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  3. Posatral 100 mg Tablet 10's

Posatral 100 mg Tablet 10's, Pack of 10 TabletS
Posatral 100 mg Tablet 10's, Pack of 10 TabletS
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Written By Bayyarapu Mahesh Kumar , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD

POSATRAL 100 TABLETS is used to prevent and treat fungal infections. It contains posaconazole which works by inhibiting fungal cell growth and causing cell death. In some cases, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, and cough. Before taking this medicine, inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Composition :

POSACONAZOLE-100MG

Manufacturer/Marketer :

Mylan Pharmaceuticals Pvt Ltd

Consume Type :

ORAL

Return Policy :

Not Returnable

Expires on or after :

About POSATRAL 100 TABLETS

POSATRAL 100 TABLETS is in a class of medications called azole antifungals. It is used to prevent and treat fungal infections when other antifungal medicines have not worked, or you have had to stop taking them. It is also indicated for preventing invasive Aspergillus and Candida infections in patients at high risk of developing these infections due to being severely immunocompromised, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

POSATRAL 100 TABLETS contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Take POSATRAL 100 TABLETS as prescribed by your doctor. You are advised to take POSATRAL 100 TABLETS for as long as your doctor has prescribed it based on your medical condition. In some cases, you may experience diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood. Most of these side effects of POSATRAL 100 TABLETS do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Inform your doctor if you are allergic or hypersensitive to any component present in POSATRAL 100 TABLETS or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe POSATRAL 100 TABLETS only if the benefits outweigh the risk. Before taking the POSATRAL 100 TABLETS , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions.

Uses of POSATRAL 100 TABLETS

POSATRAL 100 TABLETS is used in the treatment of Fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

Directions for Use

Tablet/Capsule: Swallow it as a whole with water; do not crush, break or chew it.Oral Suspension/syrup: Shake the bottle well before each use. Take the prescribed dose by mouth using the measuring cup/dosing syringe/dropper.

Medicinal Benefits

Posaconazole is an antifungal medication present in POSATRAL 100 TABLETS . It is effective in treating fungal infections in adults. It is also indicated for preventing invasive Aspergillus and Candida infections in patients who are severely immunocompromised and at high risk of developing these infections, such as hematopoietic stem cell transplant (HSCT) recipients with graft-versus-host disease (GVHD) or those with hematologic malignancies with prolonged neutropenia from chemotherapy.

How POSATRAL 100 TABLETS Works

POSATRAL 100 TABLETS contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in the inhibition of fungal cell growth and cell death. Thus, it treats infections.

Storage

Store in a cool and dry place away from sunlight

What if I have taken an overdose of POSATRAL 100 TABLETS

Take POSATRAL 100 TABLETS only as prescribed by the physician. Do not exceed the recommended dose, as it might cause an overdose. If you suspect you have taken an overdose, seek immediate medical attention.

Drug Warnings

Inform your doctor if you are allergic or hypersensitive to any component present in POSATRAL 100 TABLETS or if you are pregnant, suspect you are pregnant, plan to have a baby or are breastfeeding; your doctor will prescribe POSATRAL 100 TABLETS only if the benefits outweigh the risk. Before taking the POSATRAL 100 TABLETS , inform your doctor about your medical history and ongoing therapies to rule out any potential adverse effects or interactions. And also, let your doctor know before prescribing POSATRAL 100 TABLETS if you have Arrhythmias and QTc Prolongation, liver problems, or low potassium, magnesium, or calcium levels in your blood.

Drug-Drug Interactions

verifiedApollotooltip
PosaconazoleCisapride
Critical
PosaconazoleSirolimus
Critical

Drug-Drug Interactions

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PosaconazoleCisapride
Critical
How does the drug interact with Posatral 100 mg Tablet:
When Posatral 100 mg Tablet is taken with Cisapride, it can lower the rate at which Cisapride is broken down in the body.

How to manage the interaction:
Taking Posatral 100 mg Tablet with Cisapride is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms. Do not stop taking any medications without consulting a doctor.
PosaconazoleSirolimus
Critical
How does the drug interact with Posatral 100 mg Tablet:
Coadministration of sirolimus with Posatral 100 mg Tablet can lower the levels of sirolimus in the blood.

How to manage the interaction:
Although there is an interaction between Posatral 100 mg Tablet with sirolimus, they can be taken together if a doctor advises. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PosaconazoleAtorvastatin
Critical
How does the drug interact with Posatral 100 mg Tablet:
Taking atorvastatin with Posatral 100 mg Tablet can increase the blood levels of atorvastatin. This can increase the risk of side effects.

