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compositionComposition:ATROPINE-0.25MG+DIPHENOXYLATE-2.5MG
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Prescription Medicine
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Lomotil Tablet is used to treat diarrhoea. It contains Diphenoxylate and Atropine, which works by slowing down the intestinal movements, thereby makes the stools more solid and less frequent. Also, it helps to prevent involuntary muscle movements in the intestine. In some cases, you may experience certain common side effects such as abdominal discomfort, nausea, vomiting, headache, dry mouth and dizziness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

ATROPINE-0.25MG+DIPHENOXYLATE-2.5MG

Manufacturer/Marketer :

RPG Life Sciences Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Lomotil Tablet

Lomotil Tablet is a prescription medicine used to treat sudden or long-term diarrhoea. It works by slowing down the movement of your intestines, which helps reduce the frequency and looseness of your bowel movements. This medicine is typically taken for short periods to manage acute symptoms under medical supervision.

You should take this medicine exactly as your doctor directs, usually only until your bowel movements return to normal. It can be taken with or without food, but you should swallow it with a full glass of water. To achieve the best results, it is highly recommended to rest your digestive system, eat small meals, and drink plenty of water or electrolyte fluids to avoid getting dehydrated.

Many people using Lomotil Tablet experience mild side effects, such as drowsiness, dizziness, or a dry mouth. However, you must contact your doctor immediately if you develop serious side effects like severe abdominal pain, a swollen stomach, or a rapid heart rate.

Before taking this medicine, tell your doctor if you have a history of liver damage, kidney issues, or severe dehydration. Do not take this if you have diarrhoea caused by a bacterial infection or certain inflammatory bowel diseases, as slowing your digestion can trap harmful toxins in your body.

This medicine can interact with alcohol, sleeping pills, and muscle relaxants, which may cause extreme sleepiness or dangerously slowed breathing. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist before taking this medicine to ensure it is safe for you.

Uses of Lomotil Tablet

Lomotil Tablet is used to help control diarrhoea by slowing bowel movements. It is commonly prescribed for: 

  • Acute Diarrhoea: Lomotil Tablet helps by slowing down overactive bowel movements, which reduces the frequency of loose stools and helps your body retain essential fluids.
  • Chronic Diarrhoea: In certain cases, doctors prescribe this medicine to help manage long-term diarrhoea associated with inflammatory bowel conditions.

Key Benefits

Lomotil Tablet helps control diarrhoea by slowing the movement of the intestines, allowing more water and electrolytes to be absorbed. This helps reduce the frequency of bowel movements and supports recovery.

  • Controls Diarrhoea: Helps reduce frequent, loose stools by slowing intestinal movement.
  • Relieves Bowel Urgency: Helps decrease the sudden urge to pass stools, improving comfort and convenience.
  • Promotes Fluid Absorption: Allows the intestines to absorb more water and electrolytes, helping reduce the risk of dehydration.
  • Supports Faster Recovery: Helps restore normal bowel function and enables your body to recover more effectively.
  • Improves Daily Comfort: Better control of diarrhoea may help you regain strength and return to your normal daily activities with greater confidence.
Side effects of Lomotil Tablet
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
To prevent, manage, and treat Constipation caused by medication usage, follow these steps:
  • Preventing Vomiting (Before it Happens)
  • Take medication exactly as prescribed by your doctor. This can help minimize side effects, including vomiting.
  • Having a small meal before taking your medication can help reduce nausea and vomiting.
  • Talk to your doctor about taking anti-nausea medication along with your prescribed medication.
  • Managing Vomiting (If it Happens)
  • Try taking ginger in the form of tea, ale, or candy to help alleviate nausea and vomiting.
  • What to Do if Vomiting Persists
  • Consult your doctor if vomiting continues or worsens, consult the doctor for guidance on adjusting your medication or additional treatment.

Directions for Use

Always take Lomotil Tablet exactly as prescribed by your doctor. Follow these simple steps for safe use:

  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet.
  • If you are taking the liquid form, always use the marked measuring syringe or cup provided with the medicine to ensure an accurate dose. Do not use a regular household spoon.
  • Keep track of your symptoms and stop taking the medicine as soon as your diarrhoea resolves, or follow the specific timeline given by your doctor.
  • Your doctor will determine the appropriate duration of treatment based on your medical condition. Do not increase your dose or take this medicine more frequently than directed.
     

