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compositionComposition:DESMOPRESSIN-0.1MG
prescription
Prescription Medicine
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Minirin Nasal Spray is used to treat central cranial diabetes insipidus and temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma. It mimics the natural hormone vasopressin and works by reabsorbing water from the kidneys, which controls excessive thirst and urination. Some common side effects include weakness, headache, nasal congestion/stuffy nose, rhinitis/runny nose, nosebleeds, nausea, upset stomach, abdominal pain, and flushing.

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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DESMOPRESSIN-0.1MG

Manufacturer/Marketer :

Ferring Pharmaceuticals Pvt Ltd

Consume Type :

Nasal

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Minirin Nasal Spray

Minirin Nasal Spray is a prescription nasal spray used to manage central diabetes insipidus, a condition where the body cannot properly balance its fluid levels. It is also used to control the temporary extreme thirst and high urine output that can happen after head injuries or brain surgeries. This medication helps your body save water and prevents you from becoming dehydrated.

To get the best results, you must use this nasal spray consistently at the exact times prescribed by your doctor. Because it is absorbed through the nasal passages, food does not affect how the medicine works, but managing your daily liquid intake is highly important. Your doctor will likely ask you to limit how much water and other fluids you drink, especially in the hours leading up to your evening dose, to avoid dangerous fluid buildup.

Some people may experience mild side effects like a runny nose, nasal congestion, or mild headaches while using this spray. However, you should talk to your doctor immediately if you notice serious symptoms such as severe confusion, muscle weakness, drowsiness, or sudden seizures, as these can be signs of dangerously low sodium levels in your blood.

Talk to your doctor before starting Minirin Nasal Spray if you have a history of kidney issues, high blood pressure, or heart problems. Do not take this if you suffer from severe kidney disease, have a history of low blood sodium levels, or are currently dealing with an illness that causes vomiting, diarrhoea, or a high fever.

This medication can interact with water pills (diuretics) and certain pain relievers, which can increase your risk of developing dangerously low blood sodium. You should avoid drinking alcohol while using this nasal spray, as alcohol can increase urine production and disrupt your treatment. If you are pregnant, breastfeeding, or an older adult, consult your doctor or pharmacist to make sure this medication is safe for you.

Uses of Minirin Nasal Spray

Your doctor may prescribe Minirin Nasal Spray to help manage the following conditions:

  • Central diabetes insipidus: It helps replace a missing natural hormone in the body, which reduces the constant thirst and the large amount of pale urine your body produces.
  • Post-surgical or post-trauma excessive urination: It helps control high urine output and extreme thirst that can occur after medical procedures or head injuries.

Key Benefits

When used as directed as part of your treatment plan, Minirin Nasal Spray may provide the following benefits:

  • Helps reduce excessive urination and thirst: May help reduce frequent urination and constant thirst caused by central diabetes insipidus.
  • Helps your body maintain the right amount of water: May reduce excessive water loss and help lower the risk of dehydration when used as prescribed.
  • Improves your daily comfort: May reduce frequent trips to the toilet during the day and night, helping you sleep better and carry on with your daily activities more comfortably.
  • Helps keep your symptoms under control: When used regularly as prescribed and together with your doctor's advice on fluid intake, it helps control your symptoms over time.
Side effects of Minirin Nasal Spray 2.5 ml
Managing Medication-Triggered Rhinitis (Stuffy Nose): A Step-by-Step Guide
  • Consult your doctor if you experience nasal congestion, runny nose, or sinus pressure after taking medication.
  • Your doctor may adjust your treatment plan by changing your medication, adding new medications, or providing guidance on managing your rhinitis symptoms.
  • If advised by your doctor, use nasal decongestants or saline nasal sprays to help relieve nasal congestion.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of water and other fluids to help thin out mucus and soothe your nasal passages.
  • Drink water or other clear fluids.
  • To prevent worsening of pain, limit intake of tea, coffee, or alcohol.
  • Include bland foods like rice, toast, crackers, and rice in your diet.
  • Avoid lying down immediately after eating as it may cause indigestion or heartburn.
  • Avoid acidic and spicy food as it may cause indigestion.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
  • Rest well; get enough sleep.
  • Wear comfortable layers of clothes and get to a warm place.
  • Drink warm fluids like coffee, tea or hot chocolate.
  • Warm up using a blanket or heating pad.
  • Try eating smaller meals (4-5 times) instead of large ones to make it easier on your stomach.
  • Avoid foods that are spicy, fatty, or high in insoluble fibre.
  • Consuming soluble fibre (such as psyllium) can help with constipation, and probiotics may reduce bloating and discomfort.
  • Stay away from carbonated drinks, alcohol, caffeine, and smoking, as they can upset your stomach.
  • Reducing stress, losing weight, and exercising regularly for 20-30 minutes can help improve digestion and reduce stomach issues.
  • Poor sleep can worsen stomach problems, so focus on good sleep habits or use tools like Sleepio to improve your sleep.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.

