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  3. DEPRID 0.500MG TABLET

DEPRID 0.500MG TABLET, Pack of 10 TABLETS
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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
DEPRID 0.500MG TABLET is used to treat depression. It contains Imipramine which increases the activity of certain natural substances (neurotransmitters) which regulate mood. Additionally, it is also used to treat bed-wetting at night in children aged 6 years and older by relaxing the urinary bladder muscles. This medicine may sometimes cause side effects such as dry mouth, nausea, vomiting, increased blood pressure, lack of coordination, swelling of the breast and weakness. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.
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Composition :

IMIPRAMINE-50MG

Manufacturer/Marketer :

Sigmund Promedica

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About DEPRID 0.500MG TABLET

DEPRID 0.500MG TABLET belongs to a group of medicines called 'tricyclic anti-depressants' used to treat depression. Additionally, DEPRID 0.500MG TABLET is also used to treat bed-wetting at night in children aged 6 years and older. Depression is a mood disorder characterised by sadness, unhappiness, anger, hopelessness or loss that interferes with a person’s daily activities.
 
DEPRID 0.500MG TABLET contains ‘Imipramine’, which increases the activity of certain natural substances (neurotransmitters) in the brain required for mental balance, thereby regulating mood and treating depression. It also reduces childhood enuresis or bed-wetting in the children older than 6-7 years of age by relaxing the urinary bladder muscle, which lightens the sleep.
 
You are advised to take DEPRID 0.500MG TABLET for as long as your doctor has prescribed it for you depending on your medical condition and response to the treatment. In some cases, you may experience certain common side-effects such as dry mouth, nausea, vomiting, increased blood pressure, lack of coordination, swelling of the breast and weakness.  You are advised to talk to your doctor if you experience these side-effects persistently.
 
Please do not stop taking DEPRID 0.500MG TABLET without consulting your doctor as it could lead to withdrawal symptoms. Consult your doctor if you are pregnant or breastfeeding. Avoid driving or operating machinery as DEPRID 0.500MG TABLET may cause impaired alertness, drowsiness or blurred vision. DEPRID 0.500MG TABLET is not recommended for children below 6 years as safety and effectiveness have not been established. Avoid consuming alcohol with DEPRID 0.500MG TABLET as it could lead to increased drowsiness. Keep your doctor informed about your health condition and medicines to rule out any side-effects.

Uses of DEPRID 0.500MG TABLET

Treatment of Depression, Nocturnal enuresis (bed-wetting in children)

Directions for Use

Swallow DEPRID 0.500MG TABLET as a whole with a glass of water, do not chew or crush it.

Medicinal Benefits

DEPRID 0.500MG TABLET belongs to a group of medicines called tricyclic anti-depressants. DEPRID 0.500MG TABLET is used to treat depression. DEPRID 0.500MG TABLET works by increasing the activity of certain natural substances in the brain needed for mental balance, thereby regulating mood and treating depression. Additionally, DEPRID 0.500MG TABLET is used as an adjunct therapy in reducing bed-wetting at night in children aged 6-7 years and older. DEPRID 0.500MG TABLET helps to control childhood enuresis or bed-wetting as a part of its anti-depressant effect.

How DEPRID 0.500MG TABLET Works

DEPRID 0.500MG TABLET contains ‘Imipramine’, which increases the activity of certain natural substances (neurotransmitters) in the brain required for mental balance, thereby regulating mood and treating depression. It also reduces childhood enuresis or bed-wetting in the children older than 6-7 years of age by relaxing the urinary bladder muscle, which lightens the sleep.

