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  3. Planep 25 mg Tablet 10's

Planep 25 mg Tablet 10's, Pack of 10 TABLETS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

Planep Tablet is used to treat heart failure and high blood pressure. This medicine contains Eplerenone, which works by blocking the action of aldosterone and slowing the progression of heart failure, while also lowering blood pressure. In some cases, you may experience nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Before starting Planep Tablet , inform the doctor if you are pregnant, breastfeeding, taking any other medicines or have pre-existing medical conditions.

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Composition :

EPLERENONE-25MG

Manufacturer/Marketer :

Lupin Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About Planep Tablet

Planep Tablet is used to treat your heart failure. It reduces the risk of death or the need for hospitalisation due to heart failure. Besides this, Planep Tablet is also used to treat high blood pressure.

Planep Tablet contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

In some cases, Planep Tablet may cause side effects like nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Most of these side effects of Planep Tablet do not require medical attention and resolve over time. However, if the side effects are persistent, reach out to your doctor.

Do not take Planep Tablet if you are allergic to any of its components. Consult your doctor if you are pregnant or breastfeeding. Keep your doctor informed about your medical conditions and medicines to prevent any potential interactions.

Uses of Planep Tablet

Planep Tablet is used to treat heart failure and high blood pressure. The detailed uses of Planep Tablet are as follows:

  • Treatment of heart failure: Planep Tablet is indicated for patients with heart failure following a recent heart attack. It helps improve heart function, reduce symptoms, and lower the risk of hospitalisation and death due to heart-related complications.
  • Management of high blood pressure: Planep Tablet is also prescribed to lower elevated blood pressure, either alone or in combination with other antihypertensive medications.

Directions for Use

  • Planep Tablet can be taken with or without food.
  • Follow your doctor's instructions regarding the dosage and duration for effective results.
  • Swallow it as a whole with a glass of water.
  • Do not crush, chew, or break it.

Medicinal Benefits

  • Planep Tablet contains Eplerenone, an aldosterone antagonist that helps improve heart function and control blood pressure.
  • Planep Tablet is beneficial for stable patients with left ventricular systolic dysfunction and congestive heart failure following an acute myocardial infarction (heart attack).
  • It improves survival after a heart attack and helps reduce the risk of cardiovascular death and hospitalisation.
  • Planep Tablet is used in patients with mild but persistent heart failure symptoms, especially when previous treatments are insufficient.
  • Planep Tablet effectively lowers elevated blood pressure, which in turn reduces the risk of serious cardiovascular events such as stroke, heart attack (myocardial infarction), and heart failure. 
  • By blocking aldosterone (a hormone that can worsen heart failure and increase blood pressure), Planep Tablet helps treat heart failure and high blood pressure.

