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compositionComposition:CYCLOSPORINE-0.05%W/V
prescription
Prescription Medicine
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Cyclodrop Eye Drop 5 ml is used in the treatment of severe keratitis (inflammation of the cornea) in adults. It is also used to treat dry eyes in patients whose condition has not improved with artificial tears. This medicine contains cyclosporine, which helps increase tear production and decrease inflammation (swelling) in the eye. Inform your doctor if you are pregnant or breastfeeding.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

CYCLOSPORINE-0.05%W/V

Manufacturer/Marketer :

Zydus Cadila

Consume Type :

Ophthalmic

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Cyclodrop Eye Drop 5 ml

Cyclodrop Eye Drop 5 ml is a prescription eye drop used to help increase tear production in people whose eyes do not make enough tears due to ongoing inflammation. It is specifically designed to treat a chronic dry eye condition known as keratoconjunctivitis sicca. By calming this inflammation, the medication helps your eyes naturally produce more of their own tears.

To get the best results, you must use these drops consistently every day, typically twice a day, spaced about 12 hours apart. Because this is an ophthalmic emulsion, it is applied directly to the surface of the eye rather than taken by mouth. Making simple daily changes, like using a home humidifier and protecting your eyes from dry winds, can also significantly improve your comfort while using this treatment.

While using this medicine, you might experience mild, temporary burning or stinging in your eyes immediately after application. These common side effects usually fade quickly, but if you experience severe eye pain, persistent vision changes, or signs of an eye infection, you should stop using the drops and contact your doctor immediately.

Before starting this medication, tell your healthcare provider about any history of herpes keratitis or other eye conditions. Do not take this if you currently have an active bacterial, viral, or fungal eye infection, as the drops could interfere with your eye's healing process.

Additionally, you should tell your doctor about all other medications you use, especially other eye drops, to avoid any potential interactions. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, consult your doctor or pharmacist to ensure these drops are safe for your specific situation.

Uses of Cyclodrop Eye Drop 5 ml

A doctor will typically prescribe Cyclodrop Eye Drop 5 ml for the following reasons:

  • Chronic dry eye (Keratoconjunctivitis sicca): Cyclodrop Eye Drop 5 ml helps by increasing your eyes' natural ability to produce tears when chronic inflammation has reduced normal tear flow.
  • Ocular surface inflammation: Cyclodrop Eye Drop 5 ml targets and reduces swelling on the surface of the eye, allowing the tear glands to function more effectively.

Key Benefits

This medication helps relieve the daily discomforts of severe dry eye by targeting the underlying cause rather than just masking the symptoms. Here is how it helps you feel better:

  • Natural tear production: Unlike artificial tears that only provide temporary lubrication, this medication helps your body produce its own real tears.
  • Long-term relief from irritation: By soothing chronic inflammation, it reduces the persistent gritty, sandy, or burning feeling associated with dry eyes.
  • Protection for your vision: Consistent tear production helps protect the clear outer surface of your eye (the cornea) from the damage and scarring that severe dryness can cause.
Side effects of Cyclodrop Eye Drop 5 ml
  • To the affected part, apply warm compresses to get a temporary relief.
  • Rinse your eye carefully with clean water and try to blow any dust particle that could have entered.
  • Take over the counter medication to lubricate your eye or if there is pain due to allergy to soothe the eye.
  • If there is persistent pain in your eye, consult your doctor and follow the medication immediately.
  • Eat a healthy, well-balanced diet full of vitamins, minerals, and omega-3 fatty acids to help maintain eye health.
  • Wear UV-protecting sunglasses when you are outside or in bright light.
  • Avoid touching or rubbing your eyes it may increase irritation.
  • Seek medical care if you are experiencing extreme eye pain or discomfort.
  • Your doctor might recommend eye drops to treat dry eyes, reduce inflammation, or stop irritation.
  • Use a cold, moist towel to relieve inflammation and discomfort.
  • Refrain from rubbing or touching the affected eyelid to avoid worsening the irritation.
  • Avoid allergens like pollen or pet dander that may trigger eyelid erythema.
  • Gently wash the eyelid with mild soap and water to prevent infection.
  • Drink lots of water to keep your skin and eyes moisturized.
  • Inform your doctor if you experience severe symptoms like intense pain, vision changes, or increased sensitivity to light.
  • Avoid rubbing your eyes, which can exacerbate the issue.
  • Lubricate your eyes using artificial tears or eye drops.
  • Wear sunglasses while you are out in the sun to protect your eyes from sun and wind.
  • Avoid irritants like smoke, dust, and strong chemicals.
  • Get enough rest and sleep to help your eyes recover.
  • Stay hydrated by drinking plenty of water.
  • Get plenty of rest to help your eyes recover.
  • Eat a balanced diet low in fat and rich in fruits, vegetables, and whole grains.
  • Limit spicy and seasoned foods that can irritate your eyes.
  • Avoid seafood, which can trigger allergies or infections that worsen red eye symptoms.
  • Talk to the doctor if you notice any visual disturbances.
  • Do not drive or operate machinery unless you have a clear vision.
  • Lubricate the eyes and use a warm compress to gently massage the eyes.
  • Keep your eyes protected from harmful sun rays by wearing sunglasses and a hat.
  • Rest well and eat a balanced diet.
  • Use a humidifier and increase fluid intake.
  • Eat a healthy, low-fat diet rich in whole grains, fruits, and vegetables.
  • Drink plenty of water to stay hydrated.
  • Get adequate sleep and avoid direct sunlight.
  • Follow a low-salt diet to minimize fluid retention.
  • Apply a cold compress to reduce inflammation and soothe affected areas.

Directions for Use

  • Cyclodrop Eye Drop 5 ml is typically used 1-2 times a day, or as prescribed by your healthcare provider, based on the severity of the condition.
  • Tilt your head back, gently pull down your lower eyelid to create a small pocket, and instil the prescribed number of drops into the affected eye. Close your eye and gently press the corner of your eye near the nose for 1-2 minutes to prevent the drops from draining out.
  • Avoid touching the dropper to any surface, including your eyes, to prevent contamination.

How Cyclodrop Eye Drop 5 ml Works

To understand how Cyclodrop Eye Drop 5 ml works, it helps to understand what causes certain types of chronic dry eye. When your eyes are constantly dry, your immune system can cause inflammation in the lacrimal glands, which are the glands responsible for making tears. This inflammation acts like a roadblock, stopping the glands from releasing enough moisture. When you apply Cyclodrop Eye Drop 5 ml, the active medicine works locally as an immunomodulator. It helps calm down the overactive immune response in the tear glands. As the inflammation decreases, the lacrimal glands can heal and begin working normally again, allowing your eyes to produce a steady, natural flow of tears.
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Alcohol

Caution

The interaction of alcohol with Cyclodrop Eye Drop 5 ml is unknown. Please consult a doctor before consuming alcohol with Cyclodrop Eye Drop 5 ml.

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Pregnancy

Consult your doctor

Consult your doctor before using Cyclodrop Eye Drop 5 ml if you are pregnant. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

If you are breastfeeding, consult your doctor before using Cyclodrop Eye Drop 5 ml. Your doctor may prescribe this medicine if the benefits outweigh the risks.

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Driving

Caution

Cyclodrop Eye Drop 5 ml may cause temporary blurred vision immediately after applying. Therefore, wait until your vision is clear before driving or operating machinery.

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Liver

Consult your doctor

If you have any concerns regarding the use of Cyclodrop Eye Drop 5 ml in patients with liver problems, please consult your doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Cyclodrop Eye Drop 5 ml in patients with kidney problems, please consult your doctor.

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Children

Caution

Cyclodrop Eye Drop 5 ml should be used in children only if it is advised by a doctor. It is not recommended for use in children less than four years.

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Heart

Safe if prescribed

Cyclodrop Eye Drop 5 ml is generally considered safe for heart patients. However, please consult your doctor before using Cyclodrop Eye Drop 5 ml.

