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compositionComposition:METOPROLOL-25MG+RAMIPRIL-5MG
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Prescription Medicine
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Met XL R 25/5 Tablet belongs to the class of antihypertensive medicines used in the treatment of high blood pressure. This medicine also helps reduce the chances of heart problems such as heart attack and stroke. It is a combination medicine which suppress the contraction of blood vessels and promote smooth blood flow. It also alters the response to nerve impulses in the heart thereby making the heart pump blood easier. Common side effects include headache, nausea, dizziness, stomach upset, and weakness.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Santoshini Reddy G , M Pharmacy
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More about the Product

Composition :

METOPROLOL-25MG+RAMIPRIL-5MG

Manufacturer/Marketer :

Ajanta Pharma Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

NPPA :

Regulated

About Met XL R 25/5 Tablet

Met XL R 25/5 Tablet is a prescription tablet used to treat high blood pressure (hypertension) and reduce the risk of serious heart problems. By combining two active ingredients that work in different ways, this medicine helps relax blood vessels and slow down your heart rate. It is commonly prescribed to help protect your cardiovascular system from long-term damage.

For the best results, you should take Met XL R 25/5 Tablet regularly at the same time every day, exactly as prescribed by your doctor. It can typically be taken with or without food, though consistency in how you take it is key to maintaining stable blood pressure. Incorporating a low-sodium diet and light daily exercise can significantly improve how well this medicine works for you.

While taking Met XL R 25/5 Tablet , you might experience mild side effects like dizziness, fatigue, or a dry cough. However, if you notice serious signs such as swelling of the face or throat, difficulty breathing, or an unusually slow heartbeat, you must contact your doctor immediately.

Before starting this medicine, tell your doctor if you have a history of asthma, liver damage, kidney disease, or diabetes. Do not take this if you are pregnant, have a history of severe allergic swelling (angioedema), or have certain severe heart rhythm disorders.

Avoid drinking alcohol while taking Met XL R 25/5 Tablet , as it can cause an unsafe drop in your blood pressure and increase dizziness. Smoking can also reduce the drug's effectiveness by narrowing your blood vessels. Pregnant or breastfeeding women should not use this medication due to risks to the baby, and elderly individuals should consult their doctor for careful monitoring.

Uses of Met XL R 25/5 Tablet

Met XL R 25/5 Tablet is used to treat high blood pressure (hypertension) and reduce the risk of serious heart problems. The detailed uses of Met XL R 25/5 Tablet are as follows:

  • High Blood Pressure (Hypertension): Met XL R 25/5 Tablet helps relax and widen your blood vessels, making it easier for blood to flow and lowering your overall blood pressure.
  • Prevention of Heart Attack and Stroke: By maintaining normal blood pressure and reducing the workload on your heart, this medicine lowers your risk of experiencing a life-threatening heart attack or stroke.
  • Congestive Heart Failure: It supports heart function in certain patients by reducing the strain on the heart muscle, helping it pump blood more efficiently throughout the body.

Key Benefits

Met XL R 25/5 Tablet helps control high blood pressure, protecting your heart and other vital organs from the harmful effects of hypertension. With regular use, it supports long-term cardiovascular health, improves daily well-being, and reduces the risk of serious complications.

  • Provides Effective Blood Pressure Control: By keeping your blood pressure within a healthy range, this medicine helps reduce the strain on your heart and blood vessels.
  • Protects Vital Organs: Consistent blood pressure control helps protect the heart, kidneys, brain, and blood vessels, lowering the risk of complications such as heart attack, stroke, and kidney damage.
  • Supports an Active Lifestyle: By reducing the effects of uncontrolled high blood pressure, this medicine helps improve physical comfort during daily activities, allowing you to stay active with less fatigue over time.
Side effects of Met XL R 25/5 Tablet
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Managing Medication-Triggered Bronchitis (Inflammation of the bronchial tubes): A Step-by-Step Guide:
  • If you experience symptoms like coughing, wheezing, chest tightness, or difficulty breathing after taking medication, seek medical attention immediately.
  • Your healthcare provider will work with you to stop the medication causing the reaction, start alternative treatments, and provide supportive therapy.
  • To manage symptoms and prevent complications, follow your doctor's advice to use inhalers or nebulizers as prescribed, practice good hygiene, avoid irritants, stay hydrated, and get plenty of rest.
  • Regularly track your symptoms and report any changes or concerns to your healthcare provider.
Here are the steps to manage the medication-triggered Sinusitis (Sinus infection or Inflammation Of Sinuses):
  • Consult your doctor if you experience symptoms of sinusitis, such as nasal congestion, facial pain, or headaches, which may be triggered by your medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your sinusitis symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • If your doctor advises, you can use nasal decongestants or saline nasal sprays to help relieve nasal congestion and sinus pressure.
  • To help your body recover, get plenty of rest, stay hydrated, and engage in stress-reducing activities. If your symptoms persist or worsen, consult your doctor for further guidance.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
  • If you are having unusual stomach issues after taking the medicine, consult your doctor to determine the underlying cause and further management.
  • In mild to moderate cases, your doctor may start by recommending anti-inflammatory medications (corticosteroids) to help reduce stomach inflammation and suggest lifestyle changes.
  • Eating smaller meals (5-6 times daily) instead of big meals can help improve your digestion.
  • Make sure to drink plenty of water, but stay away from caffeine, alcohol, and carbonated drinks, as they can make your symptoms worse.
  • Smoking and stress can worsen your stomach inflammation, so try to quit smoking and manage stress with exercise and relaxation techniques.

