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  3. Epnone 25 Tablet 10's

Epnone 25 Tablet 10's, Pack of 10 TABLETS
Epnone 25 Tablet 10's, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Epnone 25 Tablet is used to treat heart failure and high blood pressure. This medicine contains Eplerenone, which works by blocking the action of aldosterone and slowing the progression of heart failure, while also lowering blood pressure. In some cases, you may experience nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Before starting Epnone 25 Tablet , inform the doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Composition :

EPLERENONE-25MG

Manufacturer/Marketer :

Msn Laboratories Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Epnone 25 Tablet

Epnone 25 Tablet is used to treat your heart failure. It reduces the risk of death or the need for hospitalisation due to heart failure. Besides this, Epnone 25 Tablet is also used to treat high blood pressure.

Epnone 25 Tablet contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

In some cases, Epnone 25 Tablet may cause side effects like nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Most of these side effects of Epnone 25 Tablet do not require medical attention and resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Epnone 25 Tablet if you are allergic to any of its components. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your medical conditions and medicines to prevent any potential interactions.

Uses of Epnone 25 Tablet

Epnone 25 Tablet is used to treat heart failure and high blood pressure. The detailed uses of Epnone 25 Tablet are as follows:

  • Treatment of heart failure: Epnone 25 Tablet is indicated for patients with heart failure following a recent heart attack. It helps improve heart function, reduce symptoms, and lower the risk of hospitalisation and death due to heart-related complications.
  • Management of high blood pressure: Epnone 25 Tablet is also prescribed to lower elevated blood pressure, either alone or in combination with other antihypertensive medications.

Have a query?

Directions for Use

  • Epnone 25 Tablet can be taken with or without food.
  • Follow your doctor's instructions regarding the dosage and duration for effective results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Epnone 25 Tablet contains Eplerenone, an aldosterone antagonist that helps improve heart function and control blood pressure.
  • Epnone 25 Tablet is beneficial for stable patients with left ventricular systolic dysfunction and congestive heart failure following an acute myocardial infarction (heart attack).
  • It improves survival after a heart attack and helps reduce the risk of cardiovascular death and hospitalisation.
  • Epnone 25 Tablet is used in patients with mild but persistent heart failure symptoms, especially when previous treatments are insufficient.
  • Epnone 25 Tablet effectively lowers elevated blood pressure, which in turn reduces the risk of serious cardiovascular events such as stroke, heart attack (myocardial infarction), and heart failure. 
  • By blocking aldosterone (a hormone that can worsen heart failure and increase blood pressure), Epnone 25 Tablet helps treat heart failure and high blood pressure.

How Epnone 25 Tablet Works

Epnone 25 Tablet contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Epnone 25 Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Epnone 25 Tablet

Do not take more than the prescribed dose of Epnone 25 Tablet as it may cause an overdose. Symptoms of overdose include dizziness, fainting, blurred vision, stomach upset, tingling in arms and legs, weakness, lack of energy, loss of muscle tone, irregular or slow heartbeat, and cold/grey skin. If you experience any of these symptoms or suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Epnone 25 Tablet if you are allergic to any of its components, have severe liver or kidney disease, or high levels of potassium.
  • Inform your doctor if you have kidney or liver disease, fungal infection, depression, HIV infection, bacterial infection or if you are taking immunosuppressants, or lithium (used to treat manic disorders).
  • Consult your doctor if you are pregnant or breastfeeding.
  • Epnone 25 Tablet is not recommended for children as the safety and effectiveness have not been established.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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EplerenoneKetoconazole
Critical
EplerenonePosaconazole
Critical

Drug-Drug Interactions

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EplerenoneKetoconazole
Critical
How does the drug interact with Epnone 25 Tablet:
Coadministration of Ketoconazole with Epnone 25 Tablet can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking ketoconazole with Epnone 25 Tablet is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenonePosaconazole
Critical
How does the drug interact with Epnone 25 Tablet:
Coadministration of posaconazole with Epnone 25 Tablet can increase the blood levels of Epnone 25 Tablet. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between posaconazole and Epnone 25 Tablet, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
EplerenonePotassium citrate
Critical
How does the drug interact with Epnone 25 Tablet:
Taking Epnone 25 Tablet with Potassium citrate may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium citrate and Epnone 25 Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneClarithromycin
Critical
How does the drug interact with Epnone 25 Tablet:
Co-administration of Epnone 25 Tablet and Clarithromycin may significantly increase the blood levels and effects of Epnone 25 Tablet.This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Clarithromycin with Epnone 25 Tablet is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the Doctor's advice.
EplerenonePotassium chloride
Critical
How does the drug interact with Epnone 25 Tablet:
Using Epnone 25 Tablet together with Potassium chloride may significantly increase potassium levels in the blood.

How to manage the interaction:
Taking potassium chloride with Epnone 25 Tablet is not recommended. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat, consult the doctor immediately. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneItraconazole
Critical
How does the drug interact with Epnone 25 Tablet:
The blood levels and effects of Epnone 25 Tablet may be greatly increased when combined with itraconazole.