How Planep Tablet Works

Planep Tablet contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

Storage

• Store in a cool and dry place away from sunlight. • Keep out of sight and reach of children. • Non cold chain - To be stored in cool places at 10ºC to 25ºC or below 30ºC.
Side effects of Planep 25 mg Tablet
Here are the 7 step-by-step strategies to manage the side effect of "inability to sleep" caused by medication usage:
  • Prepare for a restful night's sleep: Develop a calming pre-sleep routine, like reading or meditation, to help your body relax and prepare for sleep.
  • Create a sleep-conducive Environment: Make bedroom a sleep haven by ensuring it is quiet, dark and calm.
  • Follow a Sleep Schedule: Go to bed and get up at the same time every day to help regulate your body's internal clock and increase sleep quality.
  • Try relaxing techniques like deep breathing, mindfulness meditation and any others.
  • Limit stimulating activities before bedtime: Avoid stimulating activities before bedtime to improve sleep quality.
  • Monitor Progress: Keep track of your sleep patterns to identify areas for improvement.
  • Consult a doctor if needed: If these steps don't improve your sleep, consult a doctor for further guidance and therapy.
Here are the 7 steps to manage Dizziness caused by medication:
  • Inform your doctor about dizziness symptoms. They may adjust your medication regimen or prescribe additional medications to manage symptoms.
  • Follow your doctor's instructions for taking medication, and take it at the same time every day to minimize dizziness.
  • When standing up, do so slowly and carefully to avoid sudden dizziness.
  • Avoid making sudden movements, such as turning or bending quickly, which can exacerbate dizziness.
  • Drink plenty of water throughout the day to stay hydrated and help alleviate dizziness symptoms.
  • If you're feeling dizzy, sit or lie down and rest until the dizziness passes.
  • Track when dizziness occurs and any factors that may trigger it, and share this information with your doctor to help manage symptoms.
Dealing with Medication-Induced Headache:
  • Hydrate your body: Drink enough water to prevent dehydration and headaches.
  • Calm Your Mind: Deep breathing and meditation can help you relax and relieve stress.
  • Rest and Recharge: Sleep for 7-8 hours to reduce headache triggers.
  • Take rest: lie down in a quiet, dark environment.
  • Cold or warm compresses can help reduce tension.
  • Stay Upright: Maintain good posture to keep symptoms from getting worse.
  • To treat headaches naturally, try acupuncture or massage therapy.
  • Over-the-counter pain relievers include acetaminophen and ibuprofen.
  • Prescription Assistance: Speak with your doctor about more substantial drug alternatives.
  • Severe Headaches: Seek emergency medical assistance for sudden, severe headaches.
  • Frequent Headaches: If you get reoccurring headaches, consult your doctor.
  • Headaches with Symptoms: Seek medical attention if your headaches include fever, disorientation, or weakness.

What if I have taken an overdose of Planep Tablet

Do not take more than the prescribed dose of Planep Tablet as it may cause an overdose. Symptoms of overdose include dizziness, fainting, blurred vision, stomach upset, tingling in arms and legs, weakness, lack of energy, loss of muscle tone, irregular or slow heartbeat, and cold/grey skin. If you experience any of these symptoms or suspect you have taken an overdose, please consult a doctor immediately.

Drug Warnings

  • Do not take Planep Tablet if you are allergic to any of its components, have severe liver or kidney disease, or high levels of potassium.
  • Inform your doctor if you have kidney or liver disease, fungal infection, depression, HIV infection, bacterial infection or if you are taking immunosuppressants, or lithium (used to treat manic disorders).
  • Consult your doctor if you are pregnant or breastfeeding.
  • Planep Tablet is not recommended for children as the safety and effectiveness have not been established.
  • Let your doctor know if you are taking any other medicines, including supplements and herbal products.

Drug-Drug Interactions

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EplerenoneSpironolactone
Critical
EplerenoneRitonavir
Critical

Drug-Drug Interactions

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EplerenoneSpironolactone
Critical
How does the drug interact with Planep 25 mg Tablet:
Combining Planep 25 mg Tablet with Spiranolactone may significantly increase potassium levels in the blood which can lead to kidney issues and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between spironolactone and Planep 25 mg Tablet, it is not recommended as it can lead to an interaction. You can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, confusion, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or an irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneRitonavir
Critical
How does the drug interact with Planep 25 mg Tablet:
Co-administration of Planep 25 mg Tablet and Ritonavir may significantly increase the blood levels of Planep 25 mg Tablet.

How to manage the interaction:
Taking Ritonavir and Planep 25 mg Tablet together is not recommended as it can lead to an interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenoneKetoconazole
Critical
How does the drug interact with Planep 25 mg Tablet:
Coadministration of Ketoconazole with Planep 25 mg Tablet can increase the levels of blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking ketoconazole with Planep 25 mg Tablet is not recommended as it can result in an interaction, but it can be taken if a doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenonePotassium iodide
Critical
How does the drug interact with Planep 25 mg Tablet:
Combining Planep 25 mg Tablet with Potassium iodide may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium iodide and Planep 25 mg Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneItraconazole
Critical
How does the drug interact with Planep 25 mg Tablet:
The blood levels and effects of Planep 25 mg Tablet may be greatly increased when combined with itraconazole.

