction:
Although taking Enalapril together with Cleft 10 Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of liver damage like fever, chills, unusual bleeding, dark-coloured urine, light colour stools, yellowish discolouration of skin and eyes, and abdominal pain. It is advised not to consume alcohol while using these medications as it may increase the damage o the liver. Do not discontinue any medications without consulting your doctor.
Enalapril has the potential to cause liver damage; this effect can be increased by the coadministration of medications that affect the liver, such as Cleft 10 Tablet. This effect can be seen even long after discontinuing Cleft 10 Tablet as it stays in your blood longer.
How to manage the interaction:
Although taking Enalapril together with Cleft 10 Tablet may possibly result in an interaction, they can be taken together if prescribed by your doctor. However, contact your doctor immediately if you experience signs and symptoms of liver damage like fever, chills, unusual bleeding, dark-coloured urine, light colour stools, yellowish discolouration of skin and eyes, and abdominal pain. It is advised not to consume alcohol while using these medications as it may increase the damage o the liver. Do not discontinue any medications without consulting your doctor.
Severe
How does the drug interact with Cleft 10 Tablet:
Taking Ruxolitinib together with Cleft 10 Tablet may increase the risk of infections.
How to manage the interaction:
Although taking Cleft 10 Tablet and Ruxolitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
Taking Ruxolitinib together with Cleft 10 Tablet may increase the risk of infections.
How to manage the interaction:
Although taking Cleft 10 Tablet and Ruxolitinib together can cause an interaction, it can be taken if your doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without consulting a doctor.
Severe
How does the drug interact with Cleft 10 Tablet:
When linezolid is used with Cleft 10 Tablet, the risk of severe infections increases.
How to manage the interaction:
Co-administration of linezolid along with Cleft 10 Tablet can lead to an interaction, it can be taken if recommended by a doctor. However, if you develop a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in sputum, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult the doctor as soon as possible. Do not discontinue any medications without consulting a doctor.
When linezolid is used with Cleft 10 Tablet, the risk of severe infections increases.
How to manage the interaction:
Co-administration of linezolid along with Cleft 10 Tablet can lead to an interaction, it can be taken if recommended by a doctor. However, if you develop a fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in sputum, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult the doctor as soon as possible. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Cleft 10 Tablet:
Co-administration of Cleft 10 Tablet with pyrazinamide may increase the risk or severity of liver problems.
How to manage the interaction:
Although taking Cleft 10 Tablet and Pyrazinamide together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Co-administration of Cleft 10 Tablet with pyrazinamide may increase the risk or severity of liver problems.
How to manage the interaction:
Although taking Cleft 10 Tablet and Pyrazinamide together can cause an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LeflunomideCorticorelin
Severe
How does the drug interact with Cleft 10 Tablet:
Using Cleft 10 Tablet together with Corticorelin may raise the risk of severe infections.
How to manage the interaction:
Taking Cleft 10 Tablet with Corticorelin together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
Using Cleft 10 Tablet together with Corticorelin may raise the risk of severe infections.
How to manage the interaction:
Taking Cleft 10 Tablet with Corticorelin together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you experience symptoms like fever, chills, diarrhea, sore throat, muscle aches, difficulty breathing, weight loss, or pain while urinating, contact your doctor immediately. Do not stop using any medications without a doctor's advice.
Drug-Food Interactions
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.
Drug-Food Interactions
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Diet & Lifestyle Advise
- Physical activity helps in strengthening muscles and relieves joint stiffness. Gentle activities like 20-30minutes of walking or swimming would be helpful.
- Performing yoga may also help in improving joint flexibility and pain management.
- Maintain a healthy weight by performing regular low-strain exercises and eating healthy food.
- Get adequate sleep, as resting the muscles can help in reducing inflammation and swelling.
- De-stress yourself by meditating, reading books, taking a warm bubble bath or listening to soothing music.
- Acupuncture, massage and physical therapy may also be helpful.
- Eat food rich in antioxidants such as berries, spinach, kidney beans, dark chocolate, etc.
- Foods containing flavonoids help in reducing inflammation. These include soy, berries, broccoli, grapes and green tea.
- Avoid smoking and alcohol consumption.
Habit Forming
No
Therapeutic Class
ANTIRHEUMATICS
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Alcohol
Unsafe
You are recommended to avoid alcohol consumption while taking Cleft 10 Tablet . Alcohol intake, along with Cleft 10 Tablet , may cause liver disease.
Pregnancy
Unsafe
It is not recommended to take Cleft 10 Tablet while you are pregnant. Cleft 10 Tablet may cause serious birth defects.
Breast Feeding
Unsafe
It is not recommended to take Cleft 10 Tablet while you are breastfeeding. Cleft 10 Tablet passes into breast milk.
Driving
Caution
Cleft 10 Tablet may cause dizziness and tiredness; do not drive or operate heavy machinery if you feel dizzy.
Liver
Consult your doctor
Please consult your doctor if you have liver impairment before taking Cleft 10 Tablet .
Kidney
Consult your doctor
Please consult your doctor if you have kidney impairment before taking Cleft 10 Tablet .
Children
Unsafe
Cleft 10 Tablet is not approved for children under the age of 18 years.
Heart
Avoid taking Cleft 10 Tablet if you have any cardiac problems. If prescried, caution should be exercised while taking Cleft 10 Tablet .
Geriatrics
Consult your doctor
Please consult a doctor before giving Cleft 10 Tablet to geriatric patients.
FAQs
Country of origin
India
Manufacturer/Marketer address
Suite No. 704, 706, 708, Suneja Tower II Distt. center Janak Puri, New Delhi-110058, Delhi, India
Other Info - CLE0009
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