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compositionComposition:HYDROXYUREA-500MG
prescriptionPrescription Medicine
Durea 500 mg Capsule 10's

Durea 500 mg Capsule 10's is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage). It works by blocking an enzyme that is required for growing cells. This prevents the cancer cells from multiplying and growing. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs). This helps the RBCs accept a normal shape, restores the flow of blood, and protects against problems like painful sickle cell attacks. It may cause side effects such as loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

HYDROXYUREA-500MG

Manufacturer/Marketer :

Samarth Life Sciences Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Durea 500 mg Capsule 10's

Durea 500 mg Capsule 10's is an anticancer medicine used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage). Head and neck cancer is a disease including abnormal growth of the tissues of the neck and head that may also have the ability to attack or spread to other portions of the body.

In cancer, Durea 500 mg Capsule 10's works by blocking an enzyme that is required for growing cells. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs).

You may experience loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting. Most of these side effects of Durea 500 mg Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects are persistent, reach out to your doctor.

Take Durea 500 mg Capsule 10's as prescribed by your doctor. You are advised to take Durea 500 mg Capsule 10's for as long as your doctor has prescribed it for you, depending on your medical conditions. Do not chew, break, or crush the medicine. Swallow the medicine as a whole with a glass of water.

Before starting Durea 500 mg Capsule 10's, please inform your doctor if you have any allergies, kidney disease, liver disease, injury to your legs, HIV or AIDS, high levels of uric acid in your blood, or treatment with chemotherapy or radiation. Durea 500 mg Capsule 10's may increase the chances of other cancer. Inform your doctor about this risk. Immediately contact your doctor if you are pregnant because this Durea 500 mg Capsule 10's can cause harmful effects on the unborn baby.

Uses of Durea 500 mg Capsule 10's

Durea 500 mg Capsule 10's is used in the treatment of head and neck cancer, blood cancer, and sickle cell anaemia. The detailed uses of Durea 500 mg Capsule 10's are as follows:

  • Treats Head and Neck Cancer:Durea 500 mg Capsule 10's is used alone or in combination with radiotherapy to treat squamous cell carcinoma (skin cancer) of the head and neck by preventing the cancer cells from growing and multiplying.
  • Treats Blood Cancer: Durea 500 mg Capsule 10's helps slow the progression of chronic myeloid leukaemia by reducing the number of abnormal white blood cells in the bone marrow and blood.
  • Manages Ovarian Cancer: Durea 500 mg Capsule 10's is used as part of a chemotherapy treatment to help control the growth and spread of ovarian cancer cells.
  • Manages Sickle Cell Anaemia: Durea 500 mg Capsule 10's increases the level of fetal haemoglobin, which helps reduce the frequency of painful sickle cell attacks, the need for blood transfusion, and complications such as acute chest syndrome.

Key Benefits

  • Durea 500 mg Capsule 10's belongs to a group of the class known as an antimetabolite.
  • It is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage).
  • In cancer, Durea 500 mg Capsule 10's works by blocking an enzyme that is required for growing cells. This prevents the cancer cells from multiplying and growing.
  • In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs).
  • This helps the RBCs assume a normal shape, restores blood flow, and protects against problems like painful sickle cell attacks.

Directions for Use

  • Take Durea 500 mg Capsule 10's with or without food as advised by your doctor.
  • Durea 500 mg Capsule 10's is generally taken once a day or as directed by the doctor.
  • Swallow Durea 500 mg Capsule 10's as a whole with a glass of water.
  • Do not chew, crush, or break it.

How Durea 500 mg Capsule 10's Works

Durea 500 mg Capsule 10's works by blocking an enzyme required for cell growth. This prevents the cancer cells from multiplying and growing. In sickle cell disease, it works by increasing fetal haemoglobin (HbF) (haemoglobin of the unborn baby) levels in red blood cells (RBCs). This helps the RBCs assume a normal shape, restores blood flow, and protects against problems like painful sickle cell attacks.
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Alcohol

Consult your doctor

The drinking of alcohol (in small amounts) does not appear to affect the safety or usefulness of Durea 500 mg Capsule 10's. Taking alcohol in larger amounts causes dizziness.

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Pregnancy

Unsafe

Durea 500 mg Capsule 10's is not safe during pregnancy because it may cause harmful effects to the baby.

