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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Veda Maddala , M Pharmacy

Onoff OZ Tablet is used to treat bacterial infections of the urinary tract, bacterial infections by inflammation of the peritoneum, eye and ear infections, skin and soft tissue infections, sexually transmitted infections, respiratory infections, vaginal infections, protozoan infections, intra-abdominal infections, and infections during surgical procedures. It is also indicated in the treatment of diarrhoea of mixed infections in adults. It contains Ofloxacin and Ornidazole, which stops the growth of infection causing organisms. In some cases, it may cause side effects such as nausea, vomiting, abdominal pain, headache, and dizziness. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Manufacturer/Marketer :

Sun Pharmaceutical Industries Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Onoff OZ Tablet

Onoff OZ Tablet belongs to the group of medicines called antibiotics used to treat bacterial infections of the urinary tract, bacterial infections by inflammation of the peritoneum, eye and ear infections, skin and soft tissue infections, sexually transmitted infections, respiratory infections, vaginal infections, protozoan infections, intra-abdominal infections, and infections during surgical procedures. It is also indicated in the treatment of diarrhoea of mixed infections in adults.

Onoff OZ Tablet is a combination of two antibiotic drugs, namely: Ofloxacin and Ornidazole. Ofloxacin inhibits DNA gyrase, which is required for the replication, transcription, and repair of the DNA. Ornidazole inhibits protein synthesis and leads to cell death, thereby killing the bacteria. Together, Onoff OZ Tablet helps in treating bacterial infections.

Take Onoff OZ Tablet as prescribed. In some cases, Onoff OZ Tablet may cause side effects such as nausea, vomiting, abdominal pain, headache, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Talk to your doctor if you experience pain in tendons, swelling, and inflammation as Onoff OZ Tablet is associated with an increased risk of tendon rupture and tendonitis. Consult your doctor before taking Onoff OZ Tablet if you are pregnant or breastfeeding. Onoff OZ Tablet may cause dizziness and drowsiness, so drive only if you are alert. Avoid alcohol consumption while taking Onoff OZ Tablet as it may cause increased dizziness. Onoff OZ Tablet is not recommended for use in children.

Uses of Onoff OZ Tablet

Onoff OZ Tablet is used in the treatment of bacterial and parasitic infections. The detailed uses of Onoff OZ Tablet are as follows:
•Treatment of Diarrhea and Dysentery: Onoff OZ Tablet is effective in treating gastrointestinal infections caused by bacteria and parasites, such as acute diarrhea and dysentery.
•Urinary Tract Infections (UTIs): Onoff OZ Tablet can also be used to treat urinary tract infections caused by susceptible bacteria.
•Respiratory Tract Infections: Onoff OZ Tablet is helpful in lowering respiratory tract infections, including conditions like bronchitis and pneumonia.
•Skin and Soft Tissue Infections: Onoff OZ Tablet is also used to treat bacterial infections affecting the skin and soft tissues, ensuring effective relief.

Directions for Use

Swallow the medicine as a whole with water; do not chew, break or crush the tablet/capsule.

Medicinal Benefits

Onoff OZ Tablet belongs to the group of medicines called antibiotics used to treat urinary tract infections, bacterial infections by inflammation of the peritoneum, eye and ear infections, skin and soft tissue infections, sexually transmitted infections, respiratory infections, vaginal infections, protozoan infections, intra-abdominal infections, and infections during surgical procedures. It is also indicated in the treatment of diarrhoea of mixed infections in adults. Onoff OZ Tablet is a combination of two antibiotic drugs, namely: Ofloxacin and Ornidazole. Ofloxacin inhibits DNA gyrase, which is required for the replication, transcription, and repair of the DNA. Ornidazole inhibits protein synthesis and leads to cell death, thereby killing the bacteria. Together, Onoff OZ Tablet helps in treating bacterial infections. Onoff OZ Tablet is a broad-spectrum antibiotic effective against a wide range of gram-positive and gram-negative bacteria.

How Onoff OZ Tablet Works

Onoff OZ Tablet is a combination of two antibiotic drugs, namely: Ofloxacin and Ornidazole. Ofloxacin inhibits DNA gyrase, which is required for the replication, transcription, and repair of the DNA. Ornidazole inhibits protein synthesis and leads to cell death, thereby killing the bacteria. Together, Onoff OZ Tablet helps in treating bacterial infections.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of Onoff OZ Tablet

Do not take more than the prescribed dose of Onoff OZ Tablet as it may cause overdose. The symptoms of overdose include dizziness, confusion, convulsive seizures, nausea, mucosal erosions and impairment of consciousness. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Onoff OZ Tablet if you are allergic to any of its contents; if you had swelling or tearing of tendons while taking quinolone antibiotics; or if you have myasthenia gravis, as it may cause increased muscle weakness. Talk to your doctor before taking Onoff OZ Tablet if you have epilepsy, low levels of potassium, nervous or muscle problems, head injury or brain tumour, diabetes, rheumatoid arthritis, multiple sclerosis, heart, kidney or liver problems. Consult your doctor before taking Onoff OZ Tablet if you are pregnant or breastfeeding. Onoff OZ Tablet may cause dizziness and drowsiness, so drive only if you are alert. Avoid alcohol consumption while taking Onoff OZ Tablet as it may cause increased dizziness.

