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Foiri-100 Injection 5 ml is used to manage or treat Colorectal cancer (Cancer that develops in the colon or rectal tissue). It contains Irinotecan, which works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells cannot divide. As a result, Irinotecan inhibits cancer cell division and growth.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

IRINOTECAN-100MG

Manufacturer/Marketer :

Cadila Healthcare Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Foiri-100 Injection 5 ml

Foiri-100 Injection 5 ml is a prescription medication used to treat advanced cancer of the colon or rectum. It is typically prescribed when other treatments have not produced the desired results or as part of a primary treatment plan. This medicine is designed to help slow or stop the growth of cancer cells in the body.

This medicine is typically injected as an intravenous infusion once every two to three weeks, depending on your treatment plan. Consistency is vital, as keeping your scheduled appointments ensures the medication works continuously to target cancer cells. Since it is injected directly into a vein by a healthcare provider, food intake does not affect how the medication is absorbed, but eating light meals on treatment days and staying well-hydrated can improve your comfort. Making simple lifestyle adjustments, like drinking extra fluids and eating smaller, more frequent meals, can support your body during therapy.

While this medicine is highly effective, it can cause common side effects such as nausea, hair loss, and temporary tiredness. However, you must seek immediate medical attention if you experience severe, watery diarrhoea or signs of a serious infection, such as a high fever or chills.

Talk to your doctor before starting this treatment if you have a history of liver damage, asthma, or kidney disease. Do not take this if you have severe bone marrow failure, severe inflammatory bowel disease, or high levels of bilirubin in your blood.

This medication can interact with certain other medicines, herbal supplements like St. John's Wort, and alcohol, which may increase the risk of severe side effects or make the treatment less effective. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, you must consult your healthcare provider to discuss the specific risks and protective measures needed.

Uses of Foiri-100 Injection 5 ml

Your doctor may prescribe Foiri-100 Injection 5 ml to treat the following conditions:

  • Colorectal cancer (cancer of the colon or rectum): Foiri-100 Injection 5 ml helps by targeting and slowing the growth of cancer cells in the large intestine or rectum, often used when other treatments have not worked or in combination with other chemotherapy drugs.
  • Advanced pancreatic cancer: In certain combination regimens, Foiri-100 Injection 5 ml helps stop cancer cells from multiplying and spreading in pancreatic tissues.
  • Small cell lung cancer: In some clinical cases, it is used to help manage and treat advanced lung cancer by disrupting the replication of fast-growing cancer cells.

Key Benefits

Foiri-100 Injection 5 ml helps slow the growth and spread of advanced cancer cells, supporting better disease control and helping relieve symptoms caused by tumour growth. It is often used as part of combination chemotherapy to improve treatment outcomes.

  • Helps slow cancer progression: Inhibits the growth and spread of cancer cells, helping control advanced disease and delay tumour progression.
  • Relieves cancer-related symptoms: By reducing tumour growth, it may help ease symptoms such as pain, abdominal discomfort, bowel obstruction, or pressure caused by the tumour.
  • Enhances combination therapy: Works alongside other chemotherapy medicines to improve the overall effectiveness of cancer treatment in appropriate patients.
  • Supports quality of life: Better disease control may help reduce cancer-related symptoms, maintain physical function, and improve overall well-being during treatment.
Side effects of Foiri-100 Injection 5 ml
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.

Directions for Use

  • Follow your doctor’s instructions on the dosage and timing of this medication to ensure safety.
  • Foiri-100 Injection 5 ml will be administered by a trained healthcare professional.
  • Do not self-administer.

How Foiri-100 Injection 5 ml Works

Foiri-100 Injection 5 ml contains irinotecan, which works by blocking a specific protein in the body called topoisomerase I. This protein is essential for cancer cells to copy their DNA and multiply. By blocking this protein, the medicine causes damage to the DNA of the cancer cells, preventing them from dividing and ultimately causing them to die. Because cancer cells divide much faster than normal cells, they are highly sensitive to this blockage, which helps shrink tumours and control the spread of the disease.
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Alcohol

Caution

Avoid alcohol consumption while on treatment with Foiri-100 Injection 5 ml.

