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Mesacol Suppository is treating ulcerative colitis and ulcerative proctitis. It contains Mesalamine, which works by preventing the synthesis of chemical messengers such as prostaglandins in the intestines that produce inflammation (swelling). This lowers ulceration, bleeding, and stomach pain while preventing future illness flare-ups. Common side effects of Mesacol Suppository are diarrhoea, stomach pain, headache or nausea.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

MESALAMINE-500MG

Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

Rectal

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Mesacol Suppository

Mesacol Suppository is a specialised medication designed to treat inflammatory bowel diseases like ulcerative colitis and proctitis. Its primary medical purpose is to reduce swelling, redness, and irritation directly within the lining of the rectum and lower colon. By calming this inflammation, it helps control painful symptoms and allows the bowel lining to heal.

To achieve the best results, take this medicine consistently and exactly as your doctor prescribes, which is often once daily at bedtime. Because this is a rectal medication, you should insert it after emptying your bowels so it can remain in place to work overnight. Making dietary adjustments, such as avoiding spicy foods and staying well-hydrated, can also support your treatment and improve your digestive health.

While taking Mesacol Suppository, some people may experience mild side effects like gas, mild stomach pain, or slight rectal irritation. These effects are usually temporary, but if you notice serious issues like severe abdominal cramps, fever, or bloody diarrhoea, stop taking the medication and consult your doctor immediately. Your health and safety are the top priorities, so monitoring how your body responds is essential.

Before you begin taking Mesacol Suppository, you must talk to your doctor if you have certain health conditions, especially kidney disease, liver problems, or active stomach ulcers. Please avoid taking this if you have a known allergy to aspirin or similar salicylate medicines, as this can trigger a severe allergic reaction. Your doctor will help determine if this treatment is safe for your specific medical history.

This medication can interact with other drugs, including common over-the-counter pain relievers, which may increase the risk of kidney damage. If you are pregnant, breastfeeding, or planning a pregnancy, talk to your doctor or pharmacist to discuss the risks and benefits. Elderly individuals should also consult their healthcare provider, as they may require closer monitoring during treatment.

Uses of Mesacol Suppository

Mesacol Suppository is used in the treatment of Ulcerative colitis and Ulcerative proctitis. The detailed uses of Mesacol Suppository are as follows:

  • Ulcerative proctitis: Mesacol Suppository helps reduce localised swelling, bleeding, and irritation in the rectum, which is the very end of the large intestine.
  • Distal ulcerative colitis: Mesacol Suppository helps by delivering anti-inflammatory medicine directly to the lower parts of the colon to heal the damaged tissue.
  • Maintenance of remission: Mesacol Suppository helps keep your symptoms from returning, ensuring the bowel lining remains healthy and quiet over the long term.

Key Benefits

Mesacol Suppository works directly at the site of inflammation in the rectum and lower colon, helping control symptoms while limiting medicine exposure to the rest of the body. With regular use as prescribed, it can help reduce inflammation, promote healing of the bowel lining, and support long-term symptom control. 

Benefits may include:

  • Because Mesacol Suppository is used rectally, it delivers the medicine directly to the inflamed tissue in the lower bowel, providing targeted treatment where it is needed most.
  • It helps reduce symptoms such as rectal urgency, rectal bleeding, diarrhoea, and discomfort by calming inflammation in the affected area.
  • By reducing inflammation, Mesacol Suppository helps the lining of the rectum and lower colon heal over time.
  • Continued use as prescribed can help keep ulcerative colitis or proctitis under control and reduce the likelihood of symptoms returning.
Side effects of Mesacol Suppository
  • Eating and drinking slowly can help swallow less air, which reduces burps.
  • Avoid consuming foods like gum and hard candy and drinking carbonated drinks as they release carbon dioxide gas in your body.
  • Prevent smoking as it can impact your whole body.
  • Seek medical help to treat gastric problems and heart burn that may lead to frequent burps.
  • Check your dentures because if they are loosely fit, excess air can be swallowed that causes burbs more frequently.
  • If you have bowel inflammation, eat smaller quantities and more frequent meals.
  • Eat slowly and chew your food thoroughly to help digestion.
  • Eat fiber-rich foods such as fruits, whole grains, and vegetables to promote regular bowel movements.
  • Avoid gas-producing foods like cabbage, beans, broccoli and carbonated drinks.
  • Drink lots of water throughout the day to prevent dehydration and aid digestion.
  • Do regular exercise to enhance digestion and reduce bloating.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Apply a hot/cold pack to the affected area.
  • Doing gentle exercises can help cope with pain by stretching muscles.
  • Get enough sleep. It helps enhance mood and lower pain sensitivity.
  • Avoid alcohol, smoking and tobacco as they can increase pain.
  • Follow a well-balanced meal.
  • Meditation and massages may also help with pain.
Here are the steps to manage the medication-triggered Common Cold:
  • Inform your doctor about the common cold symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Drink plenty of fluids, such as warm water or soup, to help thin out mucus.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

  • Follow your doctor's instructions on the dosage and timing of this medication.
  • Check the label for directions and use it as advised by the doctor.
  • Before using, empty your bowels (if necessary) and wash your hands. Shake the bottle vigorously for at least 30 seconds. Remove the applicator's protective cap and hold the bottle by its top end. Lie on your left side, your left leg extended and your right leg bent. Insert the applicator (lubricant-coated) for easier entry into the rectum. Squeeze the bottle gently while holding it directed towards your navel. When the bottle is empty, remove the applicator from the rectum.
  • Allow the drug to spread throughout the lower section of the large intestine for at least 30 minutes by remaining in this posture.
  • Wash your hands before and after applying the medicament. Make sure that the rectal area is clean and dry before application.
  • For rectal use only.

How Mesacol Suppository Works

Mesacol Suppository works as a local anti-inflammatory agent inside the rectum and lower colon. It blocks the body's production of specific natural chemicals, such as prostaglandins and leukotrienes (chemicals your body releases that cause pain and swelling), which are responsible for causing pain, redness, and swelling in the tissue. By shutting down these pathways, the medicine stops the inflammatory response in its tracks. Since the medication acts directly on the surface of the inflamed bowel lining rather than being absorbed heavily into the bloodstream, it provides highly concentrated therapy. This targeted action helps the irritated tissues heal safely and efficiently, reducing the risk of side effects in other parts of your body.
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Alcohol

Caution

The interaction of alcohol with Mesacol Suppository is unknown. However, avoid consuming alcohol while on treatment with this medicine.

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Pregnancy

Consult your doctor

Mesacol Suppository should not be used in pregnancy unless necessary. So, inform your doctor if you are pregnant or suspect pregnancy.

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Breast Feeding

Consult your doctor

Mesacol Suppository should not be used while breastfeeding unless necessary. So, inform your doctor if you are a nursing mother.

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Driving

Safe if prescribed

Mesacol Suppository usually does not affect your ability to drive or operate machinery.

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Liver

Caution

Inform your doctor before using Mesacol Suppository if you have a history of liver disease. It should be used cautiously in patients with mild to moderately impaired liver function. It is not recommended for use in populations with severe liver impairment.

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Kidney

Caution

Inform your doctor before using Mesacol Suppository if you have a history of kidney disease. It should be used cautiously in patients with mild to moderately impaired kidney function. It is not recommended for use in populations with severe kidney impairment.

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Children

Not applicable

Mesacol Suppository is intended for adults. Not recommended for children.

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Heart

Caution

Inform your doctor before receiving the Mesacol Suppository if you have heart disease. Your doctor will prescribe only if the benefits outweigh the risks.

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Geriatrics

Caution

Mesacol Suppository should be used in the elderly only if advised by a doctor, as dose adjustment may be required.

