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compositionComposition:PALBOCICLIB-125MG
prescription
Prescription Medicine
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Piciclib 125 Capsule is an anti-cancer medicine used in the treatment of certain types of breast cancer. This medicine contains palbociclid which works by blocking proteins necessary for cell growth, thereby causing cell death and arresting the uncontrolled production of new cells. Common side effects include weakness, loss of appetite, infections and dry skin.

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Written By Veda Maddala , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

PALBOCICLIB-125MG

Manufacturer/Marketer :

Cipla Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Piciclib 125 Capsule

Piciclib 125 Capsule is an oral prescription medicine used to treat hormone receptor-positive (HR+), human epidermal growth factor receptor 2-negative (HER2-) advanced or metastatic breast cancer. It works by blocking specific proteins that help cancer cells grow and divide, thereby slowing the progression of the disease. Piciclib 125 Capsule is commonly used in combination with hormone therapy to help improve treatment outcomes and prolong disease control.

For Piciclib 125 Capsule to work effectively, it must be taken exactly as prescribed and at the same time each day. Piciclib 125 Capsule capsules should be taken with food, while the tablet formulation may be taken with or without food. Maintaining a balanced diet, staying physically active as tolerated, getting adequate rest, and attending all scheduled medical appointments can help support your overall health during treatment.

Common side effects of Piciclib 125 Capsule include fatigue, nausea, mouth sores, hair thinning, and a decrease in white blood cells, which can increase the risk of infections. Contact your healthcare provider immediately if you develop a fever, chills, difficulty breathing, chest pain, unusual bleeding, or any signs of a serious infection. Your doctor will perform regular blood tests to monitor your blood cell counts throughout treatment.

Before starting Piciclib 125 Capsule , tell your doctor if you have liver disease, kidney disease, or any history of lung problems. Do not take Piciclib 125 Capsule if you are pregnant or allergic to Piciclib 125 Capsule or any of its ingredients. Because Piciclib 125 Capsule can harm an unborn baby, effective contraception should be used during treatment and for the period recommended by your doctor after stopping Piciclib 125 Capsule .

Piciclib 125 Capsule may interact with several medicines, including certain antibiotics, antifungals, anticonvulsants, and herbal products such as St. John's wort, which can affect how Piciclib 125 Capsule works. Grapefruit and grapefruit juice should also be avoided, as they may increase Piciclib 125 Capsule levels in the body. If you are breastfeeding, planning to become pregnant, or are an older adult, discuss the potential risks and benefits with your healthcare provider before starting treatment.

Uses of Piciclib 125 Capsule

Piciclib 125 Capsule is used in the treatment of breast cancer. The detailed uses of Piciclib 125 Capsule are as follows:

  • HR-Positive, HER2-Negative Advanced Breast Cancer: Piciclib 125 Capsule helps slow the growth and spread of hormone receptor-positive, HER2-negative breast cancer that is advanced or has spread to other parts of the body. It is typically used in combination with hormone therapy to improve treatment outcomes.

Key Benefits

Piciclib 125 Capsule helps treat certain types of advanced or metastatic breast cancer by slowing the growth and spread of cancer cells. When used in combination with hormone therapy, it helps control the disease and supports improved treatment outcomes.

Benefits may include:

  • Helps slow the growth and spread of certain hormone receptor-positive (HR-positive), HER2-negative breast cancers.
  • Supports long-term disease control and helps delay cancer progression.
  • May increase the length of time patients live without their cancer worsening when used with hormone therapy.
  • Helps maintain quality of life by supporting better management of cancer-related symptoms.
  • Allows many patients to continue their daily activities during treatment.
  • Supports overall treatment goals as part of a comprehensive cancer care plan under specialist supervision.
Side effects of Piciclib 125 Capsule
Here are the steps to manage the medication-triggered Upper respiratory tract infection:
  • Inform your doctor about the symptoms you're experiencing due to medication.
  • Your doctor may adjust your treatment plan, which could include changing your medication, adding new medications, or offering advice on managing your symptoms.
  • Practice good hygiene, including frequent handwashing, avoiding close contact with others, and avoiding sharing utensils or personal items.
  • Stay hydrated by drinking plenty of fluids to help loosen and clear mucus from your nose, throat, and airways.
  • Get plenty of rest and engage in stress-reducing activities to help your body recover. If your symptoms don't subside or worsen, consult your doctor for further guidance.
  • Rest well; get enough sleep.
  • Eat a balanced diet and drink enough water.
  • Manage stress with yoga and meditation.
  • Limit alcohol and caffeine.
  • Physical activities like walking or jogging might help boost energy and make you feel less tired.

