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compositionComposition:VALPROIC ACID-500MG
prescriptionPrescription Medicine
Divalrex-500mg Tablet 10's
Divalrex-500mg Tablet 10's

Divalrex-500mg Tablet is used to treat seizures and manage manic episodes in bipolar disorder. It also helps prevent migraine attacks. It supports better brain stability and reduces symptom frequency. This helps improve daily functioning and overall quality of life.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

VALPROIC ACID-500MG

Manufacturer/Marketer :

Knoll Healthcare Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Divalrex-500mg Tablet

Divalrex-500mg Tablet is used to treat epilepsy/seizures/fits. In addition, Divalrex-500mg Tablet also treats manic episodes associated with bipolar disorder. Additionally, it can prevent migraine symptoms (such as headache).

Divalrex-500mg Tablet contains valproic acid, which helps stabilise abnormal brain activity. It supports effective seizure control and helps calm overactive neural activity. It also helps manage mood changes in bipolar disorder and reduces the frequency of migraine attacks. This improves neurological balance and supports better functioning.

Administer Divalrex-500mg Tablet with food to prevent gastrointestinal upset. You may sometimes experience nausea, upset stomach or stomach pain, tremors (shakes), sleepiness, headache, weight gain and thinning hair. Most of these side effects do not require medical attention. However, talk to your doctor if you experience these side effects persistently.

Inform your doctor if you are allergic to any components present in Divalrex-500mg Tablet . If you are pregnant, do not take Divalrex-500mg Tablet because it may cause serious congenital defects. Divalrex-500mg Tablet is generally not recommended during breastfeeding; consult your physician before taking Divalrex-500mg Tablet .

Uses of Divalrex-500mg Tablet

Divalrex-500mg Tablet is used for the treatment of epilepsy (seizures), bipolar disorder, and migraine. The detailed uses of Divalrex-500mg Tablet are as follows:

  • Controls Seizures: Divalrex-500mg Tablet helps prevent and control seizures by calming overactive neural activity.
  • Manages Bipolar Disorder: Divalrex-500mg Tablet helps to control manic episodes and stabilise mood in individuals with bipolar disorder.
  • Prevents Migraine Headaches: Divalrex-500mg Tablet is also prescribed as a preventive treatment to reduce the frequency and severity of migraine attacks.

Have a query?

Directions for Use

  • Divalrex-500mg Tablet can be taken with food to avoid stomach upset.
  • It is usually taken twice daily; however, your doctor may adjust the dosage and timing based on your medical condition and response to treatment.
  • Swallow Divalrex-500mg Tablet as a whole with a glass of water.
  • Do not crush or chew this medication.

Key Benefits

Divalrex-500mg Tablet , when used as prescribed, may provide the following benefits:

For Controls Seizures:

  • Helps stabilise abnormal electrical activity in the brain.
  • Reduces sudden episodes of excessive brain stimulation

For Managing Bipolar Disorder:

  • Helps maintain emotional balance.
  • Reduces the intensity and frequency of extreme mood changes

For Preventing Migraine Headaches:

  • Helps reduce the risk of recurrent severe headaches.
  • Reduces the impact of migraine on daily life.

How Divalrex-500mg Tablet Works

Divalrex-500mg Tablet contains valproic acid, which helps calm excessive nerve activity in the brain. As a result, it aids in controlling seizures. In bipolar disorder, Divalrex-500mg Tablet raises the concentration of a chemical molecule known as GABA, which helps to stop nerve communication across the brain and has a calming effect. In migraine, Divalrex-500mg Tablet limits the transmission of pain, thereby preventing migraine.

