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compositionComposition:METOCLOPRAMIDE-5MG
prescriptionPrescription Medicine
Perinorm Syrup 60 ml
Perinorm Syrup 60 ml
Perinorm Syrup 60 ml

Perinorm Syrup is used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, and which might occur after migraine. Additionally, it is also used to treat gastro-oesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying in people with diabetes), heartburn, ulcers and sores in the oesophagus. It contains Metoclopramide, which works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also works on the part of the brain that controls vomiting, thereby helping in preventing nausea and vomiting. In some cases, it may cause common side effects such as restlessness, fatigue, drowsiness, diarrhoea, weakness, and lassitude (lack of energy). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Bayyarapu Mahesh Kumar , M Pharmacy
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More about the Product

Composition :

METOCLOPRAMIDE-5MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Perinorm Syrup

Perinorm Syrup is used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, and which might occur after migraine. Additionally, Perinorm Syrup is also used to treat gastro-oesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying in people with diabetes), heartburn, ulcers and sores in the oesophagus.

Perinorm Syrup contains ‘metoclopramide’ that works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also works on the part of the brain that controls vomiting, thereby helping in preventing nausea and vomiting.

In some cases, Perinorm Syrup may cause common side effects such as restlessness, fatigue, drowsiness, diarrhoea, weakness, and lassitude (lack of energy). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Do not take Perinorm Syrup for more than 3 months as it might increase the risk of tardive dyskinesia (movement disorder). Consult your doctor before taking Perinorm Syrup if you are pregnant or breastfeeding. Perinorm Syrup may cause drowsiness and dizziness, so avoid driving until you know how Perinorm Syrup affects you. Avoid consuming alcohol along with Perinorm Syrup as it could lead to increased drowsiness. Keep your doctor informed about your health condition and medications to rule out any interactions.

Uses of Perinorm Syrup

Perinorm Syrup is used in the prevention of Nausea, Vomiting, gastroesophageal reflux disease (GERD), and diabetic gastroparesis (delayed gastric emptying in people with diabetes). The detailed uses of Perinorm Syrup are as follows:

  • Nausea Relief: Perinorm Syrup is frequently used to treat nausea brought on by a number of illnesses, such as those brought on by stress, anxiety, or digestive problems.
  • Control of Vomiting: The suspension works well to stop and control vomiting, particularly in individuals who are having chemotherapy, surgery, or motion sickness.
  • Gastrointestinal Disorders: It can be used to alleviate the symptoms of illnesses like gastritis or gastroenteritis and cure nausea associated with gastrointestinal disorders.

Have a query?

Directions for Use

  • Perinorm Syrup can be taken 30 minutes before food, preferably at bedtime or as advised by the doctor.
  • Follow your doctor's instructions on the dosage and timing of this medication
  • Swallow Perinorm Syrup as a whole with a glass of water.
  • Do not crush, break, or chew it.

Key Benefits

Perinorm Syrup belongs to a group of medicines called anti-emetics and prokinetic agents used to prevent nausea and vomiting caused by chemotherapy and radiotherapy, which might occur after migraines. Additionally, Perinorm Syrup is also used to treat gastro-oesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying in people with diabetes), heartburn, ulcers and sores in the oesophagus. Perinorm Syrup contains ‘metoclopramide’ that works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also affects the dopamine receptor in the brain and gut, thereby helps in preventing nausea and vomiting.

How Perinorm Syrup Works

Perinorm Syrup contains ‘metoclopramide’ that works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also works on the part of the brain that controls vomiting, thereby helps in preventing nausea and vomiting.

Storage

Store in a cool and dry place away from sunlight
Side effects of Perinorm Syrup 60 ml
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

What if I have taken an overdose of Perinorm Syrup

Do not take more than the prescribed dose of Perinorm Syrup as it may cause overdose. The symptoms of overdose include tremor, muscle spasms, shaking, confusion, drowsiness or hallucinations. If you suspect you have taken overdose or notice signs of overdose, please consult a doctor immediately.

