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  3. Lithorest SR-450 Tablet 10's

Lithorest SR-450 Tablet 10's, Pack of 10
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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
Lithorest SR-450 Tablet 10's is used to prevent and treat mood disorders like mania and bipolar disorder. It contains Lithium, which helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person's mood. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.
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Composition :

LITHIUM-450MG

Manufacturer/Marketer :

Matteo Health Care Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Lithorest SR-450 Tablet 10's

Lithorest SR-450 Tablet 10's is used to prevent and treat mood disorders like mania and bipolar disorder. Mania is a mental condition that causes intense excitement, high energy, and delusions (misbeliefs). Bipolar disorder is a mental condition associated with extreme mood swings ranging from the hyper stage of mania to low-mood depression.

Lithorest SR-450 Tablet 10's contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Take Lithorest SR-450 Tablet 10's as prescribed. Your doctor will advise how often you take Lithorest SR-450 Tablet 10's based on your medical condition. Some people may experience loss of appetite, dizziness, dry mouth, taste change, diarrhoea, blurred vision, slurred speech, shaky movements, increased thirst, and urination. Most of these side effects of Lithorest SR-450 Tablet 10's do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are known to be allergic to Lithorest SR-450 Tablet 10's or any other medicines, please tell your doctor. If you are pregnant or breastfeeding, it is advised to consult a doctor before using Lithorest SR-450 Tablet 10's. Regular blood tests are recommended while taking Lithorest SR-450 Tablet 10's to monitor the levels of lithium in blood. If you have fits, kidney or heart problems, thyroid, persistent headache, vision problems, and if you are planning or have had weight loss surgery, please inform your doctor before taking Lithorest SR-450 Tablet 10's.

Uses of Lithorest SR-450 Tablet 10's

Lithorest SR-450 Tablet 10's is used in the treatment of Bipolar disorder, Mania. The detailed uses of Lithorest SR-450 Tablet 10's are as follows:<br/>• Bipolar Disorder Treatment: Lithorest SR-450 Tablet 10's is used to treat bipolar disorder by stabilizing mood and reducing episode severity through its action on the brain.<br/>• Mania Management: Lithorest SR-450 Tablet 10's is effective in managing symptoms of mania, such as elevated mood, increased energy, and impulsive behavior, allowing patients to regain control and function normally.<br/>

Directions for Use

Take Lithorest SR-450 Tablet 10's as prescribed by your doctor.

Medicinal Benefits

Lithorest SR-450 Tablet 10's is a mood stabilizer that is used to prevent and treat mood disorders such as mania and bipolar disorder. Lithorest SR-450 Tablet 10's contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood. Thus, Lithorest SR-450 Tablet 10's relaxes nerves and calms the mood, which helps in having a better social life and enables one to do daily activities comfortably.

How Lithorest SR-450 Tablet 10's Works

Lithorest SR-450 Tablet 10's contains Lithium that helps to treat mental disorders by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping in stabilizing a person’s mood.

Storage

Keep Lithorest SR-450 Tablet 10's out of the sight and reach of children.
Side effects of Lithorest SR-450 Tablet
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.
  • Reduce fluid intake 2-3 hours prior to bedtime.
  • Limit alcohol and caffeine as they can increase urination and affect bladder health.
  • Maintain sleep hygiene.
  • Eat a low-salt and healthy diet.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.
  • Confusion is a major psychotic disorder that needs immediate medical attention.
  • Acknowledge your experience and put effort to control confusion.
  • Avoid smoking and alcohol intake as it can worsen the condition and increase your confusion.
  • Practice meditation and yoga to avoid anxiety, which can be one of the leading causes.
  • Talk to your dietician and consume food that can improve your mental health.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.
  • Limit or eliminate caffeine and alcohol from your diet, as these substances can worsen hand trembling.
  • Practice relaxation techniques like deep breathing, yoga, or mindfulness meditation to reduce stress-induced tremors.
  • Engage in regular exercise to improve muscle control and coordination.
  • Ensure adequate sleep (7-8 hours) to prevent fatigue, which can worsen tremors.
  • Identify and minimize triggers that cause tremors, such as stress or certain activities.
  • Consider occupational therapy for tailored exercises and adaptive tools to manage daily tasks with trembling hands.
  • Consult a doctor if hand trembling interferes with your daily activities or is accompanied by other concerning neurological symptoms such as weakness, numbness, or speech difficulties.

