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Palnon 0.25 mg Injection 5 ml is used to prevent nausea and vomiting during chemotherapy. It contains Palonosetron, which blocks the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone) located in the brain. Thus, it prevents nausea and vomiting. Common side effects of Palnon 0.25 mg Injection 5 ml are diarrhoea, constipation, dizziness or headache.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PALONOSETRON-0.25MG

Manufacturer/Marketer :

Medion Biotech Pvt Ltd

Consume Type :

Parenteral

Expires on or after :

Jan-28

Return Policy :

Not Returnable

About Palnon 0.25 mg Injection 5 ml

Palnon 0.25 mg Injection 5 ml is an injection used to prevent nausea and vomiting caused by cancer chemotherapy or surgery. It belongs to a group of medicines that block signals in the body that trigger the vomiting reflex. By stopping these signals, it helps keep your stomach settled during critical medical treatments.

This medicine is injected by a healthcare professional as a single dose before your medical procedure or treatment begins. Because it is given in a clinical setting, you do not need to worry about keeping a daily schedule. Eating small, balanced meals and staying well-hydrated can also help support your overall recovery.

Most people tolerate this injection well, though some may experience mild side effects like a headache or constipation. If you develop serious symptoms such as a fast or irregular heartbeat, severe dizziness, or signs of a serious allergic reaction, tell your healthcare provider immediately.

Do not receive this medicine if you have had an allergic reaction to similar anti-nausea drugs in the past. Before starting, talk to your doctor if you have a history of heart rhythm disorders, severe liver damage, or an imbalance of minerals in your blood.

This medicine can interact with certain antidepressants, which can cause a rare but serious condition that affects your nervous system. Make sure to consult your doctor if you are pregnant, breastfeeding, or planning a pregnancy before receiving this injection.

Uses of Palnon 0.25 mg Injection 5 ml

Your doctor may prescribe Palnon 0.25 mg Injection 5 ml to help manage the following conditions:

  • Chemotherapy-induced nausea and vomiting: Helps prevent the feeling of sickness and throwing up both immediately after cancer chemotherapy and during the days following treatment.
  • Post-operative nausea and vomiting: Helps prevent nausea and throwing up that can occur after undergoing surgery under general anesthesia.

Key Benefits

When used as directed as part of your treatment plan, Palnon 0.25 mg Injection 5 ml may provide the following benefits:

