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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Divaa 250mg Solution is used to treat epilepsy, seizures or fits. Additionally, it is also used to treat manic episodes associated with bipolar disorder and to prevent migraine. It contains Divalproex sodium, which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. It helps block the nerve transmission across the brain and provides a calming effect. Thereby, helps treat bipolar disorder. In some cases, it may cause common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Return Policy :

Not Returnable

About Divaa 250mg Solution

Divaa 250mg Solution is used to treat epilepsy, seizures or fits. Epilepsy is a sudden rush of electricity in the brain. In epilepsy, the brain's electrical rhythms become imbalanced, resulting in recurrent seizures.

Divaa 250mg Solution contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures.

In some cases, you may experience certain common side effects, such as abdominal pain, back pain, constipation, diarrhoea, dizziness, nausea, increased appetite, and vomiting. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Inform your doctor about your health, allergies, and medicines to avoid side effects. Do not take Divaa 250mg Solution if you are pregnant, as it could cause severe birth defects. Consult your doctor before taking Divaa 250mg Solution if you are breastfeeding. Use Divaa 250mg Solution cautiously in children under 2 years, due to higher liver risk in the first 6 months.

Uses of Divaa 250mg Solution

Divaa 250mg Solution is used in the treatment of seizures, bipolar disorder, and migraine. The detailed uses of Divaa 250mg Solution are as follows:

  • Bipolar Disorder: Divaa 250mg Solution treats manic episodes associated with bipolar disorder, stabilizes mood, and reduces symptoms.
  • Seizure Treatment: Divaa 250mg Solution is used for treating complex partial seizures, absence seizures, and multiple seizure types by stabilizing electrical activity in the brain.
  • Migraine Prevention: Divaa 250mg Solution prevents migraine headaches by reducing frequency and severity.

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Directions for Use

  • Divaa 250mg Solution can be taken with or without food, or as advised by the doctor.
  • It is usually taken once daily; however, your doctor may adjust the dose and frequency based on your medical condition.
  • Swallow Divaa 250mg Solution as a whole with a glass of water.
  • Do not crush, chew, break, or open it.

Key Benefits

  • Divaa 250mg Solution belongs to a group of medicines called anticonvulsants or anti-epileptics.
  • Divaa 250mg Solution is used to treat epilepsy/seizures/fits. Additionally, Divaa 250mg Solution is also used to treat mood disorders and to prevent migraine headaches.
  • Divaa 250mg Solution decreases the excessive and abnormal nerve activity in the brain. Thereby helps in controlling seizures.
  • Divaa 250mg Solution treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect.
  • Divaa 250mg Solution prevents migraine headaches by limiting the transmission of nerve pain.
  • Divaa 250mg Solution is used alone or in combination to treat simple seizures, complex partial seizures, and complex absence seizures.
  • Divaa 250mg Solution is used in combination to treat multiple seizures, such as absence seizures.

How Divaa 250mg Solution Works

Divaa 250mg Solution contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping in controlling seizures. Divaa 250mg Solution increases the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.

Storage

Store in a cool and dry place away from sunlight
Side effects of Divaa 250mg Solution 100ml
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.

What if I have taken an overdose of Divaa 250mg Solution

Please do not take more than the prescribed dose of Divaa 250mg Solution , as it may lead to serious side effects. The symptoms of an overdose may include heart block, excess sleepiness, and deep coma. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Do not take Divaa 250mg Solution if you are allergic to any of its contents, have/had liver problems, or urea cycle disorders.
  • Inform your doctor before taking Divaa 250mg Solution if you have pancreatitis, blood problems, or multi-organ hypersensitivity.
  • Consult your doctor immediately if you experience suicidal tendencies while taking Divaa 250mg Solution .
  • Divaa 250mg Solution may cause thrombocytopenia (low blood platelets), hyperammonemia (high levels of ammonia in the blood), hypothermia (low body temperature), and liver problems.
  • Please do not stop taking Divaa 250mg Solution without consulting your doctor to avoid worsening of seizures.
  • Do not take Divaa 250mg Solution if you are pregnant, as it could cause serious birth defects.
  • If you are of child-bearing age, use effective contraception while taking Divaa 250mg Solution .
  • Avoid driving or operating machinery, as Divaa 250mg Solution can cause dizziness and may affect thinking and motor skills.
  • Avoid consuming alcohol along with Divaa 250mg Solution as it could lead to increased dizziness.
  • Care should be taken while giving Divaa 250mg Solution to children below 2 years, as there is a higher risk of liver intoxication during the first 6 months of treatment.

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
DivalproexEsketamine
Severe

Drug-Drug Interactions

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DivalproexGlycerol phenylbutyrate
Critical
How does the drug interact with Divaa 250mg Solution 100ml:
Coadministration of Glycerol phenylbutyrate and Divaa 250mg Solution 100ml can increase ammonia levels in the blood.

