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compositionComposition:DOTHIEPIN-50MG
prescription
Prescription Medicine
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Prothidep-50 Tablet is used to treat depression and anxiety. It contains Dothiepin which works by increasing the levels of chemical messengers responsible for mood. In some cases, this medicine may cause side effects such as restlessness, irritability, tiredness, difficulty concentrating, and sleep disturbances. Inform the doctor if you are pregnant or breastfeeding, taking any other medication, or have any pre-existing medical conditions.

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Written By Santoshini Reddy G , M Pharmacy
Reviewed By Dr Aneela Siddabathuni , MPharma., PhD
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More about the Product

Composition :

DOTHIEPIN-50MG

Manufacturer/Marketer :

Anthus Pharmaceuticals Pvt Ltd

Consume Type :

Oral

Expires on or after :

Jan-27

Return Policy :

Not Returnable

About Prothidep-50 Tablet

Prothidep-50 Tablet is an oral medicine containing dothiepin, a tricyclic antidepressant used to treat depression and, in some cases, anxiety associated with depressive illness. It helps restore the balance of certain brain chemicals that regulate mood, improving emotional well-being and making it easier for patients to carry out their daily activities.

To get the best results, you must take Prothidep-50 Tablet consistently at the same time each day, usually in the evening. You can take this medication with or without food. Adopting healthy lifestyle changes, such as keeping a regular sleep schedule and eating a balanced diet, can also support your path to recovery.

Some people may experience mild side effects, like dry mouth or drowsiness, when first starting this treatment. However, if you experience serious side effects like a rapid heart rate, severe dizziness, or sudden mood changes, you must consult your doctor or seek medical help immediately.

Before starting this medicine, talk to your doctor if you have certain health conditions like heart problems, glaucoma, or difficulty urinating. Do not take this if you have recently had a heart attack. It is also not suitable for individuals with severe liver damage or untreated mania.

This medicine can interact with alcohol, causing increased drowsiness, and with other prescription drugs, which may lead to dangerous side effects. Always tell your healthcare provider about all medicines you are taking. If you are pregnant, breastfeeding, or elderly, you should consult your doctor before taking Prothidep-50 Tablet to ensure it is safe for you.

Uses of Prothidep-50 Tablet

Prothidep-50 Tablet is used to treat depression and, in some cases, anxiety associated with depressive illness. The detailed uses of Prothidep-50 Tablet are as follows:

  • Depression: It balances chemical messengers in the brain to relieve persistent sadness, low energy, and feelings of hopelessness.
  • Anxiety associated with depression: It helps calm feelings of nervousness, tension, and worry that frequently occur alongside depressive illnesses.
  • Insomnia associated with depression: It has a relaxing effect that helps improve sleep quality and makes it easier to fall asleep and stay asleep.

Key Benefits

Prothidep-50 Tablet offers meaningful relief for people struggling with the overwhelming weight of depression. By restoring the natural balance of chemicals in your brain, this medicine helps you slowly regain your interest in daily activities and find joy in life again. Key benefits of using Prothidep-50 Tablet include:

  • Improved Mood and Energy: It helps lift the fog of persistent sadness, giving you the physical and mental energy needed to manage your daily routine.
  • Better, Restful Sleep: Because of its gentle calming properties, it helps correct disrupted sleep patterns, allowing you to wake up feeling refreshed and ready for the day.
  • Reduced Anxiety and Tension: It eases the physical and emotional symptoms of anxiety, helping you feel more relaxed and less overwhelmed by daily stressors.
  • Gradual and Steady Recovery: Unlike short-term options, it provides stable, long-term support to help prevent your symptoms from returning.
Side effects of Prothidep-50 Tablet
  • Get enough sleep. Maintain a regular sleep cycle.
  • Eat a healthy diet and exercise regularly.
  • Manage stress with yoga or meditation.
  • Limit alcohol and caffeine.
  • Avoid driving or operating machinery unless you are alert.
  • Change positions or take a break from activity to relieve symptoms.
  • Avoid postures that put a lot of pressure on just one area of the body.
  • If you have vitamin deficiency, take supplements or change your diet.
  • Exercise regularly like cycling, walking or swimming.
  • Avoid sitting with your legs crossed.
  • Clench and unclench your fists and wiggle your toes.
  • Massage the affected area.
  • Maintain consistent habits, sleep patterns and food times to help maintain stability and reduce confusion.
  • Mindfulness techniques such as deep breathing or meditation help you stay focused and in the now.
  • Participate in cognitive therapy to enhance your ability to remember, focus and solve problems.
  • As directed by your physician, take your medications to help control underlying disorders like depression, anxiety or cognitive impairment.
  • Always wear loose-fitting clothes which are suitable for your activity.
  • Include the diet containing fruits like watermelon, grapes, bananas and green leafy vegetables.
  • Drink plenty of water stay hydrated.
  • Avoid moving more and staying in hot sun.
Managing Low Blood Pressure Triggered by Medication: Expert Advice:
  • If you experience low blood pressure symptoms like dizziness, lightheadedness, or fainting while taking medication, seek immediate medical attention.
  • Make lifestyle modifications and adjust your medication regimen under medical guidance to manage low blood pressure.
  • As your doctor advises, regularly check your blood pressure at home. Record your readings to detect any changes and share them with your doctor.
  • Fluid intake plays a vital role in managing blood pressure by maintaining blood volume, regulating blood pressure, and supporting blood vessel function. Drinking enough fluids helps prevent dehydration, maintain electrolyte balance, and regulate fluid balance.
  • Take regular breaks to sit or lie down if you need to stand for long periods.
  • When lying down, elevate your head with extra pillows to help improve blood flow.
  • Avoid heavy exercise or strenuous activities that can worsen low blood pressure.
  • Wear compression socks as your doctor advises to enhance blood flow, reduce oedema, and control blood pressure.
  • If symptoms persist or worsen, or if you have concerns about your condition, seek medical attention for personalized guidance and care.
Overcome Medication-Induced Nausea: A 9-Step Plan
  • Inform your doctor about the nausea and discuss possible alternatives to the medication or adjustments to the dosage.
  • Divide your daily food intake into smaller, more frequent meals to reduce nausea.
  • Opt for bland, easily digestible foods like crackers, toast, plain rice, bananas, and applesauce.
  • Avoid certain foods that can trigger nausea, such as fatty, greasy, spicy, and smelly foods.
  • Drink plenty of fluids, such as water, clear broth, or electrolyte-rich beverages like coconut water or sports drinks.
  • Use ginger (tea, ale, or candies) to help relieve nausea.
  • Get adequate rest and also avoid strenuous activities that can worsen nausea.
  • Talk to your doctor about taking anti-nausea medication if your nausea is severe.
  • Record when your nausea occurs, what triggers it, and what provides relief to help you identify patterns and manage your symptoms more effectively.
Here are the steps to manage medication-triggered tremors or involuntary shaking:
  • Notify your doctor immediately if you experience tremors or involuntary shaking after taking medication or adjusting your medication regimen.
  • Your doctor may adjust your medication regimen or recommend alternative techniques like relaxation, meditation, or journaling to alleviate tremor symptoms.
  • Your doctor may direct you to practice stress-reducing techniques, such as deep breathing exercises, yoga, or journaling.
  • Regular physical activity, such as walking or jogging, can help reduce anxiety and alleviate tremor symptoms.
  • Your doctor may recommend lifestyle changes, such as avoiding caffeine, getting enough sleep, and staying hydrated, to help manage tremors.
  • Maintain regular follow-up appointments with your doctor to monitor tremor symptoms and adjust treatment plans as needed.

Directions for Use

  • Prothidep-50 Tablet can be taken with or without food, as advised by your doctor.
  • It is usually taken once daily at bedtime. However, your doctor may adjust the dose and duration of Prothidep-50 Tablet based on your medical condition.
  • Swallow Prothidep-50 Tablet as a whole with a glass of water.
  • Do not crush, break, or chew it.