  • Helps prevent nausea and vomiting: Reduces the chance of feeling sick or being sick during and after chemotherapy or surgery.
  • Provides long-lasting protection: Helps prevent both early and delayed nausea and vomiting, especially after certain types of chemotherapy.
  • Supports your recovery: By reducing nausea and vomiting, it may help you feel more comfortable while recovering from chemotherapy or surgery.
  • Helps you eat and drink more comfortably: Preventing nausea may make it easier to maintain your fluid intake and nutrition during recovery.
  • May improve your quality of life during treatment: Better control of nausea and vomiting can help you continue your daily activities and cancer treatment more comfortably.
Side effects of Palnon 0.25 mg Injection 5 ml
Managing Medication-Triggered Anxiety: A Comprehensive Approach:
  • Inform your doctor about your anxiety symptoms so that you doctor may explore potential drug interactions and alter your treatment plan.
  • Work with your doctor to adjust your medication regimen or dosage to minimize anxiety symptoms.
  • Reduce anxiety symptoms by practicing relaxation techniques like meditation, deep breathing, or yoga.
  • Regular self-care activities, such as exercise, healthy food, and adequate sleep, can assist control anxiety.
  • Surround yourself with a supportive network of friends, family, or a support group to help manage anxiety and stay motivated.
  • Regularly track anxiety symptoms and report any changes to your doctor to ensure your treatment plan is effective and adjusted as needed.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the steps to cope with constipation as a side effect of medication:
  • Inform your doctor about your constipation symptoms. They may adjust your medication or advise alternative treatments.
  • Stay hydrated by drinking sufficient of water (at least 8-10 glasses a day) to help soften stool and promote bowel movements.
  • Increase fibre intake by eating foods high in fibre, such as fruits, whole grains, vegetables and legumes, to help bulk up the stool.
  • Establish a bowel routine by trying to go to the bathroom at the same time each day to train your bowels.
  • Engaging in regular exercise, like walking or yoga, can support in bowel movement stimulation.
  • Consult your doctor if constipation persists, and discuss alternative treatments or adjustments to your medication.
Here are the precise steps to cope with diarrhoea caused by medication usage:
  • Inform Your Doctor: Notify your doctor immediately about your diarrhoea symptoms. This allows them to adjust your medication or provide guidance on managing side effects.
  • Stay Hydrated: Drink plenty of fluids to replace lost water and electrolytes. Choose water, clear broth, and electrolyte-rich drinks. Avoid carbonated or caffeinated beverages to effectively rehydrate your body.
  • Follow a Bland Diet: Eat easy-to-digest foods to help firm up your stool and settle your stomach. Try incorporating bananas, rice, applesauce, toast, plain crackers, and boiled vegetables into your diet.
  • Avoid Trigger Foods: Steer clear of foods that can worsen diarrhoea, such as spicy, fatty, or greasy foods, high-fibre foods, and dairy products (especially if you're lactose intolerant).
  • Practice Good Hygiene: Maintain good hygiene to prevent the spread of infection. To stay healthy, wash your hands frequently, clean and disinfect surfaces regularly, and avoid exchanging personal belongings with others.
  • Take Anti-Diarrheal Medications: If your doctor advises, anti-diarrheal medications such as loperamide might help manage diarrhoea symptoms. Always follow your doctor's directions.
  • Keep track of your diarrhoea symptoms. If they don't get better or worse or are accompanied by severe stomach pain, blood, or dehydration signs (like extreme thirst or dark urine), seek medical help.
Here are the few steps for dealing with itching caused by drug use:
  • Report the itching to your doctor immediately; they may need to change your medication or dosage.
  • Use a cool, damp cloth on the itchy area to help soothe and calm the skin, reducing itching and inflammation.
  • Keep your skin hydrated and healthy with gentle, fragrance-free moisturizers.
  • Try not to scratch, as this can worsen the itching and irritate your skin.
  • If your doctor prescribes, you can take oral medications or apply topical creams or ointments to help relieve itching.
  • Track your itching symptoms and follow your doctor's guidance to adjust your treatment plan if needed. If the itching persists, consult your doctor for further advice.

Directions for Use

  • Palnon 0.25 mg Injection 5 ml is administered only in clinical settings by healthcare professionals, usually through intravenous or intramuscular injections.
  • The dosage and timing are decided by the doctor, depending on the cause and severity of symptoms.
  • Do not self-administer this medication.
  • Patients are monitored during and after administration to ensure safety and effective control of symptoms.

How Palnon 0.25 mg Injection 5 ml Works

Palnon 0.25 mg Injection 5 ml contains palonosetron. Palonosetron belongs to a group of medicines called 5-HT3 receptor antagonists (medicines that block serotonin signals that trigger nausea and vomiting). Chemotherapy and surgery can cause your body to release serotonin (a natural chemical), which attaches to 5-HT3 receptors (special proteins that receive signals) in the gut and brain. These signals can trigger nausea and vomiting. Palonosetron blocks these receptors, preventing serotonin from sending nausea and vomiting signals to the brain. This helps prevent nausea and vomiting before they start and provides long-lasting protection, particularly after chemotherapy.
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Alcohol

Caution

The interaction of alcohol with Palnon 0.25 mg Injection 5 ml is unknown. Please consult a doctor before consuming alcohol with Palnon 0.25 mg Injection 5 ml.

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Pregnancy

Consult your doctor

Palnon 0.25 mg Injection 5 ml is given to pregnant women only if the doctor thinks the benefits outweigh the risks. Please inform your doctor if you are pregnant.