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Geriatrics

Safe if prescribed

Cyclodrop Eye Drop 5 ml is generally considered safe for use in geriatric patients; however, significant precautions should be taken due to age-related sensitivities.

What if I have taken an overdose of Cyclodrop Eye Drop 5 ml

An overdose is highly unlikely when this medication is used in the eyes as directed. However, if the liquid is accidentally swallowed, or if too much is placed in the eye causing severe irritation, contact a healthcare professional or go to the nearest emergency room immediately.

Diet & Lifestyle Advise

Managing chronic dry eye often requires a combination of medication and daily habits. Here are a few evidence-based tips to help support your eye health:

  • Stay hydrated: Drink plenty of water throughout the day to support overall body moisture, including your tear film.
  • Use a humidifier: Place a humidifier in your bedroom or office to add moisture to dry indoor air, especially during winter or in air-conditioned spaces.
  • Wear protective eyewear: Wear wrap-around sunglasses when outdoors to shield your eyes from drying winds, dust, and direct sunlight.
  • Practice the 20-20-20 rule: When using screens, look away every 20 minutes at an object 20 feet away for at least 20 seconds to encourage natural blinking.
  • Avoid direct air currents: Keep car vents, fans, and heating units pointed away from your face to prevent them from drying out your eyes.
health query

Have a query?

How Soon It Starts Working

The time required for Cyclodrop Eye Drop 5 ml to start to work: The onset time of Cyclodrop Eye Drop 5 ml has not been clinically established.

The time for which the effects of Cyclodrop Eye Drop 5 ml last: The duration of Cyclodrop Eye Drop 5 ml’s effect is clinically not established.

What if you forget to take Cyclodrop Eye Drop 5 ml

If you miss a dose, apply it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular routine. Do not apply double drops to make up for a missed dose.

Storage

• Store the medicine at room temperature between 15°C and 25°C (59°F to 77°F).

Drug Warnings

  • Wash Your Hands Before Use: Always wash your hands thoroughly before applying the eye drops to reduce the risk of eye infections.
  • Avoid Contaminating the Dropper: Do not allow the dropper tip to touch your eye, eyelid, fingers, or any surface to help keep the medicine sterile.
  • Inspect the Solution Before Use: Do not use the eye drops if the liquid appears discoloured, cloudy, unusually thick, or contains visible particles.
  • Space Multiple Eye Medicines: If you use other eye drops or artificial tears, wait at least 15 minutes before applying another eye product, unless your doctor advises otherwise.
  • Remove Contact Lenses Before Application: Remove your contact lenses before using Cyclodrop Eye Drop 5 ml. Reinsert them only after the period recommended by your doctor or the product instructions, as the emulsion may interact with the lens material.

Drug-Drug Interactions

verifiedApollotooltip
  • Other ophthalmic drops: Using other eye medications immediately before or after Cyclodrop Eye Drop 5 ml can dilute the medicine or wash it out. Always separate different eye drops by at least 15 minutes.
CiclosporinBaricitinib
Critical
CiclosporinCidofovir
Critical

Drug-Drug Interactions

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CiclosporinBaricitinib
Critical
How does the drug interact with Cyclodrop Eye Drop 5 ml:
Co-administration of Baricitinib with Cyclosporine can increase the risk of infections as well as some cancers.

How to manage the interaction:
Taking Cyclodrop Eye Drop 5 ml with Baricitinib is not recommended as it can cause an interaction, but it can be taken together if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
CiclosporinCidofovir
Critical
How does the drug interact with Cyclodrop Eye Drop 5 ml:
Taking cyclosporine with cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Cyclodrop Eye Drop 5 ml with Cidofovir is not recommended, but can be taken be together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, swelling, shortness of breath, bone pain, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm, contact the doctor immediately. Do not discontinue any medications without consulting a doctor
CiclosporinSimvastatin
Critical
How does the drug interact with Cyclodrop Eye Drop 5 ml:
Combining Cyclodrop Eye Drop 5 ml and Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver damage and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Cyclodrop Eye Drop 5 ml and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of hunger, weakness, nausea, vomiting, and yellowing of the skin or eyes, contact the doctor immediately. Do not discontinue any medications without consulting your doctor.
CiclosporinBosentan
Critical
How does the drug interact with Cyclodrop Eye Drop 5 ml:
When Bosentan is taken with Cyclosporine, it may increase the risk of side effects.

