Buy Perindosyl-Am 4/5Mg Tablet online | Uses, Side Effects, Price and substitutes

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Composition:AMLODIPINE-5MG+PERINDOPRIL-4MG

Prescription Medicine

Perindosyl-Am 4/5Mg Tablet is used to treat hypertension (high blood pressure). It contains Amlodipine and Perindopril, which relax and widen the blood vessels, so that blood passes through them easily, thereby lowering the blood pressure and making it easier for your heart to pump blood around your body. Thus, it lowers high blood pressure, reducing the risk of heart attack or stroke. It may cause side effects such as ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, the increased potassium level in the blood, cough, flushing (sense of heat in the face, ears, neck, and trunk), taste change, decreased blood pressure, and upset stomach. Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

Written By Santoshini Reddy G , M Pharmacy

Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy

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More about the Product

Composition :

AMLODIPINE-5MG+PERINDOPRIL-4MG

Manufacturer/Marketer :

Elder Pharmaceuticals Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Perindosyl-Am 4/5Mg Tablet

Perindosyl-Am 4/5Mg Tablet is used to treat hypertension (high blood pressure). Hypertension is a medical condition in which the blood exerts high pressure (force exerted by circulating blood) against the walls of the blood vessels. Hypertension can cause severe health complications, including stroke, heart failure, heart attack and kidney failure.

Perindosyl-Am 4/5Mg Tablet contains Amlodipine and Perindopril. Amlodipine relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. Perindopril relaxes and widens the blood vessels.

You may experience certain side effects like ankle swelling, tiredness, headache, palpitations (irregular heartbeat), sleepiness, cough, flushing, taste change, and upset stomach. Most of these side effects do not require medical attention. However, talk to your doctor if the side effects persist or worsen.

Do not stop taking Perindosyl-Am 4/5Mg Tablet without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems. If you have angioedema (Painless swelling under the skin), diabetes then inform your doctor immediately. Reduce the amount of table salt (sodium chloride) in your food. If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet can be prescribed accordingly.

Uses of Perindosyl-Am 4/5Mg Tablet

Perindosyl-Am 4/5Mg Tablet is used in the treatment of high blood pressure. The detailed uses of Perindosyl-Am 4/5Mg Tablet are as follows:

Lowers High Blood Pressure: Perindosyl-Am 4/5Mg Tablet helps to relax and widen blood vessels, making it easier for the heart to pump blood and reducing blood pressure.
Prevents heart-related problems: Perindosyl-Am 4/5Mg Tablet helps to lower the risk of heart attacks, strokes, and other complications linked to high blood pressure.
Supports heart health: Perindosyl-Am 4/5Mg Tablet improves blood flow and reduces strain on the heart, especially in people with long-standing hypertension or heart disease.

Key Benefits

Perindosyl-Am 4/5Mg Tablet treats hypertension (high blood pressure) and consists of Amlodipine and Perindopril.
Amlodipine is a 'calcium channel blocker' and treats high blood pressure, Prinzmetal's or variant angina (chest pain), and other conditions caused by coronary artery disease.
It relaxes blood vessels, allowing blood to pass through them easily, thereby lowering blood pressure.
It also treats chest pain by improving the blood supply to the heart muscle, allowing it to receive more oxygen.
Amlodipine also improves a person's tolerance to exercise and keeps the blood pressure at acceptable levels.
Perindopril is an angiotensin-converting enzyme (ACE) inhibitor, which reduces increased blood pressure by blocking a naturally occurring substance known as angiotensin II (that tightens your blood vessels).
It relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body.
Perindosyl-Am 4/5Mg Tablet does not cure high blood pressure (hypertension) but does help control it.
In addition to this, Perindosyl-Am 4/5Mg Tablet also reduces the physical effects of anxiety.