Directions for Use

  • Take Met XL R 25/5 Tablet with or without food as advised by the doctor.
  • Follow your doctor’s recommendations on the dosage and timing of this medication to achieve optimal results.
  • Swallow Met XL R 25/5 Tablet as a whole with a glass of water.
  • Do not crush, chew, or break it.

How Met XL R 25/5 Tablet Works

Met XL R 25/5 Tablet works through the combined action of two distinct medications that target different parts of your cardiovascular system. The first component, metoprolol, is a beta-blocker. It works by blocking the effects of certain natural chemicals in your body, like adrenaline, on your heart and blood vessels. This action slows down your heart rate and reduces the force with which your heart muscle contracts, lowering the demand for oxygen and easing the heart's workload. The second component, ramipril, is an ACE (angiotensin-converting enzyme) inhibitor. It prevents your body from producing a chemical called angiotensin II, which normally causes blood vessels to tighten and narrow. By blocking this chemical, ramipril allows your blood vessels to relax and widen, which lowers your blood pressure and makes it much easier for your heart to pump blood. Together, these two actions provide comprehensive protection for your heart and blood vessels.
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Alcohol

Unsafe

You are recommended not to consume alcohol along with Met XL R 25/5 Tablet to avoid unpleasant side effects.

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Pregnancy

Unsafe

Met XL R 25/5 Tablet is not recommended during pregnancy.

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Breast Feeding

Unsafe

Met XL R 25/5 Tablet is not recommended while breastfeeding.

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Driving

Unsafe

Met XL R 25/5 Tablet may cause dizziness or tiredness. If you feel dizzy or tired, do not drive or use any tools or machines.

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Liver

Caution

Met XL R 25/5 Tablet to be taken with caution, especially if you have a history of liver disease. The dose may have to be adjusted by your doctor.

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Kidney

Caution

Met XL R 25/5 Tablet to be taken with caution, especially if you have a history of kidney disease. The dose may have to be adjusted by your doctor.

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Children

Unsafe

Met XL R 25/5 Tablet is not recommended in children. The safety and efficacy of Met XL R 25/5 Tablet in children have not been established.

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Heart

Caution

Met XL R 25/5 Tablet should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems before using Met XL R 25/5 Tablet .

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Geriatrics

Caution

Met XL R 25/5 Tablet should be given with caution in elderly patients due to an increased risk of side effects. Talk to your doctor if you have any concerns.

What if I have taken an overdose of Met XL R 25/5 Tablet

If you take too much of this medicine, you may experience severe dizziness, a dangerously slow heart rate, or fainting. Seek emergency medical attention or contact a nearby hospital immediately.

Diet & Lifestyle Advise

  • Reduce Sodium Intake: Limit your daily salt intake to help manage your blood pressure. Avoid processed foods, canned soups, and salty snacks.
  • Eat a Heart-Healthy Diet: Focus on foods rich in potassium, magnesium, and fibre, such as leafy greens, whole grains, and fresh fruits. However, discuss potassium supplements or salt substitutes with your doctor first, as some ingredients in Met XL R 25/5 Tablet can raise potassium levels.
  • Stay Physically Active: Engage in moderate aerobic exercise, like brisk walking or cycling, for at least 30 minutes most days of the week, as approved by your doctor.
  • Limit Alcohol and Avoid Tobacco: Restricting alcohol and quitting smoking can dramatically improve your blood pressure and overall cardiovascular health.
  • Monitor Your Blood Pressure: Keep a daily log of your blood pressure readings at home and share them with your doctor during check-ups.
health query

Have a query?