How to manage the interaction:
Although there is a possible interaction between Planep 25 mg Tablet and Itraconazole, it is not recommended; they can be taken if prescribed by a doctor. Consult a doctor if you have complications such as hyperkalemia (high blood potassium), which in extreme circumstances can result in kidney problems, muscle paralysis, and an irregular heartbeat. Without first consulting your doctor, never stop taking medicines.
EplerenoneClarithromycin
Critical
How does the drug interact with Planep 25 mg Tablet:
Co-administration of Planep 25 mg Tablet and Clarithromycin may significantly increase the blood levels and effects of Planep 25 mg Tablet.This may increase the risk or severity of side effects like high blood potassium which can lead to kidney damage and irregular heart rate.

How to manage the interaction:
Taking Clarithromycin with Planep 25 mg Tablet is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the Doctor's advice.
EplerenoneSaquinavir
Critical
How does the drug interact with Planep 25 mg Tablet:
Co-administration of EPELENONE and SAQUINAVIR may significantly increase the blood levels and side effects of Planep 25 mg Tablet. This can increase the risk of serious side effects like high blood potassium, which in severe cases can lead to kidney failure, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Taking saquinavir and Planep 25 mg Tablet together is not recommended as it can lead to interaction. However, it can be taken if a doctor advises it. If you experience any unusual symptoms like headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, consult a doctor immediately. Do not stop using any medications without the doctor's advice.
EplerenonePotassium citrate
Critical
How does the drug interact with Planep 25 mg Tablet:
Taking Planep 25 mg Tablet with Potassium citrate may significantly increase potassium levels in the blood which can lead to kidney issues, muscle paralysis (loss of muscle function) and irregular heart rhythm.

How to manage the interaction:
Although there is a possible interaction between Potassium citrate and Planep 25 mg Tablet, you can take these medicines if prescribed by a doctor. Consult a doctor if you experience nausea, vomiting, weakness, disorientation, tingling in your hands and feet, feelings of heaviness in your legs, a weak pulse, or irregular heartbeat. It is essential to maintain proper fluid intake while taking these medications. Do not discontinue any medications without a doctor's advice.
EplerenoneNefazodone
Critical
How does the drug interact with Planep 25 mg Tablet:
Coadministration of Nefazodone with Planep 25 mg Tablet can increase the levels of Planep 25 mg Tablet in the body.

How to manage the interaction:
Taking Nefazodone with Planep 25 mg Tablet together is not recommended as it can result in an interaction, but it can be taken if your doctor has advised it. However, if you notice any symptoms of headaches, irritation, confusion, edema (swelling caused by too much fluid accumulation), weakness, palpitations, or constipation, you should contact a doctor immediately. Do not stop using any medications without a doctor's advice.
EplerenonePosaconazole
Critical
How does the drug interact with Planep 25 mg Tablet:
Coadministration of posaconazole with Planep 25 mg Tablet can increase the blood levels of Planep 25 mg Tablet. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between posaconazole and Planep 25 mg Tablet, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Consume antioxidant-rich foods such as blueberries, cherries, tomatoes, squash, and bell peppers.
  • Use healthy cooking oils like soybean, olive, canola, and coconut oil.
  • You should avoid refined foods such as white bread, spaghetti, sugar, and red meat.
  • Reduce or eliminate trans fatty acids, which are found in commercially baked items such as cookies, cakes, crackers, French fries, onion rings, doughnuts, and processed foods.
  • Avoid the consumption of too much salt or salty food.
  • Maintain a healthy weight with a BMI of 19.5-24.9.
  • Regular physical activity or exercise, like walking, improves your blood flow.
  • Avoid standing or sitting for extended periods.
  • Avoid chronic stress, as it can raise your blood pressure.
  • Spend time with your loved ones to cope with stress and practice mindfulness techniques.
  • Quitting smoking and alcohol consumption is the best strategy to lower the risk of many health complications.