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Breast Feeding

Consult your doctor

It is unknown whether Durea 500 mg Capsule 10's is excreted in human milk. Please consult a doctor before using Durea 500 mg Capsule 10's while breastfeeding.

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Driving

Caution

Durea 500 mg Capsule 10's may cause dizziness or a severe headache. Therefore, drive only if you are alert after taking Durea 500 mg Capsule 10's.

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Liver

Consult your doctor

If you have any concerns regarding the use of Durea 500 mg Capsule 10's in patients with liver problems, please consult a doctor.

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Kidney

Consult your doctor

If you have any concerns regarding the use of Durea 500 mg Capsule 10's in patients with kidney problems, please consult a doctor.

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Children

Unsafe

The safety and efficacy of Durea 500 mg Capsule 10's have not been established in children. Therefore, it is not recommended for children.

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Heart

Consult your doctor

Please inform your doctor if you have any pre-existing heart problems

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Geriatrics

Consult your doctor

Limited information available for use of Durea 500 mg Capsule 10's in elderly patients. Please consult your doctor.

What if I have taken an overdose of Durea 500 mg Capsule 10's

Do not take more than the prescribed dose of Durea 500 mg Capsule 10's as it may cause an overdose. The symptoms of overdose include darkening of the skin, sores in the mouth and throat and pain, redness, swelling, and scaling on the hands and feet. If you suspect you have taken an overdose or notice signs of overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

  • Take Durea 500 mg Capsule 10's at the same time daily, either with or without a meal.
  • It is recommended to remain hydrated and drink a lot of fluids while taking Durea 500 mg Capsule 10's.
  • Do not miss any dose and finish the course as recommended by your doctor.
  • Use an efficient method of birth control to prevent pregnancy while taking this Durea 500 mg Capsule 10's.
  • Your doctor may get routine blood tests done to monitor your liver function, electrolyte levels, and blood cell count.

Have a query?

How Soon It Starts Working

  • The time required for Durea 500 mg Capsule 10's to start working: The time required for Durea 500 mg Capsule 10's to start working is 1 to 4 hours after administration. 
  • The time for which the effects of Durea 500 mg Capsule 10's last: The effect of Durea 500 mg Capsule 10's lasts for 24 hours.

What if you forget to take Durea 500 mg Capsule 10's

If you miss a dose of Durea 500 mg Capsule 10's, take it as soon as you remember. If it is almost time for the next dose, skip the missed dose and continue with the regular dosing schedule. Do not take a double dose to make up for the missed dose.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • Before taking Durea 500 mg Capsule 10's inform your doctor if you have any kind of infection because Durea 500 mg Capsule 10's may worsen the infections.
  • Consult your doctor if you experience any allergy symptoms.
  • Inform your doctor if you have any history of kidney disease, liver disease, injury to your legs, HIV or AIDS, high levels of uric acid in your blood, or treatment with chemotherapy or radiation.
  • Durea 500 mg Capsule 10's may increase the chances of other cancers. Inform your doctor about this risk.
  • Immediately contact your doctor if you are pregnant because this Durea 500 mg Capsule 10's can cause harmful effects on the unborn baby.
  • Both women and men using this Durea 500 mg Capsule 10's should use birth control to avoid pregnancy. 
  • The use of this Durea 500 mg Capsule 10's by either parent may result in birth defects.
  • You should not take this Durea 500 mg Capsule 10's during breastfeeding; inform your doctor if you take Durea 500 mg Capsule 10's.
  • If any powder from a damaged pill is leaked, wash it up immediately with a wet paper towel and dispose of the towel in a closed plastic bag out of reach of children.

Drug-Drug Interactions

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Drug-Drug Interaction: Durea 500 mg Capsule 10's may interact with antiviral medicines (didanosine, stavudine, and indinavir), pain killer (aspirin, ibuprofen), blood thinner (warfarin), antiallergic medicines (diphenhydramine), antigout medicine (allopurinol), medicine for sleep (zolpidem).

Drug-Food Interaction: No interactions found.

Drug-Disease Interaction: People affected with kidney disease, liver disease, reduce production of blood cells, and brain disorder.