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Breast Feeding

Consult your doctor

Please inform your doctor before taking Palnon 0.25 mg Injection 5 ml if you are breastfeeding. Palnon 0.25 mg Injection 5 ml is given to breastfeeding women only if the doctor thinks the benefits are greater than the risks.

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Driving

Caution

Palnon 0.25 mg Injection 5 ml may cause tiredness or dizziness in some people. Therefore, avoid driving or operating heavy machinery if you feel tired or dizzy after taking Palnon 0.25 mg Injection 5 ml.

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Liver

Safe if prescribed

Palnon 0.25 mg Injection 5 ml may be safe to use in patients with liver problems if prescribed by a doctor. However, if you have any concerns regarding this, please discuss them with your doctor.

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Kidney

Safe if prescribed

Palnon 0.25 mg Injection 5 ml may be safe to use in patients with kidney problems if prescribed by a doctor. However, if you have any concerns regarding this, please discuss them with your doctor.

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Children

Caution

Palnon 0.25 mg Injection 5 ml may be given to children above 1 month in doses as advised by a doctor based on the child's body weight.

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Heart

Caution

If you have a pre-existing condition or a history of heart disease, inform your doctor before receiving Palnon 0.25 mg Injection 5 ml.

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Geriatrics

Consult your doctor

Please consult a doctor if you have any concerns regarding the use of Palnon 0.25 mg Injection 5 ml in elderly patients.

What if I have taken an overdose of Palnon 0.25 mg Injection 5 ml

Since this medication is prepared and injected by clinical professionals in a controlled medical setting, an overdose is extremely rare. However, if you suspect an overdose or experience severe symptoms like extreme dizziness or a rapid heartbeat, seek immediate medical attention.

Diet & Lifestyle Advise

  • Eat small, frequent meals: Eating smaller meals more often may help reduce nausea and make eating more comfortable.
  • Choose simple foods: Plain foods such as toast, rice, crackers, bananas, or porridge may be easier to tolerate. Avoid greasy, spicy, or very rich foods if they make your nausea worse.
  • Drink enough fluids: Sip water or other clear fluids regularly throughout the day to help prevent dehydration. If tolerated, ginger tea may also help relieve mild nausea.
  • Eat slowly and rest afterwards: Eat slowly and remain sitting upright for a while after meals to help digestion and reduce stomach discomfort.
  • Avoid strong smells: Cooking odours, perfumes, or cigarette smoke may trigger nausea in some people. Avoid them whenever possible.
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Have a query?

How Soon It Starts Working

The time required for Palnon 0.25 mg Injection 5 ml to start to work: Palnon 0.25 mg Injection 5 ml ideally shows its effects in 30 minutes. The time for which the effects of Palnon 0.25 mg Injection 5 ml last: Palnon 0.25 mg Injection 5 ml effect lasts for a few days.

What if you forget to take Palnon 0.25 mg Injection 5 ml

Because this medicine is injected by a healthcare professional right before a scheduled medical procedure, it is highly unlikely that you will miss a dose. If your treatment schedule changes or you believe a dose was missed, contact your healthcare provider immediately to reschedule.

Storage

•Keep the vial in its original carton to protect the solution from direct light. Do not freeze the medicine, as freezing can damage its effectiveness.

Drug Warnings

  • Tell your healthcare provider about all your medicines: This includes prescription medicines, over-the-counter medicines, vitamins, and herbal products, as some medicines may interact with Palnon 0.25 mg Injection 5 ml.
  • Report unusual symptoms immediately: Tell your healthcare provider straight away if you develop a rash, swelling, difficulty breathing, a fast or irregular heartbeat, severe dizziness, or fainting after receiving this medicine.
  • Be aware of serotonin syndrome: Seek medical help immediately if you develop symptoms such as agitation, confusion, shivering, fever, muscle twitching, or heavy sweating, especially if you also take antidepressants or other medicines that affect serotonin.
  • Tell your doctor if you have heart rhythm problems: Inform your doctor if you have a history of an irregular heartbeat, long QT syndrome (a heart rhythm disorder), or low potassium or magnesium levels before receiving this medicine.
  • Take care if you feel dizzy: If you feel dizzy or drowsy after receiving the injection, avoid driving, cycling, or operating machinery until you feel well again.
  • Tell your doctor if constipation becomes severe: Constipation can occur with this medicine. Seek medical advice if it is severe, persistent, or accompanied by abdominal pain or swelling.