How to manage the interaction:
Taking Cyclodrop Eye Drop 5 ml with Bosentan is not recommended, but it can be taken if prescribed by the doctor. However, if you experience any symptoms like severe headache, nausea, or an increased heart rate, consult the doctor immediately. Do not stop using any medications without talking to a doctor.
CiclosporinPitavastatin
Critical
How does the drug interact with Cyclodrop Eye Drop 5 ml:
Coadministration of pitavastatin with Cyclodrop Eye Drop 5 ml may significantly increase the blood levels of pitavastatin which can increase the risk of side effects such as liver problems and rhabdomyolysis(involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Pitavastatin with Cyclodrop Eye Drop 5 ml is not recommended, as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms like unexpected bruising or bleeding, skin rash, itching, tiredness, nausea, vomiting, yellowing of the skin or eyes, unexplained muscular pain, tenderness, or weakness, fever, dark urine, chills, joint pain, or swelling, consult a doctor. Do not discontinue any medications without a doctor's advice.
CiclosporinMifepristone
Severe
How does the drug interact with Cyclodrop Eye Drop 5 ml:
Co-administration of Cyclodrop Eye Drop 5 ml with mifepristone may significantly increase the blood levels of Cyclodrop Eye Drop 5 ml which may increase the risk and/or severity of side effects.

How to manage the interaction:
Although taking Cyclodrop Eye Drop 5 ml and Mifepristone together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you notice nausea, vomiting, diarrhea, abdominal discomfort, exhaustion, headache, shaking, fits, fever, sore throat, unusual bruising or bleeding, or increased or decreased urine, consult a doctor. Do not discontinue any medication without consulting a doctor.
CiclosporinEtanercept
Severe
How does the drug interact with Cyclodrop Eye Drop 5 ml:
When etanercept is taken with cyclosporine, it can increase the risk of infections.

How to manage the interaction:
Although taking etanercept and Cyclodrop Eye Drop 5 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, contact a doctor immediately if you experience any symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
CiclosporinTacrolimus
Severe
How does the drug interact with Cyclodrop Eye Drop 5 ml:
Taking tacrolimus with Cyclodrop Eye Drop 5 ml may cause serious side effects on the kidneys.

How to manage the interaction:
Although taking tacrolimus and Cyclodrop Eye Drop 5 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. However, consult the doctor immediately if you experience symptoms such as fever, chills, body aches, and severe pain in your upper stomach spreading to your back. Do not discontinue any medications without consulting a doctor.
CiclosporinKetoconazole
Severe
How does the drug interact with Cyclodrop Eye Drop 5 ml:
Co-administration of ketoconazole with Cyclodrop Eye Drop 5 ml may increases the blood levels of Cyclodrop Eye Drop 5 ml.

How to manage the interaction:
Although taking ketoconazole and Cyclodrop Eye Drop 5 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if your condition worsens or you encounter more adverse effects, such as nausea, vomiting, diarrhea, abdominal discomfort, exhaustion, headache, shaking, fits, fever, sore throat, unusual bruising or bleeding, or increased or decreased urine, consult a doctor. Do not discontinue any medication without consulting a doctor.
CiclosporinAmiloride
Severe
How does the drug interact with Cyclodrop Eye Drop 5 ml:
Using Cyclodrop Eye Drop 5 ml with amiloride can result in increased potassium levels in the blood.

