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compositionComposition:DOXYCYCLINE-100MG
prescription
Prescription Medicine
info
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Doxybuz 100 mg Injection is an antibiotic medicine used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections, and periodontitis. This medicine contains doxycycline which works by inhibiting the protein synthesis of the bacterial cell and thereby helps fight infection-causing bacteria. This medicine is not effective for treating viral infections. Common side effects include pain, itching, swelling or redness at the site of injection, nausea, vomiting, or diarrhoea.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

DOXYCYCLINE-100MG

Manufacturer/Marketer :

Alniche Life Sciences Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Doxybuz 100 mg Injection

Doxybuz 100 mg Injection is a sterile injection used to treat a wide variety of severe bacterial infections. This medicine belongs to a class of antibiotics that stop the growth of bacteria, helping your body fight off the infection. It is typically prescribed when oral medications are not suitable or when a rapid clinical response is required.

Because this medicine is injected directly into a vein, it is usually given at regular intervals to maintain a consistent level in your body. Your healthcare provider will schedule these injections as prescribed, and it is vital to complete the entire course of treatment even if you feel better. To support your recovery, stay well-hydrated, eat a balanced diet, and get plenty of rest while receiving this therapy.

While receiving Doxybuz 100 mg Injection, you may experience mild side effects like nausea, vomiting, or irritation at the injection site. However, if you notice severe symptoms such as a severe skin rash, yellowing of your eyes or skin, or persistent watery diarrhoea, you should contact your doctor immediately. These serious reactions require prompt medical attention.

Before starting treatment, tell your doctor if you have liver disease, kidney problems, or a history of allergic reactions to similar antibiotics. Do not take this medicine if you are pregnant or breastfeeding, as it can affect developing teeth and bones. It should also be avoided in young children unless specifically directed by a doctor.

Doxybuz 100 mg Injection can interact with blood thinners such as warfarin and may increase their effect, which can raise the risk of bleeding. Your doctor may monitor you more closely if you are taking these medicines together. It is important to discuss your alcohol use with your doctor. Although alcohol is not known to significantly affect intravenous Doxybuz 100 mg Injection directly, heavy alcohol consumption may slow your recovery and increase the risk of side effects. Your doctor can advise you on what is safest during treatment.

Uses of Doxybuz 100 mg Injection

Your doctor may prescribe Doxybuz 100 mg Injection to help manage the following conditions:

  • Severe bacterial pneumonia: Doxybuz 100 mg Injection helps by stopping the growth of the bacteria causing the lung infection, allowing your lungs to clear.
  • Rickettsial infections (such as tick fevers): It targets and eliminates the specific bacteria transmitted by ticks, lice, or mites.
  • Severe urinary tract infections: It clears the bacterial overgrowth in the urinary system to relieve pain and frequent urination.
  • Skin and soft tissue infections: It halts the spread of bacteria in deep skin layers, reducing swelling, redness, and pain.
  • Intra-abdominal infections: When combined with other treatments, it helps resolve complex bacterial infections inside the abdomen.

Key Benefits

When used as directed as part of your treatment plan, this medicine may provide the following benefits:

  • Fast-Acting Infection Control: Because Doxybuz 100 mg Injection is injected directly into your bloodstream, it begins working almost immediately to fight off harmful bacteria, leading to a faster recovery from severe infections.
  • Alternative When Oral Medicines Aren't Possible: If you are unable to take oral medications due to severe illness, nausea, or surgery, this injection ensures you still receive the vital antibiotic treatment you need without relying on your digestive tract.
  • Broad-Spectrum Bacterial Coverage: This medicine is effective against many different types of bacteria when they are susceptible to Doxybuz 100 mg Injection. Your doctor may use culture or sensitivity test results, when available, to help choose the most appropriate antibiotic for your infection. 
Side effects of Doxybuz 100 mg Injection
  • Boost your immunity by including immune rich foods in your diet and always remember to stay hydrated.
  • Get sufficient sleep and manage stress which helps in improving white blood cell count.
  • Consult your doctor for an effective treatment to improve the blood cell count and get regular body check up to monitor changes in the count.
  • Try to prevent the factors that cause a decrease in the white blood cells that may lead to impaired immunity.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Heart failure needs immediate medical attention. To manage this effect, the doctor's instructions must be followed strictly.
  • Take care of change in your weight as there can be sudden changes.
  • Rest and refrain from physical activity, and restart after a few days.
  • Reduce your salt intake and control your diet with the help of a dietician.
  • Track your symptoms and keep your follow-up appointments to manage severe side effects.
  • Aim for at least five servings of a well-balanced diet per day that is full of vibrant fruits and vegetables.
  • Eat more whole foods, lean meats, and plant-based foods, and eat healthy fruits like bananas, oranges, and berries.
  • Limit alcohol intake and abstain from smoking to promote general wellbeing.
  • If you experience symptoms such as mouth ulcers, redness, difficulty in swallowing or talking, abdominal pain, and painful bowel movements as a drug side effect, consult your doctor as they may adjust the dose if necessary or prescribe alternative medication.
  • Practice good hygiene, such as washing your hands regularly, to prevent infection.
  • Drink plenty of water to keep your mucous membranes hydrated and promote healing.
  • Avoid spicy or acidic foods, which can irritate the mucous membranes and exacerbate inflammation.
  • Increase your intake of omega-3 fatty acids, found in fatty fish, nuts, and seeds, to reduce inflammation.
  • Follow a soft food diet to reduce discomfort and promote healing.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safe and effective use.
  • Doxybuz 100 mg Injection will be administered by the doctor or healthcare professional.
  • Do not self-administer.

