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Espin-1.25 Tablet is used to treat high blood pressure and angina (chest pain). It contains S-amlodipine, which works by relaxing the blood vessels; this reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. In some cases, this medicine may cause side effects such as fatigue, headache, nausea, dizziness, and abdominal pain. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

S AMLODIPINE-1.25MG

Manufacturer/Marketer :

Intas Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Espin-1.25 Tablet

Espin-1.25 Tablet is an oral prescription medication primarily used to manage high blood pressure and prevent chest pain caused by reduced blood flow to the heart. It serves to protect your cardiovascular system by keeping your blood vessels relaxed and open. This helps to significantly reduce the risk of suffering a heart attack or stroke in the future.

For optimal results, this medication must be taken consistently once every day at the same time. You can take it either with or without food, as your daily meals do not interfere with how the medicine is absorbed. Adopting a low-sodium diet and engaging in regular exercise can further enhance the positive effects of this treatment on your blood pressure.

While using this medicine, some patients might experience mild side effects such as swelling in the ankles or hands, headaches, and tiredness. Although these are common, you should seek immediate medical assistance if you experience severe chest pain, a rapidly pounding heartbeat, or sudden fainting.

Before starting your treatment, you must consult your doctor if you have a history of liver damage or narrowing of the heart valves. Do not take this if you have extremely low blood pressure or if you are allergic to any active or inactive components of this medication.

This medication can interact with other blood pressure drugs, certain antifungal medicines, and alcohol, potentially causing your blood pressure to drop to unsafe levels. Pregnant women, breastfeeding mothers, and elderly individuals should consult their doctor to ensure this treatment is safe for them.

Uses of Espin-1.25 Tablet

Espin-1.25 Tablet is used to manage high blood pressure and prevent chest pain caused by reduced blood flow to the heart. The detailed uses of Espin-1.25 Tablet are as follows:

  • High blood pressure (Hypertension): Espin-1.25 Tablet relaxes and widens the blood vessels, allowing blood to flow more easily and helping to lower elevated blood pressure levels to a safer, healthier range.
  • Chronic stable angina (Chest pain): It helps prevent episodes of chest pain by improving blood flow and oxygen delivery to the heart muscle, especially during physical exertion.
  • Vasospastic angina (Prinzmetal's angina): It prevents spasms in the coronary arteries, ensuring a steady supply of blood to the heart to avoid sudden, painful chest spasms.

Key Benefits

Espin-1.25 Tablet helps manage high blood pressure and chest pain by improving blood flow and reducing the workload on the heart. With regular use, it supports long-term cardiovascular health and helps lower the risk of serious complications.

  • Helps Control High Blood Pressure: By maintaining blood pressure within a healthy range throughout the day, Espin-1.25 Tablet helps reduce strain on the heart and protects vital organs such as the kidneys, brain, and heart from long-term damage.
  • Helps Prevent Chest Pain (Angina): By improving blood supply to the heart, Espin-1.25 Tablet helps reduce the frequency and severity of angina attacks, allowing you to carry out daily activities and light physical exercise more comfortably.
  • Supports Long-Term Heart Health: Consistent blood pressure control with Espin-1.25 Tablet helps reduce the risk of complications such as stroke, heart failure, kidney disease, and other cardiovascular events, supporting overall wellbeing.

Directions for Use

  • Take Espin-1.25 Tablet with or without food as advised by your doctor.
  • It is advised to take Espin-1.25 Tablet once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Swallow it as a whole with a glass of water.
  • Do not crush or chew it.

How Espin-1.25 Tablet Works

Espin-1.25 Tablet contains S amlodipine, which belongs to a class of medications known as calcium channel blockers. It works by blocking calcium from entering the muscle cells of your blood vessels and heart. When calcium enters these cells, it causes them to contract and tighten. By stopping this process, the medication allows the blood vessels to relax and widen. This widening reduces the resistance your heart faces when pumping blood, which lowers your overall blood pressure. It also dilates the arteries supplying the heart, ensuring that more oxygen-rich blood reaches the heart muscle to prevent chest pain.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Espin-1.25 Tablet to avoid unpleasant side effects like lowering of blood pressure (hypotension).

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Pregnancy

Consult your doctor

Espin-1.25 Tablet is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking Espin-1.25 Tablet .