Drug-Drug Interactions

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OfloxacinBepridil
Critical
OfloxacinPimozide
Critical

Drug-Drug Interactions

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OfloxacinBepridil
Critical
How does the drug interact with Onoff OZ Tablet:
Using bepridil together with Onoff OZ Tablet drugs can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Onoff OZ Tablet with Bepridil can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, or fast or pounding heartbeats. Do not stop using any medications without consulting a doctor.
OfloxacinPimozide
Critical
How does the drug interact with Onoff OZ Tablet:
Coadministration of Onoff OZ Tablet with Pimozide can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Onoff OZ Tablet with Pimozide together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinThioridazine
Critical
How does the drug interact with Onoff OZ Tablet:
Coadministration of Onoff OZ Tablet with Thioridazine can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Onoff OZ Tablet with Thioridazine together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinDronedarone
Critical
How does the drug interact with Onoff OZ Tablet:
Coadministration of Onoff OZ Tablet with Dronedarone can increase the risk or severity of irregular heart rhythm.

How to manage the interaction:
Taking Onoff OZ Tablet with Dronedarone together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinAmiodarone
Critical
How does the drug interact with Onoff OZ Tablet:
The combination of Amiodarone and Onoff OZ Tablet may significantly increase the risk of an abnormal heart rhythm.

How to manage the interaction:
Although Amiodarone and Onoff OZ Tablet interact, it can be taken if prescribed by a doctor. If you get dizziness, lightheadedness, fainting, or fast or racing heartbeats, consult a doctor. Do not stop taking any medications without consulting a doctor.
OfloxacinSotalol
Critical
How does the drug interact with Onoff OZ Tablet:
Coadministration of Onoff OZ Tablet with Sotalol can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Onoff OZ Tablet with Sotalol together is generally avoided as it can result in an interaction, it can be taken if a doctor has advised it. If you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor. Do not discontinue any medications without consulting a doctor.
OfloxacinMesoridazine
Critical
How does the drug interact with Onoff OZ Tablet:
Using Mesoridazine together with Onoff OZ Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Mesoridazine with Onoff OZ Tablet is not recommended, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OfloxacinHalofantrine
Critical
How does the drug interact with Onoff OZ Tablet:
Using halofantrine together with Onoff OZ Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
Taking Onoff OZ Tablet with Halofantrine can cause an interaction, please consult your doctor before taking it. You should seek immediate medical attention if you develop sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop using any medications without talking to a doctor.
OfloxacinSaquinavir
Critical
How does the drug interact with Onoff OZ Tablet:
Coadministration of Onoff OZ Tablet with Saquinavir can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Onoff OZ Tablet with Saquinavir together is generally avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
OfloxacinCisapride
Critical
How does the drug interact with Onoff OZ Tablet:
Coadministration of Onoff OZ Tablet with Cisapride can increase the risk or severity of irregular heart rhythms.

How to manage the interaction:
Taking Onoff OZ Tablet with Cisapride together can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, chest pain or tightness, rapid heartbeat, or memory loss, contact a doctor immediately. Do not discontinue any medications without consulting a doctor. Note: Cisapride is no longer available on the market. Cisapride should only be taken if prescribed by a doctor and closely monitored.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Antibiotics can alter the useful bacteria in the stomach, which help in digestion. Therefore, you are advised to take foods rich in probiotics such as yoghurt/curd, kefir, sauerkraut, tempeh, kimchi, miso, kombucha, buttermilk, natto and cheese.

  • Eat fibre-rich food like whole grains, beans, lentils, berries, broccoli, peas and bananas.

  • Avoid foods rich in calcium, grapefruit and grapefruit juice as they might hinder the absorption of antibiotics.

  • Avoid consumption of alcohol and usage of tobacco.

