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compositionComposition:ADAPALENE-0.1%W/W+CLINDAMYCIN-1%W/W
prescription
Prescription Medicine
info
Clisof-AD Gel 30 gm

Clisof-AD Gel 30 gm is used to treat acne (pimples). It contains Adapalene and Clindamycin, which works by loosening the cells on the skin's surface and unblocks pores by reducing the production of oil in the skin, thereby reducing the formation of pimples, whiteheads, and blackheads on the skin surface. Also, it stops or slows down the growth of bacteria and prevents the growth of acne. In some cases, you may experience side effects such as skin peeling, dry skin, irritation, redness, itching, or burning sensation at the site of application. Before using this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

ADAPALENE-0.1%W/W+CLINDAMYCIN-1%W/W

Manufacturer/Marketer :

Dermacia Healthcare

Consume Type :

Topical

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Clisof-AD Gel 30 gm

Clisof-AD Gel 30 gm is a topical prescription medication primarily used to treat acne vulgaris. It works to clear up existing pimples, whiteheads, and blackheads while actively reducing the swelling and redness associated with breakouts. This gel is designed for direct application to the affected areas of your skin.

For best results, you should apply Clisof-AD Gel 30 gm consistently, usually once daily in the evening before bedtime. Cleanse your skin gently and let it dry completely before application. Making simple lifestyle adjustments, such as switching to a gentle skincare routine and avoiding scrubbing or picking at your skin, can significantly support your treatment progress.

While using Clisof-AD Gel 30 gm, it is common to experience mild skin dryness, peeling, or a temporary warm sensation. These mild reactions are normal skin adjustments during the initial weeks. However, if you develop severe skin redness, intense burning, or signs of an allergic reaction, stop using the gel and consult your doctor immediately.

Do not use this if you have a history of inflammatory bowel conditions, such as ulcerative colitis or Crohn's disease, as the antibiotic component can occasionally absorb through the skin and affect your gut. If you have extremely sensitive skin, eczema, or active sunburn, talk to your doctor before starting this medication.

Inform your doctor or pharmacist if you are using other skin treatments, as combining Clisof-AD Gel 30 gm with products containing sulfur, salicylic acid, or alcohol can cause severe skin dryness and irritation. If you are pregnant, planning to become pregnant, or breastfeeding, consult your healthcare provider before using this topical gel.

Uses of Clisof-AD Gel 30 gm

Your doctor may prescribe this medicine to treat several conditions, including:

  • Acne vulgaris: Clisof-AD Gel 30 gm helps clear clogged pores, blackheads, and whiteheads, promoting overall skin renewal and preventing new acne lesions from forming.
  • Inflammatory acne: It targets and reduces the redness, swelling, and painful bumps associated with active, inflamed pimples.
     

Key Benefits

Clisof-AD Gel 30 gm provides targeted acne care by addressing the underlying causes of breakouts and reducing skin inflammation. By helping prevent clogged pores and calming irritated skin, this medicine offers several key health benefits:

  • Prevention of New Breakouts: Clisof-AD Gel 30 gm helps stop skin cells from sticking together and blocking pores, reducing the formation of new pimples and supporting clearer skin over time.
  • Faster Reduction of Existing Acne: By targeting acne-causing processes, Clisof-AD Gel 30 gm helps improve existing lesions and promotes a quicker recovery from active breakouts.
  • Reduced Inflammation and Skin Damage: Clisof-AD Gel 30 gm helps calm redness and swelling associated with acne, reducing irritation and lowering the risk of long-term concerns such as acne scars and dark spots.
     
Side effects of Clisof-AD Gel 30 gm
  • Apply moisturizer immediately after showering or bathing.
  • Use a moisturizer containing lanolin, petroleum jelly, glycerine, hyaluronic acid or jojoba oil.
  • Do not use hot water for bathing. Instead use warm water and limit showers and bath to 5 to 10 minutes.
  • Apply a sunscreen with SPF-30 or higher.
  • Avoid harsh soaps, detergents and perfumes.
  • Do not scratch or rub the skin.
  • Drink adequate water to prevent dehydration.
  • Wear pants, full sleeves and a wide-brimmed hat while going out in the sun.
  • Consult your doctor if you experience skin redness, itching, or irritation after taking medication.
  • Apply cool compresses or calamine lotion to the affected skin area to reduce irritation.
  • Stay hydrated by drinking plenty of water to help alleviate symptoms and keep your skin soothing.
  • Monitor your skin condition closely and promptly report any changes, worsening symptoms, or concerns to your healthcare provider.