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Breast Feeding

Consult your doctor

Espin-1.25 Tablet is not recommended for use in breastfeeding women unless necessary. All the risks and benefits should be discussed with the doctor before taking this medicine.

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Driving

Unsafe

Drive with caution, as Espin-1.25 Tablet can cause drowsiness and impair driving ability.

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Liver

Caution

Espin-1.25 Tablet should be used with caution, especially if you have or have had a history of liver disease.

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Kidney

Safe if prescribed

Espin-1.25 Tablet is generally safe to prescribe in patients with kidney diseases, and dose adjustment is generally not required. However, your doctor will decide the appropriate dosage strength depending on the severity of your condition.

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Children

Consult your doctor

Espin-1.25 Tablet can be given safely to children aged 6-12 years, provided the dose has been prescribed by a child specialist. Espin-1.25 Tablet should not be given to the children without consulting a child specialist.

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Heart

Safe if prescribed

Espin-1.25 Tablet is often prescribed to patients with heart problems to treat hypertension. However, it must be taken strictly under medical supervision, as it can affect liver and kidney function and may interact with other heart medications.

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Geriatrics

Caution

Exercise caution before using Espin-1.25 Tablet in older patients. Please consult your doctor if you have any concerns.

What if I have taken an overdose of Espin-1.25 Tablet

If you take more than your prescribed dose, seek emergency medical attention immediately. An overdose can cause your blood pressure to drop dangerously low, leading to severe dizziness, confusion, and a rapid heart rate.

Diet & Lifestyle Advise

  • Limit your sodium intake: Reduce the amount of salt in your meals and avoid processed foods, as excess sodium raises blood pressure.
  • Eat a heart-healthy diet: Incorporate more fresh fruits, vegetables, whole grains, and low-fat dairy into your daily meals.
  • Stay physically active: Engage in moderate exercises, such as brisk walking or swimming, for at least 30 minutes a day after consulting your doctor.
  • Manage your stress levels: Practice relaxation techniques such as deep breathing, meditation, or yoga to help maintain stable blood pressure.
  • Avoid smoking and limit alcohol: Smoking damages your blood vessels, and excessive alcohol can raise your blood pressure and interfere with your medication.
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How Soon It Starts Working

  • The time required for Espin-1.25 Tablet to start to work: The time required for Espin-1.25 Tablet to show its action is unknown.
  • The time for which the effects of Espin-1.25 Tablet last: Espin-1.25 Tablet effect lasts for 24 hours.

What if you forget to take Espin-1.25 Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is less than 12 hours away, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Espin-1.25 Tablet tablets at room temperature, ideally between 15°C and 30°C (59°F and 86°F). •Keep the medicine in its original blister pack or container to protect it from direct light, heat, and moisture.

Drug Warnings

  • Check your blood pressure regularly at home and keep a log to share with your doctor during visits.
  • Stand up slowly from a sitting or lying position to reduce the risk of dizziness, lightheadedness, or falls.
  • Avoid drinking grapefruit juice or eating grapefruit while on this medication, as it can increase the drug's levels in your blood and lead to severe side effects.
  • Do not stop taking this medicine suddenly, as this can cause your blood pressure to spike or your chest pain to return.
  • Let your dentist or surgeon know you are taking this medication before undergoing any medical procedures.
  • Avoid driving or operating machinery if you feel dizzy or sleepy after taking your dose.
     

Drug-Drug Interactions

verifiedApollotooltip
  • Taking this medicine with other blood pressure-lowering agents can cause your blood pressure to drop excessively.
  • Certain antifungal medications (such as ketoconazole) and antibiotics (such as erythromycin) may increase the levels of Espin-1.25 Tablet in your body, increasing the risk of side effects.
  • Some heart medications, such as beta-blockers or digoxin, may require careful monitoring when taken alongside this medicine.

Drug-Drug Interactions

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How does the drug interact with Espin-1.25 Tablet:
Taking carbamazepine and Espin-1.25 Tablet together may possibly reduce the blood levels of Espin-1.25 Tablet, which could reduce its treatment outcomes.

How to manage the interaction:
Although taking Carbamazepine and Espin-1.25 Tablet together can possibly result in an interaction, it can be taken if your doctor has prescribed it. Do not stop taking any medications without consulting your doctor.
How does the drug interact with Espin-1.25 Tablet:
Coadministration of Amlodipine with Itraconazole may significantly raise the blood levels and effects of Amlodipine.