Side effects of Perindosyl-Am 4/5Mg Tablet

Swelling In The Feet And Ankles

Wear compression garments like stockings, sleeves, or gloves to apply pressure and help stop fluid from building up, especially after the swelling goes down.
Move around and do exercises to help the fluid circulate, especially in swollen limbs. Ask your doctor for specific exercises.
Raise the swollen area above your heart level several times a day, even while sleeping, to help reduce swelling.
Gently massage the swollen area with firm but not painful pressure.
Keep the swollen area clean and moisturized to prevent injury and infection.
Reduce salt intake to help prevent fluid from building up and worsening the swelling, as advised by a doctor.
If the swelling does not get better after a few days of home treatment or worsens, consult your doctor right away.

Headache

Dealing with Medication-Induced Headache:

Hydrate your body: Drink enough water to prevent dehydration and headaches.
Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
Take rest: lie down in a quiet, dark environment.
Cold or warm compresses can help reduce tension.
Stay Upright: Maintain good posture to keep symptoms from getting worse.
To treat headaches naturally, try acupuncture or massage therapy.
Over-the-counter pain relievers include acetaminophen and ibuprofen.
Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
Frequent Headaches: If you get reoccurring headaches, consult your doctor.
Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

Dizziness

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Drowsiness

Avoid driving or operating machinery or activities that require high focus until you know how the medication affects you.
Maintain a fixed sleeping schedule, create a relaxing bedtime routine and ensure your sleeping space is comfortable to maximize your sleep quality.
Limit alcohol and caffeine as these may worsen drowsiness and disturb sleep patterns.
Drink plenty of water as it helps with alertness and keeps you hydrated and for overall well-being.
Moderate physical activity can improve energy levels, but avoid intense workouts right before bedtime.

Swelling

Reduce salt intake to minimize fluid buildup.
Use compression stockings, sleeves, or gloves.
Gently massage the affected area towards the heart.
Protect the swollen area from injury and keep it clean.
Use lotion or cream to keep the skin moisturized.

Fatigue

Rest well; get enough sleep.
Eat a balanced diet and drink enough water.
Manage stress with yoga and meditation.
Limit alcohol and caffeine.
Physical activities like walking or jogging might help boost energy and make you feel less tired.

Dizziness Or Spinning Sensation

Here are the 7 steps to manage Dizziness caused by medication:

Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
When standing up, do so slowly and carefully to avoid sudden dizziness.
Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.

Directions for Use

Take Perindosyl-Am 4/5Mg Tablet with or without food, or as advised by a doctor.
Follow your doctor's instructions on the dosage and timing of this medication to ensure safety.
Swallow the medicine as a whole with a glass of water.
Do not crush, break, or chew it.

How Perindosyl-Am 4/5Mg Tablet Works

Perindosyl-Am 4/5Mg Tablet contains Amlodipine (calcium channel blocker) and Perindopril (angiotensin-converting enzyme inhibitor). Amlodipine relaxes blood vessels, so that blood passes through them easily, thereby lowering the blood pressure. Perindopril relaxes and widens the blood vessels. This lowers your blood pressure and makes it easier for your heart to pump blood around your body. Thus, collectively, both help lower high blood pressure, reducing the chances of a heart attack or stroke.

Alcohol

Unsafe

Perindosyl-Am 4/5Mg Tablet interacts with alcohol. Therefore alcohol is not safe.

Pregnancy

Unsafe

The use of Perindosyl-Am 4/5Mg Tablet is usually contraindicated during the second and third trimester of pregnancy. It may cause harm to the unborn baby. Hence, you should always consult your doctor before using Perindosyl-Am 4/5Mg Tablet .

Breast Feeding

Consult your doctor

Use of Perindosyl-Am 4/5Mg Tablet is not recommended during the breastfeeding stage unless recommended by your doctor.

Driving

Caution

Perindosyl-Am 4/5Mg Tablet may cause dizziness and sleepiness. Therefore, drive with caution while using Perindosyl-Am 4/5Mg Tablet .

Liver

Consult your doctor

Let your doctor know if you have any history of liver diseases before using Perindosyl-Am 4/5Mg Tablet .

Kidney

Consult your doctor

Let your doctor know if you have any history of kidney diseases before using Perindosyl-Am 4/5Mg Tablet .

Children

Unsafe

Perindosyl-Am 4/5Mg Tablet is not recommended for use in children.

Heart

Safe if prescribed

Perindosyl-Am 4/5Mg Tablet is safe for use in heart patients if recommended by the physician.