How to manage the interaction:
Taking Glycerol phenylbutyrate and Divaa 250mg Solution 100ml together is generally avoided as it can lead to an interaction, it can be taken when your doctor advises. If you experience any symptoms like sudden dizziness, headaches, vomiting, and visual disturbances, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DivalproexEsketamine
Severe
How does the drug interact with Divaa 250mg Solution 100ml:
Coadministration of Esketamine and Divaa 250mg Solution 100ml can increase the side effects of esketamine.

How to manage the interaction:
Although taking Divaa 250mg Solution 100ml and Esketamine together can cause an interaction, it can be taken if your doctor has suggested it. However, if you experience any symptoms like drowsiness and impaired motor coordination, consult the doctor immediately. Do not stop using any medications without talking to your doctor.
How does the drug interact with Divaa 250mg Solution 100ml:
Co-administration of Divaa 250mg Solution 100ml and leflunomide can increase the risk of liver problems.

How to manage the interaction:
Although there is an interaction between Divaa 250mg Solution 100ml and leflunomide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, and/or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Divaa 250mg Solution 100ml:
Co-administration of Divaa 250mg Solution 100ml and Meropenem can reduce the blood levels of Divaa 250mg Solution 100ml sodium.

How to manage the interaction:
Co-administration of Divaa 250mg Solution 100ml with Meropenem can possibly result in an interaction, but it can be taken if your doctor has advised it. Do not discontinue any medications without a doctor's advice.
How does the drug interact with Divaa 250mg Solution 100ml:
Coadministration of Ertapenem with Divaa 250mg Solution 100ml may reduce the blood levels of Divaa 250mg Solution 100ml and increase the risk of developing seizures.

How to manage the interaction:
Although there is a possible interaction, ertapenem can be taken with Divaa 250mg Solution 100ml if prescribed by the doctor. Consult the doctor if you experience loss of seizure control or changes in behaviour. Do not stop using any medications without talking to your doctor.
How does the drug interact with Divaa 250mg Solution 100ml:
Co-administration of Divaa 250mg Solution 100ml and teriflunomide can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Divaa 250mg Solution 100ml and teriflunomide can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like fever, chills, joint pain, unusual bleeding, weakness, nausea, vomiting, stomach pain, dark urine, pale stools, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Divaa 250mg Solution 100ml:
Coadministration of Ketoconazole and Divaa 250mg Solution 100ml may increase the risk of liver damage.

How to manage the interaction:
Although taking Ketoconazole and Divaa 250mg Solution 100ml together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you have any of the following symptoms: fever, chills, joint pain, fatigue, nausea, vomiting, stomach pain, dark urine, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Divaa 250mg Solution 100ml:
Co-administration of Divaa 250mg Solution 100ml and Ketamine can increase the risk of side effects.

How to manage the interaction:
Co-administration of Divaa 250mg Solution 100ml and Ketamine can lead to an interaction, it can be taken if advised by your doctor. If you have any symptoms such as dizziness, drowsiness, shortness of breath, or impairment in thinking and motor coordination, make sure to contact your doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Divaa 250mg Solution 100ml:
Co-administration of Divaa 250mg Solution 100ml and Doripenem can reduce the blood levels of Divaa 250mg Solution 100ml sodium and increase the risk of developing seizures.

How to manage the interaction:
Co-administration of Divaa 250mg Solution 100ml with Doripenem can possibly result in an interaction, it can be taken when your doctor has advised it. Do not stop using any medications without first talking to your doctor.
How does the drug interact with Divaa 250mg Solution 100ml:
Coadministration of Divaa 250mg Solution 100ml and Lamotrigine can increase the risk and severity of side effects.

How to manage the interaction:
Although there is a possible interaction between Divaa 250mg Solution 100ml and Lamotrigine, you can take these medicines together if prescribed by your doctor. However, contact your doctor if you experience restlessness, rash, or muscle weakness. Do not stop using any medications without a doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • A ketogenic diet (low in carbohydrates and high in fats) is recommended for children with epilepsy. This diet helps in utilizing fat instead of glucose for energy generation.
  • The Atkins diet (high fat and controlled carbohydrates) is recommended for adolescents and adults.
  • Exercising regularly helps maintain weight and improve overall health.
  • Rest well, get plenty of sleep.
  • Avoid smoking and alcohol consumption.
  • Meditation and yoga can help lower stress, decrease pain sensitivity, and improve coping skills.
  • Have a seizure response plan, and help those around you know what to do.
  • Prepare your living area; small changes may reduce the risk of physical injury during a seizure.
  • Understand what triggers seizures and try reducing or avoiding them.
  • Please pay attention to overall health, as it can help in reducing seizure activity.
  • Install an alarm or emergency device to get assistance during a seizure attack.

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

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Alcohol

Safe if prescribed

Avoid consumption of alcohol while taking Divaa 250mg Solution , as it may cause increased dizziness.