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Pregnancy

Unsafe

Foiri-100 Injection 5 ml should not be used during pregnancy. So, inform your doctor if you are pregnant or suspect pregnancy. You or your partner must use a reliable form of contraception to prevent pregnancy while taking these medications.

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Breast Feeding

Unsafe

Foiri-100 Injection 5 ml should not be used in breastfeeding. Discuss with your doctor if you have any concerns.

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Driving

Caution

Foiri-100 Injection 5 ml can make you dizzy or impair your vision, especially in the first 24 hours after taking it. Do not drive or operate machinery until you know how this drug affects you.

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Liver

Caution

Foiri-100 Injection 5 ml should be used with caution if you have liver disease. Inform your doctor before receiving the Foiri-100 Injection 5 ml if you have had a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Caution

It is not recommended for use in patients on dialysis. Inform your doctor before receiving the Foiri-100 Injection 5 ml if you have had a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Caution

Safety and effectiveness in children have not been established. Hence, use is not recommended.

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Heart

Caution

Foiri-100 Injection 5 ml may be used in patients with heart problems, but it requires close monitoring due to risks like bradycardia and dehydration-related cardiac complications. Medical supervision is essential to ensure safe administration.

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Geriatrics

Caution

Geriatric patients can receive irinotecan injections, but they may be more prone to severe side effects like diarrhea. Dose adjustments and close medical supervision are often necessary to ensure safe treatment.

What if I have taken an overdose of Foiri-100 Injection 5 ml

Since this medication is prepared and given by trained medical staff, an overdose is highly unlikely. However, if you suspect an error or experience severe symptoms immediately after your infusion, notify your medical team right away.

Diet & Lifestyle Advise

  • Stay well hydrated: Drink plenty of clear fluids, such as water, oral rehydration solutions, or clear broths, to replace lost fluids, especially if you develop diarrhoea during treatment.
  • Eat small, easy-to-digest meals: Choose bland, low-fibre foods such as bananas, white rice, applesauce, plain toast, or crackers if you experience nausea or diarrhoea. Gradually return to your normal diet as your symptoms improve.
  • Avoid foods that worsen stomach upset: Limit dairy products (if they aggravate symptoms), caffeine, alcohol, and spicy, greasy, or highly seasoned foods, as these may increase nausea or diarrhoea.
  • Reduce your risk of infections: Wash your hands frequently, maintain good personal hygiene, and avoid close contact with people who have contagious illnesses, as this medicine may temporarily lower your white blood cell count and increase your risk of infections.
health query

Have a query?

How Soon It Starts Working

The time required for Foiri-100 Injection 5 ml to start to work: The exact onset time of Foiri-100 Injection 5 ml has not been clinically established. The time for which the effects of Foiri-100 Injection 5 ml last: The duration of Foiri-100 Injection 5 ml effect is unknown.

What if you forget to take Foiri-100 Injection 5 ml

Because this medicine is given in a clinical setting by healthcare professionals, missing a dose is rare. If you miss or have to cancel an appointment for your infusion, contact your clinic or doctor immediately to reschedule your treatment and keep your therapy on track.

Storage

•Unopened vials of Foiri-100 Injection 5 ml should be stored at room temperature, between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Manage diarrhoea promptly: Monitor your bowel movements closely. Your doctor may prescribe an anti-diarrhoeal medicine, such as loperamide, to keep at home. Start taking it at the first sign of loose stools and contact your healthcare team if diarrhoea is severe or persistent.
  • Report injection site problems immediately: During or after the infusion, tell your nurse immediately if you experience burning, pain, swelling, redness, or a cold sensation at the injection site, as leakage of the medicine outside the vein can damage surrounding tissues.
  • Avoid medicines that increase bleeding risk: Do not take aspirin, NSAIDs (such as ibuprofen), or other blood-thinning medicines unless your oncologist specifically advises you to, as Foiri-100 Injection 5 ml may lower your platelet count and increase the risk of bleeding.
  • Avoid live vaccines: Do not receive live vaccines during treatment unless your doctor specifically recommends them, as your immune system may be weakened and unable to respond safely.
  • Use effective contraception: Use reliable birth control during treatment and for the period recommended by your doctor after your final dose, as Foiri-100 Injection 5 ml can harm an unborn baby. Inform your doctor immediately if you or your partner become pregnant during treatment.