How Lomotil Tablet Works

Lomotil Tablet is a combination of two drugs: Diphenoxylate (opioid agonist) and Atropine (anti-cholinergic). Diphenoxylate works by slowing down the intestinal movements, thereby makes the stools more solid and less frequent. Atropine helps to prevent involuntary muscle movements in the intestine. Atropine is added to prevent the abuse of diphenoxylate as higher doses may cause physical dependence.
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Alcohol

Unsafe

Avoid consuming alcohol while taking Lomotil Tablet as it may cause increased dizziness and drowsiness.

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Pregnancy

Caution

Lomotil Tablet belongs to pregnancy category C. Please consult your doctor before taking Lomotil Tablet if you are pregnant; your doctor will prescribe Lomotil Tablet only if the benefits outweigh the risks.

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Breast Feeding

Caution

Lomotil Tablet may pass into breastmilk. Consult your doctor before taking Lomotil Tablet ; your doctor will decide whether Lomotil Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Lomotil Tablet may cause dizziness and drowsiness. Do not drive or operate machinery if you feel dizzy or drowsy.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking Lomotil Tablet if you have liver impairment/liver disease before taking Lomotil Tablet .

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Kidney

Caution

Dose adjustment may be needed. Please consult your doctor if you have any concerns regarding this or kidney impairment/kidney disease before taking Lomotil Tablet .

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Children

Unsafe

Lomotil Tablet should not be given to children below 13 years as the safety and effectiveness have not been established.

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Heart

Caution

Lomotil Tablet should be taken with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Lomotil Tablet .

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Geriatrics

Caution

Lomotil Tablet should be used with caution in elderly patients, as they may be at an increased risk of adverse reactions compared with younger individuals.

What if I have taken an overdose of Lomotil Tablet

In case of an accidental overdose, seek emergency medical attention or contact a poison control centre immediately. An overdose can cause serious breathing difficulties, severe drowsiness, rapid heart rate, and dry skin, especially in children.

Diet & Lifestyle Advise

  • Stay hydrated: Drink plenty of clear liquids, such as water, broths, and electrolyte-rich solutions, to replace lost fluids and prevent dehydration.
  • Eat simple, bland foods: Stick to easy-to-digest options like bananas, plain white rice, applesauce, and toast until your digestive tract recovers.
  • Avoid irritating foods: Steer clear of dairy products, high-fat or greasy foods, very spicy dishes, and caffeine, as these can aggravate diarrhoea.
  • Wash hands frequently: Practice thorough hand hygiene with soap and water to prevent the spread of infections that may have triggered the diarrhoea.

Health Queries

What medicines should I take for ongoing diarrhea and stomach cramps that started after overeating, if I also had a mild fever, have already taken Lomotil and Electrol, and have diabetes with a high blood sugar level of 300?

Dr. S Aneela

Dr. S Aneela

M. Pharm (Pharmacology)., PhD

Because you have a fever and your blood sugar is 300 mg/dL, your body is under significant stress. Please stop taking Lomotil, as slowing down diarrhea when a fever is present can trap infections. You can continue taking Electrol for hydration, but please monitor your glucose levels closely. With blood sugar at 300 mg/dL alongside an infection, it is very important that you contact your treating doctor or seek urgent medical attention immediately. They can safely adjust your diabetes medications and prescribe the correct treatment for your stomach.

What should I do if my constant urge to poop and soft, bloody stools stopped after taking Lomotil and O2, but now I am only passing a light reddish liquid with no bowel movements?

Veda Maddala

Veda Maddala

M Pharmacy

Passing light reddish liquid needs careful attention. Lomotil (diphenoxylate/atropine) works by significantly slowing down your bowel movements. This slowdown can sometimes cause residual fluid, mucus, or healing blood to pool and pass as a light reddish liquid. However, to ensure the underlying cause of your bloody stools is fully resolving and that you are healing safely, please consult your doctor promptly. In the meantime, stay well-hydrated with clear fluids or oral rehydration solutions, avoid taking further doses of Lomotil without medical advice, and seek immediate care if you experience a fever, dizziness, or worsening abdominal pain.

I have been drinking fluids and took two Lomotil pills today for vomiting and diarrhea, and though the vomiting has stopped and my loose stools have decreased, the diarrhea has not completely stopped?what should I do next?

