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  1. Home
  2. Medicine

  3. Perindosyl-Am 4/5Mg Tablet 10'S

Prescription drug
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Perindosyl-Am 4/5Mg Tablet 10'S, Pack of 10 TabletS
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Extra 15% Off with Bank Offers

Composition :

AMLODIPINE-5MG + PERINDOPRIL-4MG

Manufacturer/Marketer :

Elder Pharmaceuticals Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Perindosyl-Am 4/5Mg Tablet

Perindosyl-Am 4/5Mg Tablet is used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the walls of the blood vessels. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure.

Perindosyl-Am 4/5Mg Tablet contains Amlodipine and Perindopril. Amlodipine relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. Perindopril relaxes and widens the blood vessels.

You may experience certain side effects like ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, cough, flushing, taste change, and upset stomach. Most of these side effects do not require medical attention. However, talk to your doctor if the side effects persist or worsen.

Do not stop taking Perindosyl-Am 4/5Mg Tablet without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems. If you have angioedema (Painless swelling under the skin), diabetes then inform your doctor immediately. Reduce the amount of table salt (sodium chloride) in your food. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet can be prescribed accordingly.

Uses of Perindosyl-Am 4/5Mg Tablet

Perindosyl-Am 4/5Mg Tablet is used in the treatment of high blood pressure. The detailed uses of Perindosyl-Am 4/5Mg Tablet are as follows:

  • Lowers High Blood Pressure: Perindosyl-Am 4/5Mg Tablet helps to relax and widen blood vessels, making it easier for the heart to pump blood and reducing blood pressure.
  • Prevents heart-related problems: Perindosyl-Am 4/5Mg Tablet helps to lower the risk of heart attacks, strokes, and other complications linked to high blood pressure.
  • Supports heart health: Perindosyl-Am 4/5Mg Tablet improves blood flow and reduces strain on the heart, especially in people with long-standing hypertension or heart disease.

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Directions for Use

  • Take Perindosyl-Am 4/5Mg Tablet with or without food, or as advised by a doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
  • Swallow the medicine as a whole with a glass of water.
  • Do not crush, break, or chew it.

Medicinal Benefits

  • Perindosyl-Am 4/5Mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine and Perindopril.
  • Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease.
  • It relaxes blood vessels, allowing blood to pass through them easily, thereby lowering blood pressure.
  • It also treats chest pain by improving the blood supply to the heart muscle, allowing it to receive more oxygen.
  • Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels.
  • Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, which reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels).
  • It relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.
  • Perindosyl-Am 4/5Mg Tablet does not cure high blood pressure (hypertension) but does help control it.
  • In addition to this, Perindosyl-Am 4/5Mg Tablet also reduces the physical effects of anxiety.

How Perindosyl-Am 4/5Mg Tablet Works

Perindosyl-Am 4/5Mg Tablet contains Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. Perindopril relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. Thus, collectively, both help lower high blood pressure, reducing the chances of a heart attack or stroke.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Perindosyl-Am 4/5Mg Tablet
  • Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
  • Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
  • Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
  • Gently massage the swollen area with firm but not painful pressure.
  • Keep the swollen area clean and moisturized to prevent injury and infection.
  • Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
  • If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
  • Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
  • Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
  • Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
  • Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
  • Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.
  • Reduce salt intake to minimize fluid buildup.
  • Use compression stockings, sleeves, or gloves.
  • Gently massage the affected area towards the heart.
  • Protect the swollen area from injury and keep it clean.
  • Use lotion or cream to keep the skin moisturized.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

What if I have taken an overdose of Perindosyl-Am 4/5Mg Tablet

Do not take more than the prescribed dose of Perindosyl-Am 4/5Mg Tablet as it may cause serious adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Avoid taking Perindosyl-Am 4/5Mg Tablet if you are allergic to any of its components.
  • Do not stop taking Perindosyl-Am 4/5Mg Tablet without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems.
  • If you have angioedema (Painless swelling under the skin) or diabetes, then inform your doctor immediately.
  • If you have kidney disease, you may not use Perindosyl-Am 4/5Mg Tablet with aliskiren (other blood pressure-lowering pills).
  • Reduce the amount of table salt (sodium chloride) in your food.  
  • Avoid foods containing potassium. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, diabetes, and high potassium level in your blood.
  • If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet can be prescribed accordingly.
  • Perindosyl-Am 4/5Mg Tablet is not recommended for use in children below 18 yaers of age.

