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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Mephentine Injection 1 ml is used to treat hypotension (low blood pressure). Besides this, it is also indicated to treat hypotensive states, such as circulatory failure during spinal anaesthesia or drug-induced hypotension. It contains Mephentermine, which helps to release a chemical messenger (adrenaline), that compresses the blood vessels. It increases blood pressure rapidly by increasing the heart's pumping capacity and narrowing the heart's blood vessels. Some people may experience side effects such as systemic hypertension (high blood pressure), anxiety, insomnia (difficulty in sleeping), and CNS stimulation. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Whats That

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Composition :

MEPHENTERMINE-30MG

Manufacturer/Marketer :

Pfizer Ltd

Consume Type :

PARENTERAL

Return Policy :

Not Returnable

Expires on or after :

About Mephentine Injection 1 ml

Mephentine Injection 1 ml used to treat hypotension (low blood pressure). It is also indicated to treat hypotensive states, such as circulatory failure during spinal anaesthesia or drug-induced hypotension. Hypotension is when blood pressure drops below the normal range, which may reduce cardiac output and hypovolemia (low blood volume). It can cause dizziness, weakness, fainting, and an increased risk of falls.

Mephentine Injection 1 ml contains ‘Mephentermine,’ which is a class of medicine called sympathomimetics. It helps to release a chemical messenger (adrenaline), constricts the blood vessels. It increases blood pressure rapidly by increasing the heart's pumping capacity and narrowing the blood vessels.

Mephentine Injection 1 ml will be administered by a healthcare professional. Do not self-administer Mephentine Injection 1 ml. Some people may experience systemic hypertension (high blood pressure), anxiety, insomnia (difficulty in sleeping), and CNS stimulation. Most of these side effects of Mephentine Injection 1 ml do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

If you are pregnant or breastfeeding, it is advised to inform your doctor before taking Mephentine Injection 1 ml. It should not be used in children below 18 years. Mephentine Injection 1 ml should be used with caution in patients with heart disease, overactive thyroid, shock, dehydration, or acidosis (increased acid level in blood). Do not take Mephentine Injection 1 ml if you have taken an MAO inhibitor (anti-depressant medication like Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine) in the last 14 days. If you have high blood pressure, kidney or liver problems, or coronary artery disease, inform your doctor before taking Mephentine Injection 1 ml.

Uses of Mephentine Injection 1 ml

Mephentine Injection 1 ml used in the treatment of hypotension (low blood pressure). The detailed uses of Mephentine Injection 1 ml are as follows: <br/>• Treatment of hypotension: Mephentine Injection 1 ml helps to raise blood pressure in cases of low blood pressure.<br/>• Post-spinal anesthesia support: Mephentine Injection 1 ml helps manage low blood pressure caused by spinal anesthesia, supporting stable blood pressure during and after procedures.<br/>• Supportive treatment in shock: Mephentine Injection 1 ml is used to support blood pressure in shock cases where a drop in blood pressure occurs.<br/>

Directions for Use

• Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.• Mephentine Injection 1 ml will be administered by the doctor or healthcare professional.• Do not self-administer.

Medicinal Benefits

Mephentine Injection 1 ml consists of Mephentermine is a sympathomimetic medicine. It helps to release a chemical messenger (adrenaline), which compresses the blood vessels. It increases the blood pressure rapidly by increasing the pumping capacity of the heart and narrowing the blood vessels of the heart.  Hence, it works to increase your blood pressure. Mephentine Injection 1 ml also used by anesthesiologist and intensive care specialist to treat hypotension (decreased blood pressure) due to vasodilation caused by general, epidural, and spinal anesthesia (caesarian section).

How Mephentine Injection 1 ml Works

Mephentine Injection 1 ml contains Mephentermine, a sympathomimetic medicine. It helps to release a chemical messenger (adrenaline), which constricts the blood vessels. It increases blood pressure rapidly by increasing the heart's pumping capacity and narrowing the blood vessels.

Storage

Keep Mephentine Injection 1 ml out of the sight and reach of children.

What if I have taken an overdose of Mephentine Injection 1 ml

The overdose of Mephentine Injection 1 ml is unlikely as a doctor administers it. However, if you suspect any adverse reactions or unusual symptoms after receiving Mephentine Injection 1 ml, please inform your doctor immediately.

Drug Warnings

Tell your doctor if you are allergic to Mephentine Injection 1 ml, or any of its ingredients. Keep your doctor informed about all your medicines, including prescription, non-prescription, and herbal supplements. Mephentine Injection 1 ml is not recommended during pregnancy or breastfeeding unless prescribed by a doctor. Mephentine Injection 1 ml should not be given to children as safety and effectiveness have not been established. Before using Mephentine Injection 1 ml, tell your doctor if you have liver/kidney problems, hypertension, overactive thyroid, shock, dehydration, or acidosis. Do not drive or handle machinery unless you are alert. Mephentine Injection 1 ml is not recommended in the treatment of hypotension (low blood pressure) induced by chlorpromazine because it may potentiate, rather than correct. Inform your doctor if you are taking or have recently taken medication to treat severe depression.

Drug-Drug Interactions

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MephenterminePhenelzine
Critical

Drug-Drug Interactions

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How does the drug interact with Mephentine Injection 1 ml:
Taking linezolid and Mephentine Injection 1 ml together may cause high blood pressure.

How to manage the interaction:
Taking Mephentine Injection 1 ml with Linezolid is not recommended, as it can result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
MephenterminePhenelzine
Critical
How does the drug interact with Mephentine Injection 1 ml:
Taking Phenelzine with Mephentine Injection 1 ml together may increase the hypertensive activities of Mephentine Injection 1 ml.