Drug Warnings

Do not take Perinorm Syrup if you are allergic to any of its contents; if you have bleeding or obstruction in the stomach, tardive dyskinesia (movement disorder), pheochromocytoma (tumour in the adrenal glands), or epilepsy. Talk to your doctor before taking Perinorm Syrup if you have heart problems, diabetes, depression, high blood pressure, breast cancer, seizures, liver or kidney problems, Parkinson’s disease, methaemoglobinaemia; if you are taking levodopa or if you have gastrointestinal surgery in the last 3-4days. Do not take Perinorm Syrup for more than three months as it might increase the risk of tardive dyskinesia; the risk increases if you are older, especially if you are an older woman or if you have diabetes. Consult your doctor immediately if you cannot stop or control movements like shaking your arms and legs, blinking and moving your eyes, sticking out the tongue, frowning, lip-smacking, chewing, or puckering up the mouth.

Drug-Drug Interactions

verifiedApollotooltip
MetoclopramideTrifluoperazine
Critical
MetoclopramideVenlafaxine
Critical

Drug-Drug Interactions

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MetoclopramideTrifluoperazine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Co-administration of Perinorm Syrup 60 ml with Trifluoperazine can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Trifluoperazine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping., contact your doctor immediately. Do not discontinue any medications without consulting a doctor.
MetoclopramideVenlafaxine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Coadministration of Perinorm Syrup 60 ml with Venlafaxine might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to side effects.

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Venlafaxine together is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MetoclopramideZiprasidone
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Taking Perinorm Syrup 60 ml with Ziprasidone can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience lip-smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Do not discontinue any medications without consulting a doctor.
MetoclopramideNefazodone
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Coadministration of Perinorm Syrup 60 ml with Nefazodone can cause serotonin syndrome. Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhoea) to severe (muscle rigidity, fever, and seizures).

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Nefazodone is generally avoided as it can possibly lead to an interaction, it can be taken if prescribed by your doctor. However, if you experience symptoms such as confusion, hallucination, seizure, extreme changes in blood pressure, increased heart rate, fever, excessive sweating, shivering or shaking, blurred vision, muscle spasm or stiffness, incoordination, stomach pain, nausea, vomiting, and diarrhoea, consult the doctor. Do not discontinue any medications without consulting a doctor.
MetoclopramideParoxetine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Using Perinorm Syrup 60 ml with Paroxetine can cause serotonin syndrome. Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhoea) to severe (muscle rigidity, fever, and seizures).

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Paroxetine is not recommended, as it can possibly lead to an interaction, it can be taken if prescribed by your doctor. Do not stop using any medications without a doctor’s advice.
MetoclopramideMethyldopa
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Taking Methyldopa and Perinorm Syrup 60 ml together can decrease the levels and effects of Methyldopa.

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Methyldopa is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MetoclopramideLurasidone
Critical
How does the drug interact with Perinorm Syrup 60 ml:
The combination of Lurasidone and Perinorm Syrup 60 ml may result in significantly increased Lurasidone blood levels. This may raise the possibility of undesirable consequences such as Parkinson's disease. (It is a neurological condition that causes uncontrollable movements)and Tardive dyskinesia (uncontrollable movements, particularly of the lower face).

How to manage the interaction:
Lurasidone and Perinorm Syrup 60 ml is not recommended, as they may interact, but can be used if a doctor prescribes them. Consult a doctor if you have muscle spasms, or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning, tongue thrusting, teeth clenching, jaw twitching, jitteriness, restlessness, pacing, and foot tapping. Do not stop taking any medications without visiting a doctor.
MetoclopramideAmisulpride
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Taking Perinorm Syrup 60 ml with Amisulpride may increase the risk or severity of side effects.

How to manage the interaction:
Taking Amisulpride with Perinorm Syrup 60 ml is not recommended as it can result in an interaction, it can be taken if a doctor has advised it. However, if you have muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping, consult a doctor immediately. Do not discontinue any medications without a doctor's advice.
MetoclopramideRisperidone
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Co-administration of Perinorm Syrup 60 ml with Risperidone can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Risperidone with Perinorm Syrup 60 ml is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. If you notice any of these symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, shaking, jitteriness, restlessness, pacing, and foot tapping contact a doctor immediately. Do not stop using any medications without a doctor’s advice.
MetoclopramideCitalopram
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Coadministration of Citalopram with Perinorm Syrup 60 ml can cause serotonin syndrome. Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhoea) to severe (muscle rigidity, fever, and seizures).