Drug-Drug Interactions

verifiedApollotooltip
  • Antidepressants and other medicines that affect serotonin: Medicines such as SSRIs, SNRIs, MAOIs, or other medicines that increase serotonin may rarely increase the risk of serotonin syndrome (a serious condition caused by too much serotonin in the body). Tell your doctor immediately if you develop agitation, confusion, fever, heavy sweating, muscle twitching, or shivering.
  • Medicines that affect the heart rhythm: Some medicines used to treat irregular heart rhythms, certain antibiotics, antipsychotics, or other medicines that can prolong the QT interval (the time it takes the heart to recharge between beats) may increase the risk of abnormal heart rhythms when used together with Palnon 0.25 mg Injection 5 ml. Your doctor will decide if these medicines can be used safely together.
  • Other anti-sickness medicines: If you are receiving more than one medicine to prevent nausea and vomiting, your doctor will choose the combination that is most suitable for your treatment.

Drug-Drug Interactions

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How does the drug interact with Palnon 0.25 mg Injection 5 ml:
Combining Palnon 0.25 mg Injection 5 ml with Ziprasidone can increase the risk of side effects.

How to manage the interaction:
Taking Ziprasidone with Palnon 0.25 mg Injection 5 ml is not recommended, please consult your doctor before taking it.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
Taking Palnon 0.25 mg Injection 5 ml with Pentazocine may increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although there is a possible interaction between Pentazocine and Palnon 0.25 mg Injection 5 ml, but can be taken together if prescribed by a doctor. However, consult a doctor if you experience confusion, hallucination(seeing and hearing things that do not exist), fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
The combined use of Palnon 0.25 mg Injection 5 ml and Hydroxychloroquine can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Co-administration of palponosetron and Hydroxychloroquine can lead to an interaction, it can be taken if advised by your doctor. However, if you experience any symptoms like dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations, consult the doctor immediately. Do not stop using any medications without a doctor's advice.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
Taking fentanyl with Palnon 0.25 mg Injection 5 ml may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Although taking Fentanyl with Palnon 0.25 mg Injection 5 ml can result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, hallucinations (seeing and hearing things that do not exist), increased heart rate, fever, excessive sweating, muscle pain or stiffness, stomach cramps, vomiting, or diarrhoea, consult a doctor. Do not discontinue any medications without consulting your doctor.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
When Vilazodone is taken with Palnon 0.25 mg Injection 5 ml, may increase the risk of serotonin syndrome (a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
There may be a possibility of interaction between Vilazodone and Palnon 0.25 mg Injection 5 ml, but it can be taken if prescribed by a doctor. If you notice any of these signs - like confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhea-call a doctor right away. Do not stop using any medications without a doctor's advice.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
When venlafaxine is taken with Palnon 0.25 mg Injection 5 ml, it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although there is a possible interaction between Venlafaxine and Palnon 0.25 mg Injection 5 ml, you can take these medicines together if prescribed by a doctor. However, if you experience any of the following symptoms: confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, tremor, incoordination, stomach cramp, nausea, vomiting, and diarrhoea, seek immediate medical attention. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
Combining Palnon 0.25 mg Injection 5 ml with Amitriptyline can increase the risk of serotonin syndrome.(A condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Although using Palnon 0.25 mg Injection 5 ml and Amitriptyline together may cause an interaction, they can be taken if prescribed by a doctor. Consult a doctor if you have symptoms such as confusion, hallucination, fits, blood pressure alteration, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea. Inform a doctor if you have recently taken amitriptyline. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
Coadministration of Amiodarone with Palnon 0.25 mg Injection 5 ml can lead to or increase the risk of irregular heart rhythm.