Directions for Use

  • It is advised to use Minirin Nasal Spray once daily; however, follow your doctor’s recommendation regarding the dosage and duration.
  • Read the instructions on the label before using. Prime the nozzle, if required. Blow your nose. Tilt your head back and insert the tip of the nozzle into your nostril. Spray into the nostril while breathing in slightly. When pressing down the pump, apply even pressure and press down quickly to produce a consistent spray. Repeat the same process for another nostril if required.
  • Wipe off the tip with a clean tissue and replace the cap.

How Minirin Nasal Spray Works

Minirin Nasal Spray contains desmopressin. It works by mimicking a natural hormone in your body called vasopressin, or antidiuretic hormone. Under normal conditions, this hormone signals your kidneys to hold onto water and concentrate your urine so your body does not lose too much fluid. When your body does not produce enough of this natural hormone, your kidneys release too much water, leading to dehydration and extreme thirst. When you use Minirin Nasal Spray , the medication is absorbed through your nasal lining and travels into your system. It binds to the receptors in your kidneys, telling them to reabsorb water back into your bloodstream. This effectively reduces the volume of urine you produce and helps your body maintain a safe, balanced level of fluids.
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Alcohol

Caution

Alcohol consumption may interfere with the working of Minirin Nasal Spray ; hence it is advised to limit or avoid its intake.

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Pregnancy

Caution

Minirin Nasal Spray should be used in pregnancy only when recommended by a doctor. Please consult your doctor before starting Minirin Nasal Spray if you are pregnant or planning to conceive.

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Breast Feeding

Caution

Minirin Nasal Spray is excreted into the breast milk when used by a breastfeeding mother. Please seek medical advice before you start Minirin Nasal Spray if you are nursing.

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Driving

Safe if prescribed

Minirin Nasal Spray usually does not interfere with your driving ability. Do not drive or operate machinery if you experience unmanageable side effects with Minirin Nasal Spray .

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Liver

Caution

Please let your doctor know if you have any history of liver diseases or hepatic impairment when you are prescribed Minirin Nasal Spray .

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Kidney

Caution

Minirin Nasal Spray is contraindicated in patients with moderate to severe renal impairment. Please let your doctor know if you have any history of kidney diseases when prescribed Minirin Nasal Spray .

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Children

Caution

Minirin Nasal Spray should be used in children only when prescribed by the doctor.

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Heart

Caution

Minirin Nasal Spray should be used with caution in patients with heart problems. Therefore, please consult your doctor before using Minirin Nasal Spray .

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Geriatrics

Caution

Minirin Nasal Spray should be used with caution in elderly patients due to an increased risk of side effects. It is important to consult a healthcare professional before use.

What if I have taken an overdose of Minirin Nasal Spray

If you use too much of this medication, you may experience symptoms of water buildup, such as a severe headache, confusion, rapid weight gain, or drowsiness. Seek immediate medical attention or call emergency services if an overdose is suspected.

Diet & Lifestyle Advise

  • Monitor your fluid intake closely: It is crucial to drink only enough liquid to satisfy your thirst. Drinking too much fluid while taking Minirin Nasal Spray can lead to a dangerous buildup of water and low sodium in your blood.
  • Limit liquids before bedtime: To prevent nighttime urination and reduce the risk of fluid retention, restrict your fluid intake for at least one hour before using your evening dose and throughout the night.
  • Track your daily body weight: Weigh yourself at the same time each day. A sudden, unexplained increase in weight can be a sign that your body is holding onto too much water.
  • Avoid excessive alcohol and caffeine: Both alcohol and caffeine act as natural diuretics, which can interfere with how well Minirin Nasal Spray works to regulate your body's fluids.

Health Queries

I have been using Minirin nasal spray for diabetes insipidus for the last 6 to 7 years. Since it is expensive, are there any affordable alternative medicines or treatments available?

