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compositionComposition:DOLUTEGRAVIR-50MG
prescription
Prescription Medicine
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Best Price

₹2537 with coupons & bank offers*

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Instgra Tablet contains Dolutegravir, which belongs to a group of antiretroviral medicines indicated for the treatment of HIV infection. Instgra Tablet reduces the viral load in the body and keeps it at a low level. It also increases the count of CD4 cells, which are white blood cells that help the body fight infection. Sometimes, Instgra Tablet may cause side effects such as nausea, vomiting, headache, and diarrhoea.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

DOLUTEGRAVIR-50MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Instgra Tablet

Instgra Tablet is a prescription medication used to treat Human Immunodeficiency Virus type 1 (HIV-1) infection in adults and children. It belongs to a group of medicines called integrase inhibitors, which help lower the amount of HIV in your body. By keeping the virus under control, this medicine supports your immune system and helps protect you from developing serious infections.

For this medicine to work effectively, you must take it consistently every single day at the same time, exactly as prescribed. You can take this tablet with or without food, making it easy to fit into your daily routine. Adopting a balanced diet and reducing stress can further support your overall immune health while you are on this treatment.

While taking Instgra Tablet , some people may experience mild side effects like trouble sleeping, headache, or feeling tired. However, you should contact your doctor immediately if you experience signs of liver damage, such as yellowing of your skin or eyes, or severe allergic reactions like skin rashes.

Do not take this if you are allergic to any of its ingredients or if you are taking certain medications like dofetilide. Before starting, tell your healthcare provider if you have a history of liver disease or kidney problems, as they may need to monitor your health closely.

This medicine can interact with certain mineral supplements, alcohol, and other prescription medications, which can lower its absorption or increase side effects. If you are pregnant, planning to become pregnant, breastfeeding, or are an elderly individual, consult your doctor to discuss the risks and benefits before starting treatment.

Uses of Instgra Tablet

Instgra Tablet may be prescribed to manage the following conditions:

  • HIV-1 Infection: Instgra Tablet is prescribed to manage HIV-1 infection in both adults and children who meet specific weight requirements. It works by reducing the viral load in your blood to undetectable levels, which helps prevent the virus from damaging your immune system.
  • Prevention of HIV after exposure (PEP): In certain situations, healthcare providers may use this medicine in combination with other antiretroviral drugs to help prevent HIV infection after a potential accidental exposure to the virus.

Key Benefits

Instgra Tablet offers significant benefits for managing chronic HIV infection, helping you maintain a healthy and active lifestyle. Key benefits include:

  • Strong viral suppression: It quickly lowers the level of HIV in the blood, helping many patients reach and maintain an undetectable viral load.
  • Immune system recovery: By keeping the virus from replicating, it allows your immune system's CD4 cells to rebuild, protecting you from opportunistic infections.
  • Convenient daily routine: The once-daily oral dosing schedule, which can be taken with or without food, makes it easier to stay consistent with your treatment plan.
Side effects of Instgra Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

  • Instgra Tablet can be taken with or without as advised by your doctor.
  • It is recommended to take Instgra Tablet once daily or as advised by your doctor.
  • Swallow it as a whole with a glass of water.
  • Do not chew, crush, or break Instgra Tablet .

How Instgra Tablet Works

Instgra Tablet contains dolutegravir. It belongs to a class of antiretroviral drugs known as integrase strand transfer inhibitors (INSTIs). To reproduce, the HIV virus needs to insert its own genetic material into your healthy immune cells. It does this using a specific viral protein called integrase. Instgra Tablet works by blocking the action of the integrase protein. By binding to this enzyme, the medicine prevents the virus from multiplying and spreading to new cells. As a result, the amount of virus in your body decreases, allowing your immune system to better protect you from other illnesses.
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Alcohol

Consult your doctor

It is not known whether Instgra Tablet interacts with alcohol. Please consult your doctor.

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Pregnancy

Caution

Instgra Tablet may increase the risk of birth defects. Please consult the doctor if you are pregnant. Your doctor will weigh the benefits and potential risks before prescribing Instgra Tablet .

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Breast Feeding

Unsafe

Avoid breastfeeding while taking Instgra Tablet . HIV-positive women must not breastfeed as HIV infection can be passed to the baby in breast milk.

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Driving

Caution

Instgra Tablet may cause dizziness. Drive or operate machinery only if you are alert.

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Liver

Consult your doctor

Limited information is available. Please consult your doctor if you have liver problems. Your doctor will weigh the benefits and potential risks before prescribing Instgra Tablet .

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Kidney

Consult your doctor

Limited information is available. Please consult your doctor if you have kidney problems. Your doctor will weigh the benefits and potential risks before prescribing Instgra Tablet .

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Children

Caution

Please consult the doctor if you have any concerns regarding the usage of Instgra Tablet in children.

