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Depo-Provera 150 mg Injection 1 ml is used for contraception. It is also used in the treatment of amenorrhea (the unusual cessation of menstrual periods) and abnormal uterine bleeding, and the prevention of endometrial hyperplasia (thickening of the uterine or womb lining) in women who take conjugated estrogen.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Manufacturer/Marketer :

DKT India Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Depo-Provera 150 mg Injection 1 ml

Depo-Provera 150 mg Injection 1 ml is an injectable hormonal medication used primarily to prevent pregnancy. It is also prescribed to manage pelvic pain associated with endometriosis and as a palliative treatment for certain advanced, hormone-dependent cancers. Because it is highly effective and long-acting, it is a common choice for those seeking hassle-free therapy.

This injection must be received consistently on a regular schedule, typically once every few months, to ensure it remains effective. Since it is injected, it does not require daily dosing or daily memory checks, and it does not need to be timed around your meals. To achieve the best health outcomes while using this medicine, it is highly beneficial to adopt lifestyle adjustments, such as getting regular exercise and consuming a diet rich in calcium and vitamin D to support your bone health.

While taking Depo-Provera 150 mg Injection 1 ml, you may experience mild side effects, such as changes in your menstrual cycle, weight shifts, or mild headaches. These are generally manageable, but you should consult your doctor immediately if you notice serious symptoms, including severe pelvic pain, unusually heavy bleeding, or sudden, severe headaches.

Before starting your treatment, you must discuss your medical history with your doctor. Do not take this if you have a history of blood clots, active liver damage, breast cancer, or unexplained vaginal bleeding. Your doctor will help evaluate if this injection is safe for your specific health background.

Certain prescription medications can make Depo-Provera 150 mg Injection 1 ml less effective, and habits like smoking can increase your risk of severe vascular side effects. Always inform your healthcare provider about all the medicines you use. If you are pregnant, planning to become pregnant, or breastfeeding, you must consult your doctor before receiving this injection.

Uses of Depo-Provera 150 mg Injection 1 ml

Depo-Provera 150 mg Injection 1 ml helps prevent pregnancy and treat certain hormone-related conditions. Your doctor may recommend it for the following conditions:

  • Contraception (pregnancy prevention): Depo-Provera 150 mg Injection 1 ml is injected to provide highly effective, long-term birth control that lasts for several months per dose.
  • Endometriosis pain management: Depo-Provera 150 mg Injection 1 ml helps shrink endometrial tissue growing outside the uterus, which significantly reduces painful pelvic symptoms.
  • Hormonal cancer management: Depo-Provera 150 mg Injection 1 ml helps slow down the progression of certain hormone-sensitive advanced cancers, such as endometrial or renal cancers.

Key Benefits

Depo-Provera 150 mg Injection 1 ml provides long-lasting contraception and helps manage certain hormone-related conditions. Key benefits include:

  • Reliable, long-lasting contraception: Each injection provides highly effective pregnancy prevention for several months, eliminating the need to remember a daily contraceptive pill.
  • Relieves endometriosis symptoms: By reducing the hormonal stimulation of endometrial tissue, Depo-Provera 150 mg Injection 1 ml helps relieve pelvic pain and other symptoms associated with endometriosis, allowing many people to carry out their daily activities more comfortably.
  • Reduces menstrual bleeding: Depo-Provera 150 mg Injection 1 ml often makes menstrual periods lighter, shorter, and less painful. In some people, periods may stop altogether after several months of use, which can help reduce heavy menstrual bleeding and lower the risk of iron-deficiency anaemia.
Side effects of Depo-Provera 150 mg Injection 1 ml
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Always wear loose-fitting clothes suitable for your activity during hot flashes.
  • Include a diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water and stay hydrated.
  • Stay calm and lower your anxiety by practising yoga or meditation.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Keep your skin clean by gently washing your face two times daily and after sweating. Choose a mild and non-abrasive cleanser.
  • Use gentle alcohol-free skin care products. Avoid products that might irritate your skin such as exfoliants, astringents and toners.
  • Acne may also occur due to oil in the hair. Thus, if you have oily hair, shampoo more frequently than you do now and keep your hair away from face.
  • Keep your hands off your face as touching face throughout the day might worsen acne. Also, do not pick, squeeze or pop acne as it will prolong the healing process and increase the risk of dark spots and scarring.
  • Avoid tanning by applying a broad spectrum sunscreen and wearing sun-protective clothing when outdoors.

Directions for Use

  • The timing and frequency of Depo-Provera 150 mg Injection 1 ml will be determined by your doctor, based on your medical condition and response to treatment.
  • This medication should only be administered by a qualified healthcare provider.
  • Do not attempt self-administration of the injection.