How Soon It Starts Working

  • The time required for Met XL R 25/5 Tablet to start to work: The time required for Met XL R 25/5 Tablet to show its action is unknown.
  • The time for which the effects of Met XL R 25/5 Tablet last: The duration of action for Met XL R 25/5 Tablet is clinically unknown.

What if you forget to take Met XL R 25/5 Tablet

If you miss a dose of Met XL R 25/5 Tablet , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store Met XL R 25/5 Tablet at room temperature, ideally between 15°C and 30°C (59°F to 86°F).

Drug Warnings

  • Stand Up Slowly: To prevent dizziness or fainting, rise slowly from a sitting or lying position, especially when you first start taking this medicine.
  • Do Not Stop Suddenly: Stopping Met XL R 25/5 Tablet abruptly can cause a dangerous spike in blood pressure or chest pain. Always consult your doctor before stopping.
  • Check Your Pulse: Regularly monitor your heart rate. If your pulse drops below 50 to 55 beats per minute, or if you feel unusually weak, contact your healthcare provider.
  • Avoid Overheating: This medicine can make you sweat less, making you more prone to heatstroke. Stay hydrated and avoid excessive heat exposure.
  • Notify Surgeons: Tell any doctor or dentist performing surgery or dental work that you are taking Met XL R 25/5 Tablet , as it can interact with anaesthetics.

Drug-Drug Interactions

verifiedApollotooltip
  • Diuretics (water pills) and other blood pressure medications: May cause your blood pressure to drop too low.
  • Potassium supplements or potassium-sparing diuretics: Can lead to dangerously high levels of potassium in your blood.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen: May reduce the blood-pressure-lowering effect of this medicine and increase the risk of kidney damage.
  • Lithium: This medicine can increase lithium levels in your blood, raising the risk of toxicity.
Metoprolol + RamiprilAliskiren
Critical
Metoprolol + RamiprilPotassium acetate
Severe

Drug-Drug Interactions

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Metoprolol + RamiprilAliskiren
Critical
How does the drug interact with Met XL R 25/5 Tablet:
Taking Aliskiren together with Ramipril may increase the risk of serious side effects.

How to manage the interaction:
Taking Ramipril with Aliskiren is not recommended but can be taken if prescribed by a doctor. However, consult a doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. You must drink enough fluids while taking these medications. Do not discontinue any medications without a doctor's advice.
Metoprolol + RamiprilPotassium acetate
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Taking Ramipril with Potassium acetate may significantly increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney problems, muscle paralysis and irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Ramipril and Potassium acetate, but it can be taken if prescribed by a doctor. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.
Metoprolol + RamiprilTelmisartan
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Taking Ramipril with Telmisartan may increase the risk of side effects such as low blood pressure, kidney function impairment, and high blood potassium.

How to manage the interaction:
Although there is a possible interaction, Telmisartan can be taken with Ramipril if prescribed by the doctor. Consult the prescriber if you experience symptoms of high potassium such as nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue the medications without consulting a doctor.
Metoprolol + RamiprilAminophylline
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Co-administration of Aminophylline with Metoprolol together can make Metoprolol less effective and increase the effects of Aminophylline.

How to manage the interaction:
Taking Aminophylline with Metoprolol may lead to an interaction, it can be taken only if a doctor has advised it. If you experience nausea, vomiting, sleeplessness, restlessness, irregular heartbeats, or difficulty in breathing, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Metoprolol + RamiprilAzilsartan medoxomil
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Taking Azilsartan medoxomil with Ramipril may cause low blood pressure, kidney function impairment, and increased potassium levels in the blood.

How to manage the interaction:
Although taking Ramipril together with Azilsartan medoxomil can result in an interaction, they can be taken together if prescribed by a doctor. However, consult a doctor if you feel nausea, vomiting, weakness, confusion, tingling in the hands and feet, a sensation of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
Metoprolol + RamiprilAllopurinol
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Co-administration of Allopurinol with Ramipril may increase the risk of severe allergic reactions and infections.

How to manage the interaction:
Although there is a possible interaction between Allopurinol and Ramipril, you can take these medicines together if prescribed by a doctor. However, if you develop throat tightness, shortness of breath, itching, rash, swelling of the face, lips, or tongue, fever, and/or muscle pain or weakness, contact a doctor immediately. Also, let a doctor know if you notice signs of infection or experience chills, fever, sore throat, extreme tiredness, body pains, or other flu-like symptoms. Do not discontinue the medication without consulting a doctor.
Metoprolol + RamiprilAmiloride
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Taking Ramipril and Amiloride together may increase the levels of potassium in blood.

