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compositionComposition:METOCLOPRAMIDE-5MG
prescription
Prescription Medicine
info
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Perinorm Syrup is used to prevent nausea and vomiting caused by chemotherapy, radiotherapy, and which might occur after migraine. Additionally, it is also used to treat gastro-oesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying in people with diabetes), heartburn, ulcers and sores in the oesophagus. It contains Metoclopramide, which works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also works on the part of the brain that controls vomiting, thereby helping in preventing nausea and vomiting. In some cases, it may cause common side effects such as restlessness, fatigue, drowsiness, diarrhoea, weakness, and lassitude (lack of energy). Before taking this medicine, you should tell your doctor if you are allergic to any of its components or if you are pregnant/breastfeeding, and about all the medications you are taking and pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

METOCLOPRAMIDE-5MG

Manufacturer/Marketer :

Ipca Laboratories Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Perinorm Syrup

Perinorm Syrup is an oral prescription medication used to treat certain conditions of the stomach and intestines. It is primarily prescribed to relieve symptoms of slow stomach emptying in people with diabetes, and to treat severe heartburn caused by acid reflux when other treatments have not worked. It is also commonly used to prevent nausea and vomiting.

To get the best results, you should take Perinorm Syrup consistently at the exact times prescribed by your doctor, usually 30 minutes before meals and at bedtime. Taking it on an empty stomach helps your body absorb the medicine properly so it can work when food enters your stomach. Making simple changes, like eating smaller, more frequent meals, can also help improve your digestive symptoms while using this medicine.

While taking Perinorm Syrup, you may experience mild side effects such as drowsiness, tiredness, or restlessness. However, you must contact your doctor immediately if you notice muscle twitching, uncontrolled movements of your face or limbs, or severe mood changes. These can be signs of serious neurological issues that require prompt medical attention.

Before starting Perinorm Syrup, tell your doctor if you have a history of depression, high blood pressure, asthma, or kidney disease. Do not take this if you have a history of seizure disorders, bleeding or blockages in your stomach or intestines, or a rare adrenal gland tumor.

This medicine can interact with other drugs that make you sleepy, such as sleeping pills or muscle relaxants, and drinking alcohol while taking it can make drowsiness much worse. Smoking may also reduce the effectiveness of this medicine by altering how fast your stomach empties. If you are pregnant, breastfeeding, or an older adult, you should discuss the risks and benefits with your doctor before taking Perinorm Syrup.

Uses of Perinorm Syrup

Perinorm Syrup is used in the prevention of Nausea, Vomiting, gastroesophageal reflux disease (GERD), and diabetic gastroparesis (delayed gastric emptying in people with diabetes). The detailed uses of Perinorm Syrup are as follows:

  • Diabetic gastroparesis: Helps relieve symptoms like nausea, vomiting, feeling full too quickly, and stomach bloating caused by delayed stomach emptying in people with diabetes.
  • Gastroesophageal reflux disease (GERD): Provides short-term relief for chronic heartburn when other medications do not work, by helping clear stomach acid more quickly.
  • Prevention of nausea and vomiting: Helps control nausea and vomiting caused by medical procedures, chemotherapy, or certain illnesses

Key Benefits

  • Perinorm Syrup provides relief from persistent nausea and vomiting, allowing you to keep food and fluids down and maintain proper nutrition.
  • Speeding up the movement of food through your digestive tract relieves the uncomfortable sensations of bloating, painful fullness, and early satiety after eating.
  • It helps reduce severe heartburn and acid reflux symptoms, making it easier to sleep and go about your daily activities without pain.
Side effects of Perinorm Syrup 60 ml
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.

Directions for Use

  • Take this medicine by mouth, usually 30 minutes before meals and at bedtime, as directed by your doctor.
  • Swallow the tablet whole with a full glass of water. Do not crush, chew, or break the tablet unless your doctor or pharmacist tells you to do so.
  • If you are using an oral liquid form, measure the dose carefully using a special medical measuring device or spoon, not a regular household spoon.
  • Always follow your doctor's exact instructions regarding how long to take this medication. It is usually prescribed for short-term use, typically not exceeding 12 weeks.

How Perinorm Syrup Works

Perinorm Syrup works by acting on receptors in the brain and digestive system. It blocks dopamine (D2) receptors in the brain to help prevent nausea and vomiting. It also activates serotonin (5-HT4) receptors, which improves the movement of the stomach and intestines, helping food move more quickly into the small intestine. In addition, it has a weak blocking effect on serotonin (5-HT3) receptors, which further helps reduce nausea. Together, these actions speed up stomach emptying, reduce acid reflux, improve digestion, and effectively relieve nausea and vomiting.
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Alcohol

Unsafe

Avoid consumption of alcohol while taking Perinorm Syrup as it may make some side effects worse such as increased sleepiness and drowsiness.