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Heart

Caution

Instgra Tablet should be used with caution and under medical supervision in patients with heart problems. Therefore, please consult your doctor before using Instgra Tablet .

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Geriatrics

Caution

Instgra Tablet should be used with caution in geriatric patients. Therefore, please consult your doctor before giving Instgra Tablet to elderly individuals.

What if I have taken an overdose of Instgra Tablet

If you accidentally take too much of this medicine, seek immediate medical attention or contact your local poison control centre. Symptoms of an overdose may include severe dizziness, nausea, or fainting. Always keep the medication bottle with you so the healthcare providers know exactly what you took.

Diet & Lifestyle Advise

  • Prioritise immune-supportive nutrition: Focus on a balanced diet rich in lean proteins, whole grains, fruits, and vegetables to help your body rebuild immune cells and maintain muscle mass.
  • Practice food safety: Because HIV affects your immune system, protect yourself from foodborne illnesses by cooking meats thoroughly, washing raw produce, and avoiding unpasteurised dairy products.
  • Stay physically active: Regular, moderate exercise such as walking, cycling, or swimming can help improve your strength, reduce fatigue, and boost your mental well-being.
  • Avoid alcohol and recreational drugs: These substances can weaken your immune system and interact negatively with your medication, increasing the risk of liver damage.
  • Ensure up-to-date vaccinations: Discuss with your healthcare team which vaccines (such as the flu shot or pneumonia vaccine) are safe and recommended for you.
health query

Have a query?

How Soon It Starts Working

The time required for Instgra Tablet to start to work: Instgra Tablet ideally shows its action within 1 to 2 hours after administration. The time for which the effects of Instgra Tablet last: The duration of action for Instgra Tablet is unknown.

What if you forget to take Instgra Tablet

If you miss a dose, take it as soon as you remember. However, if your next scheduled dose is close, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one. If you are unsure, talk to your doctor or pharmacist.

Storage

• Store Instgra Tablet at room temperature, ideally between 20°C and 25°C (68°F to 77°F).

Drug Warnings

  • Do not skip doses: Skipping doses can allow the virus to become resistant to Instgra Tablet , making it harder to treat your infection in the future.
  • Watch for immune reconstitution syndrome: As your immune system gets stronger, it may react to old, hidden infections. Tell your doctor immediately if you develop fever, swollen lymph nodes, or trouble breathing after starting the medicine.
  • Check your supplements: Multivitamins, antacids, or supplements containing calcium, magnesium, iron, or aluminium can block the absorption of Instgra Tablet . Take Instgra Tablet at least 2 hours before or 6 hours after taking these supplements.
  • Monitor liver health: Regular blood tests are recommended to ensure this medicine is not causing strain or damage to your liver.
  • Discuss family planning: If you are planning a pregnancy, talk to your doctor about the safest way to manage your treatment, as specific monitoring may be required.

Drug-Drug Interactions

verifiedApollotooltip

Inform your doctor if you are taking any of the following medicines before using Instgra Tablet :

  • Dofetilide: Do not take Instgra Tablet with dofetilide (a heart rhythm medicine), as this combination can dangerously increase the levels of dofetilide in your blood, causing serious heart complications.
  • Antacids and Mineral Supplements: Medicines containing calcium, magnesium, aluminium, or iron can prevent Instgra Tablet from being fully absorbed. Take your dose at least 2 hours before or 6 hours after these products.
  • Certain Tuberculosis and Seizure Medications: Drugs like rifampin, carbamazepine, or phenytoin can lower the amount of Instgra Tablet in your body, making it less effective against the virus.
DolutegravirDofetilide
Critical
DolutegravirMagnesium chloride
Severe

Drug-Drug Interactions

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DolutegravirDofetilide
Critical
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with dofetilide may possibly reduce the blood levels and effects of Instgra Tablet. This can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Although taking Instgra Tablet with Dofetilide is not recommended, they can be taken together if prescribed by a doctor. However, contact your doctor if you experience drowsiness, lightheadedness, fainting, or irregular heartbeat. Do not stop taking any medications without consulting a doctor.
DolutegravirMagnesium chloride
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with magnesium chloride can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Magnesium chloride together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Magnesium chloride. Do not discontinue using any medications without consulting a doctor.
DolutegravirFerric citrate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with ferric citrate can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Ferric citrate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Ferric citrate. Do not discontinue using any medications without consulting a doctor.
DolutegravirFerric maltol
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with ferric maltol can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Ferric maltol together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Ferric maltol. Do not discontinue using any medications without consulting a doctor.
DolutegravirMagnesium carbonate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with magnesium carbonate can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Magnesium carbonate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Magnesium carbonate. Do not discontinue using any medications without consulting a doctor.
DolutegravirPrimidone
Severe
How does the drug interact with Instgra Tablet:
Coadministration of Instgra Tablet with primidone may significantly decrease Instgra Tablet blood levels and reduce its effectiveness.