How Doxybuz 100 mg Injection Works

Doxybuz 100 mg Injection contains doxycycline and works by entering the bacterial cells and blocking their ability to produce essential proteins. Bacteria require these proteins to grow, multiply, and survive. By stopping protein production, the medicine prevents the bacteria from spreading further. This allows your body's natural immune system to easily target and destroy the remaining bacteria, clearing the infection.
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Alcohol

Caution

It is not known if alcohol affects Doxybuz 100 mg Injection. Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Doxybuz 100 mg Injection belongs to pregnancy category D. There are no adequate and well-controlled studies on the use of Doxybuz 100 mg Injection in pregnant women. In some cases, taking Doxybuz 100 mg Injection during pregnancy may affect tooth and bone development in the unborn baby. So, if you are pregnant or planning for pregnancy contact the doctor before using Doxybuz 100 mg Injection.

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Breast Feeding

Caution

Doxybuz 100 mg Injection is excreted in the breast milk. However, the extent of absorption of Doxybuz 100 mg Injection by the breastfed infant is not known. Hence, the nursing mother should consult the doctor before using Doxybuz 100 mg Injection.

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Driving

Caution

It is not known if Doxybuz 100 mg Injection affects your ability to drive. Drive or operate machinery only if you are alert.

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Liver

Caution

Doxybuz 100 mg Injection is to be taken with caution, especially if you have a history of liver diseases/conditions. The dose may have to be adjusted by your doctor.

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Kidney

Safe if prescribed

At the recommended doses, Doxybuz 100 mg Injection is safe to use in patients with kidney disease if prescribed by a doctor.

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Children

Caution

Use of Doxybuz 100 mg Injection during tooth development in infants and children below 8 years of age may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for children below 8 years of age.

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Heart

Consult your doctor

Consult your doctor if you have a history of heart disease. Your doctor will weigh the benefits and risks before administering Doxybuz 100 mg Injection.

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Geriatrics

Consult your doctor

Please consult a doctor before receiving Doxybuz 100 mg Injection in geriatric patients, as they may be more sensitive to side effects.

What if I have taken an overdose of Doxybuz 100 mg Injection

Since this medication is given by trained medical professionals, an overdose is highly unlikely. If you suspect you have received too much or experience severe symptoms after an infusion, notify your healthcare team or seek immediate medical attention right away.

Diet & Lifestyle Advise

  • Protect your skin from the sun: This medicine can make your skin highly sensitive to sunlight. Wear protective clothing and apply a high-SPF sunscreen when outdoors, and avoid tanning beds.
  • Stay well-hydrated: Drink plenty of fluids (unless advised otherwise by your doctor) to help your body process the medication and support recovery.
  • Support your gut health: Consider eating yoghurt or taking a probiotic supplement after completing your antibiotic course to help restore the healthy bacteria in your gut. Talk to your doctor or pharmacist first.
  • Inform your healthcare team about other IV fluids: If you are receiving calcium-containing solutions intravenously, tell your healthcare provider, as they should not be mixed in the same IV line as Doxybuz 100 mg Injection.
health query

Have a query?

How Soon It Starts Working

The time required for Doxybuz 100 mg Injection to start to work: The exact onset time of Doxybuz 100 mg Injection has not been clinically established. The time for which the effects of Doxybuz 100 mg Injection last: The duration of Doxybuz 100 mg Injection’s effect is clinically not established.