What if I have taken an overdose of Mesacol Suppository

Although Mesacol Suppository is applied rectally, some of the medicine can still be absorbed into the body. If you accidentally use much more than prescribed or someone swallows the medicine, seek immediate medical attention or contact your local poison control centre. Symptoms of overdose may resemble aspirin-like overdose effects and can include ringing in the ears, nausea, vomiting, rapid breathing, dizziness, confusion, or unusual drowsiness.

Diet & Lifestyle Advise

  • Identify trigger foods: Keep a food diary to identify and avoid personal trigger foods, such as spicy, greasy, or high-fiber foods during active flare-ups.
  • Stay hydrated: Drink plenty of water throughout the day to stay hydrated, especially if you are experiencing frequent bowel movements.
  • Eat smaller meals: Eat smaller, more frequent meals rather than large portions to reduce stress on your digestive system.
  • Manage stress: Practice relaxation techniques like deep breathing, meditation, or gentle yoga, as stress can worsen inflammation in the gut.
health query

Have a query?

How Soon It Starts Working

The time required for Mesacol Suppository to start to work: The time required for Mesacol Suppository to show its action is unknown. 

The time for which the effects of Mesacol Suppository last: The duration of Mesacol Suppository’s effect is clinically not established.

What if you forget to take Mesacol Suppository

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled application, skip the missed dose and resume your regular routine. Do not take a double dose to make up for a missed one.

Storage

• Many rectal formulations are stored at controlled room temperature (20°C to 25°C), while some rectal suspension products have different storage recommendations.

Drug Warnings

  • For rectal use only: This medication is for rectal use only; do not swallow it.
  • Apply at bedtime: Apply the medicine at bedtime to help it stay in your rectum overnight, which gives it the maximum amount of time to soothe the inflamed tissues.
  • Protect clothing and bedding: Protect your clothing and bedding, as this medicine can cause permanent staining on fabrics. Consider using a protective sheet or panty liner.
  • Firm a soft suppository before use: If a suppository feels too soft to insert, hold it under cold running water or place it in the refrigerator for a few minutes before removing the wrapper.
  • Monitor worsening symptoms: Stop using the medication and contact your doctor immediately if your symptoms get worse or if you develop sudden fever and severe stomach pain.

Drug-Drug Interactions

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  • Pain killers (e.g., ibuprofen or naproxen): May significantly increase the risk of kidney damage.
  • Immune-suppressing drugs (e.g., azathioprine): May increase the risk of bone marrow problems and infections.
MesalazineIomeprol
Severe

Drug-Drug Interactions

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How does the drug interact with Mesacol Suppository:
Co-administration of Mesacol Suppository with Cidofovir can increase the risk of kidney problems.

How to manage the interaction:
Taking Mesacol Suppository with Cidofovir is generally avoided as it can possibly result in an interaction, it can be taken if a doctor has advised it. However, if you experience increased or decreased urination, sudden weight gain or loss, shortness of breath, consult a doctor. Do not discontinue any medications without consulting a doctor.
MesalazineIomeprol
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Iomeprol with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol Suppository and Iomeprol they can be taken together if your doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineMetrizamide
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Metrizamide with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesacol Suppository with Metrizamide they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, dry, itchy skin, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
MesalazineNizatidine
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Nizatidine with Mesacol Suppository can decrease the level or effect of Mesalamine by increasing gastric pH.

How to manage the interaction:
Although there may be a possible interaction between Mesacol Suppository with Nizatidine, they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
MesalazineIodamide
Severe
How does the drug interact with Mesacol Suppository:
Co-administration of Iodamide with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although, there is a possibility of interaction between Mesalamine with Iodamine they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as swelling in feet and ankles, itchy skin, shortness of breath, urinating either too much or too little. Do not discontinue any medication without consulting a doctor.
How does the drug interact with Mesacol Suppository:
Co-administration of Tenofovir alafenamide with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
There is a possibility of interaction between Mesacol Suppository with Tenofovir alafenamide, but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience increased or decreased urination, swelling, shortness of breath, bone pain, cramping in the muscles. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Mesacol Suppository:
Co-administration of Deferasirox with Mesacol Suppository may increase the risk of kidney problems.