Geriatrics

Caution

Perindosyl-Am 4/5Mg Tablet should be used under caution in geriatric patients. Please consult your physician.

What if I have taken an overdose of Perindosyl-Am 4/5Mg Tablet

Do not take more than the prescribed dose of Perindosyl-Am 4/5Mg Tablet as it may cause serious adverse effects. If you suspect you have taken an overdose, please consult a doctor immediately.

Diet & Lifestyle Advise

Keep your weight under control with body mass index (BMI) between 19.5 and 24.9.
Do regular physical activity or exercise for at least 150 minutes per week, or about 30 minutes most days of the week. Doing this can help you to lower your raised blood pressure by about 5 mm of Hg.
Limit sodium chloride intake (table salt) in your daily diet to 2300 mg per day or less than 1500 mg is ideal for most adults.
If you are taking alcohol, use only one serving for women and two servings for men.
Quit smoking to lower the risk of heart diseases.
Avoid chronic stress as it can raise your blood pressure. Try to enjoy and spent time with your loved ones to cope with stress.
Monitor your blood pressure daily, and if you notice any fluctuations frequently, please contact your doctor immediately.
Try including heart-healthy omega 3 fatty acid-containing foods in your daily diet. You can also use low-fat cooking oils like olive oil, soybean oil, canola oil, and coconut oil to lower your elevated blood pressure.

Have a query?

How Soon It Starts Working

The time required for Perindosyl-Am 4/5Mg Tablet to start to work: Perindosyl-Am 4/5Mg Tablet ideally shows its action within 1 to 2 hours after administration.
The time for which the effects of Perindosyl-Am 4/5Mg Tablet last: The effect of Perindosyl-Am 4/5Mg Tablet lasts for 24 hours.

What if you forget to take Perindosyl-Am 4/5Mg Tablet

If you miss a dose of Perindosyl-Am 4/5Mg Tablet , take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

Avoid taking Perindosyl-Am 4/5Mg Tablet if you are allergic to any of its components.
Do not stop taking Perindosyl-Am 4/5Mg Tablet without consulting your doctor, since it may worsen your condition and increase the risk of future heart problems.
If you have angioedema (Painless swelling under the skin) or diabetes, then inform your doctor immediately.
If you have kidney disease, you may not use Perindosyl-Am 4/5Mg Tablet with aliskiren (other blood pressure-lowering pills).
Reduce the amount of table salt (sodium chloride) in your food.
Avoid foods containing potassium. Immediately contact your doctor if you have heart disease, kidney disease, liver disease, diabetes, and high potassium level in your blood.
If you are pregnant or breastfeeding, please tell your doctor so that the dosage of Perindosyl-Am 4/5Mg Tablet can be prescribed accordingly.
Perindosyl-Am 4/5Mg Tablet is not recommended for use in children below 18 yaers of age.

Drug-Drug Interactions

Drug-Drug Interactions: Care should be exercised when Perindosyl-Am 4/5Mg Tablet is administered in combination with medications used for depression (lithium), medications used in cancer (estramustine), diuretics/ water pills (spironolactone, triamterene), medicines for reducing immune system (cyclosporine), blood pressure-lowering pills (aliskiren), medications for diabetes (insulin, vildagliptin), drugs that may increase the level of potassium in the blood (such as ARBs including losartan/valsartan, birth control pills containing drospirenone) and medication for gout (allopurinol).

Drug-Food Interactions: Avoid a high-potassium diet and drinking alcohol.

Drug-Disease Interactions: People affected with heart disease, liver disease, kidney disease, or fluid retention should not take this Perindosyl-Am 4/5Mg Tablet .

Amlodipine + PerindoprilDantrolene

Critical

Amlodipine + PerindoprilAliskiren

Critical

Drug-Drug Interactions

Amlodipine + PerindoprilDantrolene

Critical

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet together with dantrolene may increase the risk of hyperkalemia (high blood potassium).

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with Dantrolene together is not recommended, but it can be taken if prescribed by a doctor. You should seek medical attention if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, a weak pulse, or a slow or irregular heartbeat. Do not stop using any medications without talking to a doctor.