How to manage the interaction:
Although there is a possible interaction between Epnone 25 Tablet and Itraconazole, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.
EplerenoneNefazodone
Critical
How does the drug interact with Epnone 25 Tablet:
Coadministration of Nefazodone with Epnone 25 Tablet can increase the levels of Epnone 25 Tablet in the body.

How to manage the interaction:
Taking Nefazodone with Epnone 25 Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenonePotassium iodide
Critical
How does the drug interact with Epnone 25 Tablet:
Combining Epnone 25 Tablet with Potassium iodide may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and Epnone 25 Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneRitonavir
Critical
How does the drug interact with Epnone 25 Tablet:
Co-administration of Epnone 25 Tablet and Ritonavir may significantly increase the blood levels of Epnone 25 Tablet.

How to manage the interaction:
Taking Ritonavir and Epnone 25 Tablet together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenoneSaquinavir
Critical
How does the drug interact with Epnone 25 Tablet:
Co-administration of EPELENONE and SAQUINAVIR may significantly increase the blood levels and side effects of Epnone 25 Tablet. This can increase the risk of serious side effects like high blood potassium, which in severe cases can lead to kidney failure, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Taking saquinavir and Epnone 25 Tablet together is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the doctor's advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich foods such as blueberries, cherries, tomatoes, squash, and bell peppers.
  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid the consumption of too much salt or salty food.
  • Maintain a healthy weight with a BMI of 19.5-24.9.
  • Regular physical activity or exercise, like walking, improves your blood flow.
  • Avoid standing or sitting for extended periods.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ALDOSTERONE ANTAGONISTS

Epnone 25 Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Epnone 25 Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Epnone 25 Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks. Please consult your doctor if you are pregnant.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding. It should be used only if prescribed by a doctor and if the benefits outweigh the harms.

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Driving

Caution

Epnone 25 Tablet may cause dizziness. Dro not drive or operate machinery unless you are alert.

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Liver

Caution

Epnone 25 Tablet is not recommended for people with severe liver disease. Inform your doctor before starting Epnone 25 Tablet if you have a history of liver diseases/conditions.

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Kidney

Caution

Epnone 25 Tablet is not recommended for people with severe kidney disease. Inform your doctor before starting Epnone 25 Tablet if you have a history of kidney diseases/conditions.

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Children

Caution

Epnone 25 Tablet is not recommended for children below 12 years of age.

FAQs

Epnone 25 Tablet is used to treat heart failure and hypertension (high blood pressure).

Epnone 25 Tablet contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

Yes, Epnone 25 Tablet can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Epnone 25 Tablet . Please monitor your electrolyte level regularly to avoid increased blood potassium levels. Consult your doctor if you experience muscle cramps, diarrhoea, nausea, dizziness or headache.

No, Epnone 25 Tablet is not a blood thinner. It is a selective aldosterone blocker used to treat heart failure and high blood pressure.

Epnone 25 Tablet contains Eplerenone. It is an aldosterone antagonist type of potassium-sparing diuretic.

Epnone 25 Tablet may take up to 4 weeks to show its full effect. Keep taking Epnone 25 Tablet for the prescribed duration.

No, Epnone 25 Tablet is not known to cause erectile dysfunction. It does not have any effect on fertility.

Do not discontinue Epnone 25 Tablet without consulting the doctor. To treat your condition effectively, keep taking Epnone 25 Tablet for the prescribed duration.

Potassium-sparing diuretics increase urine production without depleting potassium reserves. Epnone 25 Tablet permits the body to lose sodium while retaining potassium. The amount of potassium may rise as a result. Therefore, your doctor may regularly check your potassium levels.

Your doctor might have recommended Eplerenone instead of Losartan as a blood pressure medication because losartan may have been insufficient in lowering your blood pressure. However, Eplerenone increases the risk of elevated potassium levels, which may not be suitable for you. Hence, the doctor has prescribed Epnone 25 Tablet along with hydrochlorothiazide to prevent the rise in potassium levels.

Before starting Epnone 25 Tablet , let the doctor know if you are taking aspirin. Taking aspirin with Epnone 25 Tablet may decrease the effects of Epnone 25 Tablet . Contact your doctor if you experience signs of high blood pressure such as headache, blurred vision, trouble concentrating, or dizziness.

Epnone 25 Tablet may cause side effects like nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Most of these side effects of Epnone 25 Tablet do not require medical attention and resolve over time. However, if the side effects are persistent, reach out to your doctor.

Country of origin

INDIA

Manufacturer/Marketer address

MSN Laboratories Pvt.Ltd., MSN House, Plot No: C-24, Industrial Estate, Sanathnagar, Hyderabad - 18 Telangana, INDIA
Other Info - EPN0004

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 30, 2025 | 8:04 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021437s013lbl.pdf
  2. https://www.nps.org.au/assets/medicines/0ebbd413-7e5c-40cc-897d-a77600780bee-reduced.pdf
  3. https://medlineplus.gov/druginfo/meds/a603004.html
  4. https://www.drugs.com/mtm/eplerenone.html
  5. https://www.medicines.org.uk/emc/product/9207/pil

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