Storage

Store in a cool and dry place away from sunlight
Side effects of Deprid 0.500mg Tablet
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
  • Exercise regularly and maintain a healthy weight.
  • Manage cholesterol and blood pressure.
  • Limit intake of caffeine and alcohol.
  • Avoid vaping and tobacco smoke.
  • Get enough sleep.
  • Talk to your doctor about antiarrhythmic drugs or other medications to treat your condition.
  • Restlessness is related to mental health and needs medical attention if it's severe.
  • Regular practice of meditation and yoga can help calm your mind. This can reduce restlessness.
  • Prevent smoking as it can impact your calmness of body and mind.
  • Talk to your friends and family about restlessness, who can provide a solution for why you feel restless.
  • Get sufficient sleep for a minimum of 6-7 hours to reduce restlessness.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
  • Manage stress by practising deep breathing, yoga or meditation.
  • Participating in activities you enjoy, or exercising may also help manage agitation.
  • Get enough sleep. Maintain a regular sleep cycle.
  • Exercise regularly. Try physical activities like walking, running, or dancing.

What if I have taken an overdose of DEPRID 0.500MG TABLET

Take DEPRID 0.500MG TABLET only as prescribed by the physician. Avoid exceeding the recommended dose as it could lead to an overdose. Symptoms of overdose may include feeling like you might pass out, irregular heartbeats, seizures, or coma. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Do not take DEPRID 0.500MG TABLET if you are allergic to any of its contents; if you are taking monoamine oxidase inhibitors (MAOI) or have taken them in the last 14 days, if you have heart diseases, mania, porphyria, glaucoma or are unable to pass urine. Avoid taking buprenorphine/opioids with DEPRID 0.500MG TABLET as it could lead to serotonin syndrome. Inform your doctor if you have/had schizophrenia or manic depression, alcohol withdrawal, enlarged prostate, overactive thyroid, epilepsy, low blood pressure, poor circulation, panic attacks, a tumour of the adrenal gland, or if you are being given electroconvulsive therapy. Talk to your doctor immediately if you have suicidal thoughts such as killing or harming yourself. Consult your doctor if you are pregnant or breastfeeding. Avoid driving or operating machinery as DEPRID 0.500MG TABLET may cause impaired alertness, drowsiness, or blurred vision. DEPRID 0.500MG TABLET is not recommended for children below 6 years as safety and effectiveness have not been established. Avoid consuming alcohol with DEPRID 0.500MG TABLET as it could lead to increased drowsiness. Rise slowly from sitting or lying position as DEPRID 0.500MG TABLET causes dizziness on standing suddenly.

Drug-Drug Interactions

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ImipramineLinezolid
Critical
ImipraminePotassium citrate
Critical

Drug-Drug Interactions

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ImipramineLinezolid
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Coadministration of Linezolid with Deprid 0.500mg Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Linezolid and Deprid 0.500mg Tablet together is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipraminePotassium citrate
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Taking Deprid 0.500mg Tablet and Potassium citrate (in tablet or capsule form) together can increase the risk of stomach ulcers, bleeding, and gastrointestinal injury.

How to manage the interaction:
Taking Potassium citrate and Deprid 0.500mg Tablet is not recommended, as it may lead to an interaction, it can be taken if prescribed by the doctor. However, if you experience severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, or dark, tarry stools, consult the doctor immediately. Do not discontinue any medications without a doctor's advice.
ImipramineSparfloxacin
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Taking Sparfloxacin with Deprid 0.500mg Tablet can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Sparfloxacin and Deprid 0.500mg Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineSelegiline
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Co-administration of Deprid 0.500mg Tablet with Selegiline might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Deprid 0.500mg Tablet and Selegiline together is not recommended as it can result in an interaction. It can be taken if a doctor has advised it. However, if you experience confusion, hallucinations, fits, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, shaking, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineDronedarone
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Taking Deprid 0.500mg Tablet with Dronedarone can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Deprid 0.500mg Tablet with Dronedarone together is not recommended as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, or a rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineSafinamide
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Coadministration of Safinamide with Deprid 0.500mg Tablet can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking safinamide and Deprid 0.500mg Tablet together is not recommended as it can result in an interaction, but they can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucinations (seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting your doctor.
ImipraminePhenelzine
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Coadministration of Deprid 0.500mg Tablet with Phenelzine might raise serotonin hormone levels in the body, affecting the brain and nerve cells.