What if you forget to take Doxybuz 100 mg Injection

Because you will receive this medicine from a healthcare provider, it is unlikely that you will miss a dose. However, if you miss an appointment for your injection, contact your healthcare provider immediately to reschedule.

Storage

•Prior to mixing, store the dry powder vials at room temperature, ideally between 20°C to 25°C (68°F to 77°F).

Drug Warnings

  • Inspect the solution: Before giving the medicine, ensure the healthcare professional inspects the liquid. It should be clear and free of particles or discolouration.
  • Monitor the injection site: Pay close attention to the area around your IV line. If you experience burning, redness, or swelling, alert your healthcare provider immediately to prevent tissue irritation.
  • Complete the full course: Even if your symptoms disappear after a few doses, finish the entire prescribed treatment to ensure the infection is completely cleared and to prevent bacterial resistance.
  • Check for pregnancy: This medicine is generally not recommended during pregnancy because it may affect the developing baby's teeth and bones. If you are pregnant or think you may be pregnant, tell your doctor before starting treatment.
  • Do not share equipment: If you are receiving this treatment at home under professional supervision, ensure all needles and IV supplies are sterile and disposed of in a proper sharps container.

Drug-Drug Interactions

verifiedApollotooltip
  • Blood thinners (like warfarin): Doxybuz 100 mg Injection may increase the effect of these medications, raising your risk of bleeding.
  • Seizure medications (like phenobarbital, phenytoin, or carbamazepine): These drugs can speed up how quickly your body processes Doxybuz 100 mg Injection, making it less effective.
  • Retinoid medicines (like isotretinoin): Combining these can increase pressure inside the skull, leading to severe headaches or vision issues.
  • Certain antibiotics (such as penicillins): In some situations, taking Doxybuz 100 mg Injection together with certain antibiotics may affect how well one or both medicines work. Your doctor will prescribe this combination only when it is appropriate for your infection.
DoxorubicinZiprasidone
Critical
DoxorubicinInfliximab
Severe

Drug-Drug Interactions

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DoxorubicinZiprasidone
Critical
How does the drug interact with Doxybuz 100 mg Injection:
Coadministration of Doxybuz 100 mg Injection with Ziprasidone can increase the risk of abnormal heart rhythm.

How to manage the interaction:
Taking Ziprasidone with Doxybuz 100 mg Injection is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
DoxorubicinInfliximab
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Combining Infliximab with Doxybuz 100 mg Injection can increase the risk or severity of developing serious infections.

How to manage the interaction:
Co-administration of Infliximab with Doxybuz 100 mg Injection can result in an interaction, but it can be taken if your doctor has advised it. If you have any of these symptoms like fever, chills, diarrhea, sore throat, muscle pain, difficulty breathing, weight loss, and pain or burning when you pee, it's important to contact a doctor right away. Do not stop using any medications without a doctor's advice.
DoxorubicinCeritinib
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Taking Doxybuz 100 mg Injection with Ceritinib can increase the risk of an irregular heart rhythm and other side effects.

How to manage the interaction:
Taking Ceritinib with Doxybuz 100 mg Injection together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without consulting doctor.
DoxorubicinChloroquine
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Using chloroquine together with doxurubicin can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking chloroquine and Doxybuz 100 mg Injection together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DoxorubicinBaricitinib
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Using baricitinib together with Doxybuz 100 mg Injection may increase the risk of serious infections.

How to manage the interaction:
Although there is an interaction, baricitinib can be taken with Doxybuz 100 mg Injection if prescribed by the doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in your coughing fluid, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor. Do not discontinue any medication without consulting a doctor.
DoxorubicinGatifloxacin
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Taking Gatifloxacin and Doxybuz 100 mg Injection can increase the risk or severity of irregular heart rhythms. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Taking Gatifloxacin and Doxybuz 100 mg Injection together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
DoxorubicinClozapine
Severe
How does the drug interact with Doxybuz 100 mg Injection:
Taking Doxybuz 100 mg Injection and clozapine may increase the risk of neutropenia.

How to manage the interaction:
Co-administration of Doxybuz 100 mg Injection with Clozapine can possibly result in an interaction, but it can be taken if your doctor has advised it. If you notice any of these symptoms - like a severe infection, fever, diarrhea, sore throat, muscle pain, or difficulty breathing - it's important to call your doctor right away." Do not discontinue any medications without first consulting your doctor.
DoxorubicinHydroxychloroquine
Severe
How does the drug interact with Doxybuz 100 mg Injection:
The combined use of Doxybuz 100 mg Injection and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Doxybuz 100 mg Injection and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
DoxorubicinEtanercept
Severe
How does the drug interact with Doxybuz 100 mg Injection:
When Etanercept is used with Doxybuz 100 mg Injection, the likelihood or severity of infection may increase.