Veda Maddala

Veda Maddala

M Pharmacy

Yes, there are more affordable alternatives. Minirin contains the active ingredient desmopressin. A direct, lower-cost option is switching to a generic desmopressin nasal spray. Alternatively, desmopressin is available as oral tablets or sublingual (under-the-tongue) melts, which are often cheaper and more convenient. In some cases, other oral medications like thiazide diuretics might be considered, though they work differently. Please do not change your medication on your own. Consult your endocrinologist to discuss switching to generic desmopressin tablets or a generic spray, as they will need to adjust your dosage and monitor your fluid balance and sodium levels during the transition.
health query

Have a query?

How Soon It Starts Working

The time required for Minirin Nasal Spray to start to work: Minirin Nasal Spray ideally shows its action within 30 minutes after administration.

The time for which the effects of Minirin Nasal Spray last: The duration of action for Minirin Nasal Spray is unknown.

What if you forget to take Minirin Nasal Spray

If you miss a dose of Minirin Nasal Spray , take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and return to your regular routine. Do not take a double dose to make up for a missed one.

Storage

• Store unopened bottles of Minirin Nasal Spray in the refrigerator between 2°C and 8°C (36°F to 46°F). Do not freeze this medication.

Drug Warnings

  • Always inspect the nasal spray solution before use: It should be clear and colourless. Do not use the spray if the liquid looks cloudy, discoloured, or contains tiny floating particles.
  • Avoid sharing your nasal spray: To prevent the spread of germs or nasal infections, never share your Minirin Nasal Spray bottle with anyone else.
  • Monitor your health during illnesses: If you develop a fever, stomach flu, vomiting, or diarrhoea, contact your doctor immediately. These conditions alter your body's fluid balance, and you may need to temporarily stop using the spray.
  • Check your nostrils regularly: If you develop a severe cold, nasal allergies, or nasal scarring, the spray may not absorb properly. Tell your doctor if your nose feels blocked or irritated.
  • Keep track of your blood tests: Your doctor will likely schedule regular blood tests to check your sodium and kidney function. Attend all scheduled appointments to ensure the medicine is working safely.

Drug-Drug Interactions

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  • Diuretics (water pills): Combining these with Minirin Nasal Spray can severely increase the risk of dangerously low blood sodium levels.
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) like ibuprofen or naproxen: These pain relievers can cause your body to hold onto more water, increasing the risk of fluid retention when taken with Minirin Nasal Spray .
  • Certain antidepressants (like SSRIs or tricyclics) and seizure medications: These can increase the release of natural antidiuretic hormone, compounding the fluid-retaining effects of this medicine.
  • Nasal decongestants: Using other nasal sprays or decongestants at the same time can change how much of Minirin Nasal Spray is absorbed through your nose.
DesmopressinCortisone
Critical
DesmopressinBetamethasone
Critical

Drug-Drug Interactions

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DesmopressinCortisone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Cortisone and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Cortisone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinBetamethasone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Minirin Nasal Spray 2.5 ml with Betamethasone can increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Co-administration of Betamethasone and Minirin Nasal Spray 2.5 ml can lead to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, and/or sudden weight gain, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
DesmopressinTorasemide
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Torasemide can make Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Torasemide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinPrednisone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Coadministration of Prednisone and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and prednisone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinBumetanide
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Bumetanide and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Bumetanide together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinDeflazacort
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Deflazacort and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
Although co- administration of Daflazacort with Desmopression can possibly lead to an interaction, it can be taken in case a doctor advices you. You should seek medical attention if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty in concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination, or sudden weight gain. Do not stop using any medications without consulting a doctor.
DesmopressinCiclesonide
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Bumetanide and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Ciclesonide together, a doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinPrednisolone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Prednisolone and Minirin Nasal Spray 2.5 ml may increase the risk of hyponatremia (low levels of sodium in the blood).

How to manage the interaction:
Taking Prednisolone with Minirin Nasal Spray 2.5 ml is not generally advised as they lead to an interaction, they can be taken together if advised by a doctor. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact a doctor immediately. Do not discontinue the medication without consulting a doctor.
DesmopressinBeclometasone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Co-administration of Minirin Nasal Spray 2.5 ml together with Beclomethasone may increase the risk of hyponatremia (low levels of salt in the blood).

How to manage the interaction:
If you have to use Minirin Nasal Spray 2.5 ml and Beclomethasone together, your doctor may adjust the dose or monitor you more frequently to safely use both medications. However, if you experience loss of appetite, headache, nausea, vomiting, lethargy (very tired), irritability, difficulty concentrating, weakness, unsteadiness, memory impairment, confusion, muscle spasm, decreased urination, and/or sudden weight gain, contact your doctor immediately as these may be symptoms of water intoxication (water poisoning) and hyponatremia (low levels of salt in the blood). Do not discontinue the medication without consulting a doctor.
DesmopressinFludrocortisone
Critical
How does the drug interact with Minirin Nasal Spray 2.5 ml:
Using Minirin Nasal Spray 2.5 ml together with fludrocortisone may increase the risk of hyponatremia( a condition associated with low levels of salt in the blood).