How to manage the interaction:
Although there is a possibility of interaction between Mesacol Suppository and Deferasirox but they can be taken together if a doctor has prescribed them. Consult a doctor immediately if you experience any symptoms such as increased or decreased urination, abrupt weight gain or loss, weakness, or dizziness. Do not discontinue the medication without consulting a doctor.
How does the drug interact with Mesacol Suppository:
Co-administration of omeprazole with Mesacol Suppository can decrease the effects of Mesacol Suppository.

How to manage the interaction:
There could be a possible interaction between Mesacol Suppository and omeprazole, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Mesacol Suppository:
Co-administration of Ranitidine with Mesacol Suppository can decrease the levels of Mesacol Suppository, which may be less effective in treating a condition.

How to manage the interaction:
There may be a possible interaction between Mesacol Suppository with Ranitidine, but they can be taken together if a doctor has prescribed them. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No clinically significant food interactions are known with Mesacol Suppository when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- INFLAMMATORY AGENTS]

FAQs

Mesacol Suppository is used to treat ulcerative colitis and ulcerative proctitis.
Mesacol Suppository contains Mesalamine, which works by inhibiting the production of certain chemical substances, such as prostaglandins, that cause pain and swelling. Thus, it helps reduce inflammation (swelling) in the intestines and relieves stomach pain or bleeding symptoms.
Mesacol Suppository may cause diarrhoea as a common side effect. However, if the condition persists or worsens with fever, watery stools or consistent stomach pain, please consult a doctor. Also, drink plenty of water while using Mesacol Suppository to prevent dehydration.
If you miss a dosage of mesalamine, take it as soon as you remember unless your next dose is approaching. In this situation, skip the missed dose and resume your regular schedule. Do not combine two doses to make up for a missed dosage.
You are recommended not to take Mesacol Suppository with other medications without doctor's notice, especially immunosuppressant medications such as Azathioprine.
No, you are not recommended to stop using Mesacol Suppository suddenly as it may cause recurring symptoms. Therefore, use Mesacol Suppository for as long as your doctor has prescribed it, and if you experience any difficulty while using Mesacol Suppository, please consult your doctor.
If you are pregnant or planning to become pregnant, tell your doctor before starting or continuing Mesacol Suppository. In many cases, doctors may recommend continuing mesalamine during pregnancy when it is needed to keep ulcerative colitis under control, as active disease can also pose risks to both the mother and the baby. Your doctor will discuss the benefits and any potential risks with you and help you make a treatment decision that is appropriate for your individual situation.
If a suppository slips out within a few minutes, you can gently try to insert it again. If it has been inside for longer or has already dissolved, wait until your next scheduled dose. Talk to your doctor if you frequently have trouble keeping the medicine inside.
Some patients notice an improvement in symptoms like bleeding and urgency within a few days, but it can take several weeks of consistent use to feel the full benefits. Talk to your doctor if you do not see any improvement after a few weeks.
While alcohol does not directly interact with this medicine, it can irritate your stomach and intestines, potentially worsening your colitis symptoms. Talk to your doctor about whether drinking alcohol is safe for you.
Yes, this medicine can cause staining on fabrics, skin, and surfaces. You may want to wear a protective liner or old clothing, and place a towel or protective cover on your bed when applying it.
Most formulations should be stored at room temperature, away from heat and direct light. You can place a soft suppository in the refrigerator briefly to firm it up before use, but do not freeze it. Check your specific product packaging or talk to your pharmacist for details.
It is generally best to take this medicine at bedtime. This allows the medicine to remain in your rectum undisturbed for several hours while you sleep, which makes it much more effective. Talk to your doctor for specific dosing instructions.
You should avoid using other rectal products at the same time unless your doctor specifically advises you to do so, as they may interfere with how well this medicine works. Talk to your doctor or pharmacist before combining treatments.

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Country of origin

India

Manufacturer/Marketer address

Sun Pharmaceutical Industries Ltd., SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - MES0001
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