G.santoshini Reddy

G.santoshini Reddy

M Pharmacy (Pharmaceutics)

It is completely normal for diarrhea to take a little time to fully resolve. Please continue staying well-hydrated with water and electrolyte solutions. Since your symptoms are already decreasing, you can continue taking the diphenoxylate/atropine (Lomotil) exactly as prescribed by your doctor, making sure not to exceed the recommended daily limit. Keep resting and eat bland foods. If the diarrhea does not fully clear up within 48 hours, or if you develop a high fever or notice blood in your stool, please reach out to your doctor for further guidance.

Why did my stomach become so sensitive after pregnancy and a past bacterial infection, causing recurring heartburn, burping, nausea, and diarrhea despite using Lomotil and Rantac, and should I see a specialist to help treat this?

Y. Lakshmi Thulasi

Y. Lakshmi Thulasi

Pharm-D (Post baccalaureate)

It is very common for pregnancy and a past infection to disrupt your gut microbiome, leading to lasting stomach sensitivity or post-infectious irritable bowel syndrome. While medications like Rantac (ranitidine) and Lomotil (diphenoxylate/atropine) help manage individual symptoms, they do not address the underlying imbalance. I highly recommend consulting a gastroenterologist. A specialist can help identify the root cause of your heartburn, nausea, and diarrhea, and guide you toward a tailored plan to safely restore your digestive health. Please be reassured that this is manageable, and seeking specialized care is a wonderful next step toward finding long-term relief.

What else can I give to someone who is feeling very weak and still has an intermittent fever and diarrhea despite taking Dolo 650 and Lomotil, and eating watery dal rice, oats gruel, and biscuits?

Veda Maddala

Veda Maddala

M Pharmacy

The most important step right now is preventing dehydration, which is causing the severe weakness. Please start Oral Rehydration Salts (ORS) dissolved in clean water, and offer coconut water. Continue the watery dal-rice and oats gruel, but avoid biscuits as they can sometimes irritate the gut. You can continue paracetamol (Dolo 650) for the fever, but please consult a doctor before continuing Lomotil. Persistent fever and diarrhea may indicate an infection requiring specific medical evaluation.
health query

Have a query?

How Soon It Starts Working

The time required for Lomotil Tablet to start to work: The time required for Lomotil Tablet to start to work is 1 hour after administration. The time for which the effects of Lomotil Tablet last: The effect of Lomotil Tablet lasts for 4 to 6 hours.

What if you forget to take Lomotil Tablet

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

•Store Lomotil Tablet at room temperature, ideally between 20°C to 25°C (68°F to 77°F). •Keep the medicine in its original container, tightly closed, to protect it from light and moisture.

Drug Warnings

  • Watch for dehydration: Seek medical help if you experience signs of extreme dehydration, such as excessive thirst, dry mouth, little to no urination, or severe dizziness.
  • Avoid driving: Do not drive, operate heavy machinery, or perform tasks requiring alertness until you know how Lomotil Tablet affects you, as it can cause significant drowsiness.
  • Limit alcohol: Avoid drinking alcohol while taking this medicine, as it can dangerously intensify drowsiness and slow down your breathing.
  • Check for signs of toxic megacolon: Stop taking this medicine and call your doctor immediately if your abdomen becomes swollen, hard, or painful, as this can be a sign of a rare but serious bowel complication.
  • Do not use for infectious diarrhoea: Do not take this medicine if your diarrhoea is accompanied by a high fever or bloody stools, as it can trap toxins or bacteria in your intestines.
  • Use Only as Prescribed: Do not use Lomotil Tablet for longer than recommended. If diarrhoea continues for more than 48 hours or worsens, contact your doctor. 

Drug-Drug Interactions

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Drug-Drug Interactions

Some medicines may affect how Lomotil Tablet works or increase the risk of side effects. Tell your doctor about all the medicines you are taking, including:

  • Sedatives and sleep medicines: Taking Lomotil Tablet with drugs that cause drowsiness (such as benzodiazepines, muscle relaxants, or sleep aids) can increase the risk of extreme sedation and slowed breathing.
  • MAO inhibitors (antidepressants): Combining this medicine with MAO inhibitors can cause a sudden, severe increase in blood pressure.
  • Anticholinergic drugs: Taking Lomotil Tablet with other medicines that have drying effects (like antihistamines or certain bladder control drugs) can cause severe dry mouth, urinary retention, and constipation.