How to manage the interaction:
Taking Deprid 0.500mg Tablet and Phenelzine together is not recommended as it can result in an interaction. It can be taken if your doctor has advised it. However, if you experience confusion, hallucinations, seizures, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremors, incoordination, stomach cramps, nausea, vomiting, and diarrhea, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
ImipramineTranylcypromine
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Taking Tranylcypromine can increase the risk of Deprid 0.500mg Tablet on serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Tranylcypromine with Deprid 0.500mg Tablet is not recommended, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
ImipramineZiprasidone
Critical
How does the drug interact with Deprid 0.500mg Tablet:
Using ziprasidone together with Deprid 0.500mg Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Deprid 0.500mg Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
ImipramineThioridazine
Critical
How does the drug interact with Deprid 0.500mg Tablet:
When Thioridazine and Deprid 0.500mg Tablet are taken together, the body's ability to break down Thioridazine may be reduced. This can increase the risk or severity of side effects.

How to manage the interaction:
Taking Deprid 0.500mg Tablet with Thioridazine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience extreme drowsiness, confusion, agitation, vomiting, blurred vision, feeling hot or cold, sweating, muscle stiffness, fainting, or seizure, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Maintain a healthy diet and exercise regularly as it helps in improving overall health and boosts self-esteem.
  • Regularly attend therapy sessions.
  • Perform meditation and yoga. This helps in relieving stress and provides relaxation.
  • Follow a regular sleep pattern to improve the amount and quality of sleep you get.
  • Include foods rich in omega fatty acids such as fish, nuts, fresh fruits, vegetables and olive oils.
  • Neurotransmitters are made up of amino acids. Amino acid-rich foods such as meat, dairy products, and certain fruits and vegetables help in the proper maintenance of neurotransmitters. 
  • Complex carbohydrates help in stimulating serotonin (a feel-good neurotransmitter). These include whole grains, legumes, spinach, broccoli, oranges and pears.
  • Exercising helps in the production of the body’s natural anti-depressants. It also helps in relieving stress, improves mood, boosts self-esteem and provides restful sleep.
  • Avoid smoking and alcohol consumption.
  • Learn about your condition, understand the risk factors and follow the doctor’s treatment plan.

Habit Forming

No

Therapeutic Class

PSYCHOTHERAPEUTICS

DEPRID 0.500MG TABLET Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

Avoid consumption of alcohol while taking DEPRID 0.500MG TABLET as it may cause increased drowsiness.

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Pregnancy

Caution

DEPRID 0.500MG TABLET belongs to pregnancy category C. Please consult your doctor if you have any concerns regarding this; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Caution

DEPRID 0.500MG TABLET may pass into breastmilk. Consult your doctor before taking DEPRID 0.500MG TABLET; your doctor will decide whether DEPRID 0.500MG TABLET can be taken by breastfeeding mothers or not.

bannner image

Driving

Unsafe

DEPRID 0.500MG TABLET may cause impaired alertness, drowsiness or blurred vision. Do not drive or operate machinery if you experience these symptoms.

bannner image

Liver

Caution

Dose adjustment may be needed in patients with liver impairment. Please consult your doctor if you have a liver impairment or any concerns regarding this.

bannner image

Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please consult your doctor if you have kidney impairment or any concerns regarding this.

bannner image

Children

Caution

DEPRID 0.500MG TABLET is not recommended for children below 6 years as its safety and effectiveness have not been established.

Have a query?

FAQs

DEPRID 0.500MG TABLET is used to treat depression. Additionally, it is also used to treat bed-wetting at night in children aged 6 years and older.

DEPRID 0.500MG TABLET works by increasing mood-enhancing chemical messengers (neurotransmitters) such as serotonin and norepinephrine in the brain that communicate between brain cells, thereby regulating mood and treating depression.