Drug-Drug Interactions

verifiedApollotooltip
  • Strong liver enzyme inducers (such as carbamazepine, phenytoin, or phenobarbital): May decrease the level of Foiri-100 Injection 5 ml in your body, making the treatment less effective.
  • Strong liver enzyme inhibitors (such as ketoconazole, clarithromycin, or atazanavir): May significantly increase the level of Foiri-100 Injection 5 ml in your body, increasing the risk of severe side effects like low blood counts and severe diarrhea.
  • St. John's Wort: Can lower the effectiveness of this medication and should be avoided during treatment.

Drug-Drug Interactions

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How does the drug interact with Foiri-100 Injection 5 ml:
Using Foiri-100 Injection 5 ml together with ketoconazole can increase the risk of side effects.

How to manage the interaction:
Taking Ketoconazole with Foiri-100 Injection 5 ml is not recommended as it can cause an interaction, but it can be taken if prescribed by the doctor. However, if you experience any symptoms such as paleness, fatigue, dizziness, fainting, unexpected bruising or bleeding, fever, chills, diarrhea, sore throat, muscle aches, breathing difficulty, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination, consult the doctor immediately.
How does the drug interact with Foiri-100 Injection 5 ml:
Taking Tofacitinib with Foiri-100 Injection 5 ml may increase the risk of serious infection.

How to manage the interaction:
Co-administration of Tofacitinib with Foiri-100 Injection 5 ml can possibly result in an interaction, but it can be taken if your doctor has advised it. However, consult the doctor immediately if you experience symptoms such as fever, chills, diarrhea, sore throat, muscle aches, shortness of breath, blood in phlegm, weight loss, red or inflamed skin, body sores, and pain or burning during urination. Do not stop using any medications without a doctor's advice.
How does the drug interact with Foiri-100 Injection 5 ml:
Taking Foiri-100 Injection 5 ml with Baricitinib can increase the risk of developing serious infections.

How to manage the interaction:
There may be a possibility of interaction between Foiri-100 Injection 5 ml and Baricitinib, but it can be taken if prescribed by a doctor. However, consult a doctor if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning when you urinate. Do not stop using any medications without a doctor's advice.
How does the drug interact with Foiri-100 Injection 5 ml:
Taking Ritonavir with Foiri-100 Injection 5 ml can increase the risk of side effects.

How to manage the interaction:
Although taking Foiri-100 Injection 5 ml and Ritonavir together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination contact a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Foiri-100 Injection 5 ml:
Co-administration of Gemfibrozil with Foiri-100 Injection 5 ml can increase the risk or severity of side effects like dehydration, lung or breathing problems, or bleeding problems.

How to manage the interaction:
Although taking Gemfibrozil and Foiri-100 Injection 5 ml together can evidently cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms like diarrhea, feeling weak, blood clots, lung problems, feeling sick, throwing up, stomach pain, mouth sores, shortness of breath, looking pale, feeling tired, dizziness, fatigue, fever or chills, a sore throat, muscle pain, bleeding, bruises, losing weight, pain or burning urination consult a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Foiri-100 Injection 5 ml:
Foiri-100 Injection 5 ml blood levels may be significantly raised by combining itraconazole and Foiri-100 Injection 5 ml.

How to manage the interaction:
Although there is a possible interaction between Foiri-100 Injection 5 ml and Itraconazole, they can be taken in case a doctor prescribes it. Consult a doctor if you notice any of the following symptoms: paleness, tiredness, dizziness, fainting, unusual bruising or bleeding, fever, chills, diarrhoea, sore throat, aches in the muscles, shortness of breath, blood in the phlegm, red or irritated skin, body sores, or pain or burning when urinating. Never stop taking any medications without talking to a doctor.
How does the drug interact with Foiri-100 Injection 5 ml:
Taking ceritinib with Foiri-100 Injection 5 ml may increase the risk of infection and other side effects.

How to manage the interaction:
Although taking Foiri-100 Injection 5 ml and Ceritinib together can evidently cause an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience fatigue, dizziness, fainting, unusual bruising or bleeding, fever, chills, loose stools, sore throat, muscle aches, shortness of breath, red or inflamed skin, body sores, and pain or burning during urination. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Foiri-100 Injection 5 ml:
Coadministration of Phenytoin and Foiri-100 Injection 5 ml may significantly reduce the blood levels of Foiri-100 Injection 5 ml.

