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About CHLORTHALIDONE

CHLORTHALIDONE belongs to a group of medicines known as diuretics (water pills which increase the production of urine) primarily used to treat high blood pressure, heart failure, and oedema (a build-up of fluid in the body).

Hypertension or high blood pressure is a lifelong or chronic condition in which the force exerted by the blood against the blood vessel (arteries wall) increases. Higher this blood pressure, harder the heart has to pump. As a result, it leads to heart diseases, irregular heartbeat, and other complications. Oedema may occur in case of high blood pressure where fluids of the body get trapped in the tissues of the hands, arms, feet, ankles, and legs leading to its swelling.

CHLORTHALIDONE works by increasing the amount of urine passed out from the kidneys. It effectively reduces excess fluid levels in the body and treats oedema (swelling) associated with heart, liver, kidney, or lung disease. This, in turn, reduces the workload on the heart and makes the heart more efficient at pumping blood throughout the body. So, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.

You can take CHLORTHALIDONE with food or empty stomach. Your doctor will tell you how to take CHLORTHALIDONE based on your medical condition. In some cases, you may experience headache, nausea, or dizziness. Most of these side effects of CHLORTHALIDONE do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Try not to stop taking this medicine of your own. Tell your doctor about this, as it may cause a rise in blood pressure and can increase the risk of getting heart complications like stroke and heart diseases. Inform your doctor if you are suffering from any kidney or liver or heart disease or are diabetic. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of CHLORTHALIDONE can be prescribed accordingly. Taking CHLORTHALIDONE during pregnancy may cause side effects like jaundice (yellowing of the skin or eyes), unexplained bleeding, low blood sugar, or an electrolyte imbalance in the newborn baby.

Do not use CHLORTHALIDONE if you are unable to urinate, have low blood pressure (hypotension), gout (excess uric acid), high cholesterol (hyperlipidaemia), cardiogenic shock (sudden stopping of blood flow to the heart). Please tell your doctor if you are taking any other medicines or are allergic to this medicine. Reducing the amount of table salt (sodium chloride) in your food often relieves the swelling of the body.

Uses of CHLORTHALIDONE

Hypertension (high blood pressure), Oedema (swelling due to fluid retention)

Medicinal Benefits

When you take CHLORTHALIDONE, the blood vessels in your body will be relaxed, and it will help in lowering the raised blood pressure. Also, it widens the blood vessels (lining of arteries wall) and helps to improve the blood flow. It helps in losing out excess fluids from the body by increasing the production of urine. This reduces the workload on the heart and makes the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke. CHLORTHALIDONE also helps decrease fluid buildup, which reduces inflammation or swelling. In addition, this relieves oedema and helps you carry out your daily activities more efficiently.

Directions for Use

CHLORTHALIDONE should not be used unless prescribed by a doctor. Always take CHLORTHALIDONE exactly as your doctor told you. Your doctor will advise you how often you should take CHLORTHALIDONE based on your medical condition. As a precautionary measure, It is best to avoid taking this medication within 4 hours of your bedtime to prevent having to get up to urinate.

Storage

Store in a cool and dry place away from sunlight

Side Effects of CHLORTHALIDONE

Like all medicines CHLORTHALIDONE also has some side effects, though it is not mandatory for everyone to experience them. Some common side effects experienced include bradycardia (slow heart rate), hyperglycemia, hyperuricemia (an excess of uric acid in the blood), muscle spasm, gastrointestinal disturbances including nausea, and extreme tiredness. Most of the side effects of CHLORTHALIDONE do not require medical attention and gradually resolve over time. However, if the side effects are persistent or if you experience any other side-effect continuously while taking CHLORTHALIDONE, reach out to your doctor.

In-Depth Precautions and Warning

Drug Warnings

CHLORTHALIDONE should not be given to the people allergic to CHLORTHALIDONE, have low blood pressure (less than 90 mm of Hg), have had a heart attack, kidney disease, liver disease, gout (high uric acid), high cholesterol (hyperlipidemia), pregnant women, or planning to get pregnant and breastfeeding women. Besides this, it is contraindicated in people with cardiogenic shock (sudden stopping of blood flow to the heart), and aortic stenosis (heart valve problem). CHLORTHALIDONE can pass into breast milk, but its effect on the baby is not known. So, it is better to tell your doctor if you are taking CHLORTHALIDONE and breastfeeding. Tell your doctor if you are on low sodium (table salt) diet. Cases of electrolyte imbalance have been observed (like low levels of sodium, potassium, or magnesium in your blood). So your doctor might advise monitoring blood pressure, kidney function test,  and electrolytes.

Drug Interactions

Drug-Drug Interaction: CHLORTHALIDONE may interact with other high blood pressure-lowering pills (metoprolol, ramipril, hydrochlorothiazide, atorvastatin), and can lower your blood pressure leading to severe condition. Besides this, it also interacts with medicine to treat erectile dysfunction (sildenafil), anti-epilepsy medicines (carbamazepine, phenobarbital), immune-suppressing drugs (cyclosporine), and painkillers (ibuprofen, aspirin) etc. If you are taking any of the above, speak with your doctor.