Directions for Use

To use this medication safely and effectively, follow these step-by-step instructions:

  • Wash your hands thoroughly before applying the gel.
  • Cleanse the affected skin with a mild, soap-free cleanser and gently pat it dry. Let the skin dry completely for 5 to 15 minutes.
  • Apply a thin film of Clisof-AD Gel 30 gm to the entire affected area of your face or body, not just individual pimples.
  • Gently rub the gel in until it is absorbed, avoiding your eyes, lips, nostrils, and any broken or sunburned skin.
  • Wash your hands immediately after application to prevent transferring the medicine to sensitive areas.

Always follow your doctor's exact instructions regarding how often and where to apply this medicine. Do not apply more gel than prescribed, as this will not speed up the healing process but may cause severe skin irritation.
 

How Clisof-AD Gel 30 gm Works

This medicine works through a combination of two active ingredients that address different aspects of acne development. Each component acts in a distinct way to provide comprehensive skin treatment. The first active component, adapalene, is a retinoid (a derivative of vitamin A) that helps regulate skin cell growth. It prevents skin cells from sticking together and clogging your pores, which stops pimples, blackheads, and whiteheads from developing in the first place. The second active component, clindamycin, is a topical antibiotic. It works by stopping the growth of acne-causing bacteria on the skin and reducing the deep inflammation and redness that make pimples look swollen and angry. Together, these two ingredients keep your pores clear and reduce bacterial growth, leading to clearer, calmer skin over time.
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Alcohol

Caution

Interaction of Clisof-AD Gel 30 gm with alcohol is unknown. Please consult a doctor before consuming alcohol while using Clisof-AD Gel 30 gm.

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Pregnancy

Caution

The safety of Clisof-AD Gel 30 gm in pregnant women is unknown. Therefore, it is given to pregnant women only if the doctor thinks benefits outweigh risks.

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Breast Feeding

Caution

Do not apply Clisof-AD Gel 30 gm on the breast. You are advised to breastfeed only if the doctor thinks benefits are greater than risks.

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Driving

Safe if prescribed

Clisof-AD Gel 30 gm usually does not affect your ability to drive or operate machinery.

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Liver

Safe if prescribed

If you have any concerns regarding the use of Clisof-AD Gel 30 gm in patients with Liver problems, please consult a doctor.

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Kidney

Safe if prescribed

If you have any concerns regarding the use of Clisof-AD Gel 30 gm in patients with kidney problems, please consult a doctor.

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Children

Unsafe

Clisof-AD Gel 30 gm is not recommended for children as the safety and effectiveness were not established.

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Heart

Consult your doctor

Please consult your doctor before using Clisof-AD Gel 30 gm if you have pre-existing heart problems. Your doctor will prescribe Clisof-AD Gel 30 gm if the benefits outweigh the risks.

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Geriatrics

Consult your doctor

Please consult a doctor before giving Clisof-AD Gel 30 gm to geriatric patients. Your doctor will prescribe Clisof-AD Gel 30 gm if the benefits outweigh the risks.

What if I have taken an overdose of Clisof-AD Gel 30 gm

Do not apply Clisof-AD Gel 30 gm in large amounts or use it for a long time than recommended, as it does not give quick or better results but increases the risk of side effects.

Diet & Lifestyle Advise

  • Use a gentle skincare routine: Avoid harsh scrubs, astringents, or alcohol-based toners, as these can severely irritate your skin when combined with Clisof-AD Gel 30 gm.
  • Protect your skin from the sun: This treatment makes your skin highly sensitive to UV rays. Wear a broad-spectrum sunscreen with SPF 30 or higher daily, and wear protective clothing when outdoors.
  • Avoid popping or squeezing pimples: This can push bacteria deeper into the skin, worsen inflammation, and lead to permanent scarring.
  • Choose non-comedogenic products: Ensure all your moisturisers, cosmetics, and sunscreens are labeled 'non-comedogenic' or 'oil-free' so they do not clog your pores.
     

Have a query?

How Soon It Starts Working

The time required for Clisof-AD Gel 30 gm to start to work: The time required for Clisof-AD Gel 30 gm to show its action is unknown. The time for which the effects of Clisof-AD Gel 30 gm last: The duration of action for Clisof-AD Gel 30 gm is unknown.