How to manage the interaction:
Taking Minirin Nasal Spray 2.5 ml with Fludrocortisone is not recommended, but it can be taken if prescribed by a doctor. However, if you experience loss of appetite, nausea, vomiting, headache, lethargy, irritability, difficulty concentrating, memory impairment, confusion, muscle spasm, weakness, unsteadiness, decreased urination and sudden weight gain contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip

No clinically significant food interactions are known with Minirin Nasal Spray when used as directed.

No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[HORMONES]

FAQs

Minirin Nasal Spray is an antidiuretic medicine used as replacement therapy in central cranial diabetes insipidus. It is also used to manage temporary polyuria (extreme urination) or polydipsia (extreme thirst) after head trauma.
Minirin Nasal Spray contains Desmopressin, a human-made form of vasopressin (antidiuretic hormone). When your body cannot produce enough vasopressin, Minirin Nasal Spray is used to replace it. It helps treat cranial diabetes insipidus, polyuria, and polydipsia.
Do not use Minirin Nasal Spray if you have polyuria that has not been diagnosed as diabetes insipidus. It is advised to use the Minirin Nasal Spray only when the doctor has suggested it for you, depending on your medical condition.
Take the missed dose as soon as possible. However, if it is time for the next dose, skip the missed dose and return to your regular dosing schedule.
Optimal intake of fluids is recommended to prevent dehydration. However, avoid excess intake of water and other liquids like coffee, tea, cola, and energy drinks during the treatment. Excessive fluid intake while using Minirin Nasal Spray may lead to a build-up of water, which dilutes the salt in the body, leading to serious problems.
No, you must carefully control your fluid intake. Drinking too much liquid while taking Minirin Nasal Spray can cause your body to retain too much water, which dilutes the sodium in your blood to dangerous levels. Talk to your doctor about how much fluid you should drink daily.
Warning signs of low blood sodium include headache, nausea, vomiting, confusion, muscle weakness, spasms, extreme tiredness, and weight gain. If you notice any of these symptoms, stop using the spray and contact your healthcare provider immediately.
A severely clogged nose, swelling from allergies, or nasal scarring can prevent Minirin Nasal Spray from being absorbed properly into your system. If you have a nasal condition that affects your breathing or absorption, talk to your doctor, as they may need to adjust your dose or recommend a different form of the medicine.
You should only use this medication during pregnancy if your doctor determines that the benefits clearly outweigh the risks. If you are pregnant or planning to become pregnant, talk to your doctor to discuss safe treatment options.
Unopened bottles should be stored in the refrigerator. Once you open a bottle, it can usually be kept at room temperature for up to 30 days, but you must keep it upright and away from extreme heat. Always check your specific product packaging or talk to your pharmacist for storage instructions.
While this medication helps reduce urine production, the nasal spray form is generally not recommended for primary nocturnal enuresis (bedwetting) due to the higher risk of severe low blood sodium in children. Other forms of this medicine may be prescribed instead. Talk to your doctor to find the safest treatment for your child.
If the spray accidentally gets into your eyes, rinse them immediately with large amounts of clean, cool running water. If you experience persistent irritation, redness, or changes in your vision, talk to your doctor right away.

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Reference

  1. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 017922S038,018938S027,019955S013Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. Electronic Medicines Compendium (EMC). Pil.8020 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Medlineplus Medlineplus. [Accessed on 04 Apr. 2019]Check here
  5. Desmopressin acetate. 2003. [Accessed on 25 Jan. 2019]Check here
  6. Fara M. Friedman and Jeffrey P. Weiss. Desmopressin in the treatment of nocturia: clinical evidence and experience. NCBI; PMC US National Library of Medicine, National Institute of Health. December 2013. [Accessed on 18th December 2023]Check here
  7. Ferring GmbH. Electronic Medicines Compendium (EMC); [Revised on October 2011] [Accessed on 18th December 2023]Check here

Country of origin

India

Manufacturer/Marketer address

K-28/1, ADDITIONAL MIDC , ANAND NAGAR , AMBERNATH - 421506 , INDIA
Other Info - MIN0009
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