How to manage the interaction:
Although there is an interaction between Posatral 100 mg Tablet with atorvastatin, they can be taken together if advised by your doctor. However, contact the doctor if you experience unexplained muscle pain, weakness, fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, loss of appetite, fatigue, nausea, vomiting, dark coloured urine, or yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.
PosaconazoleConivaptan
Critical
How does the drug interact with Posatral 100 mg Tablet:
When Posatral 100 mg Tablet is taken with Conivaptan, it can increase the blood levels and effects of conivaptan.

How to manage the interaction:
Although there is an interaction between Posatral 100 mg Tablet and conivaptan, they can be taken together if prescribed by a doctor. However, contact a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, or mood changes. Do not discontinue any medications without consulting a doctor.
PosaconazoleTolvaptan
Critical
How does the drug interact with Posatral 100 mg Tablet:
Taking Tolvaptan and Posatral 100 mg Tablet together results in an increase in the levels and effects of Tolvaptan.

How to manage the interaction:
Although there is an interaction between Tolvaptan and Posatral 100 mg Tablet, it can be taken if prescribed by a doctor. However, consult a doctor if you experience difficulty swallowing, trouble speaking, muscle weakness, trouble controlling body movements, confusion, mood changes, or seizures (fits). Do not stop using any medications without a doctor's advice.
PosaconazolePimozide
Critical
How does the drug interact with Posatral 100 mg Tablet:
Taking pimozide with Posatral 100 mg Tablet can increase the levels of pimozide in the blood, which can lead to an increased risk of abnormal heart rhythm.

How to manage the interaction:
Although there is an interaction between Posatral 100 mg Tablet and pimozide, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience severe or prolonged diarrhea, vomiting dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PosaconazoleRanolazine
Critical
How does the drug interact with Posatral 100 mg Tablet:
When Posatral 100 mg Tablet is taken with Ranolazine, may significantly increase the blood levels and effects of Ranolazine.

How to manage the interaction:
Although there is an interaction between Posatral 100 mg Tablet and ranolazine, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience sudden dizziness, lightheadedness, fainting, or shortness of breath. Do not discontinue any medications without consulting a doctor.
PosaconazoleEplerenone
Critical
How does the drug interact with Posatral 100 mg Tablet:
Coadministration of Posatral 100 mg Tablet with eplerenone can increase the blood levels of eplerenone. This can increase the risk of serious side effects, including hyperkalemia (high blood potassium).

How to manage the interaction:
Although there is an interaction between Posatral 100 mg Tablet and eplerenone, it can be taken if a doctor has advised it. However, if you experience any unusual symptoms contact a doctor immediately. Do not discontinue any medications without consulting a doctor.
PosaconazoleDronedarone
Critical
How does the drug interact with Posatral 100 mg Tablet:
When Dronedarone is taken with Posatral 100 mg Tablet, can increase the risk of an irregular heart rhythm.

How to manage the interaction:
Taking Posatral 100 mg Tablet with Dronedarone is not recommended, please consult your doctor before taking it. They can be taken together if advised by your doctor. However, contact your doctor if you experience any symptoms like sudden dizziness, lightheadedness, fainting, shortness of breath, or heart palpitations. Do not stop taking any medications without consulting a doctor.
PosaconazoleCerivastatin
Critical
How does the drug interact with Posatral 100 mg Tablet:
Taking cerivastatin with Posatral 100 mg Tablet can increase the blood levels of cerivastatin.

How to manage the interaction:
Although there is an interaction between Posatral 100 mg Tablet and cerivastatin, they can be taken together if prescribed by a doctor. However, consult a doctor if you experience fever, chills, joint pain or swelling, unusual bleeding, skin rash, itching, less desire to eat, fatigue, nausea, vomiting, dark-colored urine, and yellowing of the skin or eyes. Do not discontinue any medications without consulting a doctor.

Drug-Food Interactions

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No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Diet & Lifestyle Advise

  • Take the medication as directed by the doctor and at regular intervals if you take POSATRAL 100 TABLETS for more than one day.
  • Do not use other over-the-counter medications, herbal or vitamin supplements without informing your pharmacist or doctor when you take POSATRAL 100 TABLETS .
  • Continue taking your normal regular diet unless your doctor prescribes a specific diet.
  • It is advisable to follow a candida diet during yeast infections. This diet excludes sugar, gluten, certain dairy products, alcohol and switches to low-sugar fruits, non-starchy vegetables, and gluten-free foods.
  • A very high sugar or high-carbohydrate diet may increase the count of Candida in some people. It is better to avoid or limit alcohol and caffeine intake during POSATRAL 100 TABLETS treatment to enhance a healthy lifestyle practice.