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Pregnancy

Consult your doctor

Consult your doctor before taking Perinorm Syrup if you are pregnant; your doctor will prescribe only if the benefits outweigh the risks.

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Breast Feeding

Consult your doctor

Consult your doctor before taking Perinorm Syrup if you are breastfeeding.

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Driving

Unsafe

Perinorm Syrup may cause dizziness, drowsiness and fatigue. Do not drive or operate machinery until you know how Perinorm Syrup affects you.

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Liver

Caution

Dose adjustment may be needed. Consult your doctor before taking Perinorm Syrup if you have a liver impairment or any concerns regarding this.

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Kidney

Caution

Dose adjustment may be needed. Consult your doctor before taking Perinorm Syrup if you have kidney impairment or any concerns regarding this.

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Children

Caution

Perinorm Syrup are not recommended for children due to the risk of tardive dyskinesia, extrapyramidal symptoms as well as risk of methemoglobinemia in neonates.

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Heart

Caution

Perinorm Syrup should be administered with caution in patients with heart problems. Please inform your doctor about any existing heart problems before using Perinorm Syrup.

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Geriatrics

Caution

Perinorm Syrup should be administered with caution in elderly patients. If you have any concerns, please consult your doctor.

What if I have taken an overdose of Perinorm Syrup

If you suspect an overdose, seek emergency medical care or call a poison control centre immediately. Symptoms of an overdose may include severe drowsiness, confusion, muscle spasms, or uncontrolled movements.

Diet & Lifestyle Advise

  • Eat smaller, more frequent meals (five to six times a day) instead of three large meals to reduce the workload on your stomach.
  • Choose low-fat and low-fiber foods, as fat and fiber can slow down stomach emptying and worsen your symptoms.
  • Sit upright for at least two hours after eating to prevent stomach acid and food from flowing back up into your throat.
  • Avoid foods and beverages that can worsen heartburn, such as caffeine, chocolate, spicy foods, tomatoes, and citrus fruits.
  • Stay hydrated by sipping small amounts of water or clear liquids throughout the day, especially if you have been experiencing vomiting.
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How Soon It Starts Working

  • The time required for Perinorm Syrup to start to work: Perinorm Syrup ideally shows its action within 30 to 60 minutes after administration.
  • The time for which the effects of Perinorm Syrup last: The effect of Perinorm Syrup lasts for 1 to 2 hours.

What if you forget to take Perinorm Syrup

If you miss a dose of Perinorm Syrup, take it as soon as you remember. However, if it is almost time for your next scheduled dose, skip the missed dose and resume your regular dosing schedule. Do not take a double dose to make up for a missed one.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.

Drug Warnings

  • FDA Boxed Warning: Do not take Perinorm Syrup for longer than 12 weeks unless your doctor advises otherwise. Long-term or high-dose use increases the risk of tardive dyskinesia, a serious and sometimes permanent disorder causing involuntary muscle movements.
  • Watch for unusual movements of the face, tongue, mouth, eyes, arms, or legs. Stop the medicine and contact your doctor immediately if these occur.
  • Perinorm Syrup may cause drowsiness or dizziness. Avoid driving, operating machinery, or doing activities that require alertness until you know how it affects you.
  • Avoid or limit alcohol while taking this medicine, as it can increase drowsiness and other side effects.
  • Perinorm Syrup usually starts working within 30–60 minutes after an oral dose. Its stomach-emptying (prokinetic) effect lasts for about 1–2 hours per dose, although the overall treatment benefit depends on your condition and the duration of therapy.
  • Take this medicine exactly as prescribed and do not exceed the recommended dose or duration without consulting your doctor.

Drug-Drug Interactions

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Drug-Drug Interactions

  • Combining Perinorm Syrup with antipsychotic medications or certain antidepressants can significantly increase the risk of serious muscle spasms and movement disorders.
  • Using this medicine with strong pain relievers (like opioids) or anticholinergic drugs can reduce its effectiveness in emptying your stomach.
  • Taking it with sedatives, sleeping pills, or anxiety medications can lead to extreme drowsiness and slowed breathing.

Drug-Food Interactions

  • Drinking alcohol while taking Perinorm Syrup can intensify drowsiness, dizziness, and coordination issues.