Storage

Store in a cool and dry place away from sunlight
Side effects of Divalrex-500mg Tablet
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Do not stand up suddenly. Lie down and get up slowly only when you feel better.
  • Avoid alcohol and large meals.
  • Drink enough water before standing for long periods.
  • Exercise regularly; however, avoid exercising in extreme heat.
  • Eat small, low-carb meals.
  • Wear compression stockings.
Here are the steps to manage the medication-triggered Tachycardia (Fast Heart Rate):
  • Contact your doctor immediately if you're experiencing a fast heart rate, palpitations, or other heart-related symptoms. This is crucial to determine whether the symptoms are related to your medication.
  • Your doctor may need to adjust your medication regimen to alleviate the fast heart rate symptoms. This could involve changing the medication, reducing the dosage, or adding new medications to counteract the side effects.
  • Follow your doctor's advice on monitoring your heart rate and blood pressure. This will help track any changes and ensure your heart rate returns normal.
  • If you experience severe symptoms such as chest pain, dizziness, or shortness of breath, seek immediate medical attention. These symptoms can indicate a more serious condition that requires prompt treatment.
  • Regular exercise increases nitric oxide, relaxing blood vessels and improving circulation.
  • Avoid smoking and alcohol consumption as they can damage blood vessels and worsen vasodilation.
  • Foods high in omega-3 fatty acids such as walnuts, flaxseeds and fatty fish improve cardiovascular health and lower inflammation.
  • Limit the amount of salt in your regular diet.
  • Avoid triggers like alcohol, caffeine, and energy drinks.
  • Try relaxation techniques such as yoga, meditation, or deep breathing.
  • Exercise regularly as it helps maintain heart health.
  • Follow a nutritious and balanced diet.
  • Hallucination is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control hallucinations. You can share what is being seen with a therapist to know whether they are real or imaginary.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your imagination.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes of hallucinations.
  • Talk to your dietician and consume food that can improve your mental health.

What if I have taken an overdose of Divalrex-500mg Tablet

Avoid exceeding the prescribed dose, as this may lead to adverse effects. Symptoms of adverse effects may include sleepiness, an irregular heartbeat, and coma (loss of consciousness). If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

  • Before taking the Divalrex-500mg Tablet , let your doctor know about all your medical conditions, sensitivities, and all medications you are using.
  • Inform your doctor if you are pregnant, suspect you are pregnant, plan to have a baby, or are breastfeeding.
  • You should not become pregnant during treatment with Divalrex-500mg Tablet .
  • Consult your doctor immediately if you become pregnant while taking Divalrex-500mg Tablet .
  • Alcohol should be avoided during treatment with this medicine.
  • You must not drive or operate machinery while taking Divalrex-500mg Tablet .

Drug-Drug Interactions

verifiedApollotooltip
Sodium ValproateSodium phenylbutyrate
Critical
Sodium ValproateBuprenorphine
Severe

Drug-Drug Interactions

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Sodium ValproateSodium phenylbutyrate
Critical
How does the drug interact with Divalrex-500mg Tablet:
Combining Sodium phenylbutyrate and Divalrex-500mg Tablet can increase ammonia levels in the blood.

How to manage the interaction:
Taking Sodium phenylbutyrate with Divalrex-500mg Tablet is not recommended, but it can be taken if prescribed by a doctor. If you experience any symptoms like sudden dizziness, lightheadedness, fainting, headache, shortness of breath, nausea, vomiting, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateBuprenorphine
Severe
How does the drug interact with Divalrex-500mg Tablet:
Using buprenorphine together with Divalrex-500mg Tablet may increase the risk of severe side effects, including respiratory problems and loss of consciousness.

How to manage the interaction:
Although the administration of buprenorphine alongside Divalrex-500mg Tablet can result in an interaction, it can be taken if a doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateDoripenem
Severe
How does the drug interact with Divalrex-500mg Tablet:
Co-administration of Divalrex-500mg Tablet with doripenem can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Doripenam and Divalrex-500mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, involuntary muscle movements, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateErtapenem
Severe
How does the drug interact with Divalrex-500mg Tablet:
The combined use of Ertapenem and Divalrex-500mg Tablet can reduce the blood levels of valproic acid.

How to manage the interaction:
Co-administration of Ertapenem and Divalrex-500mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like loss of seizure control or changes in behavior, consult your doctor immediately. Do not discontinue any medications without consulting the doctor.
Sodium ValproateLeflunomide
Severe
How does the drug interact with Divalrex-500mg Tablet:
Co-administration of Leflunomide and Divalrex-500mg Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Leflunomide and Divalrex-500mg Tablet can lead to an interaction, they can be taken together if prescribed by a doctor. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, abdominal pain, or yellowing of the skin or eyes, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateLithium
Severe
How does the drug interact with Divalrex-500mg Tablet:
Co-administration of Lithium with Divalrex-500mg Tablet can increase the risk irregular heart rhythm.

