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compositionComposition:CRIZOTINIB-250MG
prescription
Prescription Medicine
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CRIZALK 250MG CAPSULE is an anti-cancer medicine used in the treatment of Non-small cell lung cancer (NSCLC). This medicine contains crizotinib which works by stopping the tyrosine kinase enzyme and stops the cancerous cell growth. Common side effects include visual disturbances or stomach upset, including vomiting, diarrhoea, nausea, tiredness, and dizziness.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy
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More about the Product

Composition :

CRIZOTINIB-250MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About CRIZALK 250MG CAPSULE

The prescription medication CRIZALK 250MG CAPSULE is a treatment designed to target specific genetic abnormalities in cancer cells. It is primarily used to treat adults with advanced non-small cell lung cancer that has spread to other parts of the body. By focusing on specific cellular pathways, it helps manage the growth and spread of the disease.

This medication is typically taken twice a day, and it is crucial to take it consistently at the same times each day to keep a steady amount of the medicine in your body. You can take this oral capsule with or without food, depending on your preference. Maintaining a balanced diet and staying well-hydrated are key lifestyle adjustments that can support your body during this treatment.

While taking CRIZALK 250MG CAPSULE, you may experience common side effects such as mild vision changes, nausea, or swelling in your limbs. However, you must contact your doctor immediately if you experience serious side effects, such as signs of liver damage or sudden breathing difficulties. Regular medical check-ups are necessary to ensure the treatment is working safely.

Before starting this medicine, tell your doctor if you have a history of liver disease, kidney problems, or heart rhythm issues. Do not take this if you are pregnant, planning to become pregnant, or breastfeeding, as the medication can harm a developing baby. Your healthcare team will help determine if this treatment is appropriate for you.

This medicine can interact with several common prescription drugs, alcohol, and grapefruit products, which may alter how the drug behaves in your system. If you are an older adult or have pre-existing health conditions, consult your doctor or pharmacist to ensure this treatment is safe for your specific situation. Always keep a complete list of everything you take to share with your healthcare provider.

Uses of CRIZALK 250MG CAPSULE

CRIZALK 250MG CAPSULE is used to treat the following types of cancer with specific genetic changes:

  • ALK-positive Non-Small Cell Lung Cancer (NSCLC): It helps block abnormal proteins that cause cancer cells to grow and spread in patients whose tumours test positive for the anaplastic lymphoma kinase (ALK) gene change.
  • ROS1-positive Non-Small Cell Lung Cancer (NSCLC): It targets and inhibits the ROS1 protein to slow down or stop the growth of cancer cells in patients with this specific genetic marker.

Key Benefits

The following are the benefits of taking CRIZALK 250MG CAPSULE as prescribed:

  • Slows cancer progression: Targets and blocks the abnormal ALK or ROS1 proteins that drive cancer growth, helping slow or stop the spread of the disease.
  • Helps relieve cancer-related symptoms: May reduce symptoms such as persistent cough, chest pain, and shortness of breath by controlling tumour growth.
  • Supports quality of life: By keeping the cancer under better control, it can help patients maintain their daily activities and overall well-being during treatment.
  • Offers convenient oral treatment: Comes as an oral capsule, allowing treatment to be taken at home without the need for regular intravenous infusions.
Side effects of Crizalk 250mg Capsule
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • High levels of liver enzymes need immediate medical attention.
  • Watch your diet and consume low-fat foods, like green leafy vegetables, fish, whole grains, nuts, etc.
  • Regularly do strengthening exercises to control your cholesterol levels.
  • Avoid drinking alcohol as it can affect your liver.
  • Focus on losing weight as it can help control cholesterol and maintain liver enzymes.
  • Practice yoga and meditation to improve liver functioning and overall health.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • CRIZALK 250MG CAPSULE can be taken with or without food as advised by your doctor.
  • CRIZALK 250MG CAPSULE is usually taken twice a day, or as prescribed by your doctor.
  • Swallow CRIZALK 250MG CAPSULE as a whole with a glass of water.
  • Do not crush, chew, split, or open it.