How Prothidep-50 Tablet Works

Prothidep-50 Tablet contains dothiepin, which works by adjusting the levels of natural chemical messengers in the brain called neurotransmitters. Specifically, it targets serotonin and norepinephrine, which are responsible for regulating your mood, sleep, and emotional balance. In people with depression, these chemicals are often in low supply or are reabsorbed too quickly by the brain's nerve cells. Prothidep-50 Tablet stops this rapid reabsorption, keeping a higher amount of serotonin and norepinephrine active in the brain. This continuous supply helps repair the chemical pathways, resulting in improved communication between brain cells and a gradual lifting of your mood.
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Alcohol

Unsafe

Do not consume alcohol while taking Prothidep-50 Tablet as it may cause serious side effects.

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Pregnancy

Unsafe

Prothidep-50 Tablet is not recommended for use in pregnancy. If you are pregnant, please inform your doctor before taking this medicine.

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Breast Feeding

Caution

Prothidep-50 Tablet passes in very small amounts in breast milk. However, caution is advised while taking it. If you are breastfeeding, inform your doctor before taking this medicine.

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Driving

Unsafe

Do not drive vehicles or operate machines after taking Prothidep-50 Tablet as it can make you feel drowsy.

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Liver

Caution

Limited information is available on the use of Prothidep-50 Tablet in patients with liver disease. Hence, if you have liver problems, inform your doctor before taking this medicine.

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Kidney

Caution

Limited information is available on the use of Prothidep-50 Tablet in patients with kidney disease. Hence, if you have kidney problems, inform your doctor before taking this medicine.

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Children

Unsafe

Prothidep-50 Tablet is not recommended for use in children below 12 years.

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Heart

Unsafe

Prothidep-50 Tablet is not recommended in cardiac patients due to its adverse effects. However, if prescribed extreme caution should be exercised.

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Geriatrics

Caution

Prothidep-50 Tablet should be taken with caution in geriatric patients. Please consult your doctor before using Prothidep-50 Tablet .

What if I have taken an overdose of Prothidep-50 Tablet

If you or someone else takes too much of Prothidep-50 Tablet , seek emergency medical care immediately. An overdose can cause serious complications, including rapid heartbeats, severe drowsiness, fits, or loss of consciousness.

Diet & Lifestyle Advise

  • Avoid drinking alcohol completely, as it can dangerously increase the drowsy effects of Prothidep-50 Tablet and worsen your depression.
  • To manage or prevent constipation, drink plenty of water throughout the day and gradually add more fibre-rich foods like whole grains, vegetables, and fruits to your meals.
  • If you experience a dry mouth, try chewing sugar-free gum, sucking on ice chips, or keeping a water bottle nearby for frequent sips.
  • To prevent dizziness or lightheadedness, make a habit of standing up very slowly and carefully from sitting or lying down positions.
  • Maintain a strict sleep schedule by going to bed and waking up at the same times every day to help your body adapt to the relaxing effects of the medicine.
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How Soon It Starts Working

The time required for Prothidep-50 Tablet to start to work: Prothidep-50 Tablet ideally shows its action within 3 to 4 weeks after administration. The time for which the effects of Prothidep-50 Tablet last: The effect of Prothidep-50 Tablet lasts for 11 to 29 hours.

What if you forget to take Prothidep-50 Tablet

If you miss a dose, take it as soon as you remember. If it is already close to the time for your next scheduled dose, skip the missed one and continue with your regular schedule. Never take two doses at the same time to make up for a missed dose. If you take your dose once daily at bedtime and miss it, do not take it the next morning; instead, contact your doctor or pharmacist for advice.

Storage

•Store Prothidep-50 Tablet tablets or capsules at room temperature, ideally between 15°C and 25°C. •Keep it stored safely in a high cupboard or locked box, completely out of reach of children and pets.

Drug Warnings

  • This medicine can cause significant drowsiness and blurry vision; do not drive, ride a bicycle, or operate heavy machinery until you are certain you can do so safely.
  • Be patient when starting your treatment, as it can take up to 2 to 4 weeks of daily use before you begin to feel the full antidepressant benefits of Prothidep-50 Tablet .
  • Do not stop taking Prothidep-50 Tablet suddenly, as this can trigger unpleasant withdrawal symptoms such as nausea, headaches, and sleep troubles. Your doctor will help you by gradually decreasing the dose.
  • Let your dentist or surgeon know that you are taking this medicine before any surgery, as it can interact with drugs used for numbing or anaesthesia.
  • Avoid sudden exposure to hot weather or hot baths, as this medicine can affect how your body regulates temperature, making you more prone to overheating.