How Depo-Provera 150 mg Injection 1 ml Works

Depo-Provera 150 mg Injection 1 ml contains medroxyprogesterone acetate, a synthetic form of the natural hormone progesterone. It works mainly by preventing the ovaries from releasing an egg each month (ovulation). Without an egg, fertilisation cannot occur. The medicine also thickens the mucus at the cervix, making it difficult for sperm to enter the uterus, and thins the lining of the uterus, making it less likely for a fertilised egg to implant. For conditions such as endometriosis and certain hormone-sensitive cancers, it lowers oestrogen activity and slows the growth of hormone-dependent endometrial or cancer cells, helping to control the condition.
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Alcohol

Consult your doctor

It is not known whether it is safe to consume alcohol with Depo-Provera 150 mg Injection 1 ml. However, as a precautionary measure, it is advisable not to take or limit alcohol.

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Pregnancy

Unsafe

Depo-Provera 150 mg Injection 1 ml must not be taken if you are pregnant, as hormonal medicines can affect the developing baby.

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Breast Feeding

Safe if prescribed

Depo-Provera 150 mg Injection 1 ml can be safely used by nursing mothers. Your doctor or healthcare professional may advise that you wait until at least 6 weeks after your baby has been born before you start using Depo-Provera 150 mg Injection 1 ml for contraception.

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Driving

Safe if prescribed

Depo-Provera 150 mg Injection 1 ml usually does not impact your ability to drive or operate machinery.

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Liver

Consult your doctor

Inform your doctor before receiving Depo-Provera 150 mg Injection 1 ml if you have a history of liver impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before receiving Depo-Provera 150 mg Injection 1 ml if you have a history of kidney impairment/disorder. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Unsafe

Depo-Provera 150 mg Injection 1 ml is not recommended for children below 12 years of age.

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Heart

Caution

Inform your doctor before receiving Depo-Provera 150 mg Injection 1 ml if you have heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Depo-Provera 150 mg Injection 1 ml should be used with caution in elderly patients. Please consult your doctor before use.

What if I have taken an overdose of Depo-Provera 150 mg Injection 1 ml

Since this medication is typically injected in a clinical setting by a professional, an overdose is highly unlikely. However, if you suspect you have received too much of this medicine, seek immediate medical attention.

Diet & Lifestyle Advise

  • Increase calcium and vitamin D: This medication can sometimes cause a temporary decrease in bone mineral density. Eat calcium-rich foods like dairy, leafy greens, and almonds, or talk to your doctor about taking daily calcium and vitamin D supplements.
  • Perform weight-bearing exercises: Regularly engage in activities like walking, jogging, hiking, or strength training to help protect and maintain your bone strength.
  • Avoid smoking: Smoking while using hormonal medications significantly increases your risk of developing blood clots, stroke, or heart issues.
  • Limit alcohol intake: Excess alcohol consumption can weaken your bones further and increase the risk of osteoporosis, especially when combined with this therapy.
  • Keep a symptoms journal: Note any changes in your bleeding patterns, mood, or weight so you can easily review them with your doctor during your routine follow-up visits.
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How Soon It Starts Working

  • The time required for Depo-Provera 150 mg Injection 1 ml to start to work: The time required for Depo-Provera 150 mg Injection 1 ml to show its action is unknown.
  • The time for which the effects of Depo-Provera 150 mg Injection 1 ml last: The duration of action for Depo-Provera 150 mg Injection 1 ml is unknown.

What if you forget to take Depo-Provera 150 mg Injection 1 ml

If you miss your scheduled injection date, contact your doctor or healthcare provider immediately to reschedule. If you are using this medication for birth control, you must use a backup, non-hormonal contraceptive method (such as condoms) to prevent pregnancy. Your doctor may also require a pregnancy test before injecting your next dose.

Storage

• Store Depo-Provera 150 mg Injection 1 ml at controlled room temperature, ideally between 20°C and 25°C (68°F and 77°F).

Drug Warnings

  • Inspect before use: Check the solution before injection. Do not use it if it contains large particles, is severely cloudy, or is discoloured.
  • Shake well: Shake the vial or pre-filled syringe vigorously immediately before use to ensure the medicine is evenly mixed.
  • Rotate injection sites: Change the injection site with each dose to help reduce the risk of skin dimpling, scarring, or local irritation.
  • Do not miss doses: Set a reminder to receive your injection on schedule, as delays may reduce its effectiveness.
  • Never reuse injection equipment: Always use a new needle and syringe for each injection and dispose of used sharps in a suitable sharps container.
  • Inform your healthcare providers: Tell your doctor, dentist, surgeon, and other healthcare providers that you are using this long-acting injection, as it may remain in your body for several months.

Drug-Drug Interactions

verifiedApollotooltip
  • Seizure medicines: Drugs such as carbamazepine, phenytoin, and phenobarbital can speed up your liver's breakdown of Depo-Provera 150 mg Injection 1 ml, making the injection less effective at preventing pregnancy.
  • Aminoglutethimide: This medication can significantly reduce the amount of the active hormone in your blood, potentially lowering its therapeutic effects.
Critical

Drug-Drug Interactions

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How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Coadministration of Acitretin with Depo-Provera 150 mg Injection 1 ml can increase the risk and severity of birth defects when taken by a pregnant woman.