Directions for Use

  • Piciclib 125 Capsule can be taken with or without food. However, avoid taking it with grapefruit or grapefruit juice.
  • It is recommended to take Piciclib 125 Capsule once daily or as prescribed by your doctor.
  • Swallow Piciclib 125 Capsule as a whole with a glass of water.
  • Do not break, chew, or crush it.

How Piciclib 125 Capsule Works

Piciclib 125 Capsule helps slow down or stop the growth of certain breast cancer cells by blocking the signals that tell them to grow and divide. By preventing cancer cells from multiplying, it helps control the progression of hormone receptor-positive, HER2-negative breast cancer and may help shrink tumors or delay their growth. It is commonly used in combination with hormone therapy to improve treatment outcomes and help patients live longer without their cancer worsening.
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Alcohol

Caution

It is not recommended to use alcohol with Piciclib 125 Capsule . Please consult your doctor if you have any concerns.

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Pregnancy

Unsafe

Piciclib 125 Capsule is not recommended for use in pregnancy. Please consult your doctor if you have any concerns.

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Breast Feeding

Unsafe

Piciclib 125 Capsule is not recommended during breastfeeding. Please consult your doctor in case of any concerns.

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Driving

Caution

Piciclib 125 Capsule may cause tiredness and lethargy, which may affect your ability to drive. Do not drive if you experience any side effects after using Piciclib 125 Capsule .

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Liver

Caution

Exercise caution before using Piciclib 125 Capsule in case of established liver disease. Please consult your doctor to address any concerns.

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Kidney

Caution

Exercise caution before using Piciclib 125 Capsule in case of established kidney disease. Please consult your doctor to address any concerns.

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Children

Unsafe

Piciclib 125 Capsule is not recommended for use in children under 18 years of age. Please consult your doctor in case of any concerns.

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Heart

Caution

Piciclib 125 Capsule should be taken with caution in patients with heart problems. Therefore, please talk to your doctor before using Piciclib 125 Capsule .

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Geriatrics

Consult your doctor

Piciclib 125 Capsule should be given to elderly patients only if prescribed by a doctor. Seek medical advice if you have any concerns.

What if I have taken an overdose of Piciclib 125 Capsule

If you accidentally take more than your prescribed dose, seek immediate emergency medical attention or contact a poison control center right away. Do not wait for symptoms to appear.

Diet & Lifestyle Advise

  • Avoid Grapefruit Products: Do not eat grapefruit or drink grapefruit juice while taking Piciclib 125 Capsule , as it can significantly increase the levels of Piciclib 125 Capsule in your blood, raising your risk of severe side effects.
  • Prioritize Infection Prevention: Because Piciclib 125 Capsule can lower your white blood cell count, wash your hands frequently, avoid close contact with people who are sick, and ensure all food is thoroughly washed and cooked.
  • Stay Well-Hydrated: Drink plenty of fluids, especially water, throughout the day to help manage mild diarrhea and support kidney function.
  • Eat Small, Frequent Meals: If you experience nausea or a loss of appetite, eating smaller portions of bland foods throughout the day can help you maintain your strength.
  • Engage in Gentle Exercise: Light physical activity, such as a daily short walk, can help combatcancer-related fatigue without overexerting your body.
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How Soon It Starts Working

The time required for Piciclib 125 Capsule to start to work: The time required for Piciclib 125 Capsule to show its action is unknown. The time for which the effects of Piciclib 125 Capsule last: The duration of action for Piciclib 125 Capsule is clinically unknown.

What if you forget to take Piciclib 125 Capsule

If you miss a dose or vomit after taking your dose, do not take an extra dose to make up for it. Skip the missed dose entirely and take your next scheduled dose at your regular time. Talk to your doctor or pharmacist if you are unsure of what to do.

Storage

• Store Piciclib 125 Capsule at room temperature, safely between 68°F to 77°F (20°C to 25°C).

Drug Warnings

  • Check Your Medication: Before taking your dose, inspect each capsule or tablet. If they are broken, leaking, or look damaged, do not take them and contact your pharmacy.
  • Monitor Your Temperature: Always keep a working digital thermometer at home. Since your body's ability to fight infections is reduced, checking your temperature immediately when you feel unwell is a critical safety step.
  • Get Regular Blood Tests: You will need frequent blood tests before starting and during your treatment cycles to check your blood cell counts. Always keep these scheduled appointments.
  • Inform All Healthcare Providers: Let every doctor, dentist, or specialist you visit know that you are taking Piciclib 125 Capsule , especially before any planned surgeries or dental procedures.
  • Use Effective Birth Control: Both men and women taking this medication must use highly effective birth control during treatment and for several months after the final dose to prevent pregnancy.