How to manage the interaction:
Although there is a possible interaction between Foiri-100 Injection 5 ml and Phenytoin, you can take these medicines together if prescribed by a doctor. Doctor can recommend other options that won't cause any problems when taken together. Do not stop using any medications without talking to a doctor.
How does the drug interact with Foiri-100 Injection 5 ml:
Taking Foiri-100 Injection 5 ml with rifampicin can decrease the blood levels of Foiri-100 Injection 5 ml, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Foiri-100 Injection 5 ml and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Foiri-100 Injection 5 ml:
Taking carbamazepine and Foiri-100 Injection 5 ml may possibly reduce the effects of Foiri-100 Injection 5 ml, which could reduce its capacity to treat cancer.

How to manage the interaction:
Although taking carbamazepine and Foiri-100 Injection 5 ml together can possibly result in an interaction, it can be taken if your doctor has prescribed it. It is good to inform your doctor if you use any other medications.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit and grapefruit juice: May interfere with how your liver breaks down this medicine, potentially increasing toxic side effects.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Foiri-100 Injection 5 ml is used to treat Colorectal cancer.
Foiri-100 Injection 5 ml contains Irinotecan works by blocking an enzyme called topoisomerase I. All cells need this enzyme to divide and grow. Irinotecan blocks this enzyme so the cancer cells can't divide. As a result, Irinotecan inhibits cancer cell division and growth.
Foiri-100 Injection 5 ml should not be used in patients with pulmonary diseases. So, inform your doctor if you have pulmonary disorders (lung problems).
While taking Foiri-100 Injection 5 ml, make sure you visit your doctor at all the appointments to ensure that treatment works. Regular monitoring of blood and lipid tests and weight checks are required. An effective way of contraception should be used by both men and women while taking the Foiri-100 Injection 5 ml.
The live vaccine may not work while on treatment with Foiri-100 Injection 5 ml. Only have immunizations/vaccinations after talking to your doctor first. Also, avoid contact with people who recently had immunizations /vaccinations.
Irinotecan therapy may lead to Neutropenia (an unusually low number of neutrophil cells). Your doctor will order laboratory testing on a regular basis before and during your treatment.
You should know that this medicine may reduce fertility in both men and women. Discuss the risks of taking an irinotecan injection with your doctor.
You are recommended to take the advice of your doctor before taking Foiri-100 Injection 5 ml. As Foiri-100 Injection 5 ml is not used during pregnancy.
The common side effects of Foiri-100 Injection 5 ml are nausea, vomiting, abdominal pain, diarrhoea, constipation, anorexia (an eating disorder), neutropenia (an unusually low number of cells called neutrophils), leukopenia (including lymphocytopenia), anaemia (not having enough healthy red blood cells), asthenia (abnormal weakness), fever, weight loss, alopecia (hair loss). If any of these side effects persist or worsen, please consult your doctor.
This medicine can irritate the digestive tract and affect the nerves that control bowel movements. This can cause early diarrhoea (during the infusion) or late diarrhoea (days after). Talk to your doctor about how to manage this with anti-diarrhoea medications.
This medicine can cause dizziness, sleepiness, or temporary vision problems shortly after administration. It is safest to have someone else drive you home after your appointment. Talk to your doctor if you experience these symptoms.
Yes, temporary hair thinning or hair loss is a common side effect of this treatment. Your hair will typically start to grow back after your chemotherapy cycles are complete. Talk to your doctor if you have concerns about managing hair loss.
It is highly recommended to avoid alcohol during treatment. Alcohol can worsen nausea, increase dehydration, and put extra strain on your liver, which is already processing the medication. Talk to your doctor or pharmacist for guidance.
A fever (especially 38°C/100.4°F or higher) is a medical emergency during this treatment because your immune system may be weak. Contact your doctor or go to the nearest emergency room immediately. Talk to your doctor about monitoring your temperature.

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Country of origin

India

Manufacturer/Marketer address

Sarkhej-Dholka Road, Bhat, Ahmedabad-382 210, INDIA.
Other Info - FOI0004
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