Habit Forming

No

Therapeutic Class

ANTIFUNGALS

POSATRAL 100 TABLETS Substitute

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Product Substitutes

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Alcohol

Consult your doctor

The interaction of POSATRAL 100 TABLETS with alcohol is unknown. If you have any concerns regarding this, please discuss with your doctor.

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Pregnancy

Consult your doctor

POSATRAL 100 TABLETS should not be used when pregnancy unless clearly necessary. So, inform your doctor if you are pregnant or suspect pregnancy. Your doctor will weigh the benefits and potential risks before prescribing POSATRAL 100 TABLETS .

bannner image

Breast Feeding

Consult your doctor

There is no substantial research yet on using POSATRAL 100 TABLETS in breastfeeding/nursing mothers. Inform your doctor if you are a nursing mother before taking POSATRAL 100 TABLETS ; your doctor will decide whether POSATRAL 100 TABLETS can be taken by breastfeeding mothers.

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Driving

Caution

It is unknown whether POSATRAL 100 TABLETS alters the ability to drive, so do not drive or operate machinery if you experience any symptoms affecting your ability to concentrate and react.

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Liver

Consult your doctor

Inform your doctor before taking the POSATRAL 100 TABLETS if you have a liver impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Kidney

Consult your doctor

Inform your doctor before taking the POSATRAL 100 TABLETS if you have a kidney impairment/disorder history. Your doctor will prescribe only if the benefits outweigh the risks.

bannner image

Children

Consult your doctor

Please consult a doctor before using POSATRAL 100 TABLETS for children.

Have a query?

FAQs

POSATRAL 100 TABLETS is used to treat fungal infections and prophylaxis of invasive Aspergillus and Candida infections in severely immunocompromised patients.

POSATRAL 100 TABLETS contains a medicine called posaconazole. It is a triazole antifungal agent and exerts its antifungal activity through the blockage of certain enzymes (P-450 dependent enzyme, sterol 14α-demethylase). This leads to inhibiting the synthesis of ergosterol, a key component of the fungal cell membrane, and the accumulation of methylated sterol precursors. This results in inhibiting fungal cell growth and, ultimately, cell death. Thus, it treats infections.

POSATRAL 100 TABLETS is not recommended for coadministration with anticoagulants, So if you are under anticoagulant therapy, inform your doctor before prescribing POSATRAL 100 TABLETS .

If you are allergic to posaconazole or similar antifungals such as fluconazole, itraconazole, ketoconazole, or voriconazole, you should not use it. When combined with certain medications, posaconazole can have unfavourable or dangerous side effects.

Like all medicines, this medicine may cause side effects such as diarrhoea, nausea, fever, vomiting, headache, coughing and low potassium levels in the blood, although not everybody gets them. Most of these side effects of POSATRAL 100 TABLETS do not require medical attention and gradually resolve over time. However, if the side effects persist or worsen, please consult your doctor.

Take POSATRAL 100 TABLETS as prescribed by your doctor. You are advised to take POSATRAL 100 TABLETS for as long as your doctor has prescribed it for you based on your medical condition.

Country of origin

India

Manufacturer/Marketer address

Mylan Pharmaceuticals Private Limited , Commercial Operations , Prestige Tech Park,Platina-3, 7th to 12th floor, Prestige Tech Park, Kadubesanahalli, Bangalore -560103.
Other Info - POS0091

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Author Details

Bayyarapu Mahesh KumarDoctor badge

Written By

Bayyarapu Mahesh Kumar

M Pharmacy

Dr Aneela SiddabathuniDoctor badge

Reviewed By

Dr Aneela Siddabathuni

MPharma., PhD

Last Updated

Jan 1, 2025 | 2:47 PM IST

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Reference

  1. https://www.medicines.org.uk/emc/product/5388/smpc
  2. https://www.medicines.org.uk/emc/files/pil.5388.pdf
  3. https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/022003s018s020,0205053s002s004,0205596s001s003lbl.pdf
  4. https://www.fda.gov/media/114097/download#:~:text=Posaconazole%20is%20an%20azole%20antifungal,2013%20and%20March%202014%2C%20respectively.&text=DPV%20will%20continue%20to%20monitor,with%20the%20use%20of%20posaconazole.
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