HydroxycarbamideMepivacaine
Severe
HydroxycarbamideNatalizumab
Severe

Drug-Drug Interactions

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HydroxycarbamideMepivacaine
Severe
How does the drug interact with Durea 500mg Cap:
Mepivacaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Durea 500mg Cap, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Durea 500mg Cap and mepivacaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideNatalizumab
Severe
How does the drug interact with Durea 500mg Cap:
Taking Durea 500mg Cap with natalizumab, especially taking both simultaneously, may raise the risk of serious infections, which may lead to infections like progressive multifocal leukoencephalopathy (PML), an uncommon but dangerous viral infection of the brain that can result in impairment.

How to manage the interaction:
Co-administration of Durea 500mg Cap with natalizumab can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult your doctor immediately if you are experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination. If you have growing weakness on one side of your body, awkwardness of limbs, visual disruption, disorientation, or changes in thinking, memory, or personality, inform your doctor.
HydroxycarbamideEtanercept
Severe
How does the drug interact with Durea 500mg Cap:
Durea 500mg Cap when used in conjunction with etanercept may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Durea 500mg Cap with etanercept, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideCertolizumab
Severe
How does the drug interact with Durea 500mg Cap:
Durea 500mg Cap when used with certolizumab may raise the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Durea 500mg Cap with certolizumab, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideClozapine
Severe
How does the drug interact with Durea 500mg Cap:
Taking Durea 500mg Cap and Clozapine can increase the risk of severe infections.

How to manage the interaction:
There may be a possibility of interaction between Clozapine and Durea 500mg Cap, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate, consult a doctor.
HydroxycarbamideDeferiprone
Severe
How does the drug interact with Durea 500mg Cap:
Deferiprone can reduce white blood cell count, and taking it with other medications that might similarly influence white blood cell count or bone marrow function may raise the risk. As a result, you may be more susceptible to get serious infections.

How to manage the interaction:
Co-administration of Durea 500mg Cap with deferiprone can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideDidanosine
Severe
How does the drug interact with Durea 500mg Cap:
Combining Durea 500mg Cap with didanosine can have serious consequences on your liver or pancreas. Didanosine may potentially induce lactic acidosis (lactic acid buildup in the body).Lactic acidosis can develop gradually and worsen over time.

How to manage the interaction:
Co-administration of Durea 500mg Cap with didanosine can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you have any of the following symptoms while taking didanosine: strong discomfort in your upper stomach that spreads to your back, rapid heart rate, nausea and vomiting, diarrhoea, lack of appetite, low fever, dark urine, clay-colored faeces, or jaundice (yellowing of the skin or eyes), unusual muscle pain and weakness, trouble breathing, fast or uneven heart rate, stomach pain, and numbness or cold feeling in your arms or legs, contact the doctor immediately.
HydroxycarbamideVoclosporin
Severe
How does the drug interact with Durea 500mg Cap:
Durea 500mg Cap when used with voclosporin may raise the risk of severe infections, some kinds of cancer, including skin cancer and cancer of the lymph glands (lymphoma).

How to manage the interaction:
There may be a possibility of interaction between Durea 500mg Cap with voclosporin, but it can be taken if prescribed by a doctor. However, if you experience fever, chills, diarrhoea, sore throat, muscular pains, shortness of breath, blood in phlegm, weight loss, red or irritated skin, body sores, or discomfort or burning during urination, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
HydroxycarbamideProcaine
Severe
How does the drug interact with Durea 500mg Cap:
Procaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Durea 500mg Cap, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficiencies may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Durea 500mg Cap and procaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
HydroxycarbamideLevobupivacaine
Severe
How does the drug interact with Durea 500mg Cap:
Levobupivacaine has the potential to cause methemoglobinemia (a rare disorder in which the iron in the haemoglobin molecule (the red blood pigment) is defective, preventing it from carrying oxygen to the tissues adequately). This risk increases when used with Durea 500mg Cap, which may lead to methemoglobinemia. When taking these drugs, those who are extremely young (particularly newborns and babies), have heart or lung conditions, certain genetic predispositions, or have a glucose-6-phosphate dehydrogenase deficit may be more likely to develop methemoglobinemia.