What if I have taken an overdose of Lithorest SR-450 Tablet 10's

Do not take more than the prescribed dose of Lithorest SR-450 Tablet 10's as too much Lithium may be dangerous. The symptoms include blurred vision, feeling or being sick, vomiting, fainting, sleepiness, lightheadedness, increased urge to urinate, lack of control over pee or poo, shaking or muscle weakness, muscle twitches, spasms or jerks affecting the face, eyes, neck or tongue, confusion and blackouts. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Regular blood tests are recommended while taking Lithorest SR-450 Tablet 10's to check lithium levels in blood. If you are pregnant or breastfeeding, please inform your doctor before taking Lithorest SR-450 Tablet 10's. If you have hypothyroidism (underactive thyroid gland), please inform your doctor before taking Lithorest SR-450 Tablet 10's as it may cause low thyroid levels. If you notice decreased amount of urine, dark, reddish urine, muscle pain or weakness, inform your doctor immediately as it may be due to a serious condition called rhabdomyolysis (muscle tissue breakdown) which may lead to kidney problems.

Drug-Drug Interactions

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LithiumCisapride
Critical
LithiumCidofovir
Critical

Drug-Drug Interactions

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LithiumCisapride
Critical
How does the drug interact with Lithorest SR-450 Tablet:
Taking Cisapride with Lithorest SR-450 Tablet can increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Lithorest SR-450 Tablet with Cisapride is not recommended as it can possibly result in an interaction, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath. Do not discontinue any medications without consulting a doctor.
LithiumCidofovir
Critical
How does the drug interact with Lithorest SR-450 Tablet:
Cidofovir can cause higher levels of Lithorest SR-450 Tablet carbonate in the blood which increases risk of kidney problems.

How to manage the interaction:
Taking Lithorest SR-450 Tablet with Cidofovir is not recommended, but can be taken together if prescribed by a doctor. However, if you experience nausea, vomiting, loss of appetite, increased or decreased urination, sudden weight gain or loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, or an irregular heart rhythm, consult a doctor. Do not discontinue any medications without consulting a doctor.
LithiumMoxifloxacin
Severe
How does the drug interact with Lithorest SR-450 Tablet:
Using Moxifloxacin together with Lithorest SR-450 Tablet can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of Moxifloxacin with Lithorest SR-450 Tablet can possibly result in an interaction, but it can be taken if a doctor has advised it. However, consult a doctor if you experience dizziness, shortness of breath, or heart palpitations Do not discontinue any medications without consulting a doctor.
LithiumIbuprofen
Severe
How does the drug interact with Lithorest SR-450 Tablet:
Coadministration of Lithorest SR-450 Tablet and Ibuprofen can increases the blood levels of Lithorest SR-450 Tablet.

How to manage the interaction:
Co-administration of Lithorest SR-450 Tablet and Ibuprofen can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like drowsiness, dizziness, confusion, diarrhea, vomiting, muscle weakness, muscle inco-ordination, tremor, blurred vision, ringing in the ear, excessive thirst, and increased urination, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
LithiumTrazodone
Severe
How does the drug interact with Lithorest SR-450 Tablet:
Combining Lithorest SR-450 Tablet carbonate with Trazodone can increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Trazodone and Lithorest SR-450 Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumGatifloxacin
Severe
How does the drug interact with Lithorest SR-450 Tablet:
Taking Gatifloxacin with Lithorest SR-450 Tablet can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Gatifloxacin with Lithorest SR-450 Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or unusual memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
LithiumSirolimus
Severe
How does the drug interact with Lithorest SR-450 Tablet:
Coadministration of Sirolimus with Lithorest SR-450 Tablet together may increase the risk or severity of kidney problems.

How to manage the interaction:
Although taking Lithorest SR-450 Tablet and Sirolimus together can cause an interaction, it can be taken if a doctor has suggested it. However, consult the doctor immediately if you experience symptoms such as nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or weight loss, fluid retention, swelling, shortness of breath, muscle cramps, tiredness, weakness, dizziness, confusion, and irregular heart rhythm. Do not discontinue any medications without consulting a doctor.
LithiumVenlafaxine
Severe
How does the drug interact with Lithorest SR-450 Tablet:
Taking Venlafaxine with Lithorest SR-450 Tablet may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a interaction between Venlafaxine and Lithorest SR-450 Tablet, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
LithiumPiroxicam
Severe
How does the drug interact with Lithorest SR-450 Tablet:
Co-administration of Piroxicam and Lithorest SR-450 Tablet can increase the levels of Lithorest SR-450 Tablet, which may lead to side effects.