Drug-Food Interaction: You are recommended not to consume alcohol along with CHLORTHALIDONE to avoid unpleasant side effects.

Drug-Disease Interaction: CHLORTHALIDONE should not be given to the people with cardiogenic shock (when the heart fails to pump required blood to the body), heart valve problem (stenosis), low blood pressure (hypotension), coronary heart disease, liver disease, or heart failure, low serum potassium (hypokalemia), patients with nil urine output (anuria) etc.

Safety Advice

  • Safety Warning

    Alcohol

    You are recommended not to consume alcohol along with CHLORTHALIDONE to avoid unpleasant side-effects.

  • Safety Warning

    Pregnancy

    CHLORTHALIDONE is classified as FDA pregnancy risk category B. So, CHLORTHALIDONE should not be used during pregnancy unless clearly necessary. Prolonged intake of CHLORTHALIDONE during pregnancy may cause jaundice (yellowing of skin and eye), unexplained bruising, low blood sugar and electrolyte imbalance in the neonates (newborn baby). Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

  • Safety Warning

    Breast Feeding

    CHLORTHALIDONE should not be used when breastfeeding unless clearly necessary. Your doctor will weigh the benefits and any potential risks before prescribing it to you. Please consult your doctor.

  • Safety Warning

    Driving

    Consult Your Doctor

    It is not recommended to drive after taking CHLORTHALIDONE as it may occasionally cause drowsiness.

  • Safety Warning

    Liver

    CHLORTHALIDONE to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

  • Safety Warning

    Kidney

    CHLORTHALIDONE to be taken with caution, especially if you have a history of kidney diseases/conditions. Your doctor may adjust your dose depending upon your current kidney conditions.

Habit Forming

No

Diet & Lifestyle Advise

  • Keep your weight under control with BMI 19.5-24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Opt for a diet rich in whole grains, fruits, veggies, and low-fat dairy products.
  • Limit intake of sodium chloride (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol then only one serving for women and two servings for men is advisable.
  • Quitting smoking is the best strategy to lower the risk of heart disease.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress and practice mindfulness techniques.
  • Monitor your blood pressure daily and if there is too much fluctuation then immediately contact your doctor.
  • Try to include heart-healthy omega 3 fatty acids containing food drinks in your daily diet. You can also use low-fat cooking oil like olive oil, soybean oil, canola oil, and coconut oil can help in lowering your elevated blood pressure.

Special Advise

 If you have taken high doses drink more water and Consult your doctor immediately.

Patients Concern

Disease/Condition Glossary

Hypertension: It is a chronic condition when blood pressure is too high. This condition can lead to hardened arteries (blood vessels), decreasing the blood and oxygen flow to the heart. Blood pressure is the measurement of the force that our heart uses to pump blood to all parts of the body. Raised blood pressure can cause chest pain (angina) and heart attack (when blood supply to the heart is blocked). Additionally, high blood pressure also causes brain damage (stroke) and kidney failure. High blood pressure can be diagnosed with the help of a blood pressure monitor or sphygmomanometer. Systolic pressure is the pressure when the heart pumps blood out. On the other hand, diastolic pressure is the pressure when your heart is at the resting stage between heartbeats. If your blood pressure is 140/90 mm of Hg, it means the systolic pressure is 140 mm of Hg and, diastolic pressure is 90 mm of Hg. Ideal blood pressure should be between 90/60 mm of Hg and 120/80 mm of Hg.

Oedema: Also known as 'dropsy' or 'hydropsy' is a condition of fluid retention in the body characterized by swelling of the body's tissue, including ankles, feet and legs. It is usually caused by standing or sitting in the same position for too long, eating too much salty food, and being overweight. Oedema mainly affects the lymphatic system (including the circulatory and immune system) and organs like tonsils, spleen, and thymus, that maintains fluid balance and fights infections.  

FAQs

Also known as 'dropsy' or 'hydropsy' it is a condition of fluid retention in the body characterized by swelling of the body's tissue including ankles, feet and legs. It is usually caused by standing or sitting in the same position for too long, eating too much salty food and being overweight. Oedema mainly affects the lymphatic system (including the circulatory and immune system) and organs like tonsils, spleen, and thymus, that maintains fluid balance and fights infections. If it does not subside, please consult your doctor immediately.

Yes, CHLORTHALIDONE can cause dizziness. It is advised to avoid driving or operate any heavy machinery while taking CHLORTHALIDONE. In case you feel dizzy or lightheaded, it is advised to rest for some time until you feel better.

Taking CHLORTHALIDONE may cause dehydration. So, to avoid dehydration, drink plenty of fluids and inform your doctor if you feel extremely thirsty.

It's unlikely that CHLORTHALIDONE affects fertility in men or women. However, some water pills like hydrochlorothiazide may lead to erectile dysfunction. There's not enough evidence to say for certain. For the best advice, consult your doctor.

CHLORTHALIDONE can be safely taken as long as your doctor has prescribed it to you. Conditions such as high blood pressure are life-long conditions and one should not abruptly discontinue it without discussing it with a doctor.

No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and not recommend discontinuing it.