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compositionComposition:FLUOXETINE-20MG+OLANZAPINE-5MG
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Prescription Medicine
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Olanex F Tablet 15's is used to treat schizophrenia and bipolar disorder (manic depression). It contains Fluoxetine and Olanzapine which work by restoring the balance of certain natural substances in the brain. In some cases, this medicine may cause side effects such as drowsiness, lightheadedness, restlessness, irritability, tremors, dry mouth, constipation, and increased appetite. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

FLUOXETINE-20MG+OLANZAPINE-5MG

Manufacturer/Marketer :

Emcure Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Dec-28

Return Policy :

Not Returnable

About Olanex F Tablet 15's

Olanex F Tablet 15's is a combination prescription medicine used to treat depressive episodes associated with bipolar I disorder. It is also prescribed for treatment-resistant depression, which is depression that has not improved after trying other antidepressant medicines.

For the best results, you must take this medicine consistently once daily, usually in the evening, exactly as your healthcare provider instructs. You can take this medication with or without food. Making healthy lifestyle choices, such as eating a balanced diet, keeping a regular sleep schedule, and engaging in light physical activity, can also support your treatment outcomes.

Like many medications that affect brain chemistry, Olanex F Tablet 15's can cause side effects. Some of the most common ones include sleepiness, dry mouth, tiredness, and an increased appetite that may lead to weight gain. While these are usually manageable, you must monitor your body and contact your doctor immediately if you experience serious symptoms like extreme mood changes, severe muscle stiffness, or signs of high blood sugar.

Do not take this if you have certain pre-existing health conditions without discussing them with your healthcare provider first. Be sure to tell your doctor if you have a history of heart issues, diabetes, seizures, or liver damage. This medicine is not suitable for everyone, and certain individuals should not take it, especially those who have recently taken specific types of antidepressants known as monoamine oxidase inhibitors (MAOIs).

This medicine can interact with alcohol, smoking, and other medications. For example, drinking alcohol while taking this medicine can cause severe drowsiness, while smoking can change how the medicine is processed in your body. If you are pregnant, planning to become pregnant, breastfeeding, or are an older adult, consult your doctor to discuss whether this medication is safe for you.

Uses of Olanex F Tablet 15's

Olanex F Tablet 15's is used to treat depressive episodes associated with bipolar I disorder. The detailed uses of Olanex F Tablet 15's are as follows:

  • Depressive episodes associated with Bipolar I disorder: This medicine helps balance mood levels, relieving the severe lows and depressive states associated with bipolar disorder.
  • Treatment-resistant depression: It helps relieve symptoms of major depressive disorder in adults whose symptoms have not improved after trying other antidepressant treatments.
     

Key Benefits

name helps manage symptoms of depression by acting on multiple chemical pathways in the brain to improve mood and emotional well-being. With regular use, it supports emotional balance, improves daily functioning, and enhances overall quality of life.

  • Effective Mood Stabilisation: By targeting multiple chemical pathways in the brain, this medicine helps stabilise mood and restore interest in daily activities, providing effective relief from symptoms of depression.
  • Relieves Depression and Anxiety Symptoms: This medicine helps reduce feelings of severe sadness and anxiety while promoting more regular sleep patterns, supporting better emotional and physical well-being.
  • Improves Daily Functioning: Over time, this medicine helps restore emotional balance, making it easier to engage in personal, social, and professional activities with greater confidence and comfort.
Side effects of Olanex F Tablet
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Eat a balanced diet containing enough proteins, fibre, healthy fats, vegetables and fruits.
  • Get quality sleep for about 7-9 hours.
  • Try to manage stress with meditation or yoga.
  • Drink enough water.
  • Exercise regularly as it helps regulate appetite.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to Dry Mouth (xerostomia) caused by medication:
  • Inform your doctor about dry mouth symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Drink plenty of water throughout the day to help keep your mouth moist and alleviate dry mouth symptoms.
  • Chew sugar-free gum or candies to increase saliva production and keep your mouth moisturized.
  • Use saliva substitutes, such as mouthwashes or sprays, only if your doctor advises them to help moisturize your mouth and alleviate dry mouth symptoms.
  • Avoid consuming smoking, alcohol, spicy or acidic foods, and other irritants that may aggravate dry mouth symptoms.
  • Schedule regular dental check-ups to keep track of your oral health and handle any dry mouth issues as they arise.

Directions for Use

  • Take Olanex F Tablet 15's with or without food as advised by your doctor.
  • It is advised to take Olanex F Tablet 15's once daily; however, follow your doctor's recommendation regarding the dosage and duration.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew or break it.

How Olanex F Tablet 15's Works

This medicine is a combination of two active components that work together to balance brain chemistry. Because it addresses multiple pathways at once, it helps relieve complex mood symptoms more effectively than either component could alone. The first active component, olanzapine, works by blocking receptors for certain chemical messengers in the brain, specifically dopamine and serotonin. By balancing these pathways, it helps improve thinking, mood, and behaviour. The second active component, fluoxetine, prevents the brain from reabsorbing serotonin, a chemical messenger responsible for maintaining emotional balance. This increases the amount of active serotonin available, which helps lift your mood and reduce anxiety.
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Alcohol

Unsafe

Patients taking Olanex F Tablet 15's should avoid taking alcohol as it may increase drowsiness.

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Pregnancy

Caution

Olanex F Tablet 15's should be used in pregnant women only when prescribed by a doctor.

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Breast Feeding

Unsafe

Olanex F Tablet 15's should not be given to breastfeeding mothers.

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Driving

Unsafe

Olanex F Tablet 15's causes drowsiness. So, avoid driving or operating heavy machinery after taking Olanex F Tablet 15's.

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Liver

Caution

Olanex F Tablet 15's should be used with caution in patients with liver diseases.

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Kidney

Caution

Olanex F Tablet 15's should be used in patients with kidney diseases only when prescribed by a doctor. Dose adjustments and regular monitoring of electrolytes may be required as it may alter electrolyte levels in the body.

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Children

Unsafe

Olanex F Tablet 15's should not be prescribed in children below 12 years of age.

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Heart

Caution

Olanex F Tablet 15's should be taken with caution in patients with heart problems. Please inform your doctor if you have any pre-existing heart problems.

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Geriatrics

Caution

Olanex F Tablet 15's should be given with caution in elderly patients due to an increased risk of side effects. Seek medical advice before using Olanex F Tablet 15's.

What if I have taken an overdose of Olanex F Tablet 15's

If you suspect an overdose, seek emergency medical attention immediately. Symptoms of an overdose may include extreme sleepiness, rapid heartbeat, slurred speech, or severe shakiness.

Diet & Lifestyle Advise

  • Monitor your weight and diet: Because this medicine can increase appetite and cause weight gain, focus on a diet rich in vegetables, fruits, lean proteins, and whole grains.
  • Stay hydrated: Drink plenty of water throughout the day to help manage dry mouth and support overall digestion.
  • Establish a regular sleep routine: Go to bed and wake up at the same time each day to help manage sleepiness and support your mental health.
  • Avoid alcohol: Do not drink alcohol while taking this medicine, as it can worsen drowsiness and increase the risk of coordination problems.
  • Incorporate light exercise: Gentle physical activities like walking can help support your mood and assist with weight management.
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How Soon It Starts Working

The time required for Olanex F Tablet 15's to start to work: The time required for Olanex F Tablet 15's to show its action is unknown. The time for which the effects of Olanex F Tablet 15's last: The duration of action for Olanex F Tablet 15's is clinically unknown.

What if you forget to take Olanex F Tablet 15's

If you miss a dose, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to make up for a missed one.

Storage

• Store Olanex F Tablet 15's at room temperature, between 20°C and 25°C (68°F to 77°F). • Keep the medicine in its original container to protect it from light and excess moisture.

Drug Warnings

  • Do not drive, operate machinery, or perform hazardous tasks until you know how this medicine affects your alertness.
  • Do not stop taking this medicine suddenly, as doing so can cause your symptoms to return or lead to withdrawal-like reactions; your doctor will help you by gradually decreasing the dose.
  • Rise slowly from a sitting or lying position to prevent a sudden drop in blood pressure, which can cause dizziness or fainting.
  • Pay close attention to any sudden changes in your mood, thoughts, or behaviour, especially when you first start taking this medicine or when your dose changes.
  • Attend all scheduled medical appointments so your doctor can check your progress, blood sugar, and cholesterol levels.

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine Oxidase Inhibitors (MAOIs): Do not take this medicine with MAOIs or within 14 days of stopping them, as this can cause a life-threatening reaction. At least 5 weeks should pass after stopping Olanex F Tablet 15's before starting an MAOI.
  • Sedatives and Sleep Medicines: Taking this medicine with other drugs that cause drowsiness can worsen coordination and cause severe sleepiness.
  • Medicines affecting heart rhythm: Combining this medicine with drugs that alter your heart rate can increase the risk of serious heart rhythm problems.
  • Serotonergic drugs: Taking other medicines that increase serotonin (such as certain migraine drugs or other antidepressants) can cause a dangerous buildup of serotonin in the body.
Olanzapine + FluoxetineMetoclopramide
Critical
Olanzapine + FluoxetinePotassium citrate
Critical

Drug-Drug Interactions

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Olanzapine + FluoxetineMetoclopramide
Critical
How does the drug interact with Olanex F Tablet:
Co-administration of metoclopramide with Olanex F Tablet can increase the risk of side effects.

How to manage the interaction:
Although there is a possible interaction between Olanex F Tablet and metoclopramide, you can take these medicines if prescribed by a doctor. However, if you experience any symptoms like muscle movements which are not controllable, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, jitteriness, restlessness, or foot tapping, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetinePotassium citrate
Critical
How does the drug interact with Olanex F Tablet:
Taking Olanex F Tablet with Potassium citrate can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although co-administration of Olanex F Tablet and Potassium citrate leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetinePotassium chloride
Critical
How does the drug interact with Olanex F Tablet:
Taking Olanex F Tablet with Potassium chloride (oral form) can increase the risk of stomach bleeding and ulcers.

How to manage the interaction:
Although co-administration of Olanex F Tablet and Potassium chloride leads to an interaction, it can be taken if advised by a doctor. However, if you experience any symptoms like severe abdominal pain, bloating, sudden dizziness or lightheadedness, nausea, vomiting (especially with blood), loss of hunger, or black, tarry stools, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineTetrabenazine
Severe
How does the drug interact with Olanex F Tablet:
Co-administration of Tetrabenazine with Olanex F Tablet can increase the risk of irregular heartrate and other side effects.

How to manage the interaction:
Although there is a possible interaction between Olanex F Tablet and Tetrabenazine, you can take these medicines if prescribed by a doctor. However, if you experience any symptoms like muscle movements which are not controllable, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, jitteriness, restlessness, loose stools, vomiting, foot tapping, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heart beat, consult a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineSodium oxybate
Severe
How does the drug interact with Olanex F Tablet:
Using sodium oxybate together with Olanex F Tablet may increase the risk side effects.

How to manage the interaction:
Co-administration of sodium oxybate and Olanex F Tablet can lead to an interaction, it can be taken if advised by a doctor. If you experience any symptoms like drowsiness, dizziness, lightheadedness, confusion, fainting, slow or rapid breathing, and difficulty in thinking, judgment, and movement of hands and legs, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineEsketamine
Severe
How does the drug interact with Olanex F Tablet:
Using esketamine together with Olanex F Tablet can increase the risk of side effects.

How to manage the interaction:
Although co-administration of esketamine and Olanex F Tablet can lead to an interaction, it can be taken if advised by your doctor. If you experience any symptoms like drowsiness, confusion, difficulty in concentrating, and impairment in thinking, judgment, reaction speed, and movement of body or limbs, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineViloxazine
Severe
How does the drug interact with Olanex F Tablet:
The combined use of Viloxazine and Olanex F Tablet can increase the blood levels of Olanex F Tablet.

How to manage the interaction:
Although co-administration of Viloxazine and Olanex F Tablet can lead to an interaction, but it can be taken if a doctor advises it. However, if you experience dizziness, drowsiness, dry mouth, difficulty in passing stools, increased hunger, priapism (prolonged and painful erection unrelated to sexual activity), rapid or slow heartbeat, or fits, contact a doctor. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineKetamine
Severe
How does the drug interact with Olanex F Tablet:
Using ketamine together with Olanex F Tablet may increase the risk of side effects.

How to manage the interaction:
Co-administration of ketamine of Olanex F Tablet can lead to an interaction, it can be taken if advised by a doctor. If you experience any symptoms like dizziness, drowsiness, confusion, difficulty in concentrating, excessive sleepiness, breathing difficulty, difficulty in thinking, judgment, and movement of hands and legs, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetinePethidine
Severe
How does the drug interact with Olanex F Tablet:
Using Olanex F Tablet together with Pethidine can increase the risk of serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Pethidine and Olanex F Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, dizziness, drowsiness, severe headache, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, and loose stools. Do not discontinue any medications without consulting a doctor.
Olanzapine + FluoxetineCitalopram
Severe
How does the drug interact with Olanex F Tablet:
Using Olanex F Tablet together with Citalopram can increase the risk of irregular heartbeat and serotonin syndrome (A condition resulting from the accumulation of high levels of serotonin in the body. Serotonin is especially a mood stabilizer).

How to manage the interaction:
Although using Citalopram and Olanex F Tablet together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, stomach pain, nausea, vomiting, sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heart beat and loose stools. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid alcohol entirely, as it can severely increase drowsiness, dizziness, and impairment.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIPSYCHOTICS]

FAQs

Olanex F Tablet 15's is used to treat schizophrenia (mental illness) and bipolar disorder (manic depression). It works by restoring the balance of certain natural substances in the brain.
Olanex F Tablet 15's can decrease anxiety, irritability or agitation. However, you should consult a doctor before using Olanex F Tablet 15's for any condition.
Long-term use of Olanex F Tablet 15's may cause dyskinesia (a movement disorder) in some cases. However, your doctor will prescribe this medication if the benefits outweigh the risks.
Olanex F Tablet 15's can be used to treat mood disorders such as schizophrenia, bipolar disorder, anxiety, and depression. However, you should not take this medication without a doctor’s advice.
Olanex F Tablet 15's may cause decreased libido in men and women. It can cause erectile dysfunction in men as it can alter testosterone levels. Consult a doctor if you experience erectile dysfunction after taking Olanex F Tablet 15's.
Stopping Olanex F Tablet 15's abruptly can cause withdrawal symptoms, and stopping it too early could make your illness come back. Please consult your doctor if you want to stop taking Olanex F Tablet 15's.
Olanex F Tablet 15's may cause severe side effects, such as memory loss and loss of contact with reality. It is important to know that it may raise blood sugar levels in diabetics and in patients who have never had diabetes. It can also induce weight gain and high blood fat levels which are more common in adolescents.
No, Olanex F Tablet 15's is not a sleeping pill. It is an antipsychotic medication used in the treatment of schizophrenia or psychosis and bipolar disorder (manic depression).
Olanex F Tablet 15's should be used by pregnant women only when prescribed by a doctor. Please consult the doctor if you are pregnant, think you may be pregnant or planning for pregnancy.
Do not discontinue Olanex F Tablet 15's without consulting your doctor as stopping Olanex F Tablet 15's suddenly may cause withdrawal symptoms. To treat your condition effectively, keep taking Olanex F Tablet 15's for the prescribed duration.
Avoid smoking as it might interfere with the working of Olanex F Tablet 15's. Do not consume alcohol while on treatment with Olanex F Tablet 15's as it may cause increased drowsiness.
Common side-effects of Olanex F Tablet 15's are drowsiness, lightheadedness, restlessness, irritability, tremors, dry mouth, constipation, increased appetite, extreme fatigue, decreased libido, swelling of the hands or feet, or weight gain. Inform your doctor if any of these side effects persist or worsen.
Yes, you can take this medicine with or without food. Taking it with food may help if you experience mild stomach upset when starting the treatment. Talk to your doctor if you have further questions.
You must contact your healthcare provider or seek medical help immediately if you experience worsening depression, sudden behavioural changes, or thoughts of self-harm. Talk to your doctor right away if you notice these signs.
No, you should avoid alcohol while taking this medicine. Alcohol can significantly increase drowsiness, affect your coordination, and interfere with how the medicine works. Talk to your doctor if you find it difficult to avoid alcohol.
Yes, an increase in appetite and weight gain are common side effects of this medicine. Managing your diet and staying physically active can help control this. Talk to your doctor or pharmacist for personalised lifestyle tips.
To manage dry mouth, try drinking water frequently, chewing sugarless gum, or sucking on sugar-free hard candies. If dry mouth persists or becomes severe, talk to your doctor or pharmacist for advice.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.3071 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. Drugs.com Clinical Review Team. Olanzapine Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  3. WebMD Medical Reference Review Board. Details Drug and Treatment Monograph. Atlanta, GA: WebMD; 2026. [Accessed on 02 Jun. 2026]Check here
  4. Olanzapine and fluoxetine hydrochloride [Prescribing Information]. 2011. [Accessed on 16 Sep. 2024]Check here
  5. Brown & Burk UK Ltd. Fluoxetine 20mg Hard Capsules. Electronic Medicines Compendium. [Revised in September 2021]. [Accessed on 21st January 2023].Check here
  6. Endo Ventures Ltd. Fluoxetine 10 mg Film-coated Tablets. Electronic Medicines Compendium. [Revised in January 2021]. [Accessed on 21st January 2023].Check here

Country of origin

India

Manufacturer/Marketer address

255/2, Hinjawadi, Pune - 411057, India
Other Info - OLA0499

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