How to manage the interaction:
Co-administration of Lithorest SR-450 Tablet with Piroxicam can result in an interaction, but it can be taken if a doctor has advised it. However, contact a doctor if you experience drowsiness, dizziness, confusion, loose stools, vomiting, muscle weakness, muscle incoordination, shaking of hands and legs, blurred vision, ringing in the ear, excessive thirst, and/or increased urination. Do not stop using any medications without talking to a doctor.
LithiumAmisulpride
Severe
How does the drug interact with Lithorest SR-450 Tablet:
Taking amisulpride with Lithorest SR-450 Tablet increases the risk of an abnormal heart rhythm.

How to manage the interaction:
Although taking amisulpride along with Lithorest SR-450 Tablet can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience abrupt dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Avoid low-sodium diet as it may increase lithium levels in blood and cause adverse effects.
  • Limit the intake of caffeine as it may reduce the effectiveness of Lithorest SR-450 Tablet 10's.
  • Do regular exercise and maintain a stable weight as Lithorest SR-450 Tablet 10's may cause weight gain.
  • Drink plenty of water to avoid dehydration and try to drink same amount of water everyday as any major changes in quantity may affect lithium levels.
  • Avoid consumption of alcohol as it may increase drowsiness.

Habit Forming

No

Therapeutic Class

ANTIPSYCHOTICS

Lithorest SR-450 Tablet 10's Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended to avoid consumption of alcohol with Lithorest SR-450 Tablet 10's as it may increase the risk of side effects such as drowsiness, dizziness or difficulty in concentrating.

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Pregnancy

Unsafe

Lithorest SR-450 Tablet 10's is a Category D pregnancy drug and is not recommended for use during pregnancy as it may cause harm to the unborn baby.

bannner image

Breast Feeding

Unsafe

Avoid breastfeeding while taking Lithorest SR-450 Tablet 10's as it may be excreted in breast milk and cause adverse effects in the baby.

bannner image

Driving

Unsafe

Lithorest SR-450 Tablet 10's may cause dizziness, drowsiness or other severe adverse effects. Therefore, avoid driving if you feel drowsy or dizzy after taking Lithorest SR-450 Tablet 10's.

bannner image

Liver

Safe if prescribed

Lithorest SR-450 Tablet 10's is safe to use in patients with Liver diseases/conditions if prescribed by a doctor.

bannner image

Kidney

Caution

Take Lithorest SR-450 Tablet 10's with caution, especially if you have a history of Kidney diseases/conditions. The dose may be adjusted by your doctor as required. Lithorest SR-450 Tablet 10's is not recommended for patients with severe kidney problems.

bannner image

Children

Caution

Lithorest SR-450 Tablet 10's is generally not recommended for children below 12 years. However, Lithorest SR-450 Tablet 10's may be used in children above 7 years for treating bipolar I disorder only if prescribed by a doctor.

Have a query?

FAQs

Lithorest SR-450 Tablet 10's is used to prevent and treat mood disorders like mania and bipolar disorder. It works by increasing the activity of chemical messengers in the brain, thereby suppressing the excessive and abnormal activity of nerve cells in the brain and helping to stabilize a person’s mood.

No, you are not recommended to take Lithorest SR-450 Tablet 10's with fluoxetine or other antidepressants such as paroxetine and sertraline as co-administration of these medicines may increase the risk of a rare and serious condition known as serotonin syndrome. If you experience blurred vision, increased heart rate, hallucination, fits, confusion, muscle stiffness or spasm, vomiting, nausea, diarrhoea, excessive sweating, stomach cramps, fever, shaking or shivering, please consult a doctor immediately. However, before using Lithorest SR-450 Tablet 10's with any other medicines, you are advised to contact your doctor.

Lithorest SR-450 Tablet 10's is not recommended for hypothyroid (underactive thyroid gland) patients as it may increase the risk of low levels of thyroid hormone. Therefore, if you have hypothyroidism, please inform your doctor before taking Lithorest SR-450 Tablet 10's. Also, thyroid levels are checked generally before starting treatment with Lithorest SR-450 Tablet 10's so that if the levels are too low, Lithorest SR-450 Tablet 10's is not advised.