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
PerindoprilAliskiren
Critical

Drug-Drug Interactions

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AmlodipineDantrolene
Critical
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with Dantrolene can cause an interaction, consult a doctor before taking it. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.
PerindoprilAliskiren
Critical
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Combining Aliskiren with Perindosyl-Am 4/5Mg Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with Aliskiren is not recommended, but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
AmlodipineRifabutin
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet and rifabutin together may lower Perindosyl-Am 4/5Mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Perindosyl-Am 4/5Mg Tablet with rifabutin, but it can be taken if a doctor has advised it. Consult the doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
AmlodipineTizanidine
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Co-administration of Tizanidine and Perindosyl-Am 4/5Mg Tablet can increase the risk or severity of developing side effects like low blood pressure.

How to manage the interaction:
Although co-administration of Perindosyl-Am 4/5Mg Tablet with tizanidine can result in an interaction, it can be taken when a doctor has advised it. However, if you experience headache, dizziness, palpitations, or irregular heart rate while taking these drugs, contact the doctor immediately. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not discontinue any medications without consulting the doctor.
AmlodipineSirolimus
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Co-administration of Perindosyl-Am 4/5Mg Tablet can make Sirolimus may increase the risk of angioedema (a condition associated with swelling of the face, eyes, lips, tongue, throat, and occasionally also the hands and feet).

How to manage the interaction:
There may be a possibility of interaction between Perindosyl-Am 4/5Mg Tablet and Sirolimus, but it can be taken if prescribed by a doctor. However, consult the doctor if you notice any swelling of the face, eyes, lips, tongue, throat, hands and feet or have trouble breathing or swallowing. Do not stop using any medications without a doctor's advice.
AmlodipineEnzalutamide
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using a combination of Perindosyl-Am 4/5Mg Tablet and enzalutamide may drastically lower Perindosyl-Am 4/5Mg Tablet blood levels, making the medicine less effective.

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with enzalutamide can result in an interaction, it can be taken if a doctor has advised it. Do not discontinue any medications without consulting a doctor.
AmlodipineDolasetron
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using dolasetron together with Perindosyl-Am 4/5Mg Tablet can increase the risk of an irregular heart rhythm that may be serious.

How to manage the interaction:
There may be a possibility of interaction between Perindosyl-Am 4/5Mg Tablet and Dolasetron, but it can be taken if prescribed by a doctor. If you have any of these symptoms, like feeling dizzy, lightheaded, or your heart beating irregularly, it's important to call a doctor right away. Do not stop using any medications without a doctor's advice.
AmlodipineFosphenytoin
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
When Perindosyl-Am 4/5Mg Tablet is taken with Fosphenytoin, it may decrease the blood levels of Perindosyl-Am 4/5Mg Tablet, which may make Perindosyl-Am 4/5Mg Tablet less effective.

How to manage the interaction:
Although taking Perindosyl-Am 4/5Mg Tablet and Fosphenytoin together can cause an interaction, it can be taken if a doctor has suggested it. Do not stop using any medications without a doctor's advice.
AmlodipineIdelalisib
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet and Idelalisib may raise Perindosyl-Am 4/5Mg Tablet levels in the blood this may lead to serious side effects (irregular heart rhythm, fluid retention, swelling, heart failure, and abnormally low blood pressure).