Do not discontinue DEPRID 0.500MG TABLET without consulting your doctor as it could lead to withdrawal symptoms. To treat your condition effectually, continue taking DEPRID 0.500MG TABLET for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking DEPRID 0.500MG TABLET. The doctor may reduce the dose gradually to prevent withdrawal symptoms.

Dry mouth could be a side-effect of DEPRID 0.500MG TABLET. Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.

Orthostatic hypotension could be a side-effect of DEPRID 0.500MG TABLET. Orthostatic hypotension is a sudden lowering in blood pressure leading to dizziness on standing. If you experience this, do not try to stand up suddenly or start walking, instead, lie down and get up slowly only when you feel better.

DEPRID 0.500MG TABLET may cause photosensitivity or increased sensitivity to sunlight. Therefore, people taking DEPRID 0.500MG TABLET should avoid excessive exposure to sunlight or tanning beds. Use effective sunscreen and wear protective clothing while going outside.

Consult your doctor before taking DEPRID 0.500MG TABLET if you are diabetic, as DEPRID 0.500MG TABLET may cause elevation or lower blood glucose levels. Regularly monitor blood sugar levels while taking DEPRID 0.500MG TABLET.

DEPRID 0.500MG TABLET may make your open-angle glaucoma worse. Your doctor may monitor your vision while you’re taking this medication.

DEPRID 0.500MG TABLET may affect blood sugar levels, especially in people with diabetes. It can cause fluctuations in blood sugar, so it's important to monitor your levels closely and consult your doctor for personalized advice.

DEPRID 0.500MG TABLET may cause weight gain in some people as it is an antidepressant that works by blocking certain neurotransmitters. This can lead to increased appetite and changes in metabolism, resulting in weight gain. Monitor your weight and discuss any changes with your doctor. They can adjust your medication or suggest lifestyle changes to manage this side effect.

DEPRID 0.500MG TABLET is not an addictive or habit-forming medication.

The common side effects of DEPRID 0.500MG TABLET you may experience are dry mouth, nausea, vomiting, increased blood pressure, lack of coordination, swelling of the breast, and weakness. However, these symptoms vanish as your body adjusts to the medication. If these symptoms become worse, please consult a doctor for relief.

No, you should not stop taking DEPRID 0.500MG TABLET suddenly without consulting your doctor. Stopping abruptly can lead to withdrawal symptoms like nervousness, anxiety, and irritability.

DEPRID 0.500MG TABLET belongs to pregnancy category C medication, meaning it may be harmful to a fetus. Please consult your doctor before taking DEPRID 0.500MG TABLET if you plan to become pregnant or are already pregnant. Your doctor will weigh the potential risks and benefits before prescribing DEPRID 0.500MG TABLET.

Store DEPRID 0.500MG TABLET in a cool, dry place away from sunlight. Keep it out of reach of children.

DEPRID 0.500MG TABLET may cause drowsiness or sleepiness, especially when first starting the medication or increasing the dosage. This sedative effect may decrease as your body adjusts to the medication. If it is not, consult the doctor.

If you forget a dose of DEPRID 0.500MG TABLET, take it immediately when you remember. However, if your next dose is near, skip the missed dose and continue with your regular schedule. Never double dose to make up for a missed dose, as this may increase side effects.

Taking more than the recommended dosage does not provide additional relief and can increase the risk of adverse effects.

Country of origin

INDIA

Manufacturer/Marketer address

30-22-118, First Floor, Eluru Road,Seetharampuram,Vijayawada 520 002,Andhra Pradesh
Other Info - DEP0059

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:48 PM IST

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Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/040903lbl.pdf
  2. https://www.medicines.org.uk/emc/files/pil.5789.pdf
  3. https://medlineplus.gov/druginfo/meds/a682389.html
  4. https://www.drugs.com/mtm/imipramine.html
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