Drug-Drug Interactions

verifiedApollotooltip
  • Monoamine oxidase inhibitors (MAOIs): Do not take Prothidep-50 Tablet if you are currently taking, or have taken within the past 14 days, an MAOI. Combining these medicines can cause a dangerous and rapid rise in blood pressure. Your doctor will advise you when it is safe to start treatment.
  • Medicines that cause drowsiness (e.g., sleeping pills, opioid pain relievers, antihistamines, or other antidepressants): Taking these medicines with Prothidep-50 Tablet may significantly increase drowsiness, dizziness, impaired coordination, slowed breathing, and the risk of central nervous system (CNS) depression. Your doctor may recommend closer monitoring or dose adjustments.
DosulepinParoxetine
Severe
DosulepinAmitriptyline
Severe

Drug-Drug Interactions

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DosulepinParoxetine
Severe
How does the drug interact with Prothidep-50 Tablet:
Coadministration of paroxetine and Prothidep-50 Tablet might raise serotonin hormone levels in the body, affecting the brain and nerve cells. Increased serotonin hormone can lead to severe side effects.

How to manage the interaction:
Although taking Prothidep-50 Tablet and paroxetine together can possibly result in an interaction, they can be taken together if prescribed by a doctor. However, if you experience confusion, increased heart rate, fever, excessive sweating, blurred vision, muscle spasms, nausea, vomiting, and diarrhea contact your doctor immediately. Do not discontinue any medications without first consulting your doctor.
DosulepinAmitriptyline
Severe
How does the drug interact with Prothidep-50 Tablet:
Coadministration of Amitriptyline and Prothidep-50 Tablet may increase the risk of irregular heartbeat. The risk increases in patients with a history of heart illness or electrolyte imbalance.

How to manage the interaction:
Although combining Amitriptyline with Prothidep-50 Tablet may result in an interaction, it can be used when a doctor recommends it. If you experience sudden dizziness or irregular heartbeats during therapy, contact your doctor immediately. Do not discontinue any medication without consulting a doctor.

Drug-Food Interactions

verifiedApollotooltip
  • Alcohol: Avoid drinking alcohol while taking Prothidep-50 Tablet , as it can greatly increase drowsiness, impair coordination, and increase the risk of slowed or difficult breathing.
No Drug - Food interactions found in our database. Some may be unknown. Consult your doctor for what to avoid during medication.

Drug-Food Interactions

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Habit Forming

No

Therapeutic Class

[PSYCHOTHERAPEUTICS]