Habit Forming

No

Therapeutic Class

ALDOSTERONE ANTAGONISTS

Planep Tablet Substitute

Substitutes safety advice

Product Substitutes

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Alcohol

Unsafe

You are recommended not to consume alcohol along with Planep Tablet to avoid unpleasant side effects.

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Pregnancy

Caution

Planep Tablet should be used in pregnant women only if clinically needed, and the benefits outweigh the risks. Please consult your doctor if you are pregnant.

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Breast Feeding

Caution

Please consult your doctor if you are breastfeeding. It should be used only if prescribed by a doctor and if the benefits outweigh the harms.

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Driving

Caution

Planep Tablet may cause dizziness. Dro not drive or operate machinery unless you are alert.

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Liver

Caution

Planep Tablet is not recommended for people with severe liver disease. Inform your doctor before starting Planep Tablet if you have a history of liver diseases/conditions.

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Kidney

Caution

Planep Tablet is not recommended for people with severe kidney disease. Inform your doctor before starting Planep Tablet if you have a history of kidney diseases/conditions.

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Children

Caution

Planep Tablet is not recommended for children below 12 years of age.

Have a query?

FAQs

Planep Tablet is used to treat heart failure and hypertension (high blood pressure).

Planep Tablet contains Eplerenone, which works by blocking the action of aldosterone, a natural substance that raises blood pressure. It also slows the progression of heart failure by reducing heart damage.

Yes, Planep Tablet can cause increased potassium levels (hyperkalemia), especially in patients with kidney problems or if you are taking potassium supplements along with Planep Tablet . Please monitor your electrolyte level regularly to avoid increased blood potassium levels. Consult your doctor if you experience muscle cramps, diarrhoea, nausea, dizziness or headache.

No, Planep Tablet is not a blood thinner. It is a selective aldosterone blocker used to treat heart failure and high blood pressure.

Planep Tablet contains Eplerenone. It is an aldosterone antagonist type of potassium-sparing diuretic.

Planep Tablet may take up to 4 weeks to show its full effect. Keep taking Planep Tablet for the prescribed duration.

No, Planep Tablet is not known to cause erectile dysfunction. It does not have any effect on fertility.

Do not discontinue Planep Tablet without consulting the doctor. To treat your condition effectively, keep taking Planep Tablet for the prescribed duration.

Potassium-sparing diuretics increase urine production without depleting potassium reserves. Planep Tablet permits the body to lose sodium while retaining potassium. The amount of potassium may rise as a result. Therefore, your doctor may regularly check your potassium levels.

Your doctor might have recommended Eplerenone instead of Losartan as a blood pressure medication because losartan may have been insufficient in lowering your blood pressure. However, Eplerenone increases the risk of elevated potassium levels, which may not be suitable for you. Hence, the doctor has prescribed Planep Tablet along with hydrochlorothiazide to prevent the rise in potassium levels.

Before starting Planep Tablet , let the doctor know if you are taking aspirin. Taking aspirin with Planep Tablet may decrease the effects of Planep Tablet . Contact your doctor if you experience signs of high blood pressure such as headache, blurred vision, trouble concentrating, or dizziness.

Planep Tablet may cause side effects like nausea, vomiting, dizziness, diarrhoea, and elevated potassium levels. Most of these side effects of Planep Tablet do not require medical attention and resolve over time. However, if the side effects are persistent, reach out to your doctor.

Country of origin

India

Manufacturer/Marketer address

Lupin Ltd, 3rd floor Kalpataru Inspire, Off. W E Highway, Santacruz (East), Mumbai 400 055. India Country of Origin: India
Other Info - PLA0042

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jul 30, 2025 | 8:04 AM IST

Doctor imageWe provide you with authentic, trustworthy and relevant information

Reference

  1. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/021437s013lbl.pdf
  2. https://www.nps.org.au/assets/medicines/0ebbd413-7e5c-40cc-897d-a77600780bee-reduced.pdf
  3. https://medlineplus.gov/druginfo/meds/a603004.html
  4. https://www.drugs.com/mtm/eplerenone.html
  5. https://www.medicines.org.uk/emc/product/9207/pil

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