How to manage the interaction:
Co-administration of Etanercept with Doxybuz 100 mg Injection can possibly result in an interaction, but it can be taken if your doctor has advised it. However, If you develop fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult your doctor immediately. Do not discontinue any medications without a doctor's advice.
DoxorubicinDisopyramide
Severe
How does the drug interact with Doxybuz 100 mg Injection:
The combined use of Doxybuz 100 mg Injection and Disopyramide can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Doxybuz 100 mg Injection and Disopyramide can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, heart palpitations, diarrhea, or vomiting, contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Doxybuz 100 mg Injection when used as directed. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIBIOTICS]

FAQs

Doxybuz 100 mg Injection belongs to a group of medications called tetracycline antibiotics used to treat bacterial infections such as urinary tract infections, intestinal infections, respiratory infections, eye infections, skin infections, sexually transmitted infections (gonorrhoea, syphilis), and gum infections (periodontitis). Besides this, Doxybuz 100 mg Injection may also be used to treat or prevent anthrax.
Doxybuz 100 mg Injection stops the growth of bacteria by preventing the synthesis of essential proteins necessary for their survival. Thereby, Doxybuz 100 mg Injection helps treat bacterial infections.
No, Doxybuz 100 mg Injection should not be stopped even if you feel better as it is an antibiotic medication and completing the full course is necessary; otherwise, the infection might re-appear in a more severe form and will also become difficult to treat due to antibiotic resistance.
If you are taking Doxybuz 100 mg Injection, avoid taking antacids containing aluminium, calcium or magnesium or other drugs containing these cations; oral zinc, iron salts or bismuth preparations within 2 hours of consumption of Doxybuz 100 mg Injection as they may affect the absorption of Doxybuz 100 mg Injection. Avoid taking dairy products within 2 hours of taking Doxybuz 100 mg Injection as they may also impair the absorption of Doxybuz 100 mg Injection.
Use of Doxybuz 100 mg Injection during tooth development (last half of pregnancy, infancy, and in children below the age of 8 years) may cause permanent staining of teeth (yellow-grey-brown). So, it is not recommended for pregnant women, breastfeeding mothers, and children below 8 years of age.
Doxybuz 100 mg Injection may make your skin sensitive to sunlight. So, apply sunscreen while going out and wear protective clothing and sunglasses. Avoid prolonged and unnecessary exposure to sunlight.
Doxybuz 100 mg Injection may lower the effectiveness of hormonal contraceptives such as birth control pills, rings, patches, or injections. Consult your doctor if you have any concerns, your doctor may advise regarding other forms of contraception.
Doxybuz 100 mg Injection does not completely prevent malaria caused by P. falciparum as Doxybuz 100 mg Injection is given as a prophylactic regimen (protection) whenever anyone enters a malaria-prone area.
Doxybuz 100 mg Injection is given parenterally, which means it is injected directly into a vein as an intravenous (IV) infusion. This is done slowly by a trained healthcare professional, usually in a hospital or clinic. Talk to your doctor or pharmacist for more details.
Doxybuz 100 mg Injection is generally not recommended for children younger than 8 years because exposure during tooth development may affect tooth colour. However, in certain serious infections, your doctor may decide that the benefits outweigh the risks. Always use this medicine exactly as prescribed by your child's doctor.
Most people can drive safely after receiving Doxybuz 100 mg Injection, as it does not typically cause drowsiness. However, if you experience dizziness or vision changes as a side effect, you should avoid driving or operating machinery. Talk to your doctor or pharmacist if you feel unwell.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.4063 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A601141 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Drugs.com Clinical Review Team. Doxycycline Injection Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Doxycycline 100 mg Capsules – Summary of Product Characteristics [Internet]. London: electronic Medicines Compendium (emc); [Accessed on 2025 Sep 16]Check here
  5. Doxycycline Hyclate (Oral Route): Drug Information [Internet]. WebMD LLC; [Accessed on 2025 Sep 16]Check here
  6. Mu Q, Tavella VJ, Luo XM. Role of Lactobacillus reuteri in Human Health and Diseases. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. April 2018. [Accessed on 11th August 2022]Check here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 28 Mar. 2019]Check here

Country of origin

INDIA

Manufacturer/Marketer address

Alniche Life Sciences Pvt. Ltd., S-14, 2nd Floor, Janta Market Rajouri Garden, New Delhi – 110 027
Other Info - DOX0286
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