FAQs

Prothidep-50 Tablet is used to treat depression. It is also used to treat disorders related to anxiety.
No, Prothidep-50 Tablet is not a muscle relaxant. It is a tricyclic antidepressant that is used for the treatment of depression and anxiety disorders.
Prothidep-50 Tablet contains ‘Dothiepin’ that works by increasing the levels of chemical messengers responsible for stabilizing and elevating the mood levels in the brain. It also stops your brain from releasing the chemicals which cause anxiety. Prothidep-50 Tablet helps improve your symptoms, such as elevating your mood and energy levels and improving sleep.
Based on your condition and symptoms, your doctor will advise the dose and duration of Prothidep-50 Tablet . Discuss with your doctor if you have any concerns.
Prothidep-50 Tablet is not recommended to treat pain. Rarely, it is advised to treat nerve pain like fibromyalgia or to prevent migraine.
No, Prothidep-50 Tablet is not a habit-forming substance. However, it can cause irritability and difficulty sleeping, especially if you stop taking it abruptly.
Prothidep-50 Tablet might cause weight gain as taking it makes you feel hungry. However, it varies from person to person, as some people might feel less hungry after taking it.
Always follow the instructions on the label or as directed by the physician for safe and effective use.
Both Prothidep-50 Tablet and amitriptyline belong to the tricyclic antidepressant class used to treat symptoms of depression. However, do not replace the Prothidep-50 Tablet with amitriptyline unless recommended by the doctor.
Prothidep-50 Tablet and doxepin belong to tricyclic antidepressant class medications used to treat symptoms of depression. However, they may have different mechanisms of action. However, do not replace the Prothidep-50 Tablet with doxepin unless recommended by the doctor.
You may take several weeks or longer to experience the full effect of Prothidep-50 Tablet . Even if you are feeling good, continue to take Prothidep-50 Tablet . Do not discontinue taking Prothidep-50 Tablet without consulting your doctor. Before quitting, your doctor will most likely recommend that you gradually reduce your dose
Prothidep-50 Tablet is associated with high mortality (death rate) in overdose. There is a low margin of safety between the maximum therapeutic dose and potentially fatal doses. So, you should strictly follow the dose and duration of Prothidep-50 Tablet as directed by the physician. Do not overdose at any cost. If you feel you or someone overdosed or experience any severe adverse events with Prothidep-50 Tablet , consult the doctor or go to the emergency room nearest hospital.
Caution should be exercised. The risk or severity of CNS depression can be increased when Diazepam is combined with Prothidep-50 Tablet .
No. Prothidep-50 Tablet is not intended to treat trigeminal neuralgia (sudden, severe facial pain. It's commonly described as a sudden shooting pain or as an electric shock to the jaw, teeth, or gums.).
No. $ name is not intended to treat burning mouth syndrome (a painful condition often described as a burning, scalding, or tingling feeling in the mouth that may occur every day for months).
Yes, Prothidep-50 Tablet is intended to treat depression. However, it is a prescription medication and should be taken only if the doctor prescribes it to you.
No. Prothidep-50 Tablet is not intended to treat IBS (irritable bowel syndrome). Prothidep-50 Tablet is a tricyclic antidepressant medication used to treat depression.
It is not intended for insomnia with depression alone. However, your doctor may suggest Prothidep-50 Tablet to treat insomnia with depression in some cases. Please consult your doctor for personalized guidance.
Prothidep-50 Tablet can change the way your nerves receive pain signals. This can help with some kinds of nerve pain, including fibromyalgia. However, it should only be taken as prescribed by the doctor.
Prothidep-50 Tablet is sometimes used to treat some types of nerve pain, such as fibromyalgia, or to prevent migraine. But it's not recommended or officially approved for pain relief.
No, you should avoid alcohol completely while taking this medicine. Alcohol can significantly increase the drowsiness and dizziness caused by Prothidep-50 Tablet , and it can also make your depression worse. Talk to your doctor.
Feeling sleepy is a common side effect, especially when you first start taking the medicine. Taking your dose in the evening or at bedtime can help. Avoid driving or operating machinery if you feel drowsy. Talk to your doctor.
No, you should never stop taking this medicine suddenly on your own. Doing so can cause withdrawal symptoms like nausea, headaches, and irritability, and your depression could return. Your doctor will help you stop safely by gradually decreasing your dose. Talk to your doctor.
This medicine is generally not recommended during pregnancy or breastfeeding unless your doctor decides the benefits outweigh the risks. Taking it late in pregnancy may affect the newborn baby. Always talk to your doctor.
In some cases, this medicine can affect your heart rate or rhythm, especially if you already have a heart condition or are taking other medications. Your doctor may want to check your heart before or during your treatment. If you feel a fast or irregular heartbeat, talk to your doctor.

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While we strive to provide complete, accurate, and expert-reviewed content on our 'Platform', we make no warranties or representations and disclaim all responsibility and liability for the completeness, accuracy, or reliability of the aforementioned content. The content on our platform is for informative purposes only, and may not cover all clinical/non-clinical aspects. Reliance on any information and subsequent action or inaction is solely at the user's risk, and we do not assume any responsibility for the same. The content on the Platform should not be considered or used as a substitute for professional and qualified medical advice. Please consult your doctor for any query pertaining to medicines, tests and/or diseases, as we support, and do not replace the doctor-patient relationship.

Country of origin

India

Manufacturer/Marketer address

S Janatha Rd, Kathrikadavu, Palarivattom, Ernakulam, Kerala 682025, India
Other Info - PRO2935

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