How to manage the interaction:
Although taking Perindosyl-Am 4/5Mg Tablet with idelalisib can result in an interaction, it can be taken if a doctor has advised it. However, if you experience dizziness or fainting, sudden, unexplained weight gain, swelling of the hands, ankles, or feet, chest discomfort, or trouble breathing while taking these drugs, consult the doctor. Use caution while getting up from a sitting or sleeping position and avoid driving or using dangerous machinery. Do not stop using any medications without a doctor's advice.
AmlodipineRifampicin
Severe
How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet and rifampicin together may lower Perindosyl-Am 4/5Mg Tablet blood levels, which makes the medicine less effective.

How to manage the interaction:
Although there is an interaction between Perindosyl-Am 4/5Mg Tablet and rifampicin, they can be taken together if prescribed by a doctor. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL-4MGPotassium rich foods
Moderate

Drug-Food Interactions

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AMLODIPINE-5MG+PERINDOPRIL-4MGPotassium rich foods
Moderate
Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Perindosyl-Am 4/5Mg Tablet.

Diet & Lifestyle Advise

  • Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
  • Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
  • Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
  • If you are taking alcohol, use only one serving for women and two servings for men.
  • Quit smoking to lower the risk of heart diseases.
  • Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
  • Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
  • Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Habit Forming

No

Therapeutic Class

ANTI- HYPERTENSIVES

Perindosyl-Am 4/5Mg Tablet Substitute

Substitutes safety advice
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Alcohol

Unsafe

Perindosyl-Am 4/5Mg Tablet interacts with alcohol. Therefore alcohol is not safe.

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Pregnancy

Unsafe

The use of Perindosyl-Am 4/5Mg Tablet is usually contraindicated during the second and third trimester of pregnancy. It may cause harm to the unborn baby. Hence, you should always consult your doctor before using Perindosyl-Am 4/5Mg Tablet .

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Breast Feeding

Consult your doctor

Use of Perindosyl-Am 4/5Mg Tablet is not recommended during the breastfeeding stage unless recommended by your doctor.

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Driving

Caution

Perindosyl-Am 4/5Mg Tablet may cause dizziness and sleepiness. Therefore, drive with caution while using Perindosyl-Am 4/5Mg Tablet .

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Liver

Consult your doctor

Let your doctor know if you have any history of liver diseases before using Perindosyl-Am 4/5Mg Tablet .

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Kidney

Consult your doctor

Let your doctor know if you have any history of kidney diseases before using Perindosyl-Am 4/5Mg Tablet .

bannner image

Children

Unsafe

Perindosyl-Am 4/5Mg Tablet is not recommended for use in children.

FAQs

Perindosyl-Am 4/5Mg Tablet is used to treat hypertension (high blood pressure).

Perindosyl-Am 4/5Mg Tablet relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.

Perindosyl-Am 4/5Mg Tablet is recommended to use in dose and duration as advised by the doctor. Do not stop taking Perindosyl-Am 4/5Mg Tablet on your own as it may lead to a sudden rise in blood pressure increases the risk of heart attack and stroke.

Perindosyl-Am 4/5Mg Tablet can cause dizziness as one of its side effects. If you feel dizzy, try getting up slowly from a sitting or lying position. If your dizziness is severe or unmanageable, please seek medical advice.

Perindosyl-Am 4/5Mg Tablet may increase blood potassium levels in people with diabetes, poor kidney function, and patients using potassium-sparing diuretics or taking potassium supplements. Please consult your doctor before taking Perindosyl-Am 4/5Mg Tablet if you have diabetes.

Even though your blood pressure becomes normal after using Perindosyl-Am 4/5Mg Tablet , it may switch back to high ranges if you stop using it. Your doctor may change the dosing schedule based on your blood pressure range.

Yes, you can take Perindosyl-Am 4/5Mg Tablet with or without food. However, it is recommended that you take it at the same time each day to maintain consistent blood levels.