Drug-Food Interactions

Certain foods and drinks may affect how Lomotil Tablet works or increase the risk of side effects. 

  • Alcohol: Consuming alcohol while taking this medicine can dangerously increase drowsiness, dizziness, and the risk of respiratory issues.

Drug-Disease Interactions

Certain medical conditions may affect how Lomotil Tablet works or increase the risk of side effects. Inform your doctor if you have any of the following conditions before starting treatment:

  • Severe liver disease: People with liver damage should use extreme caution, as the liver processes this medicine, and a buildup can lead to serious brain complications.
  • Infectious enteritis: Do not take this medicine if you have diarrhoea caused by bacteria (like Salmonella or E. coli), as slowing bowel movements can prolong the infection.
  • Ulcerative colitis: Taking this medicine during an active flare-up of ulcerative colitis can trigger toxic megacolon, a life-threatening widening of the large intestine.
Atropine + DiphenoxylateZonisamide
Severe
Atropine + DiphenoxylatePotassium chloride
Severe

Drug-Drug Interactions

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Atropine + DiphenoxylateZonisamide
Severe
How does the drug interact with Lomotil Tablet:
Coadministration of Lomotil Tablet and Zonisamide can cause increased body temperature and decreased sweating.

How to manage the interaction:
Although taking Lomotil Tablet and Zonisamide together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, or lightheadedness, or if you have reduced sweating or a fever, consult a doctor immediately. Avoid tasks that need mental attention, such as driving or operating dangerous machinery. Do not discontinue any medications without consulting a doctor.
Atropine + DiphenoxylatePotassium chloride
Severe
How does the drug interact with Lomotil Tablet:
Co-administration of Atropine with Potassium chloride can increase the risk of stomach ulcers, bleeding.

How to manage the interaction:
There may be a possibility of interaction between Atropine and Potassium chloride, but it can be taken if prescribed by a doctor. If you have any of these symptoms, it's important to contact the doctor right away: severe stomach pain, bloating, sudden lightheadedness or dizziness, nausea, vomiting (especially with blood), decreased hunger, dark, tarry stools. Do not discontinue any medications without a doctor's advice.
Atropine + DiphenoxylateSecretin
Severe
How does the drug interact with Lomotil Tablet:
When Secretin human is used with Lomotil Tablet, the therapeutic efficacy of Secretin human can be decrease.

How to manage the interaction:
Although there is a possible interaction between Lomotil Tablet and Secretin, you can take these medicines together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.
Atropine + DiphenoxylateTopiramate
Severe
How does the drug interact with Lomotil Tablet:
When Lomotil Tablet and Topiramate are taken together it can cause increased body temperature and decreased sweating.

How to manage the interaction:
Although taking Lomotil Tablet and topiramate together can result in an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, dizziness, or lightheadedness, or if you have reduced sweating or a fever, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Atropine + DiphenoxylateUmeclidinium bromide
Severe
How does the drug interact with Lomotil Tablet:
Taking Lomotil Tablet together with umeclidinium may increase risk of side effects.

How to manage the interaction:
Although taking Lomotil Tablet and Umeclidinium bromide together can cause an interaction, it can be taken if a doctor has suggested it. If you experience drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, rapid heartbeat, confusion, memory problems, and glaucoma - an eye disease that causes vision loss in one or both eyes. Do not stop using any medications without talking to a doctor.
Atropine + DiphenoxylateHydromorphone
Severe
How does the drug interact with Lomotil Tablet:
Using Hydromorphone together with Lomotil Tablet may increase the risk and/or severity of some side effects (dizziness, drowsiness, confusion, difficulty concentrating, difficulty urinating, dry mouth, abdominal cramping, and constipation).

How to manage the interaction:
Although taking Hydromorphone and Atropine together can cause an interaction, it can be taken if a doctor has suggested it. If you have any of these symptoms, it's important to contact a doctor right away: trouble peeing, feeling dizzy or sleepy, feeling confused or having trouble focusing, dry mouth, constipation, or feeling less mentally sharp. Do not discontinue any medications without consulting a doctor.
Atropine + DiphenoxylatePramlintide
Severe
How does the drug interact with Lomotil Tablet:
Coadministration of Pramlintide with Lomotil Tablet can increase the risk of reduced movement in the digestive system.