Yes, Lithorest SR-450 Tablet 10's may cause weight gain but it is not necessary for everyone taking Lithorest SR-450 Tablet 10's to experience this side effect. However, in order to avoid gaining weight while taking Lithorest SR-450 Tablet 10's, you are advised to do regular exercise and avoid high-calorie drinks. Instead take non-alcoholic drinks, herbal tea and lemon water.

It is advised to inform your doctor if you are planning or had weight loss surgery as the dose may be adjusted accordingly based on lithium levels in blood.

Yes, Lithorest SR-450 Tablet 10's may cause dehydration especially if you have low sodium levels in the body or consume too much alcohol. However, if you notice dark, strong smelling urine or decrease in urination, it indicates that you are dehydrated and may affect lithium levels in blood. Therefore, you are recommended to drink plenty of fluids while taking Lithorest SR-450 Tablet 10's to avoid dehydration.

No, you are not recommended to stop taking Lithorest SR-450 Tablet 10's without consulting your doctor as it may worsen the condition or cause recurring symptoms. Therefore, take Lithorest SR-450 Tablet 10's for as long as your doctor has prescribed it and if you experience any difficulty while taking Lithorest SR-450 Tablet 10's, please consult your doctor so that the dose may be gradually reduced.

Lithorest SR-450 Tablet 10's may cause side effects such as slurred speech, confusion, mood changes, bloating, or lightheadedness. If these side effects persist or worsen, please consult your doctor.

Lithorest SR-450 Tablet 10's takes some time to show improvement in your symptoms but it varies from person to person. This is because each patient reacts differently to particular medication. It may take 1 to 3 weeks or longer for you to see the full effects of Lithorest SR-450 Tablet 10's. Continue taking Lithorest SR-450 Tablet 10's even if you are not improving and consult your doctor.

Yes, Lithorest SR-450 Tablet 10's can cause drowsiness or sleepiness. If you feel dizzy or sleepy, avoid driving or using machines or performing any tasks that require your attention.

Yes, Lithorest SR-450 Tablet 10's may cause kidney problems. Lithorest SR-450 Tablet 10's is not advised in patients who already have severe kidney impairment. Before starting treatment with Lithorest SR-450 Tablet 10's, your doctor will recommend blood tests to see if your kidney function is normal. During treatment with Lithorest SR-450 Tablet 10's, any gradual or sudden changes in kidney function, may indicate that the treatment needs re-evaluation.

Lithorest SR-450 Tablet 10's should only be started if sufficient facilities are available for evaluating Lithorest SR-450 Tablet 10's levels as increased blood levels of Lithorest SR-450 Tablet 10's is related to Lithorest SR-450 Tablet 10's toxicity. Even at dose which is effective for treatment, Lithorest SR-450 Tablet 10's toxicity can occur. Therefore, your doctor may closely monitor your Lithorest SR-450 Tablet 10's levels weekly until stabilization is reached, then weekly for one month and then every month after that.

Take Lithorest SR-450 Tablet 10's with or without food or as advised by the doctor. Swallow it as whole with a glass of water. Do not break, crush or chew it.

Some medicines decrease Lithorest SR-450 Tablet 10's levels in blood which means that it will not work well. These include caffeine, theophylline (for asthma), medicines containing sodium bicarbonate, or a special group of diuretics (water tablets) called carbonic anhydrase inhibitors and urea (used to treat skin conditions). Therefore, please inform your doctor about the medicines you are taking before starting Lithorest SR-450 Tablet 10's to avoid drug interactions.

Country of origin

India

Manufacturer/Marketer address

3012/1, Ground Floor ,Phase Iv, Gidc, Vatva, Ahmedabad 382445, India
Other Info - LIT0306

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Author Details

Veda MaddalaDoctor badge

Written By

Veda Maddala

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 18, 2025 | 6:34 AM IST

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Reference

  1. https://www.medicines.org.uk/emc/files/pil.10828.pdf
  2. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/017812s033,018421s032,018558s027lbl.pdf
  3. https://www.drugs.com/lithium.html
  4. https://www.nhs.uk/medicines/lithium/
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