How CRIZALK 250MG CAPSULE Works

CRIZALK 250MG CAPSULE contains CRIZALK 250MG CAPSULE, a targeted anticancer medicine that belongs to a class of medicines known as tyrosine kinase inhibitors. It is used to treat certain cancers that have abnormal proteins, such as ALK or ROS1, which promote the growth and spread of cancer cells. CRIZALK 250MG CAPSULE works by blocking the activity of these abnormal proteins. By switching off the signals that tell cancer cells to grow and divide uncontrollably, it helps slow or stop the growth of the cancer. In some cases, it may also help shrink existing tumours. Together, these actions help control the progression of ALK-positive or ROS1-positive cancers and slow the spread of cancer cells.
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Alcohol

Caution

Consuming alcohol while using CRIZALK 250MG CAPSULE is not recommended since it may produce side effects or make you more sensitive to the effects of alcohol.

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Pregnancy

Caution

CRIZALK 250MG CAPSULE is not typically recommended during the pregnancy. Please consult the healthcare professional if you have any concerns regarding this.

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Breast Feeding

Caution

CRIZALK 250MG CAPSULE is not typically recommended if you are a nursing woman. Please consult the healthcare professional if you have any concerns regarding this.

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Driving

Caution

Do not drive, or you should take special care when driving and using machines as patients taking CRIZALK 250MG CAPSULE may experience visual disturbances, dizziness, and tiredness.

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Liver

Caution

Caution should be taken while using CRIZALK 250MG CAPSULE in patients with liver impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

Caution should be taken while using CRIZALK 250MG CAPSULE in patients with kidney impairment. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

It is not recommended for children as the safety and efficacy have not been established.

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Heart

Caution

CRIZALK 250MG CAPSULE should be taken with caution in patients with heart problems. Therefore, please inform your doctor before using CRIZALK 250MG CAPSULE.

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Geriatrics

Consult your doctor

CRIZALK 250MG CAPSULE should be given to elderly patients only if prescribed by a doctor. If you have any concerns about using CRIZALK 250MG CAPSULE in geriatrics, please consult your doctor.

What if I have taken an overdose of CRIZALK 250MG CAPSULE

If you suspect an overdose, seek immediate emergency medical attention or contact a poison control centre right away. Do not wait for symptoms to develop.

Diet & Lifestyle Advise

  • Avoid grapefruit: Do not eat grapefruit or drink grapefruit juice while taking this medicine, as it can raise the level of the drug in your body to unsafe levels.
  • Stay hydrated: Drink plenty of fluids throughout the day to support your kidney function and manage mild side effects like diarrhoea.
  • Eat small, frequent meals: If you experience nausea, eating smaller portions more frequently throughout the day can help keep your stomach settled.
  • Protect your eyes: Because vision changes and light sensitivity are common, consider wearing sunglasses when outdoors or in bright environments.
  • Avoid smoking: Smoking can worsen lung symptoms and interfere with your overall cancer treatment plan.
health query

Have a query?

How Soon It Starts Working

The time required for CRIZALK 250MG CAPSULE to start to work: CRIZALK 250MG CAPSULE ideally shows its action within few hours after administration. The time for which the effects of CRIZALK 250MG CAPSULE last: The duration of action for CRIZALK 250MG CAPSULE is clinically unknown.

What if you forget to take CRIZALK 250MG CAPSULE

If you miss a dose of CRIZALK 250MG CAPSULE, take it as soon as you remember. However, if your next scheduled dose is less than 6 hours away, skip the missed dose and take your next dose at your regular time. Do not take two doses at the same time to make up for a missed one.

Storage

•Store CRIZALK 250MG CAPSULE at room temperature between 20°C and 25°C (68°F to 77°F). •Keep the medicine in its original container to protect it from direct light and moisture, and do not store it in damp areas like the bathroom.

Drug Warnings

  • Avoid driving if affected: Do not drive, use tools, or operate heavy machinery if you experience blurred vision, dizziness, or tiredness while taking this medication.
  • Monitor your heart rate: Check your pulse regularly and contact your healthcare provider immediately if you notice your heart is beating much slower than normal.
  • Use effective contraception: Use highly effective birth control during treatment and for the recommended period after your final dose, as CRIZALK 250MG CAPSULE can cause serious harm to an unborn baby.
  • Keep all monitoring appointments: Attend all scheduled blood test appointments so your doctor can regularly monitor your liver function, blood cell counts, and overall response to treatment.
  • Handle damaged capsules safely: If a capsule accidentally breaks or leaks, avoid touching the powder directly. If contact occurs, wash the affected area thoroughly with soap and water immediately.