How to manage the interaction:
Taking Atropine with Pramlintide together can result in an interaction, but it can be taken if a doctor has advised it. Do not stop using any medications without talking to a doctor.
Atropine + DiphenoxylateSolifenacin
Severe
How does the drug interact with Lomotil Tablet:
Taking Lomotil Tablet with solifenacin may increase the risk of side effects.

How to manage the interaction:
Co- administration of Lomotil Tablet with solifenacin can lead to an interaction, it can be taken if a doctor has advised it. However, if you experience drowsiness, blurred vision, dry mouth, heat intolerance, flushing, decreased sweating, difficulty urinating, abdominal cramping, constipation, irregular heartbeat, confusion, and memory problems. Do not stop using any medications without talking to a doctor.
Atropine + DiphenoxylatePotassium citrate
Severe
How does the drug interact with Lomotil Tablet:
Taking potassium citrate oral tablets or capsules with Lomotil Tablet may increase the irritating effects of potassium on stomach and upper intestine.

How to manage the interaction:
Taking atropine with potassium citrate together can result in an interaction, it can be taken if a doctor has advised it. However, if you happen to experience severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of appetite, and/or black, tarry stools, consult the doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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FAQs

Lomotil Tablet is used to treat diarrhoea.
Lomotil Tablet contains Diphenoxylate and Atropine. Diphenoxylate works by slowing down intestinal movements, thereby making the stools more solid and less frequent. Atropine helps to prevent involuntary muscle movements in the intestine.
Dry mouth could be a side-effect of Lomotil Tablet . Limiting caffeine intake, avoiding smoking and mouthwashes containing alcohol, drinking water regularly, and chewing sugar-free gum/candy might stimulate saliva and prevent drying of the mouth.
Constipation might be a side-effect of Lomotil Tablet . Drink enough fluids and eat fibre-rich food if you experience constipation. Consult your doctor if the condition persists or worsens.
Do not take anti-depressants, especially MAO inhibitors, along with Lomotil Tablet as it may cause headache, high blood pressure, and hyperthermia (high temperature). Consult your doctor before taking Lomotil Tablet with other medicines to avoid unpleasant side effects.
Do not take Lomotil Tablet for longer durations unless prescribed. Generally, your condition will get better within 48hours of taking Lomotil Tablet . Talk to your doctor if there is no improvement even after taking Lomotil Tablet for 10 days.
Lomotil Tablet does not have the potentiality to be habit-forming or addictive when used as suggested by your doctor. Always follow the doctor’s instructions while taking Lomotil Tablet .
Lomotil Tablet doesn’t have potentiality to cause dental problems. If you face dental problem or any difficulty while using Lomotil Tablet please consult your doctor.
Lomotil Tablet should be stored in a cool and dry place away from sunlight and kept away from children’s reach. Dispose of unused or expired products through a drug take-back program or dispose them as advised by the pharmacist.
Lomotil Tablet may cause dizziness. So, do not drive or operate heavy machinery if you feel dizzy.
Avoid drinking alcohol while taking Lomotil Tablet . Alcohol can increase dizziness, drowsiness, and confusion.
The common side effects of Lomotil Tablet include discomfort, nausea, vomiting, headache, dry mouth and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side-effects persistently.
No, you should not take this medicine if you have a high fever or if there is blood in your stool. These symptoms suggest an infection, and slowing your bowels can prevent your body from clearing the bacteria. Talk to your doctor to find the right treatment.
This medicine is generally not recommended during pregnancy or breastfeeding unless specifically prescribed. It can pass into breast milk and affect your baby. Talk to your doctor to discuss safer alternatives.
This medicine can cause serious breathing difficulties and other severe side effects in young children. It should never be given to infants or young children without direct instruction and supervision from a pediatrician. Talk to your doctor before giving this to any child.
If your diarrhoea continues for more than 48 hours despite taking this medicine, stop taking it and contact your healthcare provider. This may be a sign of a more serious underlying infection or condition. Talk to your doctor for further guidance.

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Country of origin

India

Manufacturer/Marketer address

463, 4 th Floor, RPG HOUSE, Dr. Annie Besant Road, Worli, Mumbai – 400 030. Maharashtra, INDIA
Other Info - LOM0011

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