How to manage the interaction:
Taking Mephentine Injection 1 ml with Phenelzine together is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. If you notice any of these signs - headache, trouble seeing clearly, feeling confused or having seizures, chest pain, feeling sick, sudden numbness or weakness, difficulty speaking, having a fever, sweating a lot, feeling dizzy or passing out - contact a doctor right away. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mephentine Injection 1 ml:
When Mephentine Injection 1 ml is combined with Selegiline, may increase the risk of high blood pressure.

How to manage the interaction:
Mephentine Injection 1 ml with Selegiline is not recommended as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, consult a doctor immediately if you experience symptoms such as severe headache, blurred vision, confusion, fits, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mephentine Injection 1 ml:
Taking Procarbazine with Mephentine Injection 1 ml together may increase the hypertensive activities of Mephentine Injection 1 ml.

How to manage the interaction:
Taking Mephentine Injection 1 ml with Procarbazine is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, consult your doctor immediately if you experience symptoms such as severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without consulting a doctor.
MephentermineIsocarboxazid
Critical
How does the drug interact with Mephentine Injection 1 ml:
Taking isocarboxazid and Mephentine Injection 1 ml together can increase the risk of high blood pressure.

How to manage the interaction:
Taking Mephentine Injection 1 ml with Isocarboxazid is not recommended, but can be taken if prescribed by the doctor. However, consult your doctor immediately if you experience symptoms such as severe headache, blurred vision, confusion, seizures, chest pain, nausea or vomiting, sudden numbness or weakness (especially on one side of the body), speech difficulties, fever, sweating, lightheadedness, and/or fainting. Do not discontinue any medications without consulting a doctor.
MephentermineIobenguane (131i)
Severe
How does the drug interact with Mephentine Injection 1 ml:
Co-administration of Iobenguane (131i) and Mephentine Injection 1 ml together can decrease the effectiveness of Mephentine Injection 1 ml.

How to manage the interaction:
There may be a possibility of interaction between Mephentine Injection 1 ml and Iobenguane (131i), but it can be taken if prescribed by a doctor. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Add foods high in vitamin B12, such as eggs, fortified cereals, and nutritional yeast, to your daily diet.
  • Salty foods can increase blood pressure. Try eating canned soup, cottage cheese, olives, and pickled items.
  • Drink coffee and caffeinated tea; it may spike blood pressure by stimulating the cardiovascular system.
  • Eat small meals more frequently; eating large meals may lower blood pressure as your body works harder to digest them.
  • Drink more water and limit alcohol; dehydration lowers blood pressure.
  • Change body position, standing up slowly.
  • Avoid prolonged bed rest.
  • If you exercise outdoors in extreme heat, take frequent breaks.
  • Avoid spending a long time in saunas, hot tubs, and steam rooms, which cause dehydration.

Habit Forming

No

Therapeutic Class

ANTIHYPOTENSIVES
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Alcohol

Caution

It is not known if alcohol interacts with Mephentine Injection 1 ml. Please consult your doctor if you have any concerns regarding this.

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Pregnancy

Unsafe

Mephentine Injection 1 ml may increase uterine contractions in pregnant women, especially during the third trimester. Inform your doctor if you are pregnant before taking Mephentine Injection 1 ml.

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Breast Feeding

Unsafe

It is unknown whether Mephentine Injection 1 ml is excreted in human milk. It is given to breastfeeding mothers only if the doctor thinks the benefits outweigh the risks.

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Driving

Caution

It is not known whether Mephentine Injection 1 ml affects the ability to drive. Do not drive if you experience symptoms affecting your ability to concentrate and react.

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Liver

Caution

Mephentine Injection 1 ml to be taken with caution, especially if you have a history of liver diseases/conditions. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Kidney

Caution

Mephentine Injection 1 ml should be taken with caution, especially if you have a history of Kidney diseases or conditions. Your doctor may adjust the dose or prescribe a suitable alternative based on your condition.

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Children

Caution

Mephentine Injection 1 ml is not recommended for children below 18 years of age. However, please consult a doctor before giving Mephentine Injection 1 ml to children.

Have a query?

FAQs

Mephentine Injection 1 ml is used to treat hypotension (low blood pressure) and is also indicated to treat hypotensive states, such as circulatory failure during spinal anaesthesia or drug-induced hypotension.

Do not stop taking Mephentine Injection 1 ml on your own. You are advised to take Mephentine Injection 1 ml for as long as your doctor has prescribed it for you depending on your medical condition. Do not be hesitant to speak with your doctor if you experience any difficulty while taking Mephentine Injection 1 ml.

Do not take Mephentine Injection 1 ml if you are pregnant or planning for pregnancy unless prescribed by a doctor. Your doctor will prescribe Mephentine Injection 1 ml only if the benefits outweigh the risks.

Antidepressants, along with Mephentine Injection 1 ml, especially monoamine oxidase inhibitors (MAOI’s) may prolong and increase the effects of Mephentine Injection 1 ml. Consult your doctor before taking Mephentine Injection 1 ml with other medicines to avoid unpleasant side-effects.

Systemic hypertension (high blood pressure), Anxiety, Insomnia (difficulty in sleeping), CNS stimulation are the common side-effects of Mephentine Injection 1 ml.Â

A person should tell their doctor if they have a history of heart disease, overactive thyroid, shock, high blood pressure, persistent and lasting illness, during pregnancy, and breastfeeding.

Country of origin

India

Manufacturer/Marketer address

The Capital, 1802, 18Th Floor , Plot No. C-70, €˜G’ Block , Bandra Kurla Complex, Bandra East , Mumbai - 400051
Other Info - MEP0003

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