Amlodipine + PerindoprilAliskiren

Critical

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Combining Aliskiren with Perindosyl-Am 4/5Mg Tablet can increase the risk of low blood pressure, high potassium levels, and kidney damage.

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with Aliskiren is not recommended but can be taken if prescribed by a doctor. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Amlodipine + PerindoprilPiroxicam

Severe

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using perindopril together with piroxicam may reduce the effects of perindopril in lowering blood pressure, they may also increase the risk of kidney problems.

How to manage the interaction:
Co-administration of Piroxicam with Perindopril can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience nausea, vomiting, loss of hunger, increased or decreased urination, sudden weight gain or loss, swelling, breathing difficulty, muscle pain, and irregular heart rhythm, contact a doctor immediately. Do not stop using any medications without a doctor's advice.

Amlodipine + PerindoprilCarbamazepine

Severe

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet and carbamazepine together may significantly reduce amlodipine blood levels, making the medicine less effective.

How to manage the interaction:
Although there is an interaction between Perindosyl-Am 4/5Mg Tablet and carbamazepine, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms or worsening of existing symptoms, contact the doctor immediately. Do not stop using any medications without talking to a doctor.

Amlodipine + PerindoprilNitisinone

Severe

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Perindosyl-Am 4/5Mg Tablet and Nitisinone may increase Nitisinone's blood levels and effects.

How to manage the interaction:
Taking Nitisinone with Perindosyl-Am 4/5Mg Tablet together can result in an interaction, but it can be taken if a doctor has advised it. Contact your doctor if you experience any unusual symptoms. Do not stop using any medications without a doctor's advice.

Amlodipine + PerindoprilPotassium hydrogencarbonate

Severe

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet together with potassium hydrogencarbonate may significantly increase potassium levels in the blood.

How to manage the interaction:
Co-administration of Perindosyl-Am 4/5Mg Tablet with Potassium hydrogencarbonate can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, a weak pulse, or a slow or irregular heartbeat, contact your doctor immediately. Do not stop using any medications without a doctor's advice. Do not discontinue any medications without first consulting your doctor.

Amlodipine + PerindoprilLosartan

Severe

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Coadministration of Losartan with Perindosyl-Am 4/5Mg Tablet can increase kidney problems and irregular heart rhythm.

How to manage the interaction:
Taking Losartan with Perindosyl-Am 4/5Mg Tablet together can result in an interaction, it can be taken if your doctor has advised it. However, you should contact a doctor immediately if you notice any nausea, vomiting, weakness, confusion, tingling of the hands and feet, feelings of heaviness in the legs, or irregular heartbeat. Do not stop using any medications without talking to a doctor.

Amlodipine + PerindoprilCandesartan

Severe

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Taking Perindosyl-Am 4/5Mg Tablet with candesartan can increase the risk of kidney failure, low blood pressure, and high potassium levels.

How to manage the interaction:
Although taking Perindosyl-Am 4/5Mg Tablet and Candesartan together can evidently cause an interaction, it can be taken if your doctor has suggested it. However, consult your doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or a slow or irregular heartbeat. Do not discontinue any medications without consulting a doctor.

Amlodipine + PerindoprilMipomersen

Severe

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using Perindosyl-Am 4/5Mg Tablet together with mipomersen can increase the risk of liver problems.

How to manage the interaction:
Co-administration of Perindosyl-Am 4/5Mg Tablet with Mipomersen can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, joint pain or swelling, unusual bleeding or bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark urine, pale stools, and/or yellowing of the skin or eyes contact your doctor immediately. Do not discontinue any medications without consulting a doctor.

Amlodipine + PerindoprilLeflunomide

Severe

How does the drug interact with Perindosyl-Am 4/5Mg Tablet:
Using leflunomide together with Perindosyl-Am 4/5Mg Tablet can increase the risk of liver problems.

How to manage the interaction:
Although there is a possible interaction between Leflunomide and Perindosyl-Am 4/5Mg Tablet, you can take these medicines together if prescribed by your doctor. Contact your doctor immediately if you have any of these symptoms - fever, chills, joint pain, swelling, bruising, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, abdominal pain, dark-colored urine, liver damage, or bleeding. Do not stop using any medications without talking to your doctor.