How to manage the interaction:
Coadministration of Amlodipine and Itraconazole may interact, but if prescribed by a doctor, they can be used together. Consult a doctor if you develop chest discomfort, trouble breathing, dizziness or fainting, swelling of the hands, ankles, or feet, or any other of these symptoms. Do not discontinue any medications without consulting a doctor.
S-AmlodipineMitotane
Severe
How does the drug interact with Espin-1.25 Tablet:
Co-administration of Mitotane and Espin-1.25 Tablet can reduce the blood levels of Espin-1.25 Tablet.

How to manage the interaction:
Co-administration of Mitotane and Espin-1.25 Tablet can lead to an interaction, but they can be taken if advised by your doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Espin-1.25 Tablet:
Co-administration of Phenytoin and Espin-1.25 Tablet can reduce the blood levels of Amlodipine.

How to manage the interaction:
Co-administration of Phenytoin and Espin-1.25 Tablet can lead to an interaction, but they can be taken if advised by a doctor. Do not stop using any medications without a doctor's advice.
How does the drug interact with Espin-1.25 Tablet:
Co-administration of Simvastatin and Espin-1.25 Tablet together can increase the blood levels of simvastatin and increase the risk of side effects such as liver damage and rhabdomyolysis (breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking of Simvastatin and Espin-1.25 Tablet can lead to interaction, but they can be taken if advised by your doctor. However, if you experience any symptoms like muscle pain, tenderness, weakness, fever, dark-coloured urine, chills, joint pain, swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
S-AmlodipineDolasetron
Severe
How does the drug interact with Espin-1.25 Tablet:
Taking Dolasetron and Espin-1.25 Tablet together can increase the risk of an irregular heart rhythm.

How to manage the interaction:
The combined use of Dolasetron and Espin-1.25 Tablet can lead to an interaction, but they can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, or irregular heartbeat, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
S-AmlodipineRifapentine
Severe
How does the drug interact with Espin-1.25 Tablet:
The combined use of Rifapentine and Espin-1.25 Tablet can reduce the blood levels of Amlodipine.

How to manage the interaction:
Co-administration of Rifapentine and Espin-1.25 Tablet can lead to an interaction, but they can be taken if advised by your doctor. consult a doctor if your symptoms do not improve. Do not stop using any medications without a doctor's advice.
How does the drug interact with Espin-1.25 Tablet:
Co-administration of Tizanidine and Espin-1.25 Tablet together may have additive effects in lowering your blood pressure.

How to manage the interaction:
Co-administration of Tizanidine and Espin-1.25 Tablet can lead to an interaction, but it can be taken if your doctor advises. However, if you experience any symptoms like headache, dizziness, lightheadedness, fainting, and changes in pulse or heart rate, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Espin-1.25 Tablet:
Co-administration of Ceritinib together with Espin-1.25 Tablet can slow your heart rate and increase the risk of an irregular heart rhythm which can be severe. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Co-administration of Ceritinib and Espin-1.25 Tablet can lead to an interaction, but they can be taken if advised by your doctor. However, if you experience any symptoms of sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice can significantly increase the concentration of this medicine in your bloodstream, raising the risk of severe side effects like low blood pressure and swelling.
     
S AMLODIPINE-1.25MGCalcium rich foods
Moderate

Drug-Food Interactions

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S AMLODIPINE-1.25MGCalcium rich foods
Moderate
Common Foods to Avoid:
Tofu Set With Calcium, Ragi, Seasame Seeds, Kale, Milk, Almonds, Bok Choy, Calcium-Fortified Soy Milk, Cheese, Yogurt

How to manage the interaction:
Calcium-containing products may decrease the effectiveness of calcium channel blockers by saturating calcium channels with calcium. monitoring the effectiveness of calcium channel blocker therapy during co-administration with calcium products.