Drug-Drug Interactions

verifiedApollotooltip

The following medicines may interact with CRIZALK 250MG CAPSULE and affect its safety or effectiveness:

  • Strong CYP3A inhibitors (such as ketoconazole, itraconazole, clarithromycin, or ritonavir): These medicines can increase CRIZALK 250MG CAPSULE levels in the body, raising the risk of side effects.
  • Strong CYP3A inducers (such as rifampicin, carbamazepine, phenytoin, or St. John's wort): These medicines can reduce CRIZALK 250MG CAPSULE levels, making the treatment less effective.
  • QT-prolonging medicines: Medicines that affect heart rhythm, such as certain antiarrhythmics, antibiotics, antidepressants, or antipsychotics, may increase the risk of serious heart rhythm problems when taken with CRIZALK 250MG CAPSULE.
CrizotinibZiprasidone
Critical
CrizotinibAmitriptyline
Severe

Drug-Drug Interactions

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CrizotinibZiprasidone
Critical
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Crizalk 250mg Capsule with Ziprasidone can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Crizalk 250mg Capsule is not recommended,but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
CrizotinibAmitriptyline
Severe
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Amitriptyline and Crizalk 250mg Capsule may increase the risk of irregular heartbeat.

How to manage the interaction:
Although combining Amitriptyline with Crizalk 250mg Capsule may result in an interaction, it can be used if a doctor recommends it. If you have any heart problems or electrolyte imbalances, you may be susceptible. If you have sudden dizziness, lightheadedness, fainting, or fast or rapid heartbeats during therapy, get emergency medical help. Do not discontinue any medication without consulting a doctor.
CrizotinibPromethazine
Severe
How does the drug interact with Crizalk 250mg Capsule:
Combining Promethazine with Crizalk 250mg Capsule can increase the risk of QTc prolongation.

How to manage the interaction:
Although there is a possible interaction between Promethazine and Crizalk 250mg Capsule, you can take these medicines together if prescribed by your doctor. Do not stop using any medications without a doctor's advice.
CrizotinibCeritinib
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking Crizalk 250mg Capsule with Ceritinib may significantly increase the blood levels and effects of Crizalk 250mg Capsule.

How to manage the interaction:
Co-administration of Ceritinib with Crizalk 250mg Capsule can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms like an irregular heart rhythm, dizziness, fainting, or a fast or pounding heartbeat, it is important to contact your doctor right away. Do not discontinue any medications without first consulting your doctor.
CrizotinibGranisetron
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking granisetron with Crizalk 250mg Capsule increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking Granisetron and Crizalk 250mg Capsule together can cause an interaction, it can be taken if a doctor has suggested it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, get medical help immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibNorfloxacin
Severe
How does the drug interact with Crizalk 250mg Capsule:
Coadministration of Norfloxacin with Crizalk 250mg Capsule can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Norfloxacin with Crizalk 250mg Capsule together can result in an interaction, it can be taken if your doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
CrizotinibGoserelin
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking Goserelin and Crizalk 250mg Capsule can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Goserelin and Crizalk 250mg Capsule together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
CrizotinibDoxepin
Severe
How does the drug interact with Crizalk 250mg Capsule:
Co-administration of Crizalk 250mg Capsule with Doxepin can increase the risk of irregular heart rhythms.

How to manage the interaction:
Taking Crizalk 250mg Capsule with Doxepin together is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
CrizotinibOlaparib
Severe
How does the drug interact with Crizalk 250mg Capsule:
Using Crizalk 250mg Capsule and olaparib can increase the blood levels of olaparib. This can increase the risk and/or severity of side effects such as nausea, vomiting, diarrhea, indigestion, loss of appetite, abdominal pain or discomfort, lung problems, and impaired bone marrow function resulting in low numbers of different types of blood cells.