How to manage the interaction:
Co-administration of Lithium and Divalrex-500mg Tablet can lead to an interaction, but it can be taken if advised by your doctor. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, and difficulty concentrating. Do not discontinue any medications without consulting a doctor.
Sodium ValproateKetamine
Severe
How does the drug interact with Divalrex-500mg Tablet:
Co-administration of Ketamine and Divalrex-500mg Tablet can increase side effects and cause respiratory depression.

How to manage the interaction:
Co-administration of Ketamine and Divalrex-500mg Tablet can lead to an interaction, but it can be taken if your doctor advises. However, consult your doctor immediately if you experience any symptoms like dizziness, drowsiness, confusion, difficulty concentrating, excessive sedation, impaired thinking, judgment, and motor coordination. Avoid driving or operating hazardous machinery until you know how these medications affect you. Do not discontinue any medications without consulting the doctor.
Sodium ValproateVorinostat
Severe
How does the drug interact with Divalrex-500mg Tablet:
Co-administration of Vorinostat with Divalrex-500mg Tablet can increase the risk of unusual bleeding.

How to manage the interaction:
Co-administration of Vorinostat and Divalrex-500mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like unusual bleeding or bruising, vomiting, blood in your urine or stools, headache, dizziness, or weakness, consult your doctor immediately. Do not discontinue any medications without consulting your doctor.
Sodium ValproateMeropenem
Severe
How does the drug interact with Divalrex-500mg Tablet:
Co-administration of Meropenam and Divalrex-500mg Tablet together can reduce the effect of Divalrex-500mg Tablet.

How to manage the interaction:
Co-administration of Meropenam and Divalrex-500mg Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any unusual symptoms, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Sodium ValproateTeriflunomide
Severe
How does the drug interact with Divalrex-500mg Tablet:
Co-administration of Teriflunomide and Divalrex-500mg Tablet can increase the risk of causing liver problems.

How to manage the interaction:
Co-administration of Teriflunomide and Divalrex-500mg Tablet can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, light-colored stools, and yellowing of the skin or eyes. Avoid alcohol while taking these medications, and consult your doctor immediately. Do not discontinue any medications without consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

Diet:

  • Follow a high-fat, low-carbohydrate diet if advised by your doctor.
  • Maintain a balanced meal plan to support overall health.

Physical Activity:

  • Exercise regularly to help maintain a healthy weight and general fitness.

Safety & Preparedness:

  • Keep a seizure response plan and inform people around you.
  • Make simple home safety changes to reduce injury risk.
  • Identify and avoid known seizure triggers.
  • Use an alarm or emergency device to call for help during a seizure.

Rest & Sleep:

  • Get enough rest and sleep to reduce seizure risk.

Habits:

  • Avoid smoking and alcohol consumption.

Stress Management:

  • Practice meditation or yoga to reduce stress and improve coping ability.

Habit Forming

No

Therapeutic Class

[ANTICONVULSANT]

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Do not consume alcohol while taking Divalrex-500mg Tablet as alcohol can worsen the side effects of the Divalrex-500mg Tablet , including sleepiness and dizziness.

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Pregnancy

Unsafe

Divalrex-500mg Tablet is a Category D pregnancy drug. It is not recommended for use during pregnancy as it may cause an increase in the risk of a cleft lip, which is a congenital disability in the unborn baby. If you are a female able to have a baby, you must use an effective method of birth control (contraception) without interruption during your entire treatment with Divalrex-500mg Tablet .

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Breast Feeding

Caution

Divalrex-500mg Tablet passes into breast milk and may harm your infant. Please consult a doctor if you are breastfeeding before taking Divalrex-500mg Tablet . Breastfed infants are at risk for valproic acid-induced hepatotoxicity, so infants should be monitored for jaundice and other signs of liver damage during maternal therapy.

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Driving

Unsafe

Divalrex-500mg Tablet may cause dizziness, drowsiness, or fatigue in some individuals. Therefore, avoid driving if you feel drowsy, dizzy or tired after taking Divalrex-500mg Tablet .