Drug-Drug Interactions

verifiedApollotooltip
  • Antifungal Medicines (e.g., ketoconazole): These medicines are strong CYP3A inhibitors and may increase the amount of Piciclib 125 Capsule in the body, raising the risk of side effects.
  • Macrolide Antibiotics (e.g., clarithromycin): These medicines are strong CYP3A inhibitors and may increase the amount of Piciclib 125 Capsule in the body, raising the risk of side effects.
  • Antibiotic Medicines (e.g., rifampin): These medicines are strong CYP3A inducers and may reduce the effectiveness of Piciclib 125 Capsule by increasing its breakdown in the body.
  • Antiepileptic Medicines (e.g., phenytoin): These medicines are strong CYP3A inducers and may reduce the effectiveness of Piciclib 125 Capsule by increasing its breakdown in the body.
PalbociclibCladribine
Severe
PalbociclibKetoconazole
Severe

Drug-Drug Interactions

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PalbociclibCladribine
Severe
How does the drug interact with Piciclib 125 Capsule:
Taking Cladribine with Piciclib 125 Capsule can increase the risk of developing serious infections.

How to manage the interaction:
Taking Cladribine with Piciclib 125 Capsule together can possibly result in an interaction, but it can be taken if your doctor has advised it. However, if you experience fever, chills, diarrhea, sore throat, muscle pains, breathing difficulty, blood in your coughing fluid, weight loss, red or irritated skin, body sores, and discomfort or burning sensation when you urinate, consult a doctor. Do not stop using any medications without a doctor's advice.
PalbociclibKetoconazole
Severe
How does the drug interact with Piciclib 125 Capsule:
Coadministration of Ketoconazole and Piciclib 125 Capsule may increase the blood level of Piciclib 125 Capsule.

How to manage the interaction:
Although taking Ketoconazole and Piciclib 125 Capsule together can result in an interaction, it can be taken if a doctor has prescribed it. However, if you experience nausea, vomiting, diarrhea, loss of appetite, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet, more severely, consult a doctor. Without consulting a doctor, never stop taking any drugs.
PalbociclibPosaconazole
Severe
How does the drug interact with Piciclib 125 Capsule:
When Piciclib 125 Capsule is taken with Posaconazole can increase the blood levels of Piciclib 125 Capsule.

How to manage the interaction:
Although there is an interaction between posaconazole and Piciclib 125 Capsule, it can be taken if your doctor has advised it. However, if you experience nausea, vomiting, diarrhea, less desire to eat, mouth sores, hair loss, weakness, pain, numbness, or tingling in the hands and feet contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PalbociclibMorphine
Severe
How does the drug interact with Piciclib 125 Capsule:
Co-administration of Piciclib 125 Capsule with Morphine may increase the blood levels and side effects of morphine.

How to manage the interaction:
Taking Morphine with Piciclib 125 Capsule can result in an interaction, but it can be taken if a doctor has advised it. However, if you experience any symptoms like trouble breathing, feeling tired, or having a cough, dizziness, drowsiness, difficulty concentrating, impaired judgment, reaction speed, and motor coordination, make sure to contact a doctor immediately. Do not stop using any medications without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Grapefruit, grapefruit juice, and Seville oranges: Avoid consuming these while taking Piciclib 125 Capsule , as they may increase the amount of Piciclib 125 Capsule in your bloodstream and raise the risk of side effects. 
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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All Substitutes & Brand Comparisons

Habit Forming

No

Therapeutic Class

[CHEMOTHERAPY]

