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  1. Home
  2. Medicine

  3. Clothrol 12.5mg Tablet

Prescription drug
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Clothrol 12.5mg Tablet, Pack of 1 Tablet
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Composition :

CHLORTHALIDONE-12.5MG

Consume Type :

ORAL

Return Policy :

Not Returnable

About Clothrol 12.5mg Tablet

Clothrol 12.5mg Tablet is used to treat high blood pressure, heart failure and oedema (a build-up of fluid in the body). Higher blood pressure can lead to heart disease, irregular heartbeat, and other complications, such as oedema (when fluids in the body become trapped in the tissues of the hands, arms, feet, ankles, and legs, causing swelling).

Clothrol 12.5mg Tablet contains Chlorthalidone, which works by increasing the amount of urine that is passed out from the kidneys. Hence, it helps treat hypertension and oedema.

In some cases, you may experience headaches, nausea and dizziness. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Do not stop this medicine early, as it may raise blood pressure and increase the risk of heart disease and stroke. Inform your doctor if you are suffering from any kidney, liver, or heart disease. Inform your doctor if you are pregnant or breastfeeding before taking Clothrol 12.5mg Tablet.

Uses of Clothrol 12.5mg Tablet

Clothrol 12.5mg Tablet is used in the treatment of Hypertension (high blood pressure) and oedema (swelling due to fluid retention). The detailed uses of Clothrol 12.5mg Tablet are as follows:

  • Hypertension (High Blood Pressure): Clothrol 12.5mg Tablet helps lower blood pressure by removing excess fluid from the body.
  • Edema (Fluid Retention): Clothrol 12.5mg Tablet effectively alleviates edema (fluid retention) and swelling associated with heart, liver, or kidney disease by promoting the removal of excess fluid from the body.

Have a query?

Directions for Use

  • Clothrol 12.5mg Tablet should be taken with food, preferably after breakfast.
  • It is usually taken once daily in the morning. However, your doctor may adjust the dosage of Clothrol 12.5mg Tablet based on your medical condition and response to treatment.
  • Swallow Clothrol 12.5mg Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • When you take Clothrol 12.5mg Tablet, it relaxes the blood vessels in your body, which helps lower high blood pressure.
  • It widens the blood vessels, including the lining of the artery walls, to improve blood flow throughout the body.
  • Clothrol 12.5mg Tablet helps the body lose excess fluids by increasing urine production.
  • Reducing fluid overload decreases the workload on the heart, making the heart more efficient at pumping blood.
  • It helps lower high blood pressure, thereby reducing the risk of a future heart attack or stroke.
  • Clothrol 12.5mg Tablet also helps reduce fluid buildup in the body, which in turn reduces inflammation and swelling.
  • By reducing oedema, it supports better physical comfort and helps you carry out your daily activities more efficiently.

How Clothrol 12.5mg Tablet Works

Clothrol 12.5mg Tablet contains Chlortalodone, which works by increasing the amount of urine that is passed out from the kidneys. Thereby, it helps treat hypertension and oedema.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Clothrol 12.5mg Tablet
  • Talk to your doctor about oral potassium supplements.
  • Eat potassium rich foods such as bananas, avocados, oranges, dark leafy greens, beans and peas, fish, spinach, milk and tomatoes.
  • Limit intake of full-fat dairy products, red meat and processed foods rich in saturated fats.
  • Avoid foods with label “partially hydrogenated oils”.
  • Eat more vegetables, fruits, oats, whole grains, lentils and beans to increase fiber intake.
  • Include foods rich in monounsaturated fats like nuts, avocados, olive oil, and oily fish.
  • Limit consumption of egg yolks.
  • Exercise for at least 30 minutes 5 days a week.
  • Aim for weight loss and maintain healthy weight.
  • Quit smoking as smoking raises the risk of heart disease associated with cholesterol.
  • Limit alcohol consumption as excessive drinking may raise cholesterol levels.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
  • Quit smoking as smoking impairs erectile function by significantly damaging blood vessels.
  • Maintain a healthy weight as overweight can cause erectile dysfunction.
  • Exercise regularly as physical activity enhances blood flow and overall health, benefiting erectile function.
  • Consume a healthy diet loaded with whole grains, fruits and vegetables.
  • Limit alcohol consumption as excessive alcohol intake can impair erectile function.
  • Manage stress by practicing techniques such as yoga, relaxation exercises or meditation.
  • In case erectile dysfunction is due to psychological factors, consider couple counselling or sex therapy to address relationship and anxiety issues.
  • Openly discuss your concerns with your partner.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.