What if you forget to take Clisof-AD Gel 30 gm

Apply the missed dose as soon as you can. If it is almost time for the next dose, skip the missed dose and follow your regular schedule. Do not apply an extra amount of Clisof-AD Gel 30 gm to make up for the missed dose.

Storage

Store Clisof-AD Gel 30 gm at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the tube tightly capped when not in use to prevent the gel from drying out.

Drug Warnings

  • Check the tube seal: Ensure the safety seal is intact before your first use, and do not use the gel if the tube appears damaged or leaky.
  • Keep away from colored fabrics: Be aware that this topical gel can occasionally discolor or bleach dyed fabrics, sheets, pillowcases, or hair.
  • Avoid waxing and chemical peels: Do not undergo hair removal waxing or harsh cosmetic chemical peels on the treated areas, as your skin will be too fragile.
  • Apply to dry skin only: Applying this medicine to damp or wet skin can increase its absorption, leading to more intense irritation and dryness.
  • Limit environmental exposure: Avoid extreme wind or cold weather, as these can worsen the dryness and peeling caused by the medication.
     

Drug-Drug Interactions

verifiedApollotooltip

Drug-Drug Interactions:

Inform your doctor if you are taking any of the following medicines, as they may interact.

  • Other topical acne treatments: Products containing benzoyl peroxide, salicylic acid, or resorcinol can cause severe dryness and skin irritation if used at the exact same time as Clisof-AD Gel 30 gm.
  • Neuromuscular blocking agents: If you are undergoing surgery, inform your anesthesiologist that you use a clindamycin-containing topical, as it may increase the muscle-relaxing effects of certain surgical medicines.

Drug-Disease Interactions:

Inform your doctor if you have a history of the following conditions before taking Clisof-AD Gel 30 gm, as it may worsen your condition or cause complications.

  • Inflammatory bowel diseases: Do not use this if you have a history of regional enteritis, ulcerative colitis, or antibiotic-associated colitis, as absorption through the skin could trigger severe bowel inflammation.
  • Eczema or sunburn: Avoid applying this gel to skin affected by active eczema, open wounds, or sunburn, as it can cause extreme irritation and delay healing.
No Drug - Drug interactions found in our data. We may lack specific data on this medicine and are actively working to update our database. Consult your doctor for personalized advice

Drug-Drug Interactions

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Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS - TOPICAL]