How to manage the interaction:
Although taking Durea 500mg Cap and levobupivacaine together can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience symptoms such as grey discolouration of the skin, abnormal blood colouration, nausea, headache, dizziness, lightheadedness, fatigue, shortness of breath, rapid or shallow breathing, a rapid heartbeat, palpitation, anxiety, or confusion, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIMETABOLITES]

FAQs

Durea 500 mg Capsule 10's is used to treat head and neck cancer and sickle cell anaemia (blocking the flow of blood that causes pain and organ damage).

Take the Durea 500 mg Capsule 10's as soon as you can, but avoid the missed dose if it is nearly time for your next dose. Do not take two doses at one time. Get your prescription refilled before you run out of Durea 500 mg Capsule 10's entirely.

Immediately go to the emergency department of your nearest hospital. Be ready to tell or show what was taken, how much, and when it happened.

Durea 500 mg Capsule 10's may cause a risk of skin cancer. Avoid contact with sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outside. Do not handle Durea 500 mg Capsule 10's without the protection of skin.

Durea 500 mg Capsule 10's can cause dizziness and drowsiness during the first limited hours after you take it. These side effects are more expected to happen when you start taking Durea 500 mg Capsule 10's or when your doctor increases your dose.

Do not stop taking Durea 500 mg Capsule 10's without discussing it with your doctor. Your doctor will most likely tell you to take another medicine, folic acid (a vitamin), to reduce some of the side effects of this Durea 500 mg Capsule 10's. Take this Durea 500 mg Capsule 10's exactly as instructed.

Durea 500 mg Capsule 10's is a medication that requires careful monitoring and dosing based on your individual medical condition, weight, and other factors. Please consult your healthcare provider if you have any questions about your hydroxyurea dosage. They can provide personal guidance and ensure you're taking the correct amount.

Durea 500 mg Capsule 10's can cause diarrhoea as a side effect. If you have watery or bloody diarrhoea, call your doctor. Do not use anti-diarrhea medicine unless your paediatrician tells you to.

Yes, it is recommended that you avoid certain foods and drinks while taking Durea 500 mg Capsule 10's. Some substances can interact with the medication, potentially affecting its effectiveness or increasing the risk of side effects. Here are some things to avoid: alcohol, grapefruit, grapefruit juice, Foods high in tyramine (aged cheeses, cured meats, fermented foods, and certain types of beans), and excessive caffeine.

If you're feeling tired and weak while taking hydroxyurea, try these tips: rest when needed, eat healthy foods, drink plenty of water, and get enough sleep. Gentle exercise can also help. Discuss with your healthcare provider if you're experiencing severe fatigue or weakness that interferes with your daily activities. They may be able to adjust your treatment or recommend additional strategies.

Durea 500 mg Capsule 10's is not safe during pregnancy because it may cause harmful effects to the baby.

Durea 500 mg Capsule 10's can make your hair thin or fall out. This is a common side effect, but how much hair you lose can change from person to person. Sometimes, hair loss is temporary, but in rare cases, it can be permanent. If you're worried about hair loss, talk to your doctor. They can help you manage it.

If you notice any changes in your skin while taking Durea 500 mg Capsule 10's, talk to your doctor. It's common to have darker skin or a rash. To protect your skin, use sunscreen, moisturize, and avoid things that might irritate it. If your skin problems are severe, see a dermatologist.

If you are having trouble with constipation while taking Durea 500 mg Capsule 10's, try these tips: eat more fibre, drink plenty of water, exercise regularly, and consider using over-the-counter laxatives after talking to your doctor. Avoid food that can worsen constipation, and try to go to the bathroom at the same time each day. If your constipation is severe, talk to your doctor.

To reduce the risk of infection while taking Durea 500 mg Capsule 10's, wash your hands often, avoid sick people, keep your home clean, get vaccinated, watch for signs of infection, and follow your doctor's instructions.

Common side effects of Durea 500 mg Capsule 10's may include loss of appetite (feeling unwell and stomach upset), increased bleeding tendency, nausea, upset stomach, and vomiting. Most of these side effects of Durea 500 mg Capsule 10's do not require medical attention and gradually resolve over time. However, if the side effects persist, contact your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

Samarth House, 168, Bangur Nagar, Off Link Road, Near Ayappa Temple & Kallol Kali Temple, Goregaon (W), Mumbai - 400 090.
Other Info - DUR0078
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