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Liver

Caution

Inform your doctor before taking the Divalrex-500mg Tablet if you have a history of liver diseases. Extreme caution is recommended in patients with impaired liver function. Your doctor will weigh the benefits and potential risks before prescribing Divalrex-500mg Tablet .

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Kidney

Caution

Dose adjustment may be needed in patients with kidney impairment. Please inform your doctor if you have kidney impairment.

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Children

Caution

Use is not recommended for children under 10 years old. Your doctor will decide the dose based on your child's condition if they are more than ten years old.

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Heart

Caution

Divalrex-500mg Tablet can be used cautiously in patients with heart disease if prescribed by a physician.

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Geriatrics

Caution

Divalrex-500mg Tablet can be given to elderly patients with extreme caution if prescribed by a physician.

FAQs

Divalrex-500mg Tablet is used to treat epilepsy/seizures/fits. In addition, it also helps treat manic episodes associated with bipolar disorder and prevent migraine symptoms (like a headache).

Divalrex-500mg Tablet decreases the excessive and abnormal nerve activity in the brain. Thereby helping in controlling seizures.

Divalrex-500mg Tablet helps to treat manic episodes associated with bipolar disorder by increasing the amount of a chemical substance called GABA; this helps block nerve transmission across the brain and provides a calming effect.

Divalrex-500mg Tablet limits the transmission of nerve pain, thereby preventing migraine headaches. Migraines are a neurological condition characterised by intense headaches.

Divalrex-500mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Use an effective method of contraception during the treatment with Divalrex-500mg Tablet . Avoid getting pregnant while taking Divalrex-500mg Tablet as it could lead to serious birth defects. Do not stop taking Divalrex-500mg Tablet and consult your doctor immediately if you become pregnant.

Divalrex-500mg Tablet may cause weight gain due to an increase in appetite. Maintain a healthy weight by following a healthy diet and exercising regularly.

Divalrex-500mg Tablet may cause common side effects such as nausea, vomiting, headache, sleepiness, tremor, weakness, dizziness, stomach pain, and weight gain. If these side effects persist or worsen, please consult your doctor.

Divalrex-500mg Tablet contains Valproic acid as its active ingredient.

Take Divalrex-500mg Tablet with food to avoid stomach upset or as advised by your doctor.

You are recommended to avoid alcohol consumption while taking Divalrex-500mg Tablet as it may worsen the side effects of the Divalrex-500mg Tablet , including sleepiness and dizziness.

No, Divalrex-500mg Tablet does not cause addiction. However, Divalrex-500mg Tablet should be used as per the dose and duration prescribed by your doctor. Do not self-medicate.

Divalrex-500mg Tablet does not cure epilepsy; it only helps prevent seizures. However, you must take Divalrex-500mg Tablet for as long as your doctor advises. If you face any difficulty while taking Divalrex-500mg Tablet , consult your doctor.

If you stop taking Divalrex-500mg Tablet suddenly, it may increase the risk of recurrence of seizures. Therefore, it should be stopped gradually. If you feel the need to discontinue Divalrex-500mg Tablet , please consult your physician.

Some birth control pills (oestrogen-containing birth control pills) may lower the levels of Divalrex-500mg Tablet in blood. Thus, inform your doctor if you are using birth control pills and discuss with your doctor about a suitable method of contraception.

Divalrex-500mg Tablet is safe for long-term use in many patients when prescribed by a physician. In rare cases, prolonged use of Divalrex-500mg Tablet may weaken bones, thereby increasing the risk of fractures (osteopenia and osteoporosis). Get regular checkups for bone health if you have been taking Divalrex-500mg Tablet for a long time.

Divalrex-500mg Tablet may cause hair thinning, hair colour changes and even hair loss. If you have any concerns about this, please ask your doctor whether it is possible to reduce the dose of Divalrex-500mg Tablet . Your hair may regrow after either lowering your dose or changing medication.

Country of origin

INDIA

Manufacturer/Marketer address

M-17, Pharma Tower, Basement & Ground Floor, Badli Industrial Area, New Delhi 110 042
Other Info - DIV0212

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