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  3. Noxafil 100 Tablet 2X12's

Noxafil 100 Tablet 2X12's, Pack of 1 TABLET
Noxafil 100 Tablet 2X12's, Pack of 1 TABLET
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Noxafil 100 Tablet is used to prevent and treat fungal infections. It contains posaconazole which works by inhibiting fungal cell growth and causing cell death. In some cases, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, and cough. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

POSACONAZOLE-100MG

Manufacturer/Marketer :

Fulford India Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Noxafil 100 Tablet

Noxafil 100 Tablet is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections when other antifungal medicines have not worked, or you have had to stop taking them. It is also indicated for preventing invasive Aspergillus and Candida infections in patients at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

Noxafil 100 Tablet contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Take Noxafil 100 Tablet as prescribed by your doctor. You are advised to take Noxafil 100 Tablet for as long as your doctor has prescribed it based on your medical condition. In some cases, you may experience diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood. Most of these side effects of Noxafil 100 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in Noxafil 100 Tablet or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Noxafil 100 Tablet only if the benefits outweigh the risk. Before taking the Noxafil 100 Tablet , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of Noxafil 100 Tablet

Noxafil 100 Tablet is used in the treatment of Fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Oral Suspension/syrup: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Posaconazole is an antifungal medication present in Noxafil 100 Tablet . It is effective in treating fungal infections in adults. It is also indicated for preventing invasive Aspergillus and Candida infections in patients who are severely immunocompromised and at high risk of developing these infections, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

How Noxafil 100 Tablet Works

Noxafil 100 Tablet contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Storage

Store in a cool and dry place away from sunlight
Side effects of Noxafil 100 Tablet 2X12's
  • Avoid alcohol as it may be harmful and worsen certain condition.
  • Take nutritional supplements only as advised by your doctor.
  • Limit sodium intake.
  • Consult your doctor for medications to treat your condition effectively.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here's a comprehensive approach to managing medication-triggered fever:
  • Inform your doctor immediately if you experience a fever after starting a new medication.
  • Your doctor may adjust your medication regimen or dosage as needed to minimize fever symptoms.
  • Monitor your body temperature to monitor fever progression.
  • Drink plenty of fluids, such as water or electrolyte-rich beverages, to help your body regulate temperature.
  • Get plenty of rest and engage in relaxation techniques, such as deep breathing or meditation, to help manage fever symptoms.
  • Under the guidance of your doctor, consider taking medication, such as acetaminophen or ibuprofen, to help reduce fever.
  • If your fever is extremely high (over 103°F), or if you experience severe symptoms such as confusion, seizures, or difficulty breathing, seek immediate medical attention.
  • Skin rash caused by allergies is due to irritants or allergens. Therefore, avoid contact with such irritants.
  • Consult your doctor for proper medication and apply an anti-itch medication. Follow the schedule and use the medication whenever needed.
  • Protect your skin from extreme heat and try to apply wet compresses.
  • Soak in the cool bath, which gives a soothing impact to the affected area.
Here are the seven steps to manage medication-triggered Dyspnea (Difficulty Breathing or Shortness of Breath):
  • Tell your doctor immediately if you experience shortness of breath after taking medication.
  • Your doctor may adjust the medication regimen or dosage or give alternative medical procedures to minimize the symptoms of shortness of breath.
  • Monitor your oxygen levels and breathing rate regularly to track changes and potential side effects.
  • For controlling stress and anxiety, try relaxation techniques like deep breathing exercises, meditation, or yoga.
  • Make lifestyle changes, such as quitting smoking, exercising regularly, and maintaining a healthy weight.
  • Seek emergency medical attention if you experience severe shortness of breath, chest pain, or difficulty speaking.
  • Follow up regularly with your doctor to monitor progress, adjust treatment plans, and address any concerns or questions.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Noxafil 100 Tablet

Take Noxafil 100 Tablet only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Inform your doctor if you are allergic or hypersensitive to any component present in Noxafil 100 Tablet or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe Noxafil 100 Tablet only if the benefits outweigh the risk. Before taking the Noxafil 100 Tablet , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions. And also, let your doctor know before prescribing Noxafil 100 Tablet if you have Arrhythmias and QTc Prolongation, liver problems, or low potassium, magnesium, or calcium levels in your blood.

Drug-Drug Interactions

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PosaconazoleEliglustat
Critical
PosaconazoleRanolazine
Critical

Drug-Drug Interactions

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PosaconazoleEliglustat
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
Taking eliglustat with Noxafil 100 Tablet 2X12's can increase the levels of eliglustat in the blood.

How to manage the interaction:
Although there is an interaction between Noxafil 100 Tablet 2X12's and eliglustat, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, a slow heart rate, or a weak pulse. Do not discontinue any medications without consulting a doctor.
PosaconazoleRanolazine
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
When Noxafil 100 Tablet 2X12's is taken with Ranolazine, may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Although there is an interaction between Noxafil 100 Tablet 2X12's and ranolazine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PosaconazoleIvabradine
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
Using ivabradine together with Noxafil 100 Tablet 2X12's may significantly increase the blood levels and effects of ivabradine.