Drug-Disease Interactions

  • Parkinson's disease: May worsen symptoms like muscle stiffness and tremors.
  • Seizure disorders: Can increase the frequency or severity of seizures.
  • Stomach bleeding, blockages, or tears: Can worsen these dangerous intestinal conditions by increasing gut contractions.
  • Kidney or liver disease: May require a lower dose to avoid buildup of the medication in your body.
MetoclopramideDuloxetine
Critical
MetoclopramideFluvoxamine
Critical

Drug-Drug Interactions

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MetoclopramideDuloxetine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Coadministration of Perinorm Syrup 60 ml with duloxetine increase the risk of serotonin syndrome(a condition in which a chemical called serotonin increase in your body).

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Duloxetine is not recommended, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience any unusual symptoms. Do not discontinue any medications without consulting a doctor.
MetoclopramideFluvoxamine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Coadministration of Fluvoxamine with Perinorm Syrup 60 ml increases the risk of serotonin syndrome(a condition in which a chemical called serotonin increases in your body).

How to manage the interaction:
Taking Fluvoxamine with Perinorm Syrup 60 ml is not recommended, as it can lead to an interaction, it can be taken if prescribed by your doctor. Do not stop using any medications without a doctor’s advice.
MetoclopramideClozapine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Co-administration of Perinorm Syrup 60 ml with Clozapine can increase the risk of side effects.

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Clozapine is generally avoided as it can possibly result in an interaction, it can be taken if your doctor has advised it. Do not discontinue any medications without consulting a doctor.
MetoclopramideQuetiapine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Coadministration of Perinorm Syrup 60 ml with quetiapine can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Quetiapine is generally avoided as it can possibly result in an interaction. They can be taken together if advised by your doctor. However, contact a doctor if you experience any symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, restlessness, pacing, and foot tapping. Do not stop taking any medications without consulting a doctor.
MetoclopramideZiprasidone
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Taking Perinorm Syrup 60 ml with Ziprasidone can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Perinorm Syrup 60 ml with Ziprasidone is not recommended, but it can be taken together if prescribed by a doctor. However, consult your doctor if you experience lip-smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Do not discontinue any medications without consulting a doctor.
MetoclopramideRisperidone
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Co-administration of Perinorm Syrup 60 ml with Risperidone can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Risperidone with Perinorm Syrup 60 ml is not recommended as it can possibly result in an interaction, it can be taken if your doctor has advised it. If you notice any of these symptoms like muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, shaking, jitteriness, restlessness, pacing, and foot tapping contact a doctor immediately. Do not stop using any medications without a doctor’s advice.
MetoclopramidePromethazine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Coadministration of Perinorm Syrup 60 ml with Promethazine can increase the risk of side effects like uncontrolled movement disorder.

How to manage the interaction:
Taking Promethazine with Perinorm Syrup 60 ml is generally avoided as it can possibly result in an interaction. They can be taken together However, consult a doctor if you experience puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, tremor, jitteriness, restlessness, pacing, and foot tapping. Do not stop taking any medications without consulting a doctor.
MetoclopramideLurasidone
Critical
How does the drug interact with Perinorm Syrup 60 ml:
The combination of Lurasidone and Perinorm Syrup 60 ml may result in significantly increased Lurasidone blood levels. This may raise the possibility of undesirable consequences such as Parkinson's disease. (It is a neurological condition that causes uncontrollable movements)and Tardive dyskinesia (uncontrollable movements, particularly of the lower face).

How to manage the interaction:
Lurasidone and Perinorm Syrup 60 ml is not recommended, as they may interact, but can be used if a doctor prescribes them. Consult a doctor if you have muscle spasms, or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning, tongue thrusting, teeth clenching, jaw twitching, jitteriness, restlessness, pacing, and foot tapping. Do not stop taking any medications without visiting a doctor.
MetoclopramideCitalopram
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Coadministration of Citalopram with Perinorm Syrup 60 ml can cause serotonin syndrome. Serotonin syndrome is a condition in which a chemical called serotonin builds up in your body, causing signs and symptoms ranging from mild (shivering and diarrhoea) to severe (muscle rigidity, fever, and seizures).

How to manage the interaction:
Taking Citalopram with Perinorm Syrup 60 ml is generally avoided as it can possibly result in an interaction, it can be taken if prescribed by your doctor. Do not stop using any medications without a doctor’s advice.
MetoclopramideCariprazine
Critical
How does the drug interact with Perinorm Syrup 60 ml:
Co-administration of Perinorm Syrup 60 ml with Cariprazine can increase the risk of side effects.