Drug-Food Interactions

AMLODIPINE-5MG+PERINDOPRIL-4MGPotassium rich foods

Moderate

Drug-Food Interactions

AMLODIPINE-5MG+PERINDOPRIL-4MGPotassium rich foods

Moderate

Common Foods to Avoid:
Lentils, Orange Juice, Oranges, Raisins, Potatoes, Salmon Dried, Spinach, Sweet Potatoes, Tomatoes, Coconut Water, Beans, Beetroot, Broccoli, Bananas, Apricots, Avocado, Yogurt

How to manage the interaction:
Taking Perindosyl-Am 4/5Mg Tablet with potassium-containing salt substitutes or potassium supplements can cause high levels of potassium in the blood. Avoid taking potassium-containing salt substitutes or potassium supplements while being treated with Perindosyl-Am 4/5Mg Tablet.

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Author Details

Written By

Santoshini Reddy G
M Pharmacy

Reviewed By

Bayyarapu Mahesh Kumar
M Pharmacy

Last Updated

Jun 26, 2026 | 1:31 PM IST

We provide you with authentic, trustworthy and relevant information.

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Reference

Country of origin

India

Manufacturer/Marketer address

“Elder House” Plot No. C-9, Dalia Industrial Estate, Off Veera Desai Road, Andheri (W), Mumbai – 400053.

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Perindosyl-Am 4/5Mg Tablet 10'S

Delivery Information

More about the Product

Composition :

Manufacturer/Marketer :

Consume Type :

Expires on or after :

Return Policy :

About Perindosyl-Am 4/5Mg Tablet

Uses of Perindosyl-Am 4/5Mg Tablet

Key Benefits

Swelling In The Feet And Ankles

Headache

Dizziness

Drowsiness

Swelling

Fatigue

Dizziness Or Spinning Sensation

Directions for Use

How Perindosyl-Am 4/5Mg Tablet Works

Alcohol

Pregnancy

Breast Feeding

Driving

Liver

Kidney

Children

Heart

Geriatrics

What if I have taken an overdose of Perindosyl-Am 4/5Mg Tablet

Diet & Lifestyle Advise

How Soon It Starts Working

What if you forget to take Perindosyl-Am 4/5Mg Tablet

Storage

Drug Warnings

Drug-Drug Interactions

Drug-Drug Interactions

Drug-Food Interactions

Drug-Food Interactions

All Substitutes & Brand Comparisons

Coversyl AM 4/5 Tablet 10's

Habit Forming

Therapeutic Class

FAQs

What is the use of Perindosyl-Am 4/5Mg Tablet ?

How does Perindosyl-Am 4/5Mg Tablet work?

How long should I use Perindosyl-Am 4/5Mg Tablet ?

Can Perindosyl-Am 4/5Mg Tablet cause dizziness?

I am diabetic, can I take Perindosyl-Am 4/5Mg Tablet ?

Do I need to take Perindosyl-Am 4/5Mg Tablet even if my blood pressure becomes normal?

Can I take Perindosyl-Am 4/5Mg Tablet with food?

What are the common side effects of Perindosyl-Am 4/5Mg Tablet ?

Can I take Perindosyl-Am 4/5Mg Tablet if I am pregnant or breastfeeding?

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How should I store Perindosyl-Am 4/5Mg Tablet ?

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Can Perindosyl-Am 4/5Mg Tablet cause a dry cough?

Can I stop taking Perindosyl-Am 4/5Mg Tablet suddenly?

Can I take Perindosyl-Am 4/5Mg Tablet with other medications?

What if I miss a dose of Perindosyl-Am 4/5Mg Tablet ?

Can Perindosyl-Am 4/5Mg Tablet cause dizziness or lightheadedness?

Can Perindosyl-Am 4/5Mg Tablet cause swelling in the ankles or feet?

Can I drink alcohol while taking Perindosyl-Am 4/5Mg Tablet ?

Can Perindosyl-Am 4/5Mg Tablet cause weight gain?

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