Common side effects of Perindosyl-Am 4/5Mg Tablet may include ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, increased potassium level in the blood, cough, flushing (sense of heat in the face, ears, neck, and trunk), Taste change, decreased blood pressure, and upset stomach.

Perindosyl-Am 4/5Mg Tablet should be avoided during pregnancy as it can harm the unborn baby. It's generally advised to avoid Perindosyl-Am 4/5Mg Tablet while breastfeeding. Consult your doctor for personalized advice.

If you have kidney or liver problems, allergies, or diabetes, inform your doctor before taking Perindosyl-Am 4/5Mg Tablet . Regular monitoring of potassium and blood sugar levels may be necessary.

Store Perindosyl-Am 4/5Mg Tablet in a cool, dry place, away from light and moisture. Keep it out of the reach of children and pets.

It may take a few weeks for the whole blood pressure-lowering effect of Perindosyl-Am 4/5Mg Tablet to be felt. However, some people may notice a difference in blood pressure within a few days.

Yes, Perindosyl-Am 4/5Mg Tablet can cause a dry cough. This is a common side effect, especially in the early stages of treatment. If the cough becomes bothersome, talk to your doctor.

No, you should not stop taking Perindosyl-Am 4/5Mg Tablet suddenly. Doing so can cause a sudden spike in blood pressure. If you must stop taking it, your doctor will gradually reduce your dosage.

Inform your doctor about all the medications you are taking, including over-the-counter drugs, herbal supplements, and vitamins. Some medicines may interact with Perindosyl-Am 4/5Mg Tablet .

If you miss a dose, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed dose and take the scheduled dose. Do not double the dose.

Yes, Perindosyl-Am 4/5Mg Tablet can cause dizziness or lightheadedness, especially when you first start taking it. To minimize this risk, get up slowly from a sitting or lying position.

Yes, Perindosyl-Am 4/5Mg Tablet can cause swelling in the ankles or feet. This is a common side effect that usually goes away on its own. If the swelling is severe or bothersome, talk to your doctor.

Excessive alcohol consumption can lower blood pressure and interact with Perindosyl-Am 4/5Mg Tablet . It's best to avoid or limit your alcohol intake while taking Perindosyl-Am 4/5Mg Tablet .

While Perindosyl-Am 4/5Mg Tablet itself doesn't directly cause weight gain, it can contribute to weight gain by causing swelling or affecting appetite. If you're concerned about weight gain, talk to your doctor.

While rare, Perindosyl-Am 4/5Mg Tablet can cause a rash or skin irritation in some people. Stop taking the medication and contact your doctor immediately if you develop a rash or skin reaction.

In rare cases, Perindosyl-Am 4/5Mg Tablet can cause blurred vision or other eye-light changes. If you experience any vision problems, contact your doctor.

Yes, grapefruit and grapefruit juice can interact with Perindosyl-Am 4/5Mg Tablet , potentially increasing blood levels and leading to side effects. Avoid consuming grapefruit or grapefruit juice while taking this medication.

It's generally safe to take Perindosyl-Am 4/5Mg Tablet with over-the-counter pain relievers like paracetamol or ibuprofen. However, if you have concerns or are taking other medications, do not take them unless prescribed by the doctor.

Perindosyl-Am 4/5Mg Tablet contains Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor).

Perindosyl-Am 4/5Mg Tablet may cause dizziness and drowsiness. Therefore, drive only if you are alerted after taking the Perindosyl-Am 4/5Mg Tablet .

Country of origin

India

Manufacturer/Marketer address

“Elder House” Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.
Other Info - PER0453

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Oct 13, 2025 | 8:57 AM IST

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Reference

  1. https://www.drugs.com/food-interactions/amlodipine-perindopril.html
  2. https://www.medicines.org.uk/emc/files/pil.7197.pdf
  3. https://www.rxlist.com/prestalia-drug.htm

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