How to manage the interaction:
Taking Amiodarone with Palnon 0.25 mg Injection 5 ml together is avoided as it can result in an interaction, it can be taken if your doctor has advised it. However, if you experience sudden dizziness, lightheadedness, fainting, shortness of breath, or rapid heartbeat, contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
When linezolid is taken with Palnon 0.25 mg Injection 5 ml it can cause serotonin syndrome. (a condition in which a chemical called serotonin builds up in your body).

How to manage the interaction:
Co-administration of linezolid along with Palnon 0.25 mg Injection 5 ml can lead to an interaction, it can be taken if recommended by a doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhea, consult the doctor. Do not discontinue any medications without consulting a doctor.
How does the drug interact with Palnon 0.25 mg Injection 5 ml:
The combined use of Palnon 0.25 mg Injection 5 ml with clomipramine can increase the risk of serotonin syndrome (Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhea) to severe (muscle rigidity, fever, and seizures)).

How to manage the interaction:
Although taking clomipramine and Palnon 0.25 mg Injection 5 ml together can cause an interaction, it can be taken if your doctor has suggested it. However, if you have sudden dizziness, lightheadedness, fainting, confusion, hallucination, fits, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, pain in the muscles, or stiffness, incoordination, stomach cramps, nausea, vomiting, and diarrhea, or fast or rapid heartbeats during therapy, consult the doctor.

Drug-Food Interactions

verifiedApollotooltip
  • No clinically significant food interactions are known with Palnon 0.25 mg Injection 5 ml when used as directed.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[ANTIEMETICS]

FAQs

Palnon 0.25 mg Injection 5 ml is used to treat nausea and vomiting.
Palnon 0.25 mg Injection 5 ml contains Palonosetron which works by blocking the action of serotonin, a chemical that stimulates the vomiting centre (chemoreceptor trigger zone – CTZ) located in the brain. Thus, it prevents nausea and vomiting.
You are not recommended to take erythromycin with Palnon 0.25 mg Injection 5 ml as it may increase the risk of severe irregular heart rhythm. However, please consult your doctor before taking other medicines with Palnon 0.25 mg Injection 5 ml.
Palnon 0.25 mg Injection 5 ml may cause constipation as a side effect. It is not necessary for everyone taking Palnon 0.25 mg Injection 5 ml to experience this side effect. However, if the condition persists or worsens, please consult a doctor.
Palnon 0.25 mg Injection 5 ml should be used with caution in patients suffering from heart problems as it may worsen the condition. Therefore, inform your doctor if you have any heart problems before taking have Palnon 0.25 mg Injection 5 ml so that the dose may be adjusted appropriately.
It is given as an injection directly into a vein by a doctor or nurse in a medical clinic or hospital. Talk to your doctor if you have questions about the injection process.
Yes, it is designed to help prevent both immediate nausea and delayed nausea that can occur several days after receiving chemotherapy. Talk to your doctor for more information.
If you are pregnant or planning to become pregnant, you should discuss the risks and benefits with your doctor before receiving this injection. Talk to your doctor to find the best option for you.
While it is less likely to cause severe drowsiness than some older anti-nausea medicines, some people may still feel tired or weak after receiving it. Talk to your doctor if these symptoms persist.
This medicine can cause dizziness or fatigue in some patients. It is best to avoid driving or operating machinery until you know how the injection affects you. Talk to your doctor if you are unsure.

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Country of origin

India

Manufacturer/Marketer address

409, 4Th Floor, Devika Tower, Chander Nagar, Surya Nagar, Ghaziabad-201011, Uttar Pradesh, India
Other Info - PAL0291
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