What if I have taken an overdose of Clothrol 12.5mg Tablet

Do not take more than the prescribed dose of Clothrol 12.5mg Tablet as it may cause serious side effects. The symptoms of overdose include drowsiness, dizziness, nausea, weakness, muscle pain, extreme thirst, or rapid heartbeats. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Clothrol 12.5mg Tablet should not be given to people allergic to Clothrol 12.5mg Tablet, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, gout (high uric acid), high cholesterol (hyperlipidemia), pregnant women, or planning to get pregnant and breastfeeding women.
  • Clothrol 12.5mg Tablet is contraindicated in people with cardiogenic shock (sudden stopping of blood flow to the heart) and aortic stenosis (heart valve problem).
  • Clothrol 12.5mg Tablet can pass into breast milk, but its effect on the baby is unknown. So, it is better to tell your doctor if you are taking Clothrol 12.5mg Tablet and breastfeeding.
  • Tell your doctor if you are on low low-sodium (table salt) diet. 
  • Cases of electrolyte imbalance have been observed (like low levels of sodium, potassium, or magnesium in your blood). So your doctor might advise monitoring blood pressure, kidney function test, and electrolytes.

Drug-Drug Interactions

verifiedApollotooltip
chlorthalidoneCisapride
Critical
chlorthalidoneAmiodarone
Severe

Drug-Drug Interactions

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chlorthalidoneCisapride
Critical
How does the drug interact with Clothrol 12.5mg Tablet:
Co-administration of Clothrol 12.5mg Tablet and cisapride may increase the risk or severity of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Clothrol 12.5mg Tablet with Cisapride is not recommended, please consult your doctor before taking it. Do not discontinue the medication without consulting a doctor.
chlorthalidoneAmiodarone
Severe
How does the drug interact with Clothrol 12.5mg Tablet:
Coadministration of Clothrol 12.5mg Tablet with amiodarone may increase the risk of abnormal heart rhythms.

How to manage the interaction:
Although taking Clothrol 12.5mg Tablet with amiodarone may cause an interaction, it is safe to do so if your doctor has prescribed it. If you have a cardiac problem or electrolyte imbalances, you may be more vulnerable. If you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or a rapid heartbeat, consult a doctor. Do not stop taking any medications without visiting a doctor.
chlorthalidoneLithium
Severe
How does the drug interact with Clothrol 12.5mg Tablet:
Co-administration of Clothrol 12.5mg Tablet together with lithium can increase the effects of lithium.

How to manage the interaction:
Although there is a interaction between Clothrol 12.5mg Tablet and lithium, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience diarrhea, vomiting, drowsiness, shaking of hands and legs, thirst, increased urination, lack of coordination, or muscle weakness. Do not discontinue any medications without consulting a doctor.
chlorthalidoneArsenic trioxide
Severe
How does the drug interact with Clothrol 12.5mg Tablet:
Taking Clothrol 12.5mg Tablet can make the body eliminate Arsenic trioxide faster, leading to lower levels in the blood and potentially reducing its effectiveness.

How to manage the interaction:
Co-administration of Clothrol 12.5mg Tablet with Arsenic trioxide can possibly result in an interaction, but it can be taken if a doctor has advised it. If you have any of these symptoms, it's important to contact a doctor right away: your heart beating irregularly, feeling dizzy or lightheaded, fainting, having a fast or pounding heartbeat, feeling weak or drowsy, being confused, experiencing muscle pain, or feeling nauseous or vomiting. Do not discontinue any medications without consulting a doctor.
chlorthalidoneZiprasidone
Severe
How does the drug interact with Clothrol 12.5mg Tablet:
Co-administration of Clothrol 12.5mg Tablet with ziprasidone can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction, Clothrol 12.5mg Tablet can be taken with ziprasidone if prescribed by the doctor. but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, weakness, tiredness, drowsiness, confusion, muscle pain, cramps, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
chlorthalidonePimozide
Severe
How does the drug interact with Clothrol 12.5mg Tablet:
Co-administration of Clothrol 12.5mg Tablet with pimozide can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although there is an interaction, Clothrol 12.5mg Tablet can be taken with pimozide if prescribed by the doctor. Consult the prescriber if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats during treatment with pimozide. Also, let the doctor know if you experience signs of electrolyte disturbance, such as weakness, tiredness, drowsiness, confusion, muscle pain, cramps, dizziness, nausea, or vomiting. Do not discontinue any medications without consulting a doctor.
chlorthalidoneAminolevulinic acid
Severe
How does the drug interact with Clothrol 12.5mg Tablet:
Co-administration of Aminolevulinic acid and Clothrol 12.5mg Tablet may increase the risk of severe sunburn.

How to manage the interaction:
Taking Clothrol 12.5mg Tablet with Aminolevulinic acid together can possibly result in an interaction, but it can be taken if a doctor has advised it. If you notice that your skin is very sensitive to sunlight or if you have a really bad sunburn, it's important to contact your doctor right away. Do not discontinue any medications without consulting a doctor.
chlorthalidoneTizanidine
Severe
How does the drug interact with Clothrol 12.5mg Tablet:
Co-administration of Tizanidine and Clothrol 12.5mg Tablet may show additive effects and increase the risk of low blood pressure.