How to manage the interaction:
Although taking Instgra Tablet and Primidone together can result in an interaction, it can be taken if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
DolutegravirKaolin
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with kaolin can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Kaolin together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Kaolin. Do not discontinue using any medications without consulting a doctor.
DolutegravirFerrous gluconate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with ferrous gluconate can reduce the effectiveness of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Ferrous gluconate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. It is advised to take Instgra Tablet either two hours before or six hours after taking a dose of Ferrous gluconate. Do not discontinue using any medications without consulting a doctor.
DolutegravirMagnesium sulfate
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with magnesium sulfate can reduce the effects of Instgra Tablet.

How to manage the interaction:
Although taking Instgra Tablet and Magnesium sulfate together can possibly result in an interaction, they can be taken together if prescribed by your doctor. However, if your condition gets worse or if you develop new infections while taking these medications, it is important to contact a doctor immediately. Do not discontinue using any medications without consulting a doctor.
DolutegravirRifampicin
Severe
How does the drug interact with Instgra Tablet:
Taking Instgra Tablet with rifampicin can decrease the blood levels of Instgra Tablet, which may make the medication less effective.

How to manage the interaction:
Although there is an interaction between Instgra Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

Certain foods and supplements may affect how Instgra Tablet is absorbed:

  • Calcium-fortified foods: Consuming large amounts of calcium-fortified juices or foods at the exact same time as your medication may reduce its absorption. It is best to space them out just like calcium supplements.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIRETROVIRAL AGENTS]

FAQs

Instgra Tablet is used to treat HIV infection.
Instgra Tablet works by decreasing the amount of HIV in the blood. It also increases the count of CD4 cells, a type of white blood cells that help the body to fight infection.
Antacids used to treat heartburn or indigestion, multivitamins, calcium or iron supplements may stop the absorption of Instgra Tablet and make it less effective. Therefore, do not take antacid, multivitamins, calcium or iron supplements 6 hours before and 2 hours after taking Instgra Tablet . However, consult the doctor before taking other medicines while on treatment with Instgra Tablet .
Few people taking combination therapy for HIV may develop osteonecrosis. Consult the doctor if you experience symptoms of osteonecrosis, such as stiffness in the joints, joint pain or aches, and difficulty moving.
Yes, you can take Instgra Tablet with or without food. However, if you experience mild nausea, taking it with a small meal may help settle your stomach. Talk to your doctor if nausea persists.
Take the missed dose as soon as you remember. If your next scheduled dose is close, skip the missed dose and continue with your regular schedule. Do not take a double dose. Talk to your doctor or pharmacist if you miss multiple doses.
No, Instgra Tablet does not cure HIV infection, but it helps manage the virus effectively. It lowers the amount of virus in your body so your immune system can stay healthy. To keep the virus controlled, you must take it every day. Talk to your doctor for more information.
It is best to limit or avoid alcohol while taking Instgra Tablet . Alcohol can put extra stress on your liver and may worsen side effects like dizziness or fatigue. Talk to your doctor about what is safe for you.
If you are pregnant or planning to become pregnant, you should discuss this with your healthcare provider. Your doctor will weigh the benefits and risks to determine if Instgra Tablet is the right choice for you and your baby. Talk to your doctor before making any changes.
Some patients experience weight gain after starting certain HIV treatments, including Instgra Tablet . This can be a sign of improving health and a recovering immune system, but it can also be influenced by diet and lifestyle. Talk to your doctor if you have concerns about weight changes.
Serious liver issues are rare but possible. Watch for warning signs such as yellowing of your eyes or skin, dark tea-coloured urine, pale stools, severe nausea, or upper stomach pain. If you notice any of these symptoms, stop taking the medicine and seek emergency medical care. Contact your doctor or go to the nearest emergency room immediately; do not stop your medication without medical advice.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.5248 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. MedlinePlus. A613043 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  3. Dolutegravir Dolutegravir. 2013Check here
  4. Dolutegravir [Product Information]. 2024. [Accessed on 01 Jul. 2025]Check here
  5. U.S. Food and Drug Administration (FDA). Prescribing information: NDA 210237 [Internet]. Silver Spring (MD): FDA; [Accessed on 2026 Mar 31]Check here
  6. Central Drugs Standard Control Organization (CDSCO). Drugs [Internet]. New Delhi: Directorate General of Health Services, Ministry of Health and Family Welfare, Government of India; [Accessed on 2026 Mar 31]Check here
  7. Dolutegravir 50Mg Tablets (Dolutegravir). [Accessed on 02 Jun. 2026]Check here

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - INS0254
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