How to manage the interaction:
Combining Crizalk 250mg Capsule and olaparib can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like paleness, fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, contact the doctor immediately. Do not discontinue any medications without first consulting your doctor.
CrizotinibPosaconazole
Severe
How does the drug interact with Crizalk 250mg Capsule:
Taking Crizalk 250mg Capsule and posaconazole together can raise the risk of an abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between posaconazole and Crizalk 250mg Capsule, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

The following foods and beverages may interact with CRIZALK 250MG CAPSULE:

  • Grapefruit and grapefruit juice: Avoid consuming grapefruit, grapefruit juice, or supplements containing grapefruit extracts, as they can increase CRIZALK 250MG CAPSULE levels in your body and raise the risk of side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTINEOPLASTIC]

FAQs

CRIZALK 250MG CAPSULE belongs to the group of medicines called anti-cancer medicines. It is used to treat lung cancer called non-small cell lung cancer (NSCLC) in adults.
Crizotinib is the active ingredient in CRIZALK 250MG CAPSULE. It works by inhibiting an enzyme called tyrosine kinase and causing cancer cells to die. CRIZALK 250MG CAPSULE is only provided to individuals whose condition is caused by an ALK tyrosine kinase gene mutation.
In elderly patients, the risk of side effects is more if you take the CRIZALK 250MG CAPSULE. For the elderly, it might require dose adjustment, or your doctor might prescribe any other medication safe for the elderly.
No, avoid smoking before starting the treatment and while taking CRIZALK 250MG CAPSULE as smoking might alter the effectiveness of CRIZALK 250MG CAPSULE.
Take the missed dose as soon as you remember. Skip the missing dose and return to your regular dosing plan if it is time for the next dose. Do not take a double dose to make up for a missing dose.
CRIZALK 250MG CAPSULE may cause visual disturbances such as flashes of light, blurred vision, or double vision as a temporary side effect. If it continues or worsens your condition, seek medical advice immediately.
CRIZALK 250MG CAPSULE should be taken orally. Swallow it as a whole with a glass of water. Do not chew, crush or break it.
The side effects of CRIZALK 250MG CAPSULE include dizziness, diarrhoea, visual disturbances or stomach upset, including vomiting, nausea, and tiredness. Consult the doctor if any of these side effects persist or worsen.
Yes, you can take CRIZALK 250MG CAPSULE with or without food. The most important thing is to be consistent with how you take it each day. Talk to your doctor or pharmacist if you struggle with nausea when taking it on an empty stomach.
Vision changes, such as flashes of light or blurred vision, are common. Avoid driving or operating machinery if your vision is impaired, and report these changes to your healthcare provider as soon as possible. Talk to your doctor or pharmacist for further guidance.
No, CRIZALK 250MG CAPSULE can cause serious harm to an unborn baby. Both men and women should use reliable, highly effective methods of birth control during treatment and for a specified time after stopping the medication. Talk to your doctor or pharmacist about safe family planning options.
It is best to avoid or severely limit alcohol because both alcohol and CRIZALK 250MG CAPSULE are processed by your liver. Combining them can increase the risk of liver damage and worsen side effects like dizziness. Talk to your doctor or pharmacist before consuming alcohol.
Your doctor will monitor your blood to check your liver function and ensure your blood cell counts remain at a safe level. This helps catch potential side effects, like liver damage, before they become severe. Talk to your doctor or pharmacist if you want to understand your test results better.
No, you must swallow the capsules whole. Crushing or opening the capsules can cause the medicine to release too quickly into your body, which increases the risk of severe side effects. Talk to your doctor or pharmacist if you have difficulty swallowing pills.
If you vomit after taking your capsule, do not take an extra dose to replace it. Simply wait and take your next scheduled dose at your regular time. Talk to your doctor or pharmacist for advice on how to manage nausea during your treatment.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.2857 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Electronic Medicines Compendium (EMC). Product Summary of Product Characteristics (SmPC). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Lung Cancer - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Center for Biotechnology Information (NCBI). Crizotinib Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Crizotinib Crizotinib. 2011. [Accessed on 26 Mar. 2019]Check here
  6. Crizotinib Crizotinib. 2012. [Accessed on 26 Mar. 2019]Check here
  7. Crizotinib Crizotinib. 2022. [Accessed on 08 Jan. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ‘G’ Block , Bandra Kurla Complex, Bandra East , Mumbai – 400051.
Other Info - CRI0067
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