How to manage the interaction:
Taking Acitretin with Depo-Provera 150 mg Injection 1 ml together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. Consult a doctor if you get pregnant while taking these medications. Do not discontinue any medications without consulting a doctor.
Critical
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml and Etretinate may cause severe birth defects if the mother takes the medication during pregnancy.

How to manage the interaction:
Using etretinate and Depo-Provera 150 mg Injection 1 ml together is not recommended, but can be taken if prescribed by a doctor. However, if you experience unusual symptoms contact your doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml acetate with Tranexamic acid may increase the risk of blood clots.

How to manage the interaction:
Taking Depo-Provera 150 mg Injection 1 ml with Tranexamic acid is not recommended but can be taken if prescribed by a doctor. Consult your doctor immediately if you experience symptoms such as chest pain, shortness of breath, coughing up blood, blood in the urine, sudden loss of vision, and pain, redness, or swelling in your arm or leg. Do not stop using any medications without talking to your doctor.
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking telaprevir and Depo-Provera 150 mg Injection 1 ml may reduce the blood levels and effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
Although taking Depo-Provera 150 mg Injection 1 ml and Telaprevir together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any symptoms such as hot flashes, vaginal dryness, or abnormal bleeding, consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking griseofulvin with Depo-Provera 150 mg Injection 1 ml may reduce blood levels and the effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between Griseofulvin and Depo-Provera 150 mg Injection 1 ml, but it can be taken if prescribed by a doctor. However, if you experience any of these symptoms like unexpected bleeding or abnormal bleeding, or if you think you might be pregnant while using birth control, it's important to contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
MedroxyprogesteroneFosamprenavir
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml together with fosamprenavir may decrease the effects of fosamprenavir.

How to manage the interaction:
Although there is a possible interaction between Depo-Provera 150 mg Injection 1 ml and Fosamprenavir, you can take these medicines together if prescribed by your doctor. However, if you experience any unusual symptoms contact your doctor right away. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml and Brigatinib may, reduce the blood levels and effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
Although taking Depo-Provera 150 mg Injection 1 ml and brigatinib together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience hot flashes(feeling of heat in the body), dryness, or unusual bleeding, don't hesitate to reach out to your doctor. Do not stop using any medications without a doctor's advice.
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
Taking Depo-Provera 150 mg Injection 1 ml with bexarotene may decrease the effectiveness of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
Although taking Depo-Provera 150 mg Injection 1 ml and Bexarotene together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without consulting a doctor.
Severe
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
When Depo-Provera 150 mg Injection 1 ml is taken with sugammadex, the effect of Depo-Provera 150 mg Injection 1 ml in the blood may decrease.

How to manage the interaction:
Taking Sugammadex with Depo-Provera 150 mg Injection 1 ml together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience any unusual symptoms consult your doctor immediately. Do not discontinue any medications without first consulting your doctor.
How does the drug interact with Depo-Provera 150 mg Injection 1 ml:
When Depo-Provera 150 mg Injection 1 ml acetate is taken with Topiramate, it reduces the blood levels and effects of Depo-Provera 150 mg Injection 1 ml.

How to manage the interaction:
Co-administration of Depo-Provera 150 mg Injection 1 ml with Topiramate can possibly result in an interaction, but it can be taken if your doctor has advised it. If you're taking birth control and experiencing symptoms like hot flashes, vaginal dryness, or abnormal bleeding, contact your doctor. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

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No clinically significant food interactions are known with Depo-Provera 150 mg Injection 1 ml when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[HORMONES, CONTRACEPTIVES]

FAQs

No, it often takes several months, and in some cases up to a year or longer, for your menstrual cycle and fertility to return to normal after your last injection. This is because the medication remains in your body for a long time. Talk to your doctor if you are planning to become pregnant.
Yes, long-term use of this injection can lead to a loss of bone mineral density. This loss is usually reversible once the medication is stopped, but it is highly recommended to get plenty of calcium and vitamin D while using it. Talk to your doctor about your bone health risks.
Yes, this medication can generally be used by breastfeeding mothers. However, the timing of your first postpartum dose is important, so you should talk to your doctor or lactation consultant to determine the safest schedule.
If you are late for your scheduled injection, use a backup birth control method immediately. Do not receive your next injection until your doctor has ruled out pregnancy. Talk to your doctor to find out if you need a pregnancy test.
No, Depo-Provera 150 mg Injection 1 ml is strictly used to prevent pregnancy and manage hormonal conditions. It does not provide any protection against HIV or other STIs. You should continue to use barrier methods like condoms to protect against infections. Talk to your doctor for further guidance.
Yes, some people experience mood changes, irritability, or worsening depression while using hormonal injections. If you have a history of depression or notice significant, dark changes in your mood, talk to your doctor right away.
Yes, weight gain is a recognized side effect for many individuals using this injection. This can be due to an increased appetite or mild fluid retention. Eating a balanced diet and staying physically active can help manage this change. Talk to your doctor if you have concerns.

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Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18th Floor , Plot No. C-70, ?G? Block , Bandra Kurla Complex, Bandra East , Mumbai ? 400051.
Other Info - DEP0019
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