How to manage the interaction:
Although there is an interaction, Clothrol 12.5mg Tablet can be taken with tizanidine if prescribed by the doctor. If you experience headache, dizziness, palpitations, or sweating, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
chlorthalidoneDroperidol
Severe
How does the drug interact with Clothrol 12.5mg Tablet:
Taking Droperidol can make Clothrol 12.5mg Tablet less effective in lowering blood pressure.

How to manage the interaction:
Taking Clothrol 12.5mg Tablet with Droperidol together can possibly result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms, it's important to contact your doctor right away. These symptoms include an irregular heart rhythm, severe or long-lasting diarrhea or vomiting, complications, sudden dizziness or lightheadedness, fainting, difficulty breathing, heart palpitations, weakness, feeling sleepy or confused, muscle pain, and feeling nauseous or vomiting. Do not stop using any medications without first talking to your doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich food. Blueberries, cherries, tomatoes, squash, and bell peppers are high in antioxidants.
  • Eat natural diuretic foods. Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic are all-natural diuretic foods.
  • Use healthy cooking oils, such as soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate Trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid consuming excessive salt or foods high in salt.
  • Maintain a healthy weight with a BMI of 19.5-24.9.
  • Regular physical activity, such as walking, improves blood flow.
  • When possible, elevate your legs or the swollen area on a chair or pillows.
  • Avoid standing or sitting for extended periods.
  • Avoid chronic stress as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Clothrol 12.5mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Clothrol 12.5mg Tablet to avoid unpleasant side-effects.

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Pregnancy

Unsafe

Clothrol 12.5mg Tablet is classified as FDA pregnancy risk category B. So, Clothrol 12.5mg Tablet should not be used during pregnancy unless clearly necessary. Prolonged intake of Clothrol 12.5mg Tablet during pregnancy may cause jaundice (yellowing of skin and eye), unexplained bruising, low blood sugar and electrolyte imbalance in the neonates (newborn baby). Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

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Breast Feeding

Consult your doctor

Clothrol 12.5mg Tablet should not be used when breastfeeding unless clearly necessary. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please talk to your doctor.

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Driving

Unsafe

Driving after taking Clothrol 12.5mg Tablet is not recommended as it may occasionally cause drowsiness.

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Liver

Caution

Clothrol 12.5mg Tablet to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Clothrol 12.5mg Tablet to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions.

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Children

Caution

Clothrol 12.5mg Tablet to be taken with caution, especially if you are children below the age of 12. Your doctor may adjust your dose depending upon your age.

FAQs

Clothrol 12.5mg Tablet is used to treat high blood pressure (hypertension) and oedema (a build-up of fluid in the body).

Clothrol 12.5mg Tablet works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease. This, in turn, reduces the workload on the heart and makes the heart more efficient at pumping blood throughout the body. So, it helps to lower high blood pressure, reducing the chances of a heart attack or stroke.

Taking Clothrol 12.5mg Tablet may cause dehydration. So, to avoid dehydration, drink plenty of fluids and inform your doctor if you feel extremely thirsty.

It is unlikely that Clothrol 12.5mg Tablet affects fertility in men or women. However, some water pills like hydrochlorothiazide may lead to erectile dysfunction. There is not enough evidence to say for certain. For the best advice, consult your doctor.

Clothrol 12.5mg Tablet can be safely taken as long as your doctor has prescribed it to you. Conditions such as high blood pressure are lifelong conditions and one should not abruptly discontinue them without discussing it with a doctor.

No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.

Yes, Clothrol 12.5mg Tablet is a diuretic (water pill), which increasing the amount of urine that is passed out from the kidneys.

Take Clothrol 12.5mg Tablet as prescribed by the doctor. It can be taken daily if advised by the doctor.

You are recommended not to consume alcohol along with Clothrol 12.5mg Tablet to avoid unpleasant side-effects.

Taking more than the recommended dose of Clothrol 12.5mg Tablet may cause serious side effects. The symptoms of overdose include drowsiness, dizziness, nausea, weakness, muscle pain, extreme thirst, or rapid heartbeats. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately. Avoid exceeding the recommended dose and take Clothrol 12.5mg Tablet as advised by the doctor.

Consult the doctor before taking ibuprofen with Clothrol 12.5mg Tablet as dose adjustment may be needed to safely take both the medicines together.

Yes, Clothrol 12.5mg Tablet may increase uric acid levels leading to gout. Inform the doctor if you have gout or if you notice symptoms of gout such as sudden/severe attack of pain, swelling, redness and tenderness in one or more joints.

Clothrol 12.5mg Tablet may not cause skin cancer. However, it might cause sensitivity to sunlight. Wear protective clothing and use sunscreen while going out.

Clothrol 12.5mg Tablet may cause side effects like headaches, nausea or dizziness, which usually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Country of origin

India

Manufacturer/Marketer address

Basement And Ground Floor, Plot No. 44/3, Subhash Nagar Chandigarh, India, 160101
Other Info - CL17753

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Sep 30, 2025 | 2:16 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019574s016lbl.pdf
  2. https://www.ciplamed.com/content/techlor-tablets
  3. https://www.drugs.com/mtm/chlorthalidone.html
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