CRIZALK 250MG CAPSULE belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults. Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking.

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with lung cancer called non-small cell lung cancer (NSCLC). It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth. CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase.

Always use this medicine exactly as your doctor has told you. You must keep to your doctor's instructions to get the maximum benefit. Sometimes, you may experience specific common side effects, such as visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.

Do not take CRIZALK 250MG CAPSULE if you are allergic to CRIZALK 250MG CAPSULE or any of its ingredients. CRIZALK 250MG CAPSULE may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol with CRIZALK 250MG CAPSULE as it could lead to increased dizziness. CRIZALK 250MG CAPSULE is not recommended for children as safety and effectiveness have not been established. Inform your healthcare professional if you are a pregnant or breastfeeding woman so that your doctor decides whether CRIZALK 250MG CAPSULE can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. While on CRIZALK 250MG CAPSULE treatment, you should avoid eating grapefruit or consuming grapefruit juice since they may alter the amount of CRIZALK 250MG CAPSULE in your body.

CRIZALK 250MG CAPSULE contains the active substance Crizotinib, a medicine used to treat adults with non-small cell lung cancer (NSCLC). CRIZALK 250MG CAPSULE is only given to patients whose disease is due to an alteration in the gene for ALK tyrosine kinase. It works by inhibiting a type of enzyme called tyrosine kinase and slowing down or stopping cancer cell growth.

• Visual disturbance
• Stomach upset
• Vomiting
• Diarrhoea
• Nausea
• Constipation
• Decreased appetite
• Tiredness
• Dizziness
• Metallic taste
• Abdomen pain

Do not take CRIZALK 250MG CAPSULE if you are allergic to CRIZALK 250MG CAPSULE or any of its ingredients. CRIZALK 250MG CAPSULE may cause tiredness and dizziness, so drive with caution. Avoid consuming alcohol along with CRIZALK 250MG CAPSULE as it could lead to increased dizziness. CRIZALK 250MG CAPSULE is not recommended for children as safety and effectiveness have not been established. Consult your doctor if you are a pregnant or breastfeeding woman; your doctor will decide whether the CRIZALK 250MG CAPSULE can be taken or not. Keep your doctor informed about your health condition and medicines to rule out any side effects. It is essential to take CRIZALK 250MG CAPSULE every day, as long as your doctor prescribes it. Contact your doctor immediately if you cannot take medicine as your doctor prescribed or feel you do not need it anymore. Do not stop taking this medicine on your own. People with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders should consult the doctor before taking the CRIZALK 250MG CAPSULE.

Drug-Drug Interactions: CRIZALK 250MG CAPSULE may interact with various medications, including medicines used to treat fungal infections (e.g. ketoconazole, itraconazole, posaconazole, and voriconazole), medicines used to treat bacterial infections (e.g. clarithromycin, telithromycin, and erythromycin), medicines used to treat AIDS/HIV (e.g. atazanavir, ritonavir, and cobicistat), medicines used to treat seizures or fits (e.g. phenytoin, carbamazepine or phenobarbital), medications used to treat tuberculosis (e.g. rifabutin, rifampicin), and a herbal product used to treat depression (e.g. St. John's wort).

Drug-Food Interactions: You must not drink alcohol or grapefruit juice or eat grapefruit while on treatment.

Drug-Disease Interactions: CRIZALK 250MG CAPSULE should be used with caution in patients with liver, kidney or heart disorders, lung inflammation, stomach or intestine problems, and vision disorders.

• KETOCONAZOLE
• ITRACONAZOLE
• POSACONAZOLE
• VORICONAZOLE
• CLARITHROMYCIN
• TELITHROMYCIN
• ERYTHROMYCIN
• ATAZANAVIR
• RITONAVIR
• COBICISTAT
• CARBAMAZEPINE
• PHENOBARBITAL
• RIFABUTIN
• RIFAMPICIN
• ST JOHN'S WORT

• Watch out for triggers that worsen the cough, such as smoke, foods, air-conditioning, high altitude, etc.
• Exercise moderately. Eat healthily.
• Follow a pulmonary rehabilitation program. It includes exercise, disease education, and group therapy.
• Quit smoking and alcohol.
• Get ample rest.
• Include green leafy vegetables, sweet potatoes, broccoli, tomatoes, carrots, mangoes, citrus fruits, berries, and cocoa.
• Lean proteins such as fish, meat, and poultry are the best.
• Hydration is important. Drink plenty of water, herbal tea, and vegetable and fruit juices.
• Avoid processed and refined foods.

• If you have a fever or an infection, call your doctor. Your doctor may perform blood tests, and if the findings are abnormal, your doctor may opt to cut the dose of CRIZALK 250MG CAPSULE.
• Inform your doctor as soon as possible if you notice any vision loss or changes in your vision, such as difficulties seeing out of one or both eyes.
• During your therapy with CRIZALK 250MG CAPSULE, your doctor may recommend electrocardiograms to ensure that your heart is not causing any difficulties.

Non-small cell lung cancer (NSCLC): Non-small cell lung cancer is a condition in which malignant (cancer) cells develop in the lung tissues. Non-small cell lung cancer is classified into numerous categories. The most important risk factor for non-small cell lung cancer is smoking. There are various forms of non-small cell lung cancer. Different types of cancer cells are found in non-small cell lung cancer. Cancer cells of different types grow and spread in different ways. The several types of non-small cell lung cancer are called after the types of cells found in cancer and how the cells appear under a microscope.