All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

Espin-1.25 Tablet is used to treat hypertension (high blood pressure) and angina (chest pain).
Espin-1.25 Tablet contains S-amlodipine, a calcium channel blocker that acts by relaxing the blood vessels. This reduces the heart's workload and makes the heart more efficient at pumping blood throughout the body. Thus, it helps to lower high blood pressure, reducing the chances of heart attack or stroke.
The common side effects of Espin-1.25 Tablet are fatigue, ankle swelling, sleepiness, flushing (sense of warmth in the face, ears, neck, and trunk), headache, nausea, dizziness, palpitations, and abdominal pain resolves after some time.
No, you are advised to inform your doctor and monitor your blood pressure for at least two weeks before stopping the medicine. Depending upon your current blood pressure readings, there is a possibility your doctor may lower your medicine dosage and will not recommend discontinuing it.
In case you have missed a dose of Espin-1.25 Tablet , you are advised to take it as soon as you remember. However, try not to miss a dose in the first place, if it is time for you to take your next dose, then do not take both doses together. Take only one dose, taking a double dose of Espin-1.25 Tablet will lead to low blood pressure.
Yes, Espin-1.25 Tablet is known to cause ankle swelling upon long-term use. Please try to keep your feet up when sitting for long hours. If the problem persists still, consult your doctor and do as advised.
Eating well, exercising regularly, maintaining a healthy weight, quitting smoking, getting enough sleep, and managing stress are all lifestyle changes that can help lower blood pressure.
Uncontrolled hypertension gradually destroys the arteries, causing them to harden. As the arteries constrict and become less flexible, the heart works harder to circulate blood. Uncontrolled high blood pressure can cause a stroke, heart attack, heart failure, and other heart problems, damage to the kidneys, memory, and eyesight, and contribute to erectile dysfunction.
Espin-1.25 Tablet may cause itching, although it is not common in everyone. It usually fades with time; however, contact your doctor if you experience severe itching.
Espin-1.25 Tablet is generally safe to prescribe in patients with mild kidney dysfunctions, and dose adjustment is generally not required. However, your doctor will decide the appropriate dosage strength depending on the severity of your condition.
You can take it at any time of day but try to make sure it's around the same time every day.
No, Espin-1.25 Tablet is not a beta-blocker. It belongs to a class of medicines known as calcium channel blockers.
More frequent or more severe chest pain, rapid, pounding, or irregular heartbeat and fainting. If you experience any of these symptoms, call your doctor immediately or get emergency medical treatment.
Espin-1.25 Tablet does not interfere with contraception. However, some hormonal methods of contraception, such as the combination pill and contraceptive patch, are generally not indicated if you have high blood pressure.
Consuming significant amounts of grapefruit or grapefruit juice can raise the levels of amlodipine in your blood and exacerbate adverse effects. If you are affected, you may need to avoid eating or drinking grapefruit while taking amlodipine. Also, avoid alcohol consumption, quit smoking, and limit salt intake (Aim for no more than 6g of salt a day).
Drinking alcohol can make amlodipine lower your blood pressure more than you need. This can make you sleepy or dizzy or bring on a headache.
Espin-1.25 Tablet can make some people feel dizzy. If this happens to you, do not drive a car, ride a bike, or use tools or machinery until you feel better.
Espin-1.25 Tablet contains S-amlodipine, a calcium channel blocker.
Espin-1.25 Tablet is generally safe to take for a long time. In fact, it works best when you take it for a long time.
Espin-1.25 Tablet can be given safely to children aged 6-12 years, provided a child specialist has prescribed the dose. Espin-1.25 Tablet should only be given to the children by consulting a child specialist.
Espin-1.25 Tablet is not recommended for use in pregnant women unless necessary. All the risks and benefits should be discussed with the doctor before taking Espin-1.25 Tablet .
Avoid exceeding the recommended dose, as it could lead to an overdose. Symptoms of overdose may include excessive peripheral vasodilation with marked low blood pressure and reflex tachycardia. If you experience these symptoms or suspect you have taken an overdose, seek immediate medical attention.
Yes, some patients experience dizziness or drowsiness, especially when first starting the medicine or after a dose increase. Avoid driving or operating machinery until you know how this medication affects you, and talk to your doctor if these symptoms persist.
Yes, you can take Espin-1.25 Tablet with or without food. The most important thing is to take it consistently at the same time every day to keep your blood pressure stable. Talk to your doctor if you have persistent stomach issues.
Some pain relievers, particularly nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen, can reduce the effectiveness of blood pressure medications and strain your kidneys. Talk to your doctor or pharmacist before combining these medications.

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Country of origin

India

Manufacturer/Marketer address

Chinubhai Centre, Off. Nehru Bridge, Ashram Road, Ahmedabad - 380009. Gujarat. India.
Other Info - ESP0007
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