How to manage the interaction:
Taking Ivabradine with Noxafil 100 Tablet 2X12's together is generally not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, contact a doctor immediately if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss. Do not discontinue any medications without consulting a doctor.
PosaconazoleSirolimus
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
Coadministration of sirolimus with Noxafil 100 Tablet 2X12's can lower the levels of sirolimus in the blood.

How to manage the interaction:
Although there is an interaction between Noxafil 100 Tablet 2X12's with sirolimus, they can be taken together if a doctor advises. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PosaconazoleCisapride
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
When Noxafil 100 Tablet 2X12's is taken with Cisapride, it can lower the rate at which Cisapride is broken down in the body.

How to manage the interaction:
Taking Noxafil 100 Tablet 2X12's with Cisapride is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
PosaconazoleSimvastatin
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
Taking Noxafil 100 Tablet 2X12's with Simvastatin can increase the blood levels and effects of Simvastatin. This can increase the risk of side effects such as liver problems and rhabdomyolysis (which involves the breakdown of skeletal muscle tissue).

How to manage the interaction:
Taking Noxafil 100 Tablet 2X12's and Simvastatin together is not recommended as it can lead to an interaction, but it can be taken if advised by a doctor. However, if you experience any symptoms like muscle pain, tenderness, or weakness, fever or dark-colored urine, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, and yellowing of the skin or eyes, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
PosaconazoleDronedarone
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
When Dronedarone is taken with Noxafil 100 Tablet 2X12's, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Noxafil 100 Tablet 2X12's with Dronedarone is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
PosaconazoleLovastatin
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
Taking lovastatin with Noxafil 100 Tablet 2X12's can increase the levels of lovastatin in the blood which can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Lovastatin and Noxafil 100 Tablet 2X12's, they can be taken together if advised by a doctor. However, contact a doctor if you experience ever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark colored urine, and/or yellowing of the skin or eyes. Do not stop taking any medications without consulting a doctor.
PosaconazoleTicagrelor
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
Co-administration of Noxafil 100 Tablet 2X12's with Ticagrelor can increase the risk of bleeding.

How to manage the interaction:
Taking Ticagrelor with Noxafil 100 Tablet 2X12's is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience any unusual bleeding or bruising, swelling, vomiting, blood in your urine or stools, headache, dizziness, or weakness. Do not discontinue any medications without consulting a doctor.
PosaconazoleAtorvastatin
Critical
How does the drug interact with Noxafil 100 Tablet 2X12's:
Taking atorvastatin with Noxafil 100 Tablet 2X12's can increase the blood levels of atorvastatin. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Noxafil 100 Tablet 2X12's with atorvastatin, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take Noxafil 100 Tablet for more than one day.
  • Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take Noxafil 100 Tablet .
  • Continue taking your normal regular diet unless your doctor prescribes a specific diet.
  • It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, alcohol and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
  • A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during Noxafil 100 Tablet treatment to enhance a healthy lifestyle practice.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

Noxafil 100 Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Consult your doctor

The interaction of Noxafil 100 Tablet with alcohol is unknown. If you have any concerns regarding this, please discuss with your doctor.

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Pregnancy

Consult your doctor

Noxafil 100 Tablet should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing Noxafil 100 Tablet .

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Breast Feeding

Consult your doctor

There is no substantial research yet on using Noxafil 100 Tablet in breastfeeding/nursing mothers. Inform your doctor if you are a nursing mother before taking Noxafil 100 Tablet ; your doctor will decide whether Noxafil 100 Tablet can be taken by breastfeeding mothers.

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Driving

Caution

It is unknown whether Noxafil 100 Tablet alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Consult your doctor

Inform your doctor before taking the Noxafil 100 Tablet if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Kidney

Consult your doctor

Inform your doctor before taking the Noxafil 100 Tablet if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

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Children

Consult your doctor

Please consult a doctor before using Noxafil 100 Tablet for children.

Have a query?

FAQs

Noxafil 100 Tablet is used to treat fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

Noxafil 100 Tablet contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibiting fungal cell growth and, ultimately, cell death. Thus, it treats infections.

Noxafil 100 Tablet is not recommended for coadministration with anticoagulants, So if you are under anticoagulant therapy, inform your doctor before prescribing Noxafil 100 Tablet .

If you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole, you should not use it. When combined with certain medications, posaconazole can have unfavourable or dangerous side effects.

Like all medicines, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood, although not everybody gets them. Most of these side effects of Noxafil 100 Tablet do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Take Noxafil 100 Tablet as prescribed by your doctor. You are advised to take Noxafil 100 Tablet for as long as your doctor has prescribed it for you based on your medical condition.

Country of origin

India

Manufacturer/Marketer address

Plot No. -810, Sector - 3 , Industrial Area , Pthampur Dist. Dhar - 454 775 (M.P.) India
Other Info - NOX0057

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:47 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/5388/smpc
  2. https://www.medicines.org.uk/emc/files/pil.5388.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022003s018s020,0205053s002s004,0205596s001s003lbl.pdf
  4. https://www.fda.gov/media/114097/download#:~:text=Posaconazole%20is%20an%20azole%20antifungal,2013%20and%20March%202014%2C%20respectively.&text=DPV%20will%20continue%20to%20monitor,with%20the%20use%20of%20posaconazole.
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