How to manage the interaction:
Although taking Amiloride along with Ramipril can result in an interaction, they can be taken together if prescribed by a doctor. However, consult the doctor if you feel weakness, confusion, numbness or tingling, and uneven heartbeats. Do not stop taking any medication without consulting a doctor.
Metoprolol + RamiprilVerapamil
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Co-administration of Metoprolol with Verapamil may lead to increased side effects.

How to manage the interaction:
Although there may be an interaction, Metoprolol can be taken with Verapamil if prescribed by the doctor. Consult a prescriber if you experience fatigue, headache, fainting, swelling of the extremities, weight gain, shortness of breath, chest pain, increased or decreased heartbeat, or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
Metoprolol + RamiprilIrbesartan
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Taking Ramipril together with Irbesartan may increase the risk of side effects such as low blood pressure, kidney function impairment, and a condition called hyperkalemia (high blood potassium).

How to manage the interaction:
Although taking Irbesartan with Ramipril together can possibly result in an interaction, it can be taken if a doctor has prescribed it. However, consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in hands and feet, feelings of heaviness in legs, or a slow or irregular heartbeat. Do not discontinue any medications without a doctor's advice.
Metoprolol + RamiprilPotassium iodide
Severe
How does the drug interact with Met XL R 25/5 Tablet:
Taking Potassium Iodide with Ramipril may significantly increase potassium levels in the blood. High levels of potassium can develop into a condition known as hyperkalemia, which in severe cases can lead to kidney problems, muscle paralysis and irregular heart rhythm.

How to manage the interaction:
Although there is a interaction between Potassium iodide and Ramipril, you can take these medicines together if prescribed by a doctor. However, if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat, you should contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Salt substitutes containing potassium: Can cause potassium to build up in your body to unsafe levels.
  • Grapefruit juice: May interfere with how your body processes the medication; ask your pharmacist for specific advice.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTI- HYPERTENSIVES]

FAQs

No. Met XL R 25/5 Tablet does not cure high blood pressure; it helps control it. High blood pressure often has no symptoms, so continue taking Met XL R 25/5 Tablet exactly as prescribed even if your blood pressure becomes normal or you feel well. Do not stop taking it or change your dose without talking to your doctor, as your blood pressure may rise again.
No, you should not take Met XL R 25/5 Tablet if you are pregnant or planning to become pregnant. It contains an active ingredient that can cause serious harm or death to an unborn baby. If you suspect you are pregnant, stop taking the medication and talk to your doctor immediately.
A dry, hacking cough is a known side effect of one of the active ingredients in this medicine. If the cough becomes persistent or troublesome, do not take cough medicine on your own. Talk to your doctor, who may adjust your treatment.
You should avoid alcohol while taking Met XL R 25/5 Tablet . Alcohol can intensify the blood-pressure-lowering effect of this medicine, leading to severe dizziness, lightheadedness, or fainting. Talk to your doctor or pharmacist if you have concerns.
Your doctor may perform regular blood tests to check your kidney function and monitor the level of potassium in your blood. This helps ensure that the medicine is working safely for you. Talk to your doctor for more details.
You should avoid taking pain relievers like ibuprofen or naproxen regularly without consulting your healthcare provider. These medicines can decrease the effectiveness of Met XL R 25/5 Tablet and increase the risk of kidney strain. Talk to your doctor or pharmacist for safe pain relief alternatives.
One of the active ingredients in Met XL R 25/5 Tablet is designed to slow down your heart rate. However, if your pulse drops below 50 beats per minute, or if you feel dizzy, weak, or short of breath, contact your doctor right away.
Some patients taking this combination may experience increased sensitivity to sunlight. It is wise to apply sunscreen and wear protective clothing when spending time outdoors. If you notice severe sunburn or skin rashes, talk to your doctor.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. U.S. Food and Drug Administration (FDA). 019962S041Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  2. National Health Service (NHS). Taking Ramipril With Other Medicines And Herbal Supplements - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Metoprolol - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Zentiva k.s. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed on 9th December 2022].Check here
  5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in March 2019] [Accessed on 9th December 2022].Check here
  6. Mylan Pharmaceuticals Inc. Metoprolol succinate tablet, film coated, extended release. Dailymed.com. [Revised in August 2022] [Accessed on 9th December 2022].Check here
  7. Accord. Electronic Medicines Compendium (EMC). [Revised in May 2022] [Accessed on 9th December 2022].Check here

Country of origin

India

Manufacturer/Marketer address

Ajanta House, Charkop, Kandivli West, Mumbai 400 067, India
Other Info - MET1754
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