FAQs

Clisof-AD Gel 30 gm is used to treat acne (pimples). It works by inhibiting the growth of bacteria and reducing the production of oil in the skin, thereby reducing the formation of pimples, whiteheads, and blackheads on the skin's surface.
Yes, Clisof-AD Gel 30 gm may cause photosensitivity (increased skin sensitivity to sunlight) in the treated areas. Therefore, avoid or limit exposure to sunlight and sunlamps. You are advised to use a sunscreen and wear protective clothing while going out to prevent sunburn.
No, Clisof-AD Gel 30 gm is not recommended for eczema (itchy, cracked, swollen or rough skin) patients as it may increase the risk of severe irritation. Therefore, if you are suffering from eczema, inform your doctor before using Clisof-AD Gel 30 gm.
Yes, Clisof-AD Gel 30 gm may cause skin irritation or sensitivity as a side effect. However, if the irritation persists or worsens, stop using Clisof-AD Gel 30 gm and consult a doctor.
You are advised to use other acne products with Clisof-AD Gel 30 gm cautiously as some products may increase side effects. It is recommended to use Clisof-AD Gel 30 gm at night and other products in the morning. However, please consult a doctor before using any other medicines or products with Clisof-AD Gel 30 gm.
Yes, Clisof-AD Gel 30 gm may cause dryness of the skin. You can use a moisturizer while using Clisof-AD Gel 30 gm to prevent dry skin. However, do not apply Clisof-AD Gel 30 gm and moisturizer at the same time as it may reduce the effectiveness of Clisof-AD Gel 30 gm. Please consult a doctor before using other products with Clisof-AD Gel 30 gm.
No, you are not recommended to stop using Clisof-AD Gel 30 gm without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Clisof-AD Gel 30 gm for as long as your doctor has prescribed it, and if you experience any difficulty while taking Clisof-AD Gel 30 gm, please consult your doctor.
Do not use Clisof-AD Gel 30 gm for longer than the recommended duration. Avoid applying Clisof-AD Gel 30 gm on sunburned, windburned, skin or on open wounds. Avoid using Clisof-AD Gel 30 gm in or around the eye area, lips or inside of the nose. Rub it well and gently. Wash your hands after applying it.
You are advised to use Clisof-AD Gel 30 gm for as long as it is advised by your doctor, even if your symptoms begin to improve after a short time. If you stop using Clisof-AD Gel 30 gm too early, your acne may worsen or recur.
No, do not store Clisof-AD Gel 30 gm in the freezer, as it may change its efficacy. Store it at room temperature only.
No, do not apply Clisof-AD Gel 30 gm in excess amount or more often than advised or on large areas of the body as it may cause hormonal imbalance. It may affect the growth and development in children. Usually, it is not to be used for children below 12 years of age unless it is prescribed by a dermatologist depending upon the clinical condition.
Clisof-AD Gel 30 gm should not be used to treat a single pimple as it is not a spot treatment. Clisof-AD Gel 30 gm should be applied to the entire face. Using it daily can help you get rid of acne.
Clisof-AD Gel 30 gm may take up to 2-3 weeks for your symptoms to improve. It may take some time to show effective results. Use Clisof-AD Gel 30 gm as advised and inform your doctor know if your symptoms do not improve or worsen.
It is advisable to avoid cosmetic procedures while using Clisof-AD Gel 30 gm. As, the cosmetic products with an abrasive, peeling or drying action may increase irritant effect. Please consult your doctor if you have any concerns regarding this.
Clisof-AD Gel 30 gm contains Adapalene (human-made vitamin A) and Clindamycin (antibiotic). Adapalene works by loosening the cells on the skin’s surface and unblocks pores by reducing the production of oil in the skin, thereby reducing the formation of pimples, whiteheads, and blackheads on the skin surface. Clindamycin works by inhibiting the production of essential proteins that are necessary for bacteria to grow, multiply and increase in numbers. Altogether it stops or slows down the growth of bacteria and prevents the growth of acne.
Apply a thin layer of Clisof-AD Gel 30 gm to clean and dry affected areas. Do not forget to wash your hands after applying.
You are recommended to consult your doctor before using Clisof-AD Gel 30 gm if you are pregnant or breastfeeding, as the safety is important in these conditions.
Clisof-AD Gel 30 gm may cause side effects such as irritation, redness, itching or burning sensation at the site of application, skin peeling or dry skin. If these side effects persist or worsen, please consult your doctor.
No, you should not use this medication more than once a day. Applying it more frequently will not clear your acne faster and will likely cause severe skin irritation, redness, and peeling. Talk to your doctor if you feel your treatment is not working.
It is usually best to apply your moisturiser after Clisof-AD Gel 30 gm has fully dried on your skin. This helps combat the dryness and peeling associated with the treatment without diluting the medication. Talk to your doctor or pharmacist for a personalised skincare routine.
Yes, during the first few weeks, you may experience a temporary increase in acne flares, peeling, and dryness. This is often called "purging" and is a normal sign that the skin cells are turning over quickly. Talk to your doctor if this irritation becomes severe or does not improve.
Rinse your eyes immediately with large amounts of cool, clean water. If you experience persistent burning, pain, redness, or changes in your vision, seek medical help. Talk to your doctor if symptoms continue.
Yes, you can apply cosmetics after the gel has dried completely. Ensure you use light, water-based, and non-comedogenic makeup so you do not clog your pores. Talk to your doctor or pharmacist for product recommendations.
It is generally recommended to avoid harsh, exfoliating, or medicated washes while using this gel, as they can cause extreme dryness and skin peeling. Stick to a gentle, soap-free cleanser. Talk to your doctor or pharmacist before combining skincare products.

Disclaimer

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Reference

  1. Drugs.com Clinical Review Team. Adapalene Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  2. Drugs.com Clinical Review Team. Clindamycin Topical Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026] Check here
  3. Adapalene [EMC SmPC]. 2018. [Accessed on 29 Jan. 2019] Check here
  4. Adapalene [FDA Drug Label]. 2007. [Accessed on 03 Apr. 2019] Check here
  5. Adapalene, Clindamycin Phosphate [Summary of Product Characteristics]. 2023. [Accessed on 06 Mar. 2025] Check here
  6. Dalacin - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 27 Oct 2025] Check here
  7. Differin - Summary of Product Characteristics (SmPC) - (emc) [Internet]. Medicines.org.uk. 2025 [Accessed on 27 Oct 2025]Check here

Country of origin

India

Manufacturer/Marketer address

Corp. Office- Weghmens Business Centre 2 Nd Floor, 21 Veer Savarkar Block Shakarpur Delhi - 110092
Other Info - CLI0777

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