How to manage the interaction:
Taking Citalopram with Perinorm Syrup 60 ml is generally avoided as it can possibly result in an interaction, it can be taken if prescribed by your doctor. Do not stop using any medications without a doctor’s advice.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Eat smaller meals more often.
  • Drink fluids to stay hydrated.
  • Avoid solid foods until vomiting stops.
  • Avoid foods that might cause stomach upset.
  • Take ample rest. Avoid any activity immediately after eating.
  • Consume plain, light foods such as bread and biscuits.
  • Avoid food with strong flavours and fried food.
  • Ginger tea might help in proper digestion.

Habit Forming

No

Therapeutic Class

[ANTIEMETICS, GASTROPROKINETIC AGENTS]

All Substitutes & Brand Comparisons

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Alcohol

Unsafe

Avoid consumption of alcohol while taking Perinorm Syrup as it may make some side effects worse such as increased sleepiness and drowsiness.

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Pregnancy

Consult your doctor

Consult your doctor before taking Perinorm Syrup if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Perinorm Syrup if you are breastfeeding.

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Driving

Unsafe

Perinorm Syrup may cause dizziness, drowsiness and fatigue. Do not drive or operate machinery until you know how Perinorm Syrup affects you.

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Liver

Caution

Dose adjustment may be needed. Consult your doctor before taking Perinorm Syrup if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking Perinorm Syrup if you have kidney impairment or any concerns regarding this.

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Children

Caution

Perinorm Syrup are not recommended for children due to the risk of tardive dyskinesia, extrapyramidal symptoms as well as risk of methemoglobinemia in neonates.

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Heart

Caution

Perinorm Syrup should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Perinorm Syrup.

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Geriatrics

Caution

Perinorm Syrup should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

FAQs

Perinorm Syrup belongs to a group of medicines called anti-emetics and prokinetic agents used to prevent nausea and vomiting caused by chemotherapy and radiotherapy, which might occur after migraines. Perinorm Syrup is also used to treat gastro-oesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying in people with diabetes), heartburn, ulcers and sores in the oesophagus.

Perinorm Syrup works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also works on the part of the brain that controls vomiting, thereby helps in preventing nausea and vomiting.

Take Perinorm Syrup only for as long as the doctor has prescribed it for you. Do not take Perinorm Syrup for more than three months as it might increase the risk of tardive dyskinesia (movement disorder), which is often irreversible. The risk of developing tardive dyskinesia increases with the total dosage and duration of treatment.

Diarrhoea might be a side-effect of Perinorm Syrup. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if the condition persists or worsens.

Maintain a minimum gap of 6 hours between each dose. Do not take another dose of Perinorm Syrup even in case of vomiting and rejection of dose to avoid an overdose.

Perinorm Syrup may cause uncontrollable movements such as shaking, tics, twisting movements, muscle stiffness and rigidity. Consult your doctor if you experience these symptoms.

Take Perinorm Syrup 30 minutes before food, preferably at bedtime or as advised by the doctor.

Before starting Perinorm Syrup, inform the doctor if you have heart problems, diabetes, depression, high blood pressure, breast cancer, seizures, liver or kidney problems, Parkinson's disease, methemoglobinemia (blood disorder); if you are taking levodopa or if you have had gastrointestinal surgery in the last 3-4 days.

No, Perinorm Syrup should not be taken after meals. It works best when taken on an empty stomach.

Perinorm Syrup is not known to cause constipation. Drink enough fluids and eat fibre-rich food if you have constipation. Consult the doctor if the condition persists or worsens.

Perinorm Syrup is not indicated for the treatment of morning sickness. It is used to treat nausea, vomiting, gastroesophageal reflux disease (GERD), and diabetic gastroparesis (delayed gastric emptying in people with diabetes). Talk to the doctor if you have morning sickness; the doctor will prescribe appropriate medicine based on your condition.

Perinorm Syrup can be taken with ranitidine if prescribed by the doctor. No interaction has been reported between both these medicines.

Perinorm Syrup may cause side effects such as restlessness, fatigue, drowsiness, diarrhoea, weakness, and lassitude (lack of energy). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - PER0383

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Author Details

Santoshini Reddy GDoctor badge

Written By

Santoshini Reddy G

M Pharmacy

Bayyarapu Mahesh KumarDoctor badge

Reviewed By

Bayyarapu Mahesh Kumar

M Pharmacy

Last Updated

Dec 3, 2025 | 7:38 AM IST

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