FAQs

Piciclib 125 Capsule belongs to the group of anti-cancer drugs used to treat certain types of breast cancer.
Piciclib 125 Capsule works blocking proteins responsible for cell growth and division, thereby arresting the progression of cancer cells.
Do not stop taking Piciclib 125 Capsule on your own. You are advised to take Piciclib 125 Capsule for as long as your doctor has prescribed it for you depending on your medical condition. Do not be reluctant to speak with your doctor if you experience any difficulty while taking Piciclib 125 Capsule .
A fibroadenoma is a benign state. Piciclib 125 Capsule is indicated only in case of cancers. Please consult your doctor in case of any concerns.
Piciclib 125 Capsule may reduce fertility in men. Men who wish to father children in the future should discuss sperm preservation before starting treatment. The effects on female fertility are not fully established. Talk to your doctor if fertility preservation is important to you before beginning treatment.
Piciclib 125 Capsule may reduce white blood cell count, thereby weakening the immune system. This might increase your risk of infections. If you notice any signs or symptoms of infections, consult your doctor.
Piciclib 125 Capsule is a type of targeted cancer drug. It is a treatment for breast cancer that is oestrogen receptor-positive (ER+) and human epidermal growth factor receptor-negative (HER2 -).
Most side effects associated with Piciclib 125 Capsule are temporary and can be effectively managed. However, certain side effects may persist or have a lasting impact in some cases. Common reversible side effects include fatigue, nausea, and hair loss, which typically resolve once treatment is stopped. In rare instances, more serious and potentially irreversible side effects may occur, such as permanent hair loss, increased infection risk, or heart problems. Regular monitoring and open communication with your healthcare team are essential to mitigate these risks and address any concerns that may arise during treatment.
Whether you should take Piciclib 125 Capsule with food depends on the formulation you have been prescribed. Follow your doctor's instructions and the directions on your prescription label. If you are unsure, ask your pharmacist or healthcare provider before taking your dose.
In some cases, side effects can be serious. If you experience any of the following symptoms, call your doctor immediately or seek emergency medical treatment: fever, chills, or signs of infection; difficulty breathing or shortness of breath; cough with or without mucus; chest pain; dizziness; fast, irregular, or pounding heartbeat; weakness; unusual bleeding or bruising; nosebleeds; or redness, pain, swelling, or blisters on the palms of your hands or soles of your feet, as well as skin blistering, peeling, or redness.
No. Do not take Piciclib 125 Capsule if you are pregnant or breastfeeding because it can seriously harm an unborn baby. Women of childbearing potential should have a pregnancy test before starting treatment and use effective birth control during treatment and for at least 3 weeks after the last dose. Men with female partners should use effective birth control during treatment and for at least 3 months after the last dose. Tell your doctor if you are pregnant, planning a pregnancy, or planning to father a child.
Yes. Regular blood tests are required because Piciclib 125 Capsule can lower your white blood cell count, increasing your risk of infection. Your healthcare provider will monitor your blood counts closely, especially during the first six treatment cycles, and then at regular intervals (often every 3 months if counts remain stable) to determine whether your treatment needs to be adjusted or temporarily stopped.
It is highly recommended to avoid or severely limit alcohol while taking Piciclib 125 Capsule . Alcohol can worsen common side effects like fatigue, dizziness, and nausea, and it can also place extra strain on your liver. Talk to your doctor or pharmacist about what is safe for you.
If you develop a fever of 100.4°F (38°C) or higher, call your doctor or seek emergency medical care immediately. A fever can be a sign of a low white blood cell count and a serious, potentially life-threatening infection. Do not take fever-reducing medications without contacting your healthcare provider first.
Yes, hair thinning or mild hair loss is a recognized side effect of Piciclib 125 Capsule , although it does not typically cause complete baldness. This is usually temporary, and hair often grows back after the treatment is completed. Talk to your doctor if this is causing you distress.
You should consult your doctor before taking any over-the-counter pain relievers or anti-inflammatory drugs. Some pain relievers can interact with your treatment or mask symptoms of an infection, such as a fever. Talk to your doctor or pharmacist for a safe recommendation.
You will usually take Piciclib 125 Capsule in repeated treatment cycles (typically 21 days on treatment followed by 7 days off) for as long as it continues to control your cancer and the side effects remain manageable. Your doctor will monitor your response with regular blood tests and scans and adjust treatment as needed.

Disclaimer

While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Reference

  1. Electronic Medicines Compendium (EMC). Pil.4449 Patient Information Leaflet (PIL). Cheshire, UK: Datapharm; 2025. [Accessed on 02 Jun. 2026]Check here
  2. National Center for Biotechnology Information (NCBI). Palbociclib Scientific Research Publication. Bethesda, MD: NLM; 2025. [Accessed on 02 Jun. 2026]Check here
  3. National Health Service (NHS). Fulvestrant Palbociclib - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  4. National Health Service (NHS). Palbociclib Protocol Crp13 B033 V1.0 - NHS Medicines Reference Guide. London, UK: NHS; 2025. [Accessed on 02 Jun. 2026]Check here
  5. Palbociclib Palbociclib. 2015. [Accessed on 25 Jun. 2019]Check here
  6. Medicines and Healthcare products Regulatory Agency. (2023, July 26). IBRANCE 75 mg, 100 mg and 125 mg hard capsules - Summary of Product Characteristics (SmPC). Electronic Medicines CompendiumCheck here
  7. Central Drugs Standard Control Organisation (CDSCO). [Accessed on 26 Mar. 2019]Check here

Country of origin

India

Manufacturer/Marketer address

Cipla House, Peninsula Business Park, Ganpatrao Kadam Marg, Lower Parel, Mumbai-400013
Other Info - PIC0197
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