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Pregnancy

Consult your doctor

Divaa 250mg Solution belongs to pregnancy category D. Avoid taking Divaa 250mg Solution if you are pregnant, as it could lead to serious birth defects. Consult your doctor for further advice.

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Breast Feeding

Consult your doctor

Divaa 250mg Solution may pass into breastmilk. Consult your doctor before taking Divaa 250mg Solution if you are breastfeeding.

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Driving

Safe if prescribed

Divaa 250mg Solution causes dizziness and may affect thinking and motor skills. Do not drive or operate machinery until you are mentally alert.

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Liver

Consult your doctor

Divaa 250mg Solution should not be used if you have liver problems or your family has a history of liver problems. Please consult your doctor if you have liver problems or any concerns regarding this.

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Kidney

Consult your doctor

Please consult your doctor if you have kidney impairment or any concerns regarding this. Dose adjustment may be needed in patients with kidney impairment.

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Children

Safe if prescribed

Divaa 250mg Solution can be given to children if prescribed by the doctor. The doctor will adjust the dose depending on the child's body weight. Care should be taken in children below 2 years as they are at a higher risk of liver toxicity.

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Heart

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Divaa 250mg Solution can be given in elderly patients with extreme caution due to the serious adverse effects.

FAQs

Divaa 250mg Solution belongs to a group of medicines called anticonvulsants or anti-epileptics used to treat epilepsy/seizures/fits. Additionally, Divaa 250mg Solution is also used to treat manic episodes associated with bipolar disorder and to prevent migraine.

Divaa 250mg Solution contains 'Divalproex sodium', which decreases the brain's excessive and abnormal nerve activity, thereby helping to control seizures. Divaa 250mg Solution increases the amount of a chemical substance called GABA, which helps block the nerve transmission across the brain and provides a calming effect. Thereby, it helps treat bipolar disorder.

Divaa 250mg Solution helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA, which helps in blocking the nerve transmission across the brain and provides a calming effect.

Divaa 250mg Solution limits the transmission of nerve pain, thereby preventing migraine headaches. Migraine is a neurological condition characterised by intense headaches.

Do not discontinue Divaa 250mg Solution without consulting your doctor. To treat your condition effectively, continue taking Divaa 250mg Solution for as long as prescribed. Do not be reluctant to speak with your doctor if you feel any difficulty while taking Divaa 250mg Solution . Your doctor will reduce the dose gradually to avoid worsening of seizures.

Divaa 250mg Solution may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with Divaa 250mg Solution . Avoid getting pregnant while taking Divaa 250mg Solution as it could lead to serious birth defects. Do not stop taking Divaa 250mg Solution and consult your doctor immediately if you become pregnant.

Divaa 250mg Solution may cause thrombocytopenia (low levels of platelets). This might increase the risk of bleeding and bruising. Be cautious while using sharp objects. Consult your doctor if you notice unexplained bleeding or bruising. Regular monitoring of blood count is advised while taking Divaa 250mg Solution .

Topiramate (anticonvulsant) should not be taken along with Divaa 250mg Solution as it may cause hyperammonemia (excess ammonia in the blood), hypothermia (low body temperature) and liver problems.

It is crucial to consult with your doctor before discontinuing Divaa 250mg Solution . Abruptly stopping this medication can lead to severe consequences, mainly if it's prescribed to treat conditions like epilepsy.

Divaa 250mg Solution is also used to treat mood disorders. It treats mood disorders by increasing the amount of a chemical substance called GABA, which helps block nerve transmission across the brain and provides a calming effect.

Divaa 250mg Solution can indeed make you sleepy. This is a common side effect of the medication. If you're experiencing excessive drowsiness, please consult your doctor.

Yes, Divaa 250mg Solution can cause hair loss as a side effect. While this isn't a common side effect, it can occur in some people. If you notice significant hair loss while taking Divaa 250mg Solution , it's essential to consult with your doctor.

Yes, Divaa 250mg Solution can potentially damage your liver. While this is a rare side effect, being aware of the risk is essential. Signs of liver damage may include yellowing of the skin or eyes or jaundice, dark urine, abdominal pain, light-coloured stools, nausea and vomiting. If you experience any of these symptoms while taking Divaa 250mg Solution , seeking medical attention is crucial.

Avoid consumption of alcohol while taking Divaa 250mg Solution , as it may cause increased dizziness.

If you experience abdominal pain, nausea, and anorexia while taking Divaa 250mg Solution , it's essential to contact your doctor immediately. These symptoms can be signs of a severe side effect, such as liver damage.

An overdose of Divaa 250mg Solution can be a severe medical emergency. The symptoms of an overdose may include heart block, excess sleepiness, and deep coma. If you or someone you know has taken an overdose of Divaa 250mg Solution , please seek immediate medical attention.

Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - DIV0177

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