How to manage the interaction:
Although taking amiloride and Cyclodrop Eye Drop 5 ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor, if you have symptoms such as a slow, rapid, or irregular heartbeat, rapid breathing, numbness or tingling, or pain in the muscles or weakness. Do not discontinue any medications without a doctor's advice.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Cyclodrop Eye Drop 5 ml when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[IMMUNOSUPPRESSANTS]

FAQs

Cyclodrop Eye Drop 5 ml is used in the treatment of severe keratitis (inflammation of the cornea) in adults. Also, it is used to treat dry eyes in patients whose condition has not improved with artificial tears.
Cyclodrop Eye Drop 5 ml contains Cyclosporine, which works by increasing tear production and decreasing inflammation (swelling) in the eye. Thereby, it provides a soothing effect and relieves irritation and dryness caused by decreased tear flow.
You are recommended to use Cyclodrop Eye Drop 5 ml after 15 minutes of using other eye medications only if advised by your doctor. Therefore, inform your doctor if you are using any other medicines before using Cyclodrop Eye Drop 5 ml.
Cyclodrop Eye Drop 5 ml may cause temporary blurred vision immediately after applying. Therefore, you are recommended to wait until your vision is clear before driving or operating machinery.
You are recommended to discuss with your doctor before using eye drops containing steroids with Cyclodrop Eye Drop 5 ml as there is a risk of side effects if both medicines are used simultaneously.
It can take several weeks to a few months of consistent daily use to notice a significant increase in your natural tear production. Talk to your doctor if your dry eye symptoms do not begin to improve after several weeks.
No. You should remove your contact lenses before applying Cyclodrop Eye Drop 5 ml. Wait at least 15 minutes before reinserting them. Wearing contact lenses while using the drops may increase eye irritation. If you experience persistent pain, stinging, or an abnormal sensation in your eyes, contact your doctor.
Mild, temporary burning or stinging is the most common side effect and typically stops within a few minutes. If the burning is severe, worsens over time, or does not go away, stop using the drops and talk to your doctor.
Yes, you can use artificial tears to keep your eyes comfortable, especially during the first few weeks of treatment. However, you must wait at least 15 minutes between using Cyclodrop Eye Drop 5 ml and your artificial tears. Talk to your doctor or pharmacist to establish a safe schedule.
Because these are eye drops, very little of the medicine enters your bloodstream. However, you should always discuss the potential risks and benefits with your healthcare provider. Talk to your doctor if you are pregnant, planning to become pregnant, or breastfeeding.
If you stop using the drops, the underlying inflammation on the surface of your eye is likely to return, which can cause your natural tear production to decrease again. Always talk to your doctor before stopping this medication.
No, this medication is specifically designed for dry eye caused by inflammation (keratoconjunctivitis sicca). It may not be effective for other types of dry eye, such as those caused by blocked oil glands or physical eyelid issues. Talk to your doctor for an accurate diagnosis.
The standard recommendation is to apply one drop in each eye twice a day, approximately 12 hours apart. However, your doctor will determine the best schedule for your specific condition. Talk to your doctor or pharmacist if you are unsure about your dosing schedule.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Product Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Ciclosporin Info Sheet - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. RESTASIS® (cyclosporine ophthalmic emulsion) 0.05% [Internet]. [Accessed on 27 Feb 2025]Check here
  4. Tapia C, Nessel TA, Zito PM. Cyclosporine. [Updated 2023 Aug 28]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing;[Accessed on 27 Feb 2025]Check here
  5. National Center for Biotechnology Information (2025). PubChem Compound Summary for CID 5280754, Cyclosporine. Retrieved February 27, 2025Check here
  6. DrugBank. Cyclosporine. DrugBank.[Accessed on 27 Feb 2025]Check here
  7. Novartis Pharmaceuticals UK Limited. Electronic Medicines Compendium (EMC) [Revised in May 2022] [ Accessed on 21st November 2022]Check here

Country of origin

India

Manufacturer/Marketer address

Zydus Tower, Satellite Cross Roads,Ahmedabad – 380015 Gujarat, India.
Other Info - CYC0158
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