How to manage the interaction:
Taking Cariprazine with Perinorm Syrup 60 ml is generally avoided, but can be taken together if prescribed by a doctor. However, if you experience muscle spasms or movements that you can't stop or control, such as lip smacking, chewing, puckering, frowning or scowling, tongue thrusting, teeth clenching, jaw twitching, blinking, eye-rolling, shaking or jerking of arms and legs, shaking of hands and legs, jitteriness, restlessness, pacing, and foot tapping, contact a doctor immediately. Do not stop using any medications without talking to a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[ANTIEMETICS, GASTROPROKINETIC AGENTS]

FAQs

Perinorm Syrup belongs to a group of medicines called anti-emetics and prokinetic agents used to prevent nausea and vomiting caused by chemotherapy and radiotherapy, which might occur after migraines. Perinorm Syrup is also used to treat gastro-oesophageal reflux disease (GERD), diabetic gastroparesis (delayed gastric emptying in people with diabetes), heartburn, ulcers and sores in the oesophagus.
Perinorm Syrup works by increasing the motility of the upper gastrointestinal tract; this allows faster transit of food and reduces the symptoms of GERD and gastric emptying. It also works on the part of the brain that controls vomiting, thereby helps in preventing nausea and vomiting.
Take Perinorm Syrup only for as long as the doctor has prescribed it for you. Do not take Perinorm Syrup for more than three months as it might increase the risk of tardive dyskinesia (movement disorder), which is often irreversible. The risk of developing tardive dyskinesia increases with the total dosage and duration of treatment.
Diarrhoea might be a side-effect of Perinorm Syrup. Drink enough fluids and eat non-spicy food if you experience diarrhoea. Consult your doctor if the condition persists or worsens.
Maintain a minimum gap of 6 hours between each dose. Do not take another dose of Perinorm Syrup even in case of vomiting and rejection of dose to avoid an overdose.
Perinorm Syrup may cause uncontrollable movements such as shaking, tics, twisting movements, muscle stiffness and rigidity. Consult your doctor if you experience these symptoms.
Take Perinorm Syrup 30 minutes before food, preferably at bedtime or as advised by the doctor.
Before starting Perinorm Syrup, inform the doctor if you have heart problems, diabetes, depression, high blood pressure, breast cancer, seizures, liver or kidney problems, Parkinson's disease, methemoglobinemia (blood disorder); if you are taking levodopa or if you have had gastrointestinal surgery in the last 3-4 days.
No, Perinorm Syrup should not be taken after meals. It works best when taken on an empty stomach.
Perinorm Syrup is not known to cause constipation. Drink enough fluids and eat fibre-rich food if you have constipation. Consult the doctor if the condition persists or worsens.
Perinorm Syrup is not indicated for the treatment of morning sickness. It is used to treat nausea, vomiting, gastroesophageal reflux disease (GERD), and diabetic gastroparesis (delayed gastric emptying in people with diabetes). Talk to the doctor if you have morning sickness; the doctor will prescribe appropriate medicine based on your condition.
Perinorm Syrup can be taken with ranitidine if prescribed by the doctor. No interaction has been reported between both these medicines.
Perinorm Syrup may cause side effects such as restlessness, fatigue, drowsiness, diarrhoea, weakness, and lassitude (lack of energy). Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if the side effects persist or worsen.
Perinorm Syrup usually begin to work within 30 to 60 minutes after taking them. The effects typically last for about 1 to 2 hours. Talk to your doctor if you do not notice an improvement in your symptoms.
If you notice any unusual, uncontrolled muscle movements, especially in your face, tongue, or limbs, stop taking the medicine and contact your doctor immediately. This could be a sign of a serious side effect. Talk to your doctor right away.
You should only take Perinorm Syrup during pregnancy if your doctor determines that the benefits outweigh the potential risks to the baby. If you are pregnant or planning to become pregnant, talk to your doctor.
No, Perinorm Syrup is generally not recommended for use longer than 12 weeks. Prolonged use increases the risk of developing tardive dyskinesia, a serious and potentially irreversible movement disorder. Talk to your doctor about your treatment duration.

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Reference

  1. Electronic Medicines Compendium (EMC). Pil.5880 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. U.S. Food and Drug Administration (FDA). 017854S062Lbl [FDA Prescribing Information]. Silver Spring, MD: FDA; 2024. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Metoclopramide - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. Drugs.com Clinical Review Team. Metoclopramide Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  5. MedlinePlus. A684035 Patient Information Monograph. Bethesda, MD: U.S. National Library of Medicine (NLM); 2025. [Accessed on 02 Jun. 2026]Check here
  6. Drugs.com Clinical Review Team. Metoclopramide Orally Disintegratings Clinical Drug Monograph. Auckland, NZ: Drugs.com; 2026. [Accessed on 02 Jun. 2026]Check here
  7. Webmed.metoclopramide. [[Accessed on 27.Jun].2019]Check here

Country of origin

India

Manufacturer/Marketer address

142 AB, Kandivli Industrial Estate, Kandivli (West), Mumbai - 400 067, Maharashtra
Other Info - PER0383

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