Habit Forming

No

Therapeutic Class

ANTIBIOTICS

Onoff OZ Tablet Substitute

Substitutes safety advice
  • Nicoflox-O Tablet 10's

    by Others

    15.30per tablet
  • O2 Tablet 10's

    by Others

    18.68per tablet
  • Oflox OZ Tablet 10's

    by Others

    18.00per tablet
  • Ornof Tablet 10's

    by Others

    14.85per tablet
  • Zenflox-OZ 200 mg/500 mg Tablet 10's

    by AYUR

    12.83per tablet
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Alcohol

Unsafe

Avoid consuming alcohol while taking Onoff OZ Tablet as it may cause increased dizziness.

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Pregnancy

Caution

Please consult your doctor if you are pregnant; your doctor will prescribe Onoff OZ Tablet only if the benefits outweigh the risks.

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Breast Feeding

Caution

Consult your doctor before taking Onoff OZ Tablet if you are breastfeeding. Your doctor will decide if Onoff OZ Tablet can be taken by breastfeeding mothers or not.

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Driving

Caution

Onoff OZ Tablet may cause dizziness and drowsiness. So, drive only if you are alert.

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Liver

Caution

Dose adjustment may be needed. Please consult your doctor before taking Onoff OZ Tablet if you have liver impairment/liver disease.

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Kidney

Caution

Please consult your doctor if you have any concerns regarding this or if you have kidney impairment/kidney disease before taking Onoff OZ Tablet .

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Children

Unsafe

Onoff OZ Tablet is not recommended for children as safety and effectiveness have not been established.

FAQs

Onoff OZ Tablet is used to treat bacterial infections of the urinary tract, bacterial infections by inflammation of the peritoneum, eye and ear infections, skin and soft tissue infections, sexually transmitted infections, respiratory infections, vaginal infections, protozoan infections, intra-abdominal infections, and infections during surgical procedures. It is also indicated in the treatment of diarrhoea of mixed infections in adults.

Onoff OZ Tablet contains Ofloxacin and Ornidazole. Ofloxacin inhibits DNA gyrase which is required for the production of DNA replication, transcription, and repair. Ornidazole inhibits protein synthesis and leads to cell death, thereby kills the bacteria. Together, Onoff OZ Tablet helps in treating bacterial infections.

Onoff OZ Tablet may cause photosensitivity (sensitivity to sunlight) and can make you sunburn easily. Avoid prolonged exposure to sunlight or tanning beds. Always wear protective clothing and sunscreen with SPF 30 or higher before going out.

It is recommended to complete the course of Onoff OZ Tablet even if you feel better as it is an antibiotic, and leaving it in between may lead to even severe infection. To treat your condition effectually, continue taking Onoff OZ Tablet for as long as your doctor has prescribed it.

Co-administration of magnesium and aluminium-containing antacids, sucralfate, and iron-containing preparations with Onoff OZ Tablet may reduce the absorption. Therefore, you are advised to take Onoff OZ Tablet two hours before such preparations.

Do not take Onoff OZ Tablet on your own as self-medication may lead to antibiotic-resistance in which antibiotics fail to act against specific bacterial infections.

Consult your doctor before taking Onoff OZ Tablet if you have diabetes, as Onoff OZ Tablet may cause hypoglycaemia (low blood sugar levels). Regularly monitor blood sugar levels while taking Onoff OZ Tablet to avoid unpleasant events.

It depending on the medical problem being treated. To treat your condition effectually, continue taking Onoff OZ Tablet for as long as your doctor has prescribed it.

No, Onoff OZ Tablet is not a habit-forming drug.

It is recommended to complete the course of Onoff OZ Tablet even if you feel better as it is an antibiotic and leaving it in between may lead to even severe infection. To treat your condition effectually, continue taking Onoff OZ Tablet for as long as your doctor has prescribed it.

If you miss the dose of Onoff OZ Tablet . Take it as soon as you remember, but if it is almost time for the next dose, skip the forgotten dose and go back to your regular schedule. Do not take double to compensate for the forgotten dose.

Please consult the doctor if you are not feeling better even after completing the recommended dose. Your doctor may prolong the duration or prescribe other medications to treat your condition.

You may take this medicine with or without food.

It is recommended not to use Onoff OZ Tablet if you are allergic to any component present in it.

Onoff OZ Tablet may cause side effects such as nausea, vomiting, abdominal pain, headache, and dizziness. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Yes, you can take it, but it should be taken only if recommended by the doctor. If you use multiple medications, your doctor will check their interactions and advise how to take them.

Store in a cool and dry place away from sunlight. Keep Onoff OZ Tablet out of reach and sight of children.

Country of origin

India

Manufacturer/Marketer address

SUN HOUSE, CTS No. 201 B/1, Western Express Highway